Published in Cell Cycle on March 21, 2013
Molecular mechanisms of DNA replication checkpoint activation. Genes (Basel) (2014) 0.80
The dimeric Mcm8-9 complex of Xenopus laevis likely has a conserved function for resistance to DNA damage. Cell Cycle (2013) 0.79
Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. Biochim Biophys Acta (1966) 16.27
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol (2006) 6.36
Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc Natl Acad Sci U S A (2006) 5.66
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell (2009) 5.56
Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat Cell Biol (2001) 5.37
Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. Mol Cell (2010) 4.24
A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication. Proc Natl Acad Sci U S A (2009) 3.68
Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J Cell Biol (2006) 3.27
Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor. J Cell Biol (1997) 2.58
Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins. BMC Biochem (2001) 2.36
The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. J Cell Biol (2004) 1.89
Characterization of the Xenopus replication licensing system. Methods Enzymol (1997) 1.88
Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. EMBO J (2004) 1.84
MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination. Mol Cell (2012) 1.64
Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import. Curr Biol (2002) 1.63
MCM2-7 form double hexamers at licensed origins in Xenopus egg extract. J Biol Chem (2011) 1.55
Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks. Mol Cell (2012) 1.47
MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation. Cell (2005) 1.40
REC, Drosophila MCM8, drives formation of meiotic crossovers. PLoS Genet (2005) 1.39
Identification and functional characterization of a new member of the human Mcm protein family: hMcm8. Nucleic Acids Res (2003) 1.23
MCM9 binds Cdt1 and is required for the assembly of prereplication complexes. Mol Cell (2008) 1.21
Ancient diversification of eukaryotic MCM DNA replication proteins. BMC Evol Biol (2009) 1.17
Differential requirements for MCM proteins in DNA replication in Drosophila S2 cells. PLoS One (2007) 1.13
Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression. Proc Natl Acad Sci U S A (2011) 1.12
Involvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatin. Mol Cell Biol (2005) 1.06
MCM-BP is required for repression of life-cycle specific genes transcribed by RNA polymerase I in the mammalian infectious form of Trypanosoma brucei. PLoS One (2013) 1.03
A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13. Nucleic Acids Res (2003) 1.02
The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol Cell Biol (2013) 0.98
Identification of a novel cell-cycle-induced MCM family protein MCM9. Biochem Biophys Res Commun (2005) 0.97
Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family. Gene (2005) 0.95
Colocalization of MCM8 and MCM7 with proteins involved in distinct aspects of DNA replication. Microsc Res Tech (2008) 0.93
Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos. Development (2011) 0.92
Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins. Methods (2012) 0.92
REC, a new member of the MCM-related protein family, is required for meiotic recombination in Drosophila. Genes Genet Syst (2003) 0.91
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev (2007) 4.60
Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories. Cell (2006) 3.56
Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J Cell Biol (2006) 3.27
Regulating the licensing of DNA replication origins in metazoa. Curr Opin Cell Biol (2006) 2.08
Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene (2002) 1.91
The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. J Cell Biol (2004) 1.89
Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. EMBO J (2004) 1.84
Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision. Mol Cell (2006) 1.73
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus. J Cell Sci (2004) 1.72
Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import. Curr Biol (2002) 1.63
Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories. J Cell Biol (2010) 1.63
ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensing. Curr Biol (2007) 1.61
MCM2-7 form double hexamers at licensed origins in Xenopus egg extract. J Biol Chem (2011) 1.55
Mammalian nuclei become licensed for DNA replication during late telophase. J Cell Sci (2002) 1.51
Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination. Nat Cell Biol (2004) 1.45
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Mol Cell (2011) 1.24
Bod1, a novel kinetochore protein required for chromosome biorientation. J Cell Biol (2007) 1.22
The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription. Nucleic Acids Res (2005) 1.22
DNA replication licensing in somatic and germ cells. J Cell Sci (2004) 1.21
Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels. J Cell Biol (2010) 1.20
Functional domains of the Xenopus replication licensing factor Cdt1. Nucleic Acids Res (2005) 1.16
Clusters, factories and domains: The complex structure of S-phase comes into focus. Cell Cycle (2010) 1.15
Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment. Mol Cell (2013) 1.14
PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192. Dev Cell (2013) 1.12
The dynamics of replication licensing in live Caenorhabditis elegans embryos. J Cell Biol (2012) 1.11
A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication. BMC Mol Biol (2004) 1.06
Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibition. Curr Biol (2008) 1.04
Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts. Exp Cell Res (2008) 1.03
Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation. J Cell Sci (2012) 1.02
The elusive determinants of replication origins. EMBO Rep (2007) 1.01
Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template. Genes Dev (2013) 1.00
Dormant origins, the licensing checkpoint, and the response to replicative stresses. Cold Spring Harb Perspect Biol (2012) 0.99
Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts. Nucleic Acids Res (2013) 0.99
PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage. DNA Repair (Amst) (2008) 0.95
Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos. Development (2011) 0.92
Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins. Methods (2012) 0.92
The licensing checkpoint opens up. Cell Cycle (2009) 0.86
Stochastic association of neighboring replicons creates replication factories in budding yeast. J Cell Biol (2013) 0.85
Optimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approach. Proteome Sci (2004) 0.85
Histone acetylation by HBO1 tightens replication licensing. Mol Cell (2010) 0.85
Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1. Open Biol (2014) 0.85
Negative regulation of geminin by CDK-dependent ubiquitination controls replication licensing. Cell Cycle (2004) 0.81
Optimal placement of origins for DNA replication. Phys Rev Lett (2012) 0.81
Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication. Biochim Biophys Acta (2011) 0.81
The role of the replication licensing system in cell proliferation and cancer. Prog Cell Cycle Res (2003) 0.81
The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing. J Biol Chem (2013) 0.81
A role for dormant origins in tumor suppression. Mol Cell (2011) 0.79
Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity. Nucleus (2011) 0.77
Cell Cycle Synchronization in Xenopus Egg Extracts. Methods Mol Biol (2016) 0.77
Degradation ensures integrity. Nature (2003) 0.76
Erratum: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Nat Commun (2015) 0.75