An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes.

PubWeight™: 5.74‹?› | Rank: Top 1%

🔗 View Article (PMC 231272)

Published in Mol Cell Biol on June 01, 1996

Authors

G N Filippova1, S Fagerlie, E M Klenova, C Myers, Y Dehner, G Goodwin, P E Neiman, S J Collins, V V Lobanenkov

Author Affiliations

1: Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.

Articles citing this

(truncated to the top 100)

Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66

CTCF: master weaver of the genome. Cell (2009) 15.09

Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data. Nucleic Acids Res (2008) 8.89

A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell (2014) 8.79

Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14

Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41

Emerging landscape of oncogenic signatures across human cancers. Nat Genet (2013) 6.48

Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution. Cell (2011) 6.29

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. Nature (2011) 5.50

The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome. PLoS Genet (2008) 4.91

High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells. Genome Res (2010) 4.69

Spatial organization of gene expression: the active chromatin hub. Chromosome Res (2003) 3.91

Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages. Cell (2012) 3.48

Transcriptional dysregulation in NIPBL and cohesin mutant human cells. PLoS Biol (2009) 2.89

Structural and functional conservation at the boundaries of the chicken beta-globin domain. EMBO J (2000) 2.88

CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep (2005) 2.80

The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide. Genome Res (2004) 2.78

Conserved CTCF insulator elements flank the mouse and human beta-globin loci. Mol Cell Biol (2002) 2.69

BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A (2002) 2.62

Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster. EMBO J (2009) 2.56

Widespread plasticity in CTCF occupancy linked to DNA methylation. Genome Res (2012) 2.45

Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF. Mol Cell Biol (1997) 2.37

Adaptive evolution in zinc finger transcription factors. PLoS Genet (2009) 2.35

Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. Mol Cell Biol (2004) 2.24

CTCF genomic binding sites in Drosophila and the organisation of the bithorax complex. PLoS Genet (2007) 2.12

Functional analysis of transcription factor binding sites in human promoters. Genome Biol (2012) 2.12

Characterization and predictive discovery of evolutionarily conserved mammalian alternative promoters. Genome Res (2007) 2.12

CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide. Mol Cell Biol (2007) 2.07

Comparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture. Cell Rep (2015) 2.00

A genome-wide map of CTCF multivalency redefines the CTCF code. Cell Rep (2013) 1.92

Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA. Genes Dev (2010) 1.88

Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing. Nucleic Acids Res (2009) 1.88

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol (2013) 1.88

Regulation of the human catalytic subunit of telomerase (hTERT). Gene (2012) 1.81

The c-myc insulator element and matrix attachment regions define the c-myc chromosomal domain. Mol Cell Biol (2003) 1.77

Transcriptional repression by the insulator protein CTCF involves histone deacetylases. Nucleic Acids Res (2000) 1.74

The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression. EMBO J (2006) 1.73

Widespread site-dependent buffering of human regulatory polymorphism. PLoS Genet (2012) 1.72

Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites. Mol Cell Biol (2005) 1.66

How cohesin and CTCF cooperate in regulating gene expression. Chromosome Res (2009) 1.62

CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53. Genes Dev (2014) 1.62

Cancer epigenetics takes center stage. Proc Natl Acad Sci U S A (2001) 1.60

Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene. Nucleic Acids Res (2007) 1.59

Differential effect of zinc finger deletions on the binding of CTCF to the promoter of the amyloid precursor protein gene. Nucleic Acids Res (2000) 1.59

Positional enhancer-blocking activity of the chicken beta-globin insulator in transiently transfected cells. Proc Natl Acad Sci U S A (1999) 1.56

Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells. Genome Res (2011) 1.53

Drosophila CTCF tandemly aligns with other insulator proteins at the borders of H3K27me3 domains. Genome Res (2012) 1.52

Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control region. Mol Cell Biol (2002) 1.49

Thyroid hormone-regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor. EMBO J (2003) 1.49

Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF. Mol Cell Biol (2001) 1.48

Rasgrf1 imprinting is regulated by a CTCF-dependent methylation-sensitive enhancer blocker. Mol Cell Biol (2005) 1.43

Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1. Mol Cell Biol (2007) 1.40

DXZ4 chromatin adopts an opposing conformation to that of the surrounding chromosome and acquires a novel inactive X-specific role involving CTCF and antisense transcripts. Genome Res (2008) 1.40

DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. J Exp Med (2010) 1.39

CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region. Mol Cell Biol (2007) 1.38

CTCF binding site classes exhibit distinct evolutionary, genomic, epigenomic and transcriptomic features. Genome Biol (2009) 1.38

The CTCF insulator protein is posttranslationally modified by SUMO. Mol Cell Biol (2008) 1.37

Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase. Nucleic Acids Res (2006) 1.36

Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development (2008) 1.32

CTCF: the protein, the binding partners, the binding sites and their chromatin loops. Philos Trans R Soc Lond B Biol Sci (2013) 1.32

Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes. Nat Struct Mol Biol (2011) 1.31

CTCF binds the proximal exonic region of hTERT and inhibits its transcription. Nucleic Acids Res (2005) 1.27

CTCF controls expression and chromatin architecture of the human major histocompatibility complex class II locus. Mol Cell Biol (2010) 1.26

Molecular weight abnormalities of the CTCF transcription factor: CTCF migrates aberrantly in SDS-PAGE and the size of the expressed protein is affected by the UTRs and sequences within the coding region of the CTCF gene. Nucleic Acids Res (1997) 1.26

Genome-wide studies of CCCTC-binding factor (CTCF) and cohesin provide insight into chromatin structure and regulation. J Biol Chem (2012) 1.25

Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol Med (2013) 1.23

Comprehensive identification and annotation of cell type-specific and ubiquitous CTCF-binding sites in the human genome. PLoS One (2012) 1.23

CTCF functions as a critical regulator of cell-cycle arrest and death after ligation of the B cell receptor on immature B cells. Proc Natl Acad Sci U S A (2003) 1.23

β-globin gene transfer to human bone marrow for sickle cell disease. J Clin Invest (2013) 1.22

Nuclear organization and genome function. Annu Rev Cell Dev Biol (2012) 1.21

You Don't Muck with MYC. Genes Cancer (2010) 1.20

MECP2 promoter methylation and X chromosome inactivation in autism. Autism Res (2008) 1.19

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1). Mol Cancer Ther (2009) 1.19

Adding fingers to an engineered zinc finger nuclease can reduce activity. Biochemistry (2011) 1.17

Regulation of major histocompatibility complex class II genes. Curr Opin Immunol (2010) 1.15

EBV latency types adopt alternative chromatin conformations. PLoS Pathog (2011) 1.15

The generation of zinc finger proteins by modular assembly. Methods Mol Biol (2010) 1.15

Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation. Mol Cell Biol (2009) 1.14

The evolution of epigenetic regulators CTCF and BORIS/CTCFL in amniotes. PLoS Genet (2008) 1.14

CTCFBSDB 2.0: a database for CTCF-binding sites and genome organization. Nucleic Acids Res (2012) 1.13

An Overview of Genome Organization and How We Got There: from FISH to Hi-C. Microbiol Mol Biol Rev (2015) 1.10

CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia. PLoS Genet (2010) 1.07

Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet (2013) 1.07

Identification of CTCF as a master regulator of the clustered protocadherin genes. Nucleic Acids Res (2011) 1.07

RNA-mediated toxicity in neurodegenerative disease. Mol Cell Neurosci (2012) 1.07

Targeted deletion of multiple CTCF-binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expression. PLoS One (2009) 1.05

Chromatin loops, gene positioning, and gene expression. Front Genet (2012) 1.03

Roles of chromatin insulator proteins in higher-order chromatin organization and transcription regulation. Nucleus (2011) 1.02

Epigenetic regulation of EBV persistence and oncogenesis. Semin Cancer Biol (2014) 1.02

Evolutionary diversification of SPANX-N sperm protein gene structure and expression. PLoS One (2007) 1.02

Genome-wide analysis of the relationships between DNaseI HS, histone modifications and gene expression reveals distinct modes of chromatin domains. Nucleic Acids Res (2011) 1.01

Chromatin insulators: a role in nuclear organization and gene expression. Adv Cancer Res (2011) 1.01

The CCCTC-binding factor (CTCF) of Drosophila contributes to the regulation of the ribosomal DNA and nucleolar stability. PLoS One (2011) 1.00

Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis. Exp Cell Res (2007) 0.99

CTCF: making the right connections. Genes Dev (2016) 0.97

The CTCF insulator protein forms an unusual DNA structure. BMC Mol Biol (2010) 0.96

A co-ordinated interaction between CTCF and ER in breast cancer cells. BMC Genomics (2011) 0.96

Expression of a testis-specific form of Gal3st1 (CST), a gene essential for spermatogenesis, is regulated by the CTCF paralogous gene BORIS. Mol Cell Biol (2010) 0.96

Repression of c-Myc and inhibition of G1 exit in cells conditionally overexpressing p300 that is not dependent on its histone acetyltransferase activity. Proc Natl Acad Sci U S A (2003) 0.96

Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex. Elife (2012) 0.95

Articles cited by this

Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res (1987) 15.65

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture. Nature (1977) 12.57

A simple phase-extraction assay for chloramphenicol acyltransferase activity. Gene (1988) 8.40

A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Res (1989) 8.06

A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. Cell (1989) 7.42

myc function and regulation. Annu Rev Biochem (1992) 5.33

Control of c-myc regulation in normal and neoplastic cells. Adv Cancer Res (1991) 4.60

The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region. Genes Dev (1992) 4.20

A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene. Oncogene (1990) 3.96

GAL4 activates gene expression in mammalian cells. Cell (1988) 3.81

Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell (1988) 3.75

Hold back of RNA polymerase II at the transcription start site mediates down-regulation of c-myc in vivo. EMBO J (1992) 3.15

CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms. Mol Cell Biol (1993) 3.08

Mammalian ets-1 and ets-2 genes encode highly conserved proteins. Proc Natl Acad Sci U S A (1988) 3.01

Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP. Genes Dev (1993) 2.96

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Mol Cell Biol (1991) 2.88

The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature (1988) 2.87

Evidence of changes in protease sensitivity and subunit exchange rate on DNA binding by C/EBP. Science (1990) 1.95

A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. J Biol Chem (1991) 1.83

c-Myc and apoptosis. Biochim Biophys Acta (1995) 1.80

Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein. Mol Cell Biol (1991) 1.77

Stereochemical basis of DNA recognition by Zn fingers. Nucleic Acids Res (1994) 1.65

Target sequences for cis-acting regulation within the dual promoter of the human c-myc gene. Mol Cell Biol (1987) 1.63

Characterization of the DNA-binding properties of the myeloid zinc finger protein MZF1: two independent DNA-binding domains recognize two DNA consensus sequences with a common G-rich core. Mol Cell Biol (1994) 1.60

Zinc finger proteins: what we know and what we would like to know. Mech Dev (1991) 1.57

Cloning and analysis of the entire Escherichia coli ams gene. ams is identical to hmp1 and encodes a 114 kDa protein that migrates as a 180 kDa protein. J Mol Biol (1992) 1.57

BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription. Mol Cell Biol (1994) 1.28

Sequence-specific DNA-binding proteins which interact with (G + C)-rich sequences flanking the chicken c-myc gene. Eur J Biochem (1986) 1.24

Absence of a paused transcription complex from the c-myc P2 promoter of the translocation chromosome in Burkitt's lymphoma cells: implication for the c-myc P1/P2 promoter shift. Oncogene (1993) 1.17

Activation of pausing RNA polymerases by nuclear run-on experiments. Anal Biochem (1994) 1.14

The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG. Oncogene (1994) 1.12

Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution. Proc Natl Acad Sci U S A (1990) 1.03

Proteolytic footprinting of transcription factor TFIIIA reveals different tightly binding sites for 5S RNA and 5S DNA. Mol Cell Biol (1993) 0.94

Structural analysis of the chicken max gene. Oncogene (1994) 0.92

Early down-regulation of c-myc in dimethylsulfoxide-induced mouse erythroleukemia (MEL) cells is mediated at the P1/P2 promoters. Oncogene (1993) 0.91

Transcription from the P2 promoter of human protooncogene myc is suppressed by retinoic acid through an interaction between the E2F element and its binding proteins. Cell Growth Differ (1994) 0.88

Articles by these authors

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture. Nature (1977) 12.57

Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation (1974) 10.91

Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. Proc Natl Acad Sci U S A (1978) 9.59

Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group. J Clin Oncol (1999) 9.22

Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Natl Acad Sci U S A (1980) 6.65

Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr Biol (2000) 5.34

Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease. Brain (2009) 5.03

Interactive memory systems in the human brain. Nature (2001) 4.53

Levels of c-myc oncogene mRNA are invariant throughout the cell cycle. Nature (1985) 4.35

Bone-marrow transplantation (second of two parts). N Engl J Med (1975) 4.11

A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene. Oncogene (1990) 3.96

Positive selection of a gene family during the emergence of humans and African apes. Nature (2001) 3.68

Expression of the c-myb proto-oncogene during cellular proliferation. Nature (1986) 3.45

Bone-marrow transplantation (first of two parts). N Engl J Med (1975) 3.33

Iatrogenic Creutzfeldt-Jakob disease at the millennium. Neurology (2000) 3.23

CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms. Mol Cell Biol (1993) 3.08

Measurement of endogenous leukosis virus nucleotide sequences in the DNA of normal avian embryos by RNA-DNA hybridization. Virology (1973) 2.94

CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus. Nat Genet (2001) 2.93

Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide. J Exp Med (1979) 2.80

Nucleotide sequence relationships of avian RNA tumor viruses: measurement of the deletion in a transformation-defective mutant of Rous sarcoma virus. J Virol (1974) 2.61

Human midbrain sensitivity to cognitive feedback and uncertainty during classification learning. J Neurophysiol (2004) 2.41

Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF. Mol Cell Biol (1997) 2.37

One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation. Blood (1977) 2.36

GATAAG; a cis-control region binding an erythroid-specific nuclear factor with a role in globin and non-globin gene expression. Nucleic Acids Res (1989) 2.31

Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid. Blood (1981) 2.16

Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment. Cell (1987) 2.15

A prospective analysis interstitial pneumonia and opportunistic viral infection among recipients of allogeneic bone marrow grafts. J Infect Dis (1977) 2.10

Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562. Proc Natl Acad Sci U S A (1983) 2.08

Two distinct candidate transforming genes of lymphoid leukosis virus-induced neoplasms. Nature (1981) 2.03

Rous sarcoma virus nucleotide sequences in cellular DNA: measurement by RNA-DNA hybridization. Science (1972) 2.00

Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration. Proc Natl Acad Sci U S A (1985) 1.94

Transforming genes of neoplasms induced by avian lymphoid leukosis viruses. Nature (1980) 1.90

Molecular cloning and nucleotide sequence of a transforming gene detected by transfection of chicken B-cell lymphoma DNA. Nature (1983) 1.88

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB. J Exp Med (1996) 1.87

A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. J Biol Chem (1991) 1.83

Lithium for maintenance treatment of mood disorders. Cochrane Database Syst Rev (2001) 1.82

A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers. Genes Chromosomes Cancer (1998) 1.79

Leukaemic transformation of engrafted human marrow cells in vivo. Lancet (1971) 1.79

Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site. Cancer Res (2001) 1.69

11C-PiB PET studies in typical sporadic Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry (2009) 1.66

Neonatal megaloblastic anemia due to inherited transcobalamin II deficiency in two siblings. N Engl J Med (1971) 1.65

A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage. Proc Natl Acad Sci U S A (1993) 1.63

Negative transcriptional regulation mediated by thyroid hormone response element 144 requires binding of the multivalent factor CTCF to a novel target DNA sequence. J Biol Chem (1999) 1.62

Controlled trial of lamotrigine (Lamictal) for refractory partial seizures. Epilepsia (1989) 1.62

MRI lesion profiles in sporadic Creutzfeldt-Jakob disease. Neurology (2009) 1.61

Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL-60) by componuds which induce differentiation of murine leukemia cells. Int J Cancer (1980) 1.61

Infection of chick cells by subgroup E viruses. Virology (1976) 1.60

The effect of alterations in myc gene expression on B cell development in the bursa of Fabricius. Cell (1987) 1.57

From laminin to lamin: regulation of tissue-specific gene expression by the ECM. Trends Cell Biol (1995) 1.52

Base-sequence relationships between avian ribonucleic acid endogenous and sarcoma viruses assayed by competitive ribonucleic acid-deoxyribonucleic acid hybridization. Biochemistry (1974) 1.50

Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF. Mol Cell Biol (2001) 1.48

Lithium for maintenance treatment of mood disorders. Cochrane Database Syst Rev (2001) 1.46

Conserved synteny between the chicken Z sex chromosome and human chromosome 9 includes the male regulatory gene DMRT1: a comparative (re)view on avian sex determination. Cytogenet Cell Genet (2000) 1.45

A mutated retinoic acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line. Genes Dev (1992) 1.44

Marrow transplantation for acute nonlymphoblastic leukemia in first remission. N Engl J Med (1979) 1.44

Altered transcription of the c-abl oncogene in K-562 and other chronic myelogenous leukemia cells. Science (1984) 1.44

Characterisation of chicken erythroid nuclear proteins which bind to the nuclease hypersensitive regions upstream of the beta A- and beta H-globin genes. Nucleic Acids Res (1986) 1.43

Cell growth inhibition by the multifunctional multivalent zinc-finger factor CTCF. Cancer Res (2001) 1.42

Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J Natl Cancer Inst (1992) 1.41

All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells. Blood (2000) 1.39

Aplastic anaemia treated by marrow transplantation. Lancet (1972) 1.39

Organization of shared and unshared sequences in the genomes of chicken endogenous and sarcoma viruses. Cell (1977) 1.36

Replacement of serum by insulin and transferrin supports growth and differentiation of the human promyelocytic cell line, HL-60. Exp Cell Res (1980) 1.35

Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. Hum Mol Genet (1999) 1.31

Expression of retinoic acid receptor beta mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells. Cell Growth Differ (1995) 1.30

Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor. Nat Med (1996) 1.28

A randomized controlled trial assessing the prevention of doxorubicin cardiomyopathy by N-acetylcysteine. Semin Oncol (1983) 1.27

Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF. J Biol Chem (2000) 1.26

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126. Biochemistry (2001) 1.26

Molecular weight abnormalities of the CTCF transcription factor: CTCF migrates aberrantly in SDS-PAGE and the size of the expressed protein is affected by the UTRs and sequences within the coding region of the CTCF gene. Nucleic Acids Res (1997) 1.26

A monoclonal immunoblastic sarcoma in donor cells bearing Epstein-Barr virus genomes following allogeneic marrow grafting for acute lymphoblastic leukemia. Blood (1982) 1.25

All-trans retinoic acid delays the differentiation of primitive hematopoietic precursors (lin-c-kit+Sca-1(+)) while enhancing the terminal maturation of committed granulocyte/monocyte progenitors. Blood (1999) 1.24

Sequence-specific DNA-binding proteins which interact with (G + C)-rich sequences flanking the chicken c-myc gene. Eur J Biochem (1986) 1.24

The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors. Mol Cell Biol (2000) 1.23

Toxicity and efficacy of human leukocyte interferon for treatment of cytomegalovirus pneumonia after marrow transplantation. J Infect Dis (1980) 1.22

Chicken leukosis virus genome sequences in DNA from normal chick cells and virus-induced bursal lymphomas. Cell (1975) 1.22

Bone-marrow transplantation for hematologic neoplasia in 16 patients with identical twins. N Engl J Med (1974) 1.22

Activities of L-dopa decarboxylase and diamine oxidase (histaminase) in human lung cancers and decarboxylase as a marker for small (oat) cell cancer in cell culture. Cancer Res (1980) 1.21

A novel T-cell protein which recognizes a palindromic sequence in the negative regulatory element of the human immunodeficiency virus long terminal repeat. J Virol (1990) 1.21

Interactions of the CelS binding ligand with various receptor domains of the Clostridium thermocellum cellulosomal scaffolding protein, CipA. J Bacteriol (1996) 1.20

Measurement of RD114 virus nucleotide sequences in feline cellular DNA. Nat New Biol (1973) 1.17

Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. Oncogene (1996) 1.17

A phase I-II trial of lovastatin for anaplastic astrocytoma and glioblastoma multiforme. Am J Clin Oncol (1998) 1.17

Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity. Blood (1992) 1.16

Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats. Toxicol Sci (1999) 1.14

Inhibition of retroviral replication by anti-sense RNA. Mol Cell Biol (1986) 1.13

The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. Hum Mol Genet (1997) 1.13

Folate for depressive disorders. Cochrane Database Syst Rev (2003) 1.11

PRH represses transcription in hematopoietic cells by at least two independent mechanisms. J Biol Chem (2000) 1.11