Published in PLoS One on November 21, 2012
Ezrin Peptide (HEP-1) for Treatment of Coronavirus Disease (COVID-19) Infection | NCT04627233
Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus. MBio (2014) 2.50
Ezrin is a component of the HIV-1 virological presynapse and contributes to the inhibition of cell-cell fusion. J Virol (2014) 0.88
Murine Leukemia Virus (MLV)-based Coronavirus Spike-pseudotyped Particle Production and Infection. Bio Protoc (2016) 0.76
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med (2003) 29.55
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science (1996) 28.95
Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med (2003) 27.97
Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet (2003) 24.78
Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes. Virology (1995) 14.30
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol (1997) 12.11
Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Nat Genet (1997) 9.60
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature (2003) 8.77
Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome. Lancet (2003) 6.52
Organizing the cell cortex: the role of ERM proteins. Nat Rev Mol Cell Biol (2010) 5.05
Protein interaction mapping: a Drosophila case study. Genome Res (2005) 4.15
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proc Natl Acad Sci U S A (2005) 4.07
Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker. J Cell Biol (1993) 3.96
Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J Cell Biol (1998) 3.39
Coronavirus diversity, phylogeny and interspecies jumping. Exp Biol Med (Maywood) (2009) 3.27
Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J Cell Biol (2004) 3.03
Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry. Proc Natl Acad Sci U S A (2004) 3.03
The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor. Immunity (2010) 2.75
Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells. J Cell Biol (1997) 2.51
Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J (2000) 2.49
Coronavirus avian infectious bronchitis virus. Vet Res (2007) 2.29
Entry of the two infectious forms of vaccinia virus at the plasma membane is signaling-dependent for the IMV but not the EEV. Mol Biol Cell (2000) 2.16
Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection. J Virol (2002) 2.11
ERM proteins in epithelial cell organization and functions. Biochim Biophys Acta (2006) 1.80
Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis. J Virol (2005) 1.76
Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex. EMBO J (2003) 1.70
Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells. EMBO J (2006) 1.64
The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors. Proc Natl Acad Sci U S A (2006) 1.64
The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation. Immunity (2001) 1.61
Hemagglutinin pseudotyped lentiviral particles: characterization of a new method for avian H5N1 influenza sero-diagnosis. J Clin Virol (2007) 1.58
Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide. J Virol (2008) 1.47
Expression cloning of functional receptor used by SARS coronavirus. Biochem Biophys Res Commun (2004) 1.44
Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions. J Biol Chem (2002) 1.41
Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse. EMBO J (2010) 1.40
Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits. J Virol (2012) 1.39
Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2. J Virol (2004) 1.36
Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes. J Cell Sci (2008) 1.35
The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain. J Cell Sci (2004) 1.31
Lipid rafts and B cell signaling. Semin Cell Dev Biol (2007) 1.29
Structural basis for CD44 recognition by ERM proteins. J Biol Chem (2008) 1.26
Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity. J Exp Med (2011) 1.25
Intracellular targeting signals contribute to localization of coronavirus spike proteins near the virus assembly site. J Virol (2004) 1.23
Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E. J Gen Virol (2005) 1.16
Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarization, immune synapse formation and in T cell receptor-mediated signaling. Front Biosci (2006) 1.08
Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro. PLoS One (2009) 1.05
The Ezrin-radixin-moesin family member ezrin regulates stable microtubule formation and retroviral infection. J Virol (2008) 1.04
The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles. J Virol (2008) 1.03
Retroviral vectors pseudotyped with severe acute respiratory syndrome coronavirus S protein. J Virol (2004) 1.03
More and More Coronaviruses: Human Coronavirus HKU1. Viruses (2009) 1.03
Intracellular curvature-generating proteins in cell-to-cell fusion. Biochem J (2011) 1.02
Molecular characterization of a novel coronavirus associated with epizootic catarrhal enteritis (ECE) in ferrets. Virology (2006) 1.01
The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis. Mol Biol Cell (2010) 1.01
Fusion-pore expansion during syncytium formation is restricted by an actin network. J Cell Sci (2008) 0.99
Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcgammaRII-dependent entry into B cells in vitro. Vaccine (2006) 0.97
Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation. Immunol Rev (2002) 0.95
Palmitoylation of the cysteine-rich endodomain of the SARS-coronavirus spike glycoprotein is important for spike-mediated cell fusion. Virology (2006) 0.93
Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH- and cysteine protease-independent FcγR pathway. J Virol (2011) 0.93
Genetic analysis of the SARS-coronavirus spike glycoprotein functional domains involved in cell-surface expression and cell-to-cell fusion. Virology (2005) 0.90
Ezrin, Radixin, and Moesin (ERM) proteins function as pleiotropic regulators of human immunodeficiency virus type 1 infection. Virology (2008) 0.90
Glutamate receptor-mediated phosphorylation of ezrin/radixin/moesin proteins is implicated in filopodial protrusion of primary cultured hippocampal neuronal cells. J Neurochem (2010) 0.89
Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection. J Virol (2011) 0.88
SARS-CoV, but not HCoV-NL63, utilizes cathepsins to infect cells: viral entry. Adv Exp Med Biol (2006) 0.85
Ezrin-radixin-moesin family proteins are involved in parvovirus replication and spreading. J Virol (2009) 0.84
Palmitoylation of SARS-CoV S protein is necessary for partitioning into detergent-resistant membranes and cell-cell fusion but not interaction with M protein. Virology (2010) 0.80
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74
The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99
Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol (2013) 3.32
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med (2005) 2.62
Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes. Immunity (2004) 2.47
Cell-cell communication beyond connexins: the pannexin channels. Physiology (Bethesda) (2006) 2.13
Function, structure, and evolution of the RubisCO-like proteins and their RubisCO homologs. Microbiol Mol Biol Rev (2007) 1.89
Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science (2003) 1.73
Tumor-suppressive effects of pannexin 1 in C6 glioma cells. Cancer Res (2007) 1.70
Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells. Nat Cell Biol (2003) 1.66
H5N1 influenza viruses in Lao People's Democratic Republic. Emerg Infect Dis (2006) 1.64
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann Neurol (2009) 1.58
Detection of SARS coronavirus in patients with suspected SARS. Emerg Infect Dis (2004) 1.50
Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. J Am Chem Soc (2008) 1.47
Open source clinical science for emerging infections. Lancet Infect Dis (2014) 1.47
Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: a mechanism for the pathogenesis of avian influenza H5N1 infection. J Infect Dis (2008) 1.46
Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model. J Am Chem Soc (2010) 1.45
Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase. Nat Struct Mol Biol (2003) 1.45
p38 mitogen-activated protein kinase-dependent hyperinduction of tumor necrosis factor alpha expression in response to avian influenza virus H5N1. J Virol (2005) 1.45
High-resolution crystal structures and spectroscopy of native and compound I cytochrome c peroxidase. Biochemistry (2003) 1.44
Differential onset of apoptosis in influenza A virus H5N1- and H1N1-infected human blood macrophages. J Gen Virol (2007) 1.41
Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping. J Med Chem (2009) 1.37
Structural basis for novel delta-regioselective heme oxygenation in the opportunistic pathogen Pseudomonas aeruginosa. Biochemistry (2004) 1.36
An expanded multilocus sequence typing scheme for propionibacterium acnes: investigation of 'pathogenic', 'commensal' and antibiotic resistant strains. PLoS One (2012) 1.34
Pan-genome and comparative genome analyses of propionibacterium acnes reveal its genomic diversity in the healthy and diseased human skin microbiome. MBio (2013) 1.33
Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives. J Med Chem (2010) 1.31
Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks. Biochim Biophys Acta (2004) 1.31
Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. J Biol Chem (2010) 1.28
Connexin30 mutations responsible for hidrotic ectodermal dysplasia cause abnormal hemichannel activity. Hum Mol Genet (2004) 1.23
Crystallographic and single-crystal spectral analysis of the peroxidase ferryl intermediate. Biochemistry (2010) 1.23
Formation of virus-like particles from human cell lines exclusively expressing influenza neuraminidase. J Gen Virol (2010) 1.22
Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1. J Biol Chem (2002) 1.20
A novel network pharmacology approach to analyse traditional herbal formulae: the Liu-Wei-Di-Huang pill as a case study. Mol Biosyst (2014) 1.19
Holo- and apo-bound structures of bacterial periplasmic heme-binding proteins. J Biol Chem (2007) 1.18
Crystal structure and characterization of a cytochrome c peroxidase-cytochrome c site-specific cross-link. Proc Natl Acad Sci U S A (2004) 1.17
Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors. J Med Chem (2003) 1.15
Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase. J Med Chem (2011) 1.15
Structural basis for effector control and redox partner recognition in cytochrome P450. Science (2013) 1.15
Pathogenetic role of the deafness-related M34T mutation of Cx26. Hum Mol Genet (2006) 1.14
Efficient assembly and secretion of recombinant subviral particles of the four dengue serotypes using native prM and E proteins. PLoS One (2009) 1.13
Crystal structure of putidaredoxin reductase from Pseudomonas putida, the final structural component of the cytochrome P450cam monooxygenase. J Mol Biol (2004) 1.12
Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection. Proc Natl Acad Sci U S A (2014) 1.11
Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase. J Am Chem Soc (2010) 1.10
Virtual cloning, functional expression, and gating analysis of human connexin31.9. Am J Physiol Cell Physiol (2002) 1.10
Hearing loss: frequency and functional studies of the most common connexin26 alleles. Biochem Biophys Res Commun (2002) 1.09
Redox-dependent structural changes in the Azotobacter vinelandii bacterioferritin: new insights into the ferroxidase and iron transport mechanism. Biochemistry (2006) 1.09
Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation. J Biol Chem (2003) 1.09
Responses of antioxidant gene, protein and enzymes to salinity stress in two genotypes of perennial ryegrass (Lolium perenne) differing in salt tolerance. J Plant Physiol (2011) 1.08
H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44. J Virol (2007) 1.08
Coronin-1A links cytoskeleton dynamics to TCR alpha beta-induced cell signaling. PLoS One (2008) 1.07
Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. Br J Pharmacol (2011) 1.07
Cell coupling and Cx43 expression in embryonic mouse neural progenitor cells. J Cell Sci (2002) 1.05
Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro. PLoS One (2009) 1.05
Modulation of perch connexin35 hemi-channels by cyclic AMP requires a protein kinase A phosphorylation site. J Neurosci Res (2003) 1.04
Crystal structure of putidaredoxin, the [2Fe-2S] component of the P450cam monooxygenase system from Pseudomonas putida. J Mol Biol (2003) 1.02
Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK. J Biol Chem (2003) 1.02
Class II ADP-ribosylation factors are required for efficient secretion of dengue viruses. J Biol Chem (2011) 1.02
The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis. Mol Biol Cell (2010) 1.01
Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem (2012) 1.01
H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades. J Infect Dis (2011) 1.01
Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications. J Mol Biol (2003) 1.01
Integrated pathways for neutrophil recruitment and inflammation in leprosy. J Infect Dis (2010) 1.00
Structure-guided design of selective inhibitors of neuronal nitric oxide synthase. J Med Chem (2013) 1.00
A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia. Cancer Genet Cytogenet (2008) 0.99
Analysis of complete genomes of Propionibacterium acnes reveals a novel plasmid and increased pseudogenes in an acne associated strain. Biomed Res Int (2013) 0.98
Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcgammaRII-dependent entry into B cells in vitro. Vaccine (2006) 0.97
Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound. Biochemistry (2004) 0.97
Calmodulin activates neuronal nitric oxide synthase by enabling transitions between conformational states. FEBS Lett (2012) 0.96
Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase. Bioorg Med Chem Lett (2010) 0.96
PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion. Eur J Pharmacol (2011) 0.96
Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase . Biochemistry (2010) 0.96
Structural basis for isoform-selective inhibition in nitric oxide synthase. Acc Chem Res (2012) 0.96
Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase. J Med Chem (2011) 0.96
An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. J Biol Chem (2008) 0.96
Structural and biological studies on bacterial nitric oxide synthase inhibitors. Proc Natl Acad Sci U S A (2013) 0.96
Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation. Immunol Rev (2002) 0.95
Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam. Biochemistry (2004) 0.94
Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem (2010) 0.94
Single crystal structural and absorption spectral characterizations of nitric oxide synthase complexed with N(omega)-hydroxy-L-arginine and diatomic ligands. Biochemistry (2009) 0.93
Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments. Biochem Biophys Res Commun (2004) 0.93
Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH- and cysteine protease-independent FcγR pathway. J Virol (2011) 0.93
Preliminary characterization and crystal structure of a thermostable cytochrome P450 from Thermus thermophilus. J Biol Chem (2002) 0.92
Hepatitis C virus IRES efficiency is unaffected by the genomic RNA 3'NTR even in the presence of viral structural or non-structural proteins. J Gen Virol (2003) 0.92
Phylogenomic analysis of the Chlamydomonas genome unmasks proteins potentially involved in photosynthetic function and regulation. Photosynth Res (2010) 0.92
Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina. J Biol Chem (2003) 0.91
Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations. J Am Chem Soc (2012) 0.91
Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency. J Am Chem Soc (2010) 0.91
Structure-based hypothesis on the activation of the CO-sensing transcription factor CooA. Acta Crystallogr D Biol Crystallogr (2007) 0.91
Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors. J Med Chem (2009) 0.91
Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water. J Med Chem (2007) 0.91
Crystal structure of the Leishmania major peroxidase-cytochrome c complex. Proc Natl Acad Sci U S A (2012) 0.90
In vivo evidence for the involvement of the carboxy terminal domain in assembling connexin 36 at the electrical synapse. Mol Cell Neurosci (2010) 0.90
Two gastroenteritis outbreaks caused by GII Noroviruses: host susceptibility and HBGA phenotypes. PLoS One (2013) 0.89
A single residue substitution in the receptor-binding domain of H5N1 hemagglutinin is critical for packaging into pseudotyped lentiviral particles. PLoS One (2012) 0.89