Published in Adv Enzymol Relat Areas Mol Biol on January 01, 1979
Crystal structure of a complex between the phosphorelay protein YPD1 and the response regulator domain of SLN1 bound to a phosphoryl analog. J Mol Biol (2007) 1.07
Quantifying the mechanism of phosphate monoester hydrolysis in aqueous solution by evaluating the relevant ab initio QM/MM free-energy surfaces. J Phys Chem B (2013) 0.95
Addressing open questions about phosphate hydrolysis pathways by careful free energy mapping. J Phys Chem B (2012) 0.92
Quantitative exploration of the molecular origin of the activation of GTPase. Proc Natl Acad Sci U S A (2013) 0.91
Proceedings of the British Pharmacological Society. 10th-12th September, 1980. Abstracts. Br J Pharmacol (1981) 0.75
ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins. Proc Natl Acad Sci U S A (1986) 5.55
Deoxynucleoside [1-thio]triphosphates prevent proofreading during in vitro DNA synthesis. Proc Natl Acad Sci U S A (1981) 4.14
Spinach leaf phosphoenolpyruvate carboxylase: purification, properties, and kinetic studies. Arch Biochem Biophys (1974) 2.46
Zinc in DNA polymerases. Biochem Biophys Res Commun (1971) 2.15
On the fidelity of DNA replication: manganese mutagenesis in vitro. Biochemistry (1985) 1.90
Aspects of enzyme mechanisms studies by nuclear spin relazation induced by paramagnetic probes. Adv Enzymol Relat Areas Mol Biol (1970) 1.90
Kinetic and ultraviolet spectroscopic studies of active-site mutants of delta 5-3-ketosteroid isomerase. Biochemistry (1989) 1.85
Kinetic and magnetic resonance studies of the pyruvate kinase reaction. II. Complexes of enzyme, metal, and substrates. J Biol Chem (1966) 1.79
Environments and mechanistic roles of the tyrosine residues of delta 5-3-ketosteroid isomerase. Biochemistry (1993) 1.53
Kinetic and magnetic resonance studies of active-site mutants of staphylococcal nuclease: factors contributing to catalysis. Biochemistry (1987) 1.46
NMR docking of a substrate into the X-ray structure of staphylococcal nuclease. Proteins (1992) 1.46
Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions. Biochemistry (1994) 1.46
Vaccinia DNA topoisomerase I: evidence supporting a free rotation mechanism for DNA supercoil relaxation. Biochemistry (1997) 1.35
NMR evidence for the participation of a low-barrier hydrogen bond in the mechanism of delta 5-3-ketosteroid isomerase. Proc Natl Acad Sci U S A (1996) 1.33
The role of metal ions in the mechanisms of DNA and RNA polymerases. CRC Crit Rev Biochem (1979) 1.33
Stuies on the interaction of substrate and monovalent and divalent cations with pyruvate kinase. Biochemistry (1966) 1.33
Mechanism of malic enzyme from pigeon liver. Magnetic resonance and kinetic studies of the role of Mn2+. J Biol Chem (1976) 1.32
Proton magnetic relaxation studies of the interaction of D-xylose and xylitol with D-xylose isomerase. Characterization of metal-enzyme-substrate interactions. J Biol Chem (1975) 1.27
Kinetic analysis of Escherichia coli deoxyribonucleic acid polymerase I. J Biol Chem (1975) 1.27
The mechanism of aconitase action. I. Preparation, physical properties of the enzyme, and activation by iron (II). J Biol Chem (1971) 1.25
Escherichia coli deoxyribonucleic acid polymerase I, a zinc metalloenzyme. Nuclear quadrupolar relaxation studies of the role of bound zinc. J Biol Chem (1973) 1.24
Kinetic and magnetic resonance studies of effects of genetic substitution of a Ca2+-liganding amino acid in staphylococcal nuclease. Biochemistry (1986) 1.24
4-Oxalocrotonate tautomerase: pH dependence of catalysis and pKa values of active site residues. Biochemistry (1996) 1.24
Conformation of deoxynucleoside triphosphate substrates on DNA polymerase I from Escherichia coli as determined by nuclear magnetic relaxation. J Biol Chem (1975) 1.23
The role of Glu 57 in the mechanism of the Escherichia coli MutT enzyme by mutagenesis and heteronuclear NMR. Biochemistry (1996) 1.21
Catalytic role of the amino-terminal proline in 4-oxalocrotonate tautomerase: affinity labeling and heteronuclear NMR studies. Biochemistry (1996) 1.20
The mechanism of Escherichia coli deoxyribonucleic acid polymerase I. Magnetic resonance and kinetic studies of the role of metals. J Biol Chem (1972) 1.17
Solution structure of the MutT enzyme, a nucleoside triphosphate pyrophosphohydrolase. Biochemistry (1995) 1.17
Structures of enzyme-bound metal-nucleotide complexes in the phosphoryl transfer reaction of muscle pyruvate kinase. 31P NMR studies with magnesium and kinetic studies with chromium nucleotides. J Biol Chem (1977) 1.15
Escherichia coli orf17 codes for a nucleoside triphosphate pyrophosphohydrolase member of the MutT family of proteins. Cloning, purification, and characterization of the enzyme. J Biol Chem (1996) 1.13
Kinetic and magnetic resonance studies of the mechanism of D-xylose isomerase. I. Binary and ternary complexes with manganese(II), substrates, and inhibitors. J Biol Chem (1972) 1.12
Electron paramagnetic resonance, 1-H, and 13C nuclear magnetic resonance studies of the interaction of manganese and bicarbonate with ribulose 1, 5-diphosphate carboxylase. J Biol Chem (1974) 1.12
Combined effects of two mutations of catalytic residues on the ketosteroid isomerase reaction. Biochemistry (1990) 1.09
15N NMR relaxation studies of free and inhibitor-bound 4-oxalocrotonate tautomerase: backbone dynamics and entropy changes of an enzyme upon inhibitor binding. Biochemistry (1996) 1.09
Catalytic mechanism of an active-site mutant (D38N) of delta 5-3-ketosteroid isomerase. Direct spectroscopic evidence for dienol intermediates. Biochemistry (1991) 1.08
Hydrogen bonding at the active site of delta 5-3-ketosteroid isomerase. Biochemistry (1997) 1.08
Studies of the mechanism of the delta 5-3-ketosteroid isomerase reaction by substrate, solvent, and combined kinetic deuterium isotope effects on wild-type and mutant enzymes. Biochemistry (1990) 1.08
Nuclear relaxation measurements of the geometry of enzyme-bound substrates and analogs. Methods Enzymol (1978) 1.07
NMR studies of conformations and interactions of substrates and ribonucleotide templates bound to the large fragment of DNA polymerase I. Biochemistry (1986) 1.07
Solution structure of Delta 5-3-ketosteroid isomerase complexed with the steroid 19-nortestosterone hemisuccinate. Biochemistry (1998) 1.06
Vaccinia DNA topoisomerase I: kinetic evidence for general acid-base catalysis and a conformational step. Biochemistry (1994) 1.06
High-precision measurement of hydrogen bond lengths in proteins by nuclear magnetic resonance methods. Proteins (1999) 1.05
Nuclear magnetic resonance studies of the function of potassium in the mechanism of pyruvate kinase. Biochemistry (1972) 1.05
NMR studies of the role of hydrogen bonding in the mechanism of triosephosphate isomerase. Biochemistry (1997) 1.05
NMR studies of the MgATP binding site of adenylate kinase and of a 45-residue peptide fragment of the enzyme. Biochemistry (1985) 1.04
Mutational, kinetic, and NMR studies of the roles of conserved glutamate residues and of lysine-39 in the mechanism of the MutT pyrophosphohydrolase. Biochemistry (2000) 1.03
Proton transfer in the mechanism of triosephosphate isomerase. Biochemistry (1998) 1.02
Magnetic resonance and kinetic studies of the manganese(II) ion and substrate complexes of the catalytic subunit of adenosine 3',5'-monophosphate dependent protein kinase from bovine heart. Biochemistry (1979) 1.02
Studies of the catalytic mechanism of an active-site mutant (Y14F) of delta 5-3-ketosteroid isomerase by kinetic deuterium isotope effects. Biochemistry (1991) 1.02
Positioning of a spin-labeled substrate analogue into the structure of delta 5-3-ketosteroid isomerase by combined kinetic, magnetic resonance, and X-ray diffraction methods. Biochemistry (1987) 1.02
The enzymatic carboxylation of phosphoenolpyruvate. IV. The binding of manganese and substrates by phosphoenolpyruvate carbosy-kinase and phosphoenolypyruvate carboxylase. J Biol Chem (1968) 1.02
Kinetic, stereochemical, and structural effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase. Biochemistry (1999) 1.01
Dual divalent cation requirement of the MutT dGTPase. Kinetic and magnetic resonance studies of the metal and substrate complexes. J Biol Chem (1994) 1.01
Nuclear Overhauser effect studies of the conformations and binding site environments of deoxynucleoside triphosphate substrates bound to DNA polymerase I and its large fragment. Biochemistry (1985) 1.01
Pyruvate carboxylase. VII. A possible role for tightly bound manganese. J Biol Chem (1966) 1.00
Solution structure of the quaternary MutT-M2+-AMPCPP-M2+ complex and mechanism of its pyrophosphohydrolase action. Biochemistry (1997) 0.99
Arrangement and conformations of substrates at the active site of pyruvate kinase from model building studies based on magnetic resonance data. J Biol Chem (1976) 0.99
Ultraviolet spectroscopic evidence for decreased motion of the active site tyrosine residue of delta 5-3-ketosteroid isomerase by steroid binding. Biochemistry (1995) 0.99
Magnetic resonance studies of the anomeric distribution and manganese binding properties of fructose phosphates. Biochem Biophys Res Commun (1972) 0.98
Magnetic resonance measurements of intersubstrate distances at the active site of protein kinase using substitution-inert cobalt(III) and chromium(III) complexes of adenosine 5'-(beta, gamma-methylenetriphosphate). Biochemistry (1980) 0.98
Electron and nuclear magnetic resonance studies of the interaction of pyruvate with transcarboxylase. Biochemistry (1974) 0.97
Magnetic resonance studies of the conformation of enzyme-bound adenylyl(3' leads to 5')uridine and adenosine 5'-triphosphate on RNA polymerase from Esherichia coli. Biochemistry (1977) 0.97
Stereochemistry of the concerted enolization catalyzed by delta 5-3-ketosteroid isomerase. Biochemistry (1991) 0.97
Effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase on the pKa values of active site residues and on the pH dependence of catalysis. Biochemistry (1999) 0.97
Electron spin resonance studies with dioldehydrase. Evidence for radical intermediates in reactions catalyzed by coenzyme B 12. J Biol Chem (1973) 0.97
Computer simulation studies of mammalian pyruvate kinase. J Biol Chem (1967) 0.97
Role of magnesium and other divalent cations in ATP-utilizing enzymes. Magnesium (1987) 0.97
The structural basis for the perturbed pKa of the catalytic base in 4-oxalocrotonate tautomerase: kinetic and structural effects of mutations of Phe-50. Biochemistry (2001) 0.97
NMR studies of the backbone protons and secondary structure of pentapeptide and heptapeptide substrates bound to bovine heart protein kinase. Biochemistry (1984) 0.96
Nuclear relaxation and kinetic studies of the role of Mn 2+ in the mechanism of enolase. Biochemistry (1973) 0.96
Magnetic resonance studies of the role of the divalent cation in the mechanism of yeast aldolase. Biochemistry (1971) 0.95
Mechanism of enzyme action. Annu Rev Biochem (1974) 0.95
13C NMR relaxation studies of backbone and side chain motion of the catalytic tyrosine residue in free and steroid-bound delta 5-3-ketosteroid isomerase. Biochemistry (1996) 0.95
Mechanistic studies of cAMP-dependent protein kinase action. CRC Crit Rev Biochem (1984) 0.95
Magnetic resonance and kinetic studies of initiator-substrate distances on RNA polymerase from Escherichia coli. Biochemistry (1978) 0.94
Magnetic resonance studies of the proximity and spatial arrangement of propionyl coenzyme A and pyruvate on a biotin-metalloenzyme, transcarboxylase. Biochemistry (1976) 0.94
Pyruvate carboxylase. X. The demonstration of direct coordination of pyruvate and alpha-ketobutyrate by the bound manganese and the formation of enzyme-metal-substrate bridge complexes. Biochemistry (1967) 0.94
Fluorocitrate inhibition of aconitase: relative configuration of inhibitory isomer by x-ray crystallography. Science (1970) 0.94
Substrate polarization by residues in delta 5-3-ketosteroid isomerase probed by site-directed mutagenesis and UV resonance Raman spectroscopy. Protein Sci (1992) 0.94
Nuclear magnetic resonance studies of the conformation and kinetics of the peptide-substrate at the active site of bovine heart protein kinase. Biochemistry (1981) 0.94
Role of peripheral side chains of vitamin B12 coenzymes in the reaction catalyzed by dioldehydrase. Biochemistry (1979) 0.93
Metal binding to DNA polymerase I, its large fragment, and two 3',5'-exonuclease mutants of the large fragment. J Biol Chem (1990) 0.93
Magnetic resonance studies of the effect of the regulatory subunit on metal and substrate binding to the catalytic subunit of bovine heart protein kinase. J Biol Chem (1980) 0.93
Short, strong hydrogen bonds at the active site of human acetylcholinesterase: proton NMR studies. Biochemistry (2001) 0.93
NMR studies of the mechanism of enzyme action. Adv Enzymol Relat Areas Mol Biol (1987) 0.93
Chromium(III)-adenosine triphosphate as a paramagnetic probe to determine intersubstrate distances on pyruvate kinase. Detection of an active enzyme-metal-ATP-metal complex. J Biol Chem (1976) 0.93
Nuclear magnetic resonance studies of the nucleotide binding sites of porcine adenylate kinase. Biochemistry (1982) 0.92
Electron spin echo modulation and nuclear relaxation studies of staphylococcal nuclease and its metal-coordinating mutants. Biochemistry (1988) 0.92
Proton NMR studies of the histidine residues of rabbit muscle pyruvate kinase and of its phosphoenolpyruvate complex. J Biol Chem (1981) 0.92
Role of divalent cations in the 3',5'-exonuclease reaction of DNA polymerase I. Biochemistry (1991) 0.90
The mechanism of aconitase action. 3. Detection and properties of enzyme-metal-substrate and enzyme-metal-inhibitor bridge complexes with manganese(II) and iron(II). J Biol Chem (1972) 0.90
Stereoselective interactions of phosphoenolpyruvate analogues with phosphoenolpyruvate-utilizing enzymes. J Biol Chem (1970) 0.90
Thallium-205 nuclear relaxation and kinetic studies of sodium and potassium ion-activated adenosine triphosphatase. J Biol Chem (1974) 0.89
Substrate and DNA binding to a 50-residue peptide fragment of DNA polymerase I. Comparison with the enzyme. J Biol Chem (1989) 0.89
The mechanism of aconitase action. II. Magnetic resonance studies of the complexes of enzyme, manganese(II), iron(II), and substrates. J Biol Chem (1971) 0.89
Conformation of an enzyme-bound substrate of staphylococcal nuclease as determined by NMR. Biochemistry (1991) 0.88
NMR studies of the conformations and location of nucleotides bound to the Escherichia coli MutT enzyme. Biochemistry (1995) 0.88
GDP-mannose mannosyl hydrolase catalyzes nucleophilic substitution at carbon, unlike all other Nudix hydrolases. Biochemistry (2000) 0.88
Interaction of a spin-labeled analog of nicotinamide-adenine dinucleotide with alcohol dehydrogenase. II. Proton relaxation rate and electron paramagnetic resonance studies of binary and ternary complexes. Biochemistry (1969) 0.88