Clinical significance and functional studies of myeloid-derived suppressor cells in chronic hepatitis C patients.

PubWeight™: 1.02‹?› | Rank: Top 15%

🔗 View Article (PMID 23354838)

Published in J Clin Immunol on January 26, 2013

Authors

Weiping Cai1, Aiping Qin, Pengle Guo, Dehong Yan, Fengyu Hu, Qiong Yang, Min Xu, Yongshui Fu, Jie Zhou, Xiaoping Tang

Author Affiliations

1: Department of Infectious Diseases, the Affiliated Guangzhou No.8 People's Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Guangzhou No.8 People's Hospitall, Guangzhou, China, 510080.

Articles citing this

Reciprocal relationship between myeloid-derived suppressor cells and T cells. J Immunol (2013) 1.34

Myeloid-derived suppressor cells: the dark knight or the joker in viral infections? Immunol Rev (2013) 1.05

Myeloid-derived suppressor cells are associated with viral persistence and downregulation of TCR ζ chain expression on CD8(+) T cells in chronic hepatitis C patients. Mol Cells (2014) 0.91

Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease. Age (Dordr) (2014) 0.81

Expansion of myeloid-derived suppressor cells promotes differentiation of regulatory T cells in HIV-1+ individuals. AIDS (2016) 0.81

Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1. J Immunol (2016) 0.80

Lack of significant elevation of myeloid-derived suppressor cells in peripheral blood of chronically hepatitis C virus-infected individuals. J Virol (2014) 0.80

The role of myeloid cell activation and arginine metabolism in the pathogenesis of virus-induced diseases. Front Immunol (2014) 0.79

Kinetics of human myeloid-derived suppressor cells after blood draw. J Transl Med (2016) 0.79

Expansion of myeloid-derived suppressor cells from peripheral blood decreases after 4-week antiviral treatment in patients with chronic hepatitis C. Int J Clin Exp Med (2014) 0.79

Myeloid-Derived Suppressor Cells in Bacterial Infections. Front Cell Infect Microbiol (2016) 0.78

Analysis of monocytic and granulocytic myeloid-derived suppressor cells subsets in patients with hepatitis C virus infection and their clinical significance. Biomed Res Int (2015) 0.77

Hepatitis C virus-induced myeloid-derived suppressor cells regulate T-cell differentiation and function via the signal transducer and activator of transcription 3 pathway. Immunology (2016) 0.77

The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury. Protein Cell (2014) 0.76

Emerging roles of myeloid derived suppressor cells in hepatic inflammation and fibrosis. World J Gastrointest Pathophysiol (2015) 0.76

The Role of Myeloid-Derived Suppressor Cells in Viral Infection. Viral Immunol (2017) 0.75

Decline of miR-124 in myeloid cells promotes regulatory T-cell development in hepatitis C virus infection. Immunology (2016) 0.75

Paradoxical myeloid-derived suppressor cell reduction in the bone marrow of SIV chronically infected macaques. PLoS Pathog (2017) 0.75

Articles cited by this

Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol (2009) 25.96

Global epidemiology of hepatitis C virus infection. Lancet Infect Dis (2005) 16.44

Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med (2001) 8.47

Natural history of chronic hepatitis C. Hepatology (2002) 7.70

Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res (2006) 7.02

Analysis of a successful immune response against hepatitis C virus. Immunity (1999) 6.31

Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature (2005) 5.50

Myeloid-derived suppressor cell heterogeneity and subset definition. Curr Opin Immunol (2010) 4.62

Regulatory T cells and mechanisms of immune system control. Nat Med (2004) 4.23

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest (2009) 3.80

Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood (2001) 3.66

An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology (2004) 3.18

CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress. J Immunol (2006) 3.15

Flying under the radar: the immunobiology of hepatitis C. Annu Rev Immunol (2007) 2.65

Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway. Gastroenterology (2008) 2.56

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest (2008) 2.46

Myeloid derived suppressor cells in human diseases. Int Immunopharmacol (2011) 2.43

Histological changes in HCV antibody-positive, HCV RNA-negative subjects suggest persistent virus infection. Hepatology (2008) 2.21

Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection. J Virol (2005) 2.14

Myeloid-derived suppressor cells in cancer patients: a clinical perspective. J Immunother (2012) 1.87

Systemic and intrahepatic interferon-gamma-inducible protein 10 kDa predicts the first-phase decline in hepatitis C virus RNA and overall viral response to therapy in chronic hepatitis C. Hepatology (2010) 1.61

Current standards in the treatment of chronic hepatitis C. Dtsch Arztebl Int (2012) 1.60

Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples. J Immunol Methods (2012) 1.46

Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence. J Exp Med (2012) 1.43

Notch and wingless signaling cooperate in regulation of dendritic cell differentiation. Immunity (2009) 1.37

Peripheral CXCR3-associated chemokines as biomarkers of fibrosis in chronic hepatitis C virus infection. J Infect Dis (2009) 1.36

Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species. Hepatology (2012) 1.36

Chronic progressive HIV-1 infection is associated with elevated levels of myeloid-derived suppressor cells. AIDS (2012) 1.28

Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus. Clin Exp Immunol (2011) 1.26

The importance of myeloid-derived suppressor cells in the regulation of autoimmune effector cells by a chronic contact eczema. J Immunol (2007) 1.21

Recent successes and noteworthy future prospects in the treatment of chronic hepatitis C. Clin Infect Dis (2012) 1.14

Kinetics of serum cytokines reflect changes in the severity of chronic hepatitis C presenting minimal fibrosis. J Viral Hepat (2002) 1.14

Serum HCV RNA levels correlate with histological liver damage and concur with steatosis in progression of chronic hepatitis C. Dig Dis Sci (2001) 1.11

The changing epidemiology and natural history of hepatitis C virus infection. Clin Liver Dis (2006) 1.11

Chronic immune activation in the T cell compartment of HCV/HIV-1 co-infected patients. Virulence (2010) 0.94

Cytokine--chemokine and apoptotic signatures in patients with hepatitis C. Transl Res (2007) 0.91

PD-1 expression on peripheral CD8+ TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients. Virol J (2010) 0.87

Articles by these authors

(truncated to the top 100)

Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65

Prevalence and control of diabetes in Chinese adults. JAMA (2013) 11.73

The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am J Epidemiol (2007) 9.90

Genome-scale RNAi screen for host factors required for HIV replication. Cell Host Microbe (2008) 6.24

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet (2008) 5.89

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88

New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58

Genomewide association studies of stroke. N Engl J Med (2009) 5.29

The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet (2007) 5.02

Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet (2009) 4.78

Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A (2007) 4.62

Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature (2009) 4.49

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28

A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet (2009) 4.28

The protein kinase IKKepsilon regulates energy balance in obese mice. Cell (2009) 3.93

Trends in prevalence of HIV, syphilis, hepatitis C, hepatitis B, and sexual risk behavior among men who have sex with men. Results of 3 consecutive respondent-driven sampling surveys in Beijing, 2004 through 2006. J Acquir Immune Defic Syndr (2007) 3.83

GWAF: an R package for genome-wide association analyses with family data. Bioinformatics (2009) 3.81

TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing. Brain (2010) 3.66

A pathogenic picornavirus acquires an envelope by hijacking cellular membranes. Nature (2013) 3.55

Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. J Exp Med (2004) 3.43

Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature (2008) 3.06

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04

Candidate gene association resource (CARe): design, methods, and proof of concept. Circ Cardiovasc Genet (2010) 2.91

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle (2010) 2.80

Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. Circulation (2010) 2.78

IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections. Hepatology (2015) 2.76

CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70

Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A (2007) 2.67

1-(2-Chloro-phen-yl)-2-(isopropyl-amino)ethanol. Acta Crystallogr Sect E Struct Rep Online (2009) 2.65

Nitric oxide donors: chemical activities and biological applications. Chem Rev (2002) 2.55

Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Ann Neurol (2011) 2.37

Genomewide linkage analysis to serum creatinine, GFR, and creatinine clearance in a community-based population: the Framingham Heart Study. J Am Soc Nephrol (2004) 2.36

Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A (2004) 2.30

Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans. J Clin Invest (2003) 2.27

Transforming the untransformable: application of direct transformation to manipulate genetically Staphylococcus aureus and Staphylococcus epidermidis. MBio (2012) 2.26

Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion. Cancer Res (2007) 2.25

Consumption of whole grains and cereal fiber and total and cause-specific mortality: prospective analysis of 367,442 individuals. BMC Med (2015) 2.22

Crystal structure and association behaviour of the GluR2 amino-terminal domain. EMBO J (2009) 2.19

Description of the Framingham Heart Study data for Genetic Analysis Workshop 13. BMC Genet (2003) 2.17

Elevated ATPase activity of KaiC applies a circadian checkpoint on cell division in Synechococcus elongatus. Cell (2010) 2.15

Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases. Mol Biol Cell (2003) 2.11

Heritable stochastic switching revealed by single-cell genealogy. PLoS Biol (2007) 2.11

Uromodulin levels associate with a common UMOD variant and risk for incident CKD. J Am Soc Nephrol (2009) 2.10

Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study. Acta Diabetol (2010) 2.01

Impact of the Serum Uric Acid Level on Subclinical Atherosclerosis in Middle-aged and Elderly Chinese. J Atheroscler Thromb (2015) 2.00

IgE⁺ memory B cells and plasma cells generated through a germinal-center pathway. Nat Immunol (2012) 2.00

Hepatitis C virus genotype distribution in China: predominance of closely related subtype 1b isolates and existence of new genotype 6 variants. J Med Virol (2005) 1.98

Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet (2010) 1.97

microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci U S A (2010) 1.97

Genome-wide association meta-analysis for total serum bilirubin levels. Hum Mol Genet (2009) 1.96

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol (2011) 1.95

Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance. Nat Genet (2013) 1.95

Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. PLoS Genet (2011) 1.94

Study design for genetic analysis in the Jackson Heart Study. Ethn Dis (2005) 1.93

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci U S A (2003) 1.92

Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. PLoS Genet (2010) 1.91

p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proc Natl Acad Sci U S A (2009) 1.89

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1). J Med Chem (2004) 1.87

RNA-seq differential expression studies: more sequence or more replication? Bioinformatics (2013) 1.87

Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. Am J Pathol (2009) 1.87

Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia. Pediatr Blood Cancer (2008) 1.85

Use of erythrocyte sedimentation rate and C-reactive protein level to diagnose infection before revision total knee arthroplasty. A prospective evaluation. J Bone Joint Surg Am (2007) 1.84

HIF-1α and HIF-2α correlate with migration and invasion in gastric cancer. Cancer Biol Ther (2010) 1.83

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82

Heritability of age at natural menopause in the Framingham Heart Study. J Clin Endocrinol Metab (2005) 1.80

CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. Circulation (2005) 1.76

OsPTF1, a novel transcription factor involved in tolerance to phosphate starvation in rice. Plant Physiol (2005) 1.76

Relationship of urinary bisphenol A concentration to risk for prevalent type 2 diabetes in Chinese adults: a cross-sectional analysis. Ann Intern Med (2011) 1.74

Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J (2003) 1.73

Modeling the cell cycle: why do certain circuits oscillate? Cell (2011) 1.72

The MYH9/APOL1 region and chronic kidney disease in European-Americans. Hum Mol Genet (2011) 1.71

Cross-sectional and longitudinal association of serum alanine aminotransaminase and γ-glutamyltransferase with metabolic syndrome in middle-aged and elderly Chinese people. J Diabetes (2011) 1.71

Transferability and fine-mapping of genome-wide associated loci for adult height across human populations. PLoS One (2009) 1.68

Further understanding human disease genes by comparing with housekeeping genes and other genes. BMC Genomics (2006) 1.68

Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet (2012) 1.68

Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD. PLoS Genet (2011) 1.68

Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering. Biomaterials (2003) 1.67

Physical properties of alginate hydrogels and their effects on in vitro follicle development. Biomaterials (2007) 1.66

A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma. Cancer Res (2004) 1.65

Multiple loci are associated with white blood cell phenotypes. PLoS Genet (2011) 1.65

Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease. Circ Cardiovasc Genet (2010) 1.64

Apoptosis and mitochondrial dysfunction in human chondrocytes following exposure to lidocaine, bupivacaine, and ropivacaine. J Bone Joint Surg Am (2010) 1.63

Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. J Clin Endocrinol Metab (2011) 1.63

N-[2-(2-Chloro-phen-yl)-2-hydroxy-ethyl]propan-2-aminium hemioxalate. Acta Crystallogr Sect E Struct Rep Online (2009) 1.62

Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science (2012) 1.62

DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine (2008) 1.60

Identification and subcellular localization of the RP1 protein in human and mouse photoreceptors. Invest Ophthalmol Vis Sci (2002) 1.58

Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox. Proc Natl Acad Sci U S A (2004) 1.56

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem (2003) 1.54

Xanthomonas campestris cell-cell communication involves a putative nucleotide receptor protein Clp and a hierarchical signalling network. Mol Microbiol (2007) 1.53

Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. Hum Mol Genet (2010) 1.53

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis. Chem Soc Rev (2012) 1.53

Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest (2012) 1.52

Distribution and characterization of over 1000 T-DNA tags in rice genome. Plant J (2003) 1.50

Biliary tract injury caused by different relative warm ischemia time in liver transplantation in rats. Hepatobiliary Pancreat Dis Int (2009) 1.50

Rapid, simple, and high-throughput antimicrobial susceptibility testing and antibiotics screening. Angew Chem Int Ed Engl (2011) 1.50

LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 1.50

Facile synthesis of spiroisoquinolines based on photocycloaddition of isoquinoline-1,3,4-trione with oxazoles. Org Biomol Chem (2011) 1.49