Published in Mol Cell Biol on December 01, 1993
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J (1994) 3.88
Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol Biol Cell (1994) 2.78
Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. EMBO J (1994) 2.08
A phosphotyrosine displacement mechanism for activation of Src by PTPalpha. EMBO J (2000) 1.90
Site-directed mutagenesis studies of the high-affinity streptavidin-biotin complex: contributions of tryptophan residues 79, 108, and 120. Proc Natl Acad Sci U S A (1995) 1.89
Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen. Proc Natl Acad Sci U S A (1994) 1.55
Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation. EMBO J (1997) 1.45
Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Mol Biol Cell (2004) 1.39
Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling. Cell (2015) 1.38
Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation. Proc Natl Acad Sci U S A (2007) 1.16
Src SH2 arginine 175 is required for cell motility: specific focal adhesion kinase targeting and focal adhesion assembly function. Mol Cell Biol (2006) 1.11
PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex. EMBO J (2006) 1.07
FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration. Dev Cell (2013) 1.03
Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors. PLoS One (2012) 1.01
Quantitative relation between intermolecular and intramolecular binding of pro-rich peptides to SH3 domains. Biophys J (2006) 0.97
PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1. J Biol Chem (2010) 0.97
Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62. J Exp Med (1997) 0.95
Transforming potentials of epidermal growth factor and nerve growth factor receptors inversely correlate with their phospholipase C gamma affinity and signal activation. EMBO J (1996) 0.95
SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and phosphatidylinositol 3-kinase. Mol Cell Biol (1997) 0.91
Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected. Mol Cell Proteomics (2013) 0.90
Temperature-sensitive transformation by an Abelson virus mutant encoding an altered SH2 domain. J Virol (2001) 0.90
Src regulated by C-terminal phosphorylation is monomeric. Proc Natl Acad Sci U S A (1997) 0.86
Activated Fes protein tyrosine kinase induces terminal macrophage differentiation of myeloid progenitors (U937 cells) and activation of the transcription factor PU.1. Mol Cell Biol (2002) 0.85
Enhanced cellular uptake of short polyarginine peptides through fatty acylation and cyclization. Mol Pharm (2014) 0.83
Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of v-src. J Virol (1994) 0.81
The evolutionarily conserved arrangement of domains in SRC family kinases is important for substrate recognition. Biochemistry (2008) 0.81
Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. J Biol Chem (2014) 0.80
Pannexin-1 as a potentiator of ligand-gated receptor signaling. Channels (Austin) (2014) 0.80
Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity. Mol Cell Biol (1994) 0.80
pp60v-src transformation of rat cells but not chicken cells strongly correlates with low-affinity phosphopeptide binding by the SH2 domain. Mol Biol Cell (1997) 0.79
Novel Role of Src in Priming Pyk2 Phosphorylation. PLoS One (2016) 0.78
Contribution of Crk adaptor proteins to host cell and bacteria interactions. Biomed Res Int (2014) 0.76
HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms. Oncogene (2016) 0.75
SH2 domains recognize specific phosphopeptide sequences. Cell (1993) 17.28
Oncogenes and signal transduction. Cell (1991) 14.84
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science (1991) 12.93
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell (1992) 8.20
SH2 and SH3 domains: from structure to function. Cell (1992) 7.65
Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation. Cell (1987) 6.91
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src. Cell (1987) 5.84
EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling. Cell (1989) 5.68
Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell (1993) 5.47
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell (1992) 5.09
Tyr527 is phosphorylated in pp60c-src: implications for regulation. Science (1986) 4.99
PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell (1990) 4.85
Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell (1990) 4.83
Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. Cell (1989) 4.52
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature (1992) 4.46
Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science (1990) 4.21
Binding of GAP to activated PDGF receptors. Science (1990) 3.89
Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. Science (1990) 3.67
Signalling through SH2 and SH3 domains. Trends Cell Biol (1993) 3.43
A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine. Mol Cell Biol (1991) 3.20
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma. EMBO J (1992) 2.82
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J (1992) 2.79
Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex. Mol Cell Biol (1990) 2.71
Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus. EMBO J (1987) 2.67
Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases. EMBO J (1993) 2.46
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src. Mol Cell Biol (1990) 2.39
BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell (1991) 2.29
The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor. Mol Cell Biol (1992) 1.99
Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants. J Virol (1989) 1.95
Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively. Mol Cell Biol (1993) 1.88
Regulation of c-Src tyrosine kinase activity by the Src SH2 domain. Oncogene (1993) 1.79
Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor. EMBO J (1993) 1.76
Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src. Proc Natl Acad Sci U S A (1991) 1.71
Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability. J Virol (1989) 1.53
Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells. Proc Natl Acad Sci U S A (1990) 1.50
Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain. Mol Cell Biol (1990) 1.45
CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J (1993) 1.37
The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus. Mol Cell Biol (1988) 1.26
Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62. J Biol Chem (1992) 1.26
In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase. Mol Cell Biol (1993) 1.23
Structural differences between repressed and derepressed forms of p60c-src. Mol Cell Biol (1989) 1.23
Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases. Cell Growth Differ (1991) 0.97
Quantitative analysis of SH2 domain binding. Evidence for specificity and competition. J Biol Chem (1992) 0.92
Host range mutants of v-src: alterations in kinase activity and substrate interactions. J Virol (1992) 0.92
Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA. Cell (1978) 13.33
The molecular biology of the hepatitis B viruses. Annu Rev Biochem (1987) 12.32
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein. Cell (1978) 11.17
Correct integration of retroviral DNA in vitro. Cell (1987) 10.73
Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature (1988) 10.69
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature (1976) 9.81
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science (1984) 9.64
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell (1982) 9.29
Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature (1982) 9.12
Form and function of retroviral proviruses. Science (1982) 8.80
A nucleoprotein complex mediates the integration of retroviral DNA. Genes Dev (1989) 8.80
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature (1983) 8.18
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. Proc Natl Acad Sci U S A (1989) 8.13
Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proc Natl Acad Sci U S A (1979) 7.55
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell (1978) 7.46
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J Virol (1980) 7.37
Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region. Cell (1988) 7.14
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc Natl Acad Sci U S A (1983) 7.01
Analysis of avian leukosis virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumor state. Cell (1981) 6.98
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell (1988) 6.48
Structure and variability of human chromosome ends. Mol Cell Biol (1990) 6.18
Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Science (1985) 5.90
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration. Proc Natl Acad Sci U S A (1984) 5.81
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Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription. Nature (1990) 5.68
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev (2001) 5.67
The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses. Cell (1977) 5.23
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. Nature (1980) 5.22
Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses. J Mol Biol (1976) 5.07
A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor. Cell (1993) 4.97
Retroviruses as mutagens: insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus. Cell (1981) 4.66
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Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. Cell (1983) 4.53
Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates. Proc Natl Acad Sci U S A (1978) 4.47
Nucleotide sequences at host-proviral junctions for mouse mammary tumour virus. Nature (1981) 4.38
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture. Nature (1985) 4.31
Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts. Proc Natl Acad Sci U S A (1973) 4.19
A joint produce of the genes gag and pol of avian sarcoma virus: a possible precursor of reverse transcriptase. Cell (1977) 4.18
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature (1995) 4.14
Biochemical and genetic evidence for the hepatitis B virus replication strategy. Science (1986) 4.12
Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA. Cell (1977) 4.06
Kinetics of synthesis, structure and purification of avian sarcoma virus-specific DNA made in the cytoplasm of acutely infected cells. J Mol Biol (1978) 4.04
Information access. Building a "GenBank" of the published literature. Science (2001) 3.95
The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine. J Biol Chem (1980) 3.95
Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus. J Virol (1984) 3.91
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Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins. Proc Natl Acad Sci U S A (1987) 3.84
Nucleotide sequence of cloned unintegrated avian sarcoma virus DNA: viral DNA contains direct and inverted repeats similar to those in transposable elements. Proc Natl Acad Sci U S A (1981) 3.82
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev (1998) 3.68
Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus. Nature (1975) 3.63
Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse. Cell (1979) 3.63
Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection. Cell (1992) 3.60
Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis). Nature (1974) 3.58
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Nature (1983) 3.56
Isolation of a chicken gene that confers susceptibility to infection by subgroup A avian leukosis and sarcoma viruses. J Virol (1993) 3.46
Mapping of linear and circular forms of mouse mammary tumor virus DNA with restriction endonucleases: evidence for a large specific deletion occurring at high frequency during circularization. Proc Natl Acad Sci U S A (1978) 3.45
Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action. Cell (1975) 3.44
Corrections to the nucleotide sequence of the src gene of Rous sarcoma virus. Nature (1983) 3.42
Transduction of a cellular oncogene: the genesis of Rous sarcoma virus. Proc Natl Acad Sci U S A (1983) 3.41
Production of mouse mammary tumor virus by cultured cells in the absence and presence of hormones: assay by molecular hybridization. Virology (1975) 3.40
Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development. Proc Natl Acad Sci U S A (1986) 3.34
Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA. Proc Natl Acad Sci U S A (1977) 3.31
Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region. J Virol (1984) 3.30
Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells). Proc Natl Acad Sci U S A (1972) 3.28
Regulation of lac mRNA synthesis in a soluble cell-free system. Nat New Biol (1971) 3.25
The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant. Mol Cell Biol (1988) 3.24
Appearance of virus-specific DNA in mammalian cells following transformation by Rous sarcoma virus. J Mol Biol (1973) 3.21
Proposal for naming host cell-derived inserts in retrovirus genomes. J Virol (1981) 3.18
The nucleotide sequence of an untranslated but conserved domain at the 3' end of the avian sarcoma virus genome. Nucleic Acids Res (1980) 3.16
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Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Mol Cell (1999) 3.15
Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting. Nature (1989) 3.10
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Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide. Science (1986) 3.01
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c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes Dev (1995) 2.72
Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro. J Biol Chem (1993) 2.69
An RNA pseudoknot and an optimal heptameric shift site are required for highly efficient ribosomal frameshifting on a retroviral messenger RNA. Proc Natl Acad Sci U S A (1992) 2.57
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Nucleotide sequence of the 5' noncoding region and part of the gag gene of Rous sarcoma virus. J Virol (1982) 2.53
The leader sequence of the subgenomic mRNA's of Rous sarcoma virus is approximately 390 nucleotides. J Virol (1982) 2.51
Characteristics of cellular RNA related to the transforming gene of avian sarcoma viruses. Cell (1978) 2.50
The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid. J Virol (1987) 2.49
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DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes. EMBO J (1994) 2.48
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