Epidermal stem cell diversity and quiescence.

Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration. Nature (2012) 3.53

Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells. Cell Stem Cell (2011) 3.19

Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Cancer Cell (2011) 2.38

Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling. Proc Natl Acad Sci U S A (2011) 2.13

Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis. Nat Protoc (2010) 1.72

Hair follicle dermal papilla cells at a glance. J Cell Sci (2011) 1.72

Quiescent, slow-cycling stem cell populations in cancer: a review of the evidence and discussion of significance. J Oncol (2010) 1.63

Tracking adult stem cells. EMBO Rep (2011) 1.56

The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. PLoS Genet (2011) 1.48

Epithelialization in Wound Healing: A Comprehensive Review. Adv Wound Care (New Rochelle) (2014) 1.45

Cutaneous wound healing: recruiting developmental pathways for regeneration. Cell Mol Life Sci (2012) 1.40

Cell-extracellular matrix interactions in normal and diseased skin. Cold Spring Harb Perspect Biol (2011) 1.37

An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature (2012) 1.32

Modulating the stem cell niche for tissue regeneration. Nat Biotechnol (2014) 1.28

Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation. Nat Med (2014) 1.22

Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development (2011) 1.15

Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome. EMBO Mol Med (2012) 1.13

The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin. EMBO J (2011) 1.11

Heterogeneity and plasticity of epidermal stem cells. Development (2014) 1.08

Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation. Dev Biol (2010) 1.06

Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development (2011) 1.05

Somatic correction of junctional epidermolysis bullosa by a highly recombinogenic AAV variant. Mol Ther (2014) 1.03

Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation. EMBO Mol Med (2010) 1.02

Differentiation of progenitors in the liver: a matter of local choice. J Clin Invest (2013) 1.00

Markers of epidermal stem cell subpopulations in adult mammalian skin. Cold Spring Harb Perspect Med (2014) 0.95

aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation. J Cell Biol (2013) 0.94

Taste bud regeneration and the search for taste progenitor cells. Arch Ital Biol (2010) 0.89

Ascl3 marks adult progenitor cells of the mouse salivary gland. Stem Cell Res (2012) 0.89

Biochemistry of epidermal stem cells. Biochim Biophys Acta (2012) 0.88

Expression of Kruppel-like factor KLF4 in mouse hair follicle stem cells contributes to cutaneous wound healing. PLoS One (2012) 0.88

Refining the role for adult stem cells as cancer cells of origin. Trends Cell Biol (2014) 0.88

Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Development (2013) 0.87

Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells. Proc Natl Acad Sci U S A (2013) 0.87

Taste bud cells of adult mice are responsive to Wnt/β-catenin signaling: implications for the renewal of mature taste cells. Genesis (2011) 0.87

A novel validation algorithm allows for automated cell tracking and the extraction of biologically meaningful parameters. PLoS One (2011) 0.87

Searching for adult stem cells in the intestine. EMBO Mol Med (2009) 0.86

Lineage analysis of epidermal stem cells. Cold Spring Harb Perspect Med (2014) 0.86

Endogenous retinoids in the hair follicle and sebaceous gland. Biochim Biophys Acta (2011) 0.85

Niche interactions in epidermal stem cells. World J Stem Cells (2015) 0.85

The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells. J Invest Dermatol (2015) 0.84

Transcriptional dissection of human limbal niche compartments by massive parallel sequencing. PLoS One (2013) 0.83

Epiprofin orchestrates epidermal keratinocyte proliferation and differentiation. J Cell Sci (2014) 0.83

Targeted inactivation of integrin-linked kinase in hair follicle stem cells reveals an important modulatory role in skin repair after injury. Mol Biol Cell (2011) 0.83

Lrig1: a new master regulator of epithelial stem cells. EMBO J (2012) 0.82

The effect of porcine ADM to improve the burn wound healing. Int J Clin Exp Pathol (2013) 0.81

BLIMP1 is required for postnatal epidermal homeostasis but does not define a sebaceous gland progenitor under steady-state conditions. Stem Cell Reports (2014) 0.81

β1 integrin signaling maintains human epithelial progenitor cell survival in situ and controls proliferation, apoptosis and migration of their progeny. PLoS One (2013) 0.81

Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity. Cell Rep (2016) 0.80

Cellular reprogramming in skin cancer. Semin Cancer Biol (2014) 0.80

Stem Cell-Associated Marker Expression in Canine Hair Follicles. J Histochem Cytochem (2016) 0.78

LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells. Oncogene (2015) 0.78

Nanog and β-catenin: a new convergence point in EpSC proliferation and differentiation. Int J Mol Med (2011) 0.78

Genetically induced cell death in bulge stem cells reveals their redundancy for hair and epidermal regeneration. Stem Cells (2015) 0.78

Epidermal stem cells and their epigenetic regulation. Int J Mol Sci (2013) 0.77

The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells. Development (2014) 0.77

Local microenvironment provides important cues for cell differentiation in lingual epithelia. PLoS One (2012) 0.77

Protein Kinase C ε , Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells. J Skin Cancer (2013) 0.77

Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration. FASEB J (2016) 0.77

Update on acute myeloid leukemia stem cells: New discoveries and therapeutic opportunities. World J Stem Cells (2016) 0.76

NTPDase2+ Cells Generate Lingual Epithelia and Papillae. Front Genet (2012) 0.76

Epidermal polarity genes in health and disease. Cold Spring Harb Perspect Med (2014) 0.76

Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages. Exp Cell Res (2014) 0.76

Stem cells behind the barrier. Int J Mol Sci (2013) 0.76

Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence. J Invest Dermatol (2015) 0.76

Environmental stimuli and intestinal stem cell behavior. Cell Cycle (2012) 0.75

Spatial Distribution of Stem Cell-Like Keratinocytes in Dissected Compound Hair Follicles of the Dog. PLoS One (2016) 0.75

A van der Waals-like Transition Between Normal and Cancerous Phases in Cell Populations Dynamics of Colorectal Cancer. Sci Rep (2016) 0.75

Stem Cell Markers (Cytokeratin 17 and Cytokeratin 19) in Scarring and Nonscarring Alopecia. J Cutan Aesthet Surg (2016) 0.75

Nanog down-regulates the Wnt signaling pathway via β-catenin phosphorylation during epidermal stem cell proliferation and differentiation. Cell Biosci (2015) 0.75

The Co-Expression Pattern of p63 and HDAC1: A Potential Way to Disclose Stem Cells in Interfollicular Epidermis. Int J Mol Sci (2017) 0.75

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature (2004) 16.56

Defining the epithelial stem cell niche in skin. Science (2003) 14.93

Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell (1990) 12.13

Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell (2004) 10.79

Capturing and profiling adult hair follicle stem cells. Nat Biotechnol (2004) 10.35

Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med (2005) 8.01

Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95

De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell (1998) 7.95

Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55

Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell (2000) 6.93

WNT signals are required for the initiation of hair follicle development. Dev Cell (2002) 6.63

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science (1995) 6.58

Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell (1989) 6.49

Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell (2001) 6.37

A single type of progenitor cell maintains normal epidermis. Nature (2007) 6.32

Three clonal types of keratinocyte with different capacities for multiplication. Proc Natl Acad Sci U S A (1987) 6.30

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell (1993) 5.86

Modelling Myc inhibition as a cancer therapy. Nature (2008) 5.81

Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol (2003) 5.28

Strain-dependent epithelial defects in mice lacking the EGF receptor. Science (1995) 5.22

Stem cell patterning and fate in human epidermis. Cell (1995) 5.22

Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature (2007) 5.19

Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell (2008) 5.02

Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes. Nature (1977) 4.90

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature (2008) 4.67

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature (1995) 4.56

Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell (2005) 3.98

Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development (2003) 3.84

NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81

Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell (2006) 3.79

Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev (2005) 3.67

Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell (2009) 3.44

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev (1994) 3.42

Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J Clin Invest (2006) 3.41

WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism. Science (2006) 3.36

The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis. Development (1999) 3.31

Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development (2004) 3.24

c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol (2001) 3.22

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc Natl Acad Sci U S A (2007) 3.16

Epithelial stem cells in vivo. J Cell Sci Suppl (1988) 2.99

Location of stem cells of human hair follicles by clonal analysis. Cell (1994) 2.96

Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Science (1997) 2.93

Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. Proc Natl Acad Sci U S A (2006) 2.91

Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin. EMBO J (2001) 2.89

Epidermal stem cells arise from the hair follicle after wounding. FASEB J (2007) 2.81

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes Dev (1991) 2.78

Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. Dev Cell (2005) 2.71

Contribution of stem cells and differentiated cells to epidermal tumours. Nat Rev Cancer (2003) 2.69

Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med (2006) 2.59

Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters. Curr Biol (2000) 2.58

The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci (1998) 2.58

The hair cycle. J Cell Sci (2006) 2.58

Stem cells: the generation and maintenance of cellular diversity. Development (1989) 2.54

An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution. J Invest Dermatol (2007) 2.53

Stem cells are dispensable for lung homeostasis but restore airways after injury. Proc Natl Acad Sci U S A (2009) 2.28

The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell (2000) 2.22

Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Dev Cell (2005) 2.21

Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion. Stem Cells (2006) 2.09

A distinct population of clonogenic and multipotent murine follicular keratinocytes residing in the upper isthmus. J Cell Sci (2008) 2.06

The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells. Development (2006) 2.04

A community effect in animal development. Nature (1989) 2.04

Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96

Sic transit gloria: farewell to the epidermal transit amplifying cell? Cell Stem Cell (2007) 1.91

Epidermal stem cells: an update. Curr Opin Genet Dev (2006) 1.87

Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1. Proc Natl Acad Sci U S A (2007) 1.85

MYC in mammalian epidermis: how can an oncogene stimulate differentiation? Nat Rev Cancer (2008) 1.78

Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J (1993) 1.70

Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21(WAF1/CIP1) expression in keratinocyte differentiation. Proc Natl Acad Sci U S A (2001) 1.63

Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. Am J Pathol (1997) 1.62

Designer skin: lineage commitment in postnatal epidermis. Trends Cell Biol (2002) 1.59

Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol (2008) 1.47

Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development (2008) 1.27

Organization of stem cells and their progeny in human epidermis. J Invest Dermatol (2005) 1.23

Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin. Stem Cells (2008) 1.22

Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling. Dev Biol (2008) 1.19

Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes. Am J Physiol Cell Physiol (2003) 1.16

Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells. Proc Natl Acad Sci U S A (2008) 1.13

Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype. EMBO Rep (2005) 1.11

Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture. J Cell Sci (2007) 1.08

KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development (2009) 1.03

Embryonic hair follicle fate change by augmented beta-catenin through Shh and Bmp signaling. Development (2009) 0.99

Cyclosporin A-induced hair growth in mice is associated with inhibition of hair follicle regression. Arch Dermatol Res (2004) 0.86

Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development (2009) 2.82

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol (2012) 2.51

The epidermis comprises autonomous compartments maintained by distinct stem cell populations. Cell Stem Cell (2013) 1.64

Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell (2013) 1.39

Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation. Dev Biol (2010) 1.06

Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports (2013) 1.05

Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells. Development (2013) 1.04

Necl2 regulates epidermal adhesion and wound repair. Development (2009) 1.01

LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development. J Pathol (2013) 0.92

Polyclonal origin and hair induction ability of dermal papillae in neonatal and adult mouse back skin. Dev Biol (2012) 0.84

Reporting live from the epidermal stem cell compartment! Cell Stem Cell (2012) 0.76

Hippo signalling directs intestinal fate. Nat Cell Biol (2015) 0.76

Environmental stimuli and intestinal stem cell behavior. Cell Cycle (2012) 0.75

Biological techniques: An embryonic view of tumour development. Nature (2013) 0.75

Synthesis of unsymmetrical tweezer receptor libraries and identification of receptors for lys-D-ala-D-ala in aqueous solution. Chemistry (2006) 0.75

Trifluoroacetyl as an orthogonal protecting group for guanidines. J Org Chem (2003) 0.75