Published in Diabetes on November 13, 2013
Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells. Nature (2014) 1.60
Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro. EMBO J (2015) 1.34
Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease. Cell Stem Cell (2014) 1.21
A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome. Proc Natl Acad Sci U S A (2014) 0.99
Getting the better of ER stress. J Cell Commun Signal (2014) 0.96
Wolfram Syndrome: Diagnosis, Management, and Treatment. Curr Diab Rep (2016) 0.95
Natural history of β-cell adaptation and failure in type 2 diabetes. Mol Aspects Med (2014) 0.91
Toward beta cell replacement for diabetes. EMBO J (2015) 0.86
Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome. PLoS Biol (2016) 0.83
Generation of stem cell-derived β-cells from patients with type 1 diabetes. Nat Commun (2016) 0.82
The pancreatic β cell: recent insights from human genetics. Trends Endocrinol Metab (2014) 0.80
Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement. Transplantation (2016) 0.79
Diabetes: Targeting endoplasmic reticulum to combat juvenile diabetes. Nat Rev Endocrinol (2014) 0.79
Role of the unfolded protein response in β cell compensation and failure during diabetes. J Diabetes Res (2014) 0.79
Stem Cell-Derived Beta Cells for Treatment of Type 1 Diabetes? EBioMedicine (2014) 0.78
Phenotype Prediction of Pathogenic Nonsynonymous Single Nucleotide Polymorphisms in WFS1. Sci Rep (2015) 0.77
Wolfram syndrome iPS cells: the first human cell model of endoplasmic reticulum disease. Diabetes (2014) 0.76
When is it MODY? Challenges in the Interpretation of Sequence Variants in MODY Genes. Rev Diabet Stud (2016) 0.76
Modeling Kidney Disease with iPS Cells. Biomark Insights (2015) 0.76
Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum. Diabetes (2016) 0.76
Research resource: Monitoring endoplasmic reticulum membrane integrity in β-cells at the single-cell level. Mol Endocrinol (2015) 0.75
Endoplasmic Reticulum (ER) Stress and Endocrine Disorders. Int J Mol Sci (2017) 0.75
A novel CISD2 mutation associated with a classical Wolfram syndrome phenotype alters Ca2+ homeostasis and ER-mitochondria interactions. Hum Mol Genet (2017) 0.75
Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology. F1000Res (2016) 0.75
Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools. Mol Metab (2015) 0.75
Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells. Mol Metab (2017) 0.75
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08
Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ (2004) 9.96
The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol (2012) 8.52
The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature (1988) 7.98
Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc Jpn Acad Ser B Phys Biol Sci (2009) 5.58
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia (2007) 4.30
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab (2006) 4.11
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet (1998) 3.65
Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet (2007) 3.58
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39
Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell (2009) 2.31
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. J Biol Chem (2005) 2.25
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest (2010) 2.22
ER chaperone functions during normal and stress conditions. J Chem Neuroanat (2004) 2.13
Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion. Hum Mol Genet (2004) 2.10
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis. Diabetologia (2005) 2.08
A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus. N Engl J Med (1989) 2.08
Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes (2012) 1.98
Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nat Biotechnol (2012) 1.90
Glucoreceptor mechanisms and the control of insulin release and biosynthesis. Diabetologia (1980) 1.90
WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain. Hum Mol Genet (2001) 1.86
Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation. J Biol Chem (2007) 1.55
Wolfram (DIDMOAD) syndrome. J Med Genet (1997) 1.52
Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis. Invest Ophthalmol Vis Sci (2007) 1.41
Thiazolidinediones improve beta-cell function in type 2 diabetic patients. Am J Physiol Endocrinol Metab (2006) 1.41
Inhibition of protein synthesis and early protein processing by thapsigargin in cultured cells. Biochem J (1993) 1.35
Transplantation of pancreatic islets into the kidney capsule of diabetic mice. J Vis Exp (2007) 1.28
Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia (2012) 1.27
Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram's syndrome. Diabetes Care (1989) 1.23
iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2013) 1.23
Retracted Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Nat Cell Biol (2012) 1.20
HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response. PLoS One (2011) 1.13
WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum. FEBS Lett (2006) 1.08
Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice. Exp Mol Med (2010) 1.08
Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells. Hum Mol Genet (2011) 1.06
Improvements in insulin sensitivity and beta-cell function (HOMA) with weight loss in the severely obese. Homeostatic model assessment. Diabet Med (2003) 1.05
Molecular detection of novel WFS1 mutations in patients with Wolfram syndrome by a DHPLC-based assay. Hum Mutat (2003) 1.02
Structure-function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cells. Biochem Biophys Res Commun (2011) 1.01
Cyclic AMP signaling in pancreatic islets. Adv Exp Med Biol (2010) 0.98
Palmitate causes endoplasmic reticulum stress and apoptosis in human mesenchymal stem cells: prevention by AMPK activator. Endocrinology (2012) 0.91
Mechanism of arginine-stimulated Ca2+ influx into pancreatic B cell. Am J Physiol (1984) 0.90
Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein. Biochemistry (2009) 0.88
Efflux of 86Rb from rat and mouse pancreatic islets: the role of membrane depolarization. Br J Pharmacol (1984) 0.83
Insulin and glucagon release of human islets in vitro: effects of chronic exposure to glucagon. J Endocrinol (1997) 0.76
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Strong association of de novo copy number mutations with autism. Science (2007) 27.84
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science (2008) 14.26
CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N Engl J Med (2009) 6.89
The long-term stability of the human gut microbiota. Science (2013) 5.15
Gene expression patterns in blood leukocytes discriminate patients with acute infections. Blood (2006) 5.05
A functionally characterized test set of human induced pluripotent stem cells. Nat Biotechnol (2011) 4.95
Glycemia treatment strategies in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Am J Cardiol (2007) 4.78
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell (2009) 4.64
Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Nat Methods (2009) 4.38
Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet (2011) 4.30
Human oocytes reprogram somatic cells to a pluripotent state. Nature (2011) 4.03
Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. J Exp Med (2007) 3.51
Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol (2008) 3.49
Usability in the real world: assessing medical information technologies in patients' homes. J Biomed Inform (2003) 3.45
Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43
Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial. Lancet (2011) 3.13
Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest (2005) 3.10
Columbia University's Informatics for Diabetes Education and Telemedicine (IDEATel) Project: rationale and design. J Am Med Inform Assoc (2001) 3.06
A randomized trial comparing telemedicine case management with usual care in older, ethnically diverse, medically underserved patients with diabetes mellitus. J Am Med Inform Assoc (2005) 3.01
A randomized trial comparing telemedicine case management with usual care in older, ethnically diverse, medically underserved patients with diabetes mellitus: 5 year results of the IDEATel study. J Am Med Inform Assoc (2009) 2.90
Recommendations for standardizing glucose reporting and analysis to optimize clinical decision making in diabetes: the Ambulatory Glucose Profile (AGP). Diabetes Technol Ther (2013) 2.85
Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab (2010) 2.79
Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab (2002) 2.76
Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signaling. J Immunol (2005) 2.51
Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2010) 2.45
Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials. Lancet (2013) 2.45
Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest (2008) 2.44
Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell (2009) 2.31
Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am J Physiol Regul Integr Comp Physiol (2003) 2.28
Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. Proc Natl Acad Sci U S A (2008) 2.18
A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation. Int Immunol (2005) 2.18
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science (2011) 2.17
Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. Circ Cardiovasc Genet (2012) 2.16
Is the energy homeostasis system inherently biased toward weight gain? Diabetes (2003) 2.14
Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr (2008) 2.13
Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model. J Clin Invest (2006) 2.08
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes (2012) 2.02
11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med (2009) 1.99
Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches. Cell Stem Cell (2011) 1.98
Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants. Nature (2012) 1.95
Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons. J Neurosci (2009) 1.92
Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Obesity (Silver Spring) (2007) 1.87
Outcomes of congenital diaphragmatic hernia in the modern era of management. J Pediatr (2013) 1.80
Attitudes and practices among internists concerning genetic testing. J Genet Couns (2012) 1.75
Responses of gut microbiota to diet composition and weight loss in lean and obese mice. Obesity (Silver Spring) (2011) 1.73
To eat or not to eat - how the gut talks to the brain. N Engl J Med (2003) 1.68
A cognitive framework for understanding barriers to the productive use of a diabetes home telemedicine system. AMIA Annu Symp Proc (2003) 1.65
Return of secondary genomic findings vs patient autonomy: implications for medical care. JAMA (2013) 1.60
Gender-specific care of the patient with diabetes: review and recommendations. Gend Med (2006) 1.59
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest (2011) 1.55
Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun (2011) 1.49
Ebola virus disease cluster in the United States--Dallas County, Texas, 2014. MMWR Morb Mortal Wkly Rep (2014) 1.49
Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. Genes Dev (2005) 1.46
Dietary fat is not a major determinant of body fat. Am J Med (2002) 1.46
Determinants of leptin gene expression in fat depots of lean mice. Am J Physiol Regul Integr Comp Physiol (2002) 1.45
Epidemiologic investigation of a 2007 outbreak of Serratia marcescens bloodstream infection in Texas caused by contamination of syringes prefilled with heparin and saline. Infect Control Hosp Epidemiol (2009) 1.41
BRCA1 and BRCA2 mutation carriers in the Breast Cancer Family Registry: an open resource for collaborative research. Breast Cancer Res Treat (2008) 1.40
Glycemic control and health disparities in older ethnically diverse underserved adults with diabetes: five-year results from the Informatics for Diabetes Education and Telemedicine (IDEATel) study. Diabetes Care (2011) 1.40
Current progress in non-invasive imaging of beta cell mass of the endocrine pancreas. Curr Med Chem (2006) 1.38
The Congenital Heart Disease Genetic Network Study: rationale, design, and early results. Circ Res (2013) 1.35
Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity. J Neurosci (2009) 1.34
Body fat redistribution after weight gain in women with anorexia nervosa. Am J Clin Nutr (2005) 1.34
Observational study of spinal muscular atrophy type 2 and 3: functional outcomes over 1 year. Arch Neurol (2011) 1.32
Analysis of significance patterns identifies ubiquitous and disease-specific gene-expression signatures in patient peripheral blood leukocytes. Ann N Y Acad Sci (2005) 1.28
Disclosures of Huntington disease risk within families: patterns of decision-making and implications. Am J Med Genet A (2007) 1.28
A model for personalized in vivo analysis of human immune responsiveness. Sci Transl Med (2012) 1.27
Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys. Am J Physiol Endocrinol Metab (2006) 1.27
Cell-autonomous control of interferon type I expression by indoleamine 2,3-dioxygenase in regulatory CD19+ dendritic cells. Eur J Immunol (2007) 1.27
A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response. PLoS One (2007) 1.26
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem (2010) 1.26
B-lymphocyte depletion with rituximab and β-cell function: two-year results. Diabetes Care (2013) 1.25
Long-term safety and efficacy of human-induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa. Mol Med (2012) 1.24
iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2013) 1.23
Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Res (2011) 1.22
Energy intake in weight-reduced humans. Brain Res (2010) 1.21
Challenges and opportunities of defining clinical leptin resistance. Cell Metab (2012) 1.21
Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment. Diabetes Care (2013) 1.21
The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha. Biochem Biophys Res Commun (2009) 1.21
VMAT2 gene expression and function as it applies to imaging beta-cell mass. J Mol Med (Berl) (2007) 1.19