Published in Am J Clin Nutr on October 01, 2008
Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss. PLoS One (2009) 2.56
Predicting metabolic adaptation, body weight change, and energy intake in humans. Am J Physiol Endocrinol Metab (2009) 2.33
Behavioral treatment of obesity. Psychiatr Clin North Am (2011) 2.03
Toward a more complete (and less controversial) understanding of energy expenditure and its role in obesity pathogenesis. Diabetes (2011) 1.92
Persistent metabolic adaptation 6 years after "The Biggest Loser" competition. Obesity (Silver Spring) (2016) 1.71
Adaptive thermogenesis in humans. Int J Obes (Lond) (2010) 1.69
Biology's response to dieting: the impetus for weight regain. Am J Physiol Regul Integr Comp Physiol (2011) 1.53
Molecular physiology of weight regulation in mice and humans. Int J Obes (Lond) (2008) 1.49
Low energy intake plus low energy expenditure (low energy flux), not energy surfeit, predicts future body fat gain. Am J Clin Nutr (2016) 1.44
Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity. Dis Model Mech (2011) 1.40
Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metab (2017) 1.39
Metabolic slowing with massive weight loss despite preservation of fat-free mass. J Clin Endocrinol Metab (2012) 1.39
Effects of anti-obesity drugs, diet, and exercise on weight-loss maintenance after a very-low-calorie diet or low-calorie diet: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr (2013) 1.27
Effects of chronic weight perturbation on energy homeostasis and brain structure in mice. Am J Physiol Regul Integr Comp Physiol (2011) 1.25
Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity. Int J Obes (Lond) (2013) 1.24
Energy intake in weight-reduced humans. Brain Res (2010) 1.21
Leptin reverses declines in satiation in weight-reduced obese humans. Am J Clin Nutr (2012) 1.19
Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss. Metabolism (2011) 1.17
Hypothalamic inflammation: marker or mechanism of obesity pathogenesis? Diabetes (2013) 1.13
Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss. Am J Physiol Regul Integr Comp Physiol (2009) 1.06
20 years of leptin: role of leptin in energy homeostasis in humans. J Endocrinol (2014) 1.05
The gut microbiota in human energy homeostasis and obesity. Trends Endocrinol Metab (2015) 1.01
Nutritional rehabilitation in anorexia nervosa: review of the literature and implications for treatment. BMC Psychiatry (2013) 1.00
Surgical weight loss: impact on energy expenditure. Obes Surg (2013) 1.00
Lifestyle intervention in childhood obesity: changes and challenges. Nat Rev Endocrinol (2013) 0.98
Obesity, health at every size, and public health policy. Am J Public Health (2013) 0.97
Increased postprandial energy expenditure may explain superior long term weight loss after Roux-en-Y gastric bypass compared to vertical banded gastroplasty. PLoS One (2013) 0.97
Appetite and body weight regulation after bariatric surgery. Obes Rev (2015) 0.96
Weight suppression predicts weight change over 5 years in bulimia nervosa. Psychiatry Res (2010) 0.95
Effect of dietary adherence on the body weight plateau: a mathematical model incorporating intermittent compliance with energy intake prescription. Am J Clin Nutr (2014) 0.94
Effect of calorie restriction on the free-living physical activity levels of nonobese humans: results of three randomized trials. J Appl Physiol (1985) (2011) 0.92
The relation of weight suppression and BMI to bulimic symptoms. Int J Eat Disord (2010) 0.91
Gestational diabetes mellitus and obesity. Diabetes Care (2010) 0.91
Effects of chronic leptin infusion on subsequent body weight and composition in mice: Can body weight set point be reset? Mol Metab (2014) 0.89
Brown adipose tissue in the treatment of obesity and diabetes: Are we hot enough? J Diabetes Investig (2011) 0.87
Long-term weight maintenance after a 17-week weight loss intervention with or without a one-year maintenance program: a randomized controlled trial. J Obes (2015) 0.87
Salivary habituation to food stimuli in successful weight loss maintainers, obese and normal-weight adults. Int J Obes (Lond) (2009) 0.86
Weight loss in nonalcoholic Fatty liver disease patients in an ambulatory care setting is largely unsuccessful but correlates with frequency of clinic visits. PLoS One (2014) 0.86
The fall in leptin concentration is a major determinant of the metabolic adaptation induced by caloric restriction independently of the changes in leptin circadian rhythms. J Clin Endocrinol Metab (2011) 0.86
Does the method of weight loss effect long-term changes in weight, body composition or chronic disease risk factors in overweight or obese adults? A systematic review. PLoS One (2014) 0.85
The adaptive metabolic response to exercise-induced weight loss influences both energy expenditure and energy intake. Eur J Clin Nutr (2014) 0.85
Effects of reduced weight maintenance and leptin repletion on functional connectivity of the hypothalamus in obese humans. PLoS One (2013) 0.84
Core body temperature in obesity. Am J Clin Nutr (2011) 0.83
Effect of diet composition and weight loss on resting energy expenditure in the POUNDS LOST study. Obesity (Silver Spring) (2012) 0.83
Dietary habits and weight maintenance success in high versus low exercisers in the National Weight Control Registry. J Phys Act Health (2013) 0.82
Measuring energy expenditure in clinical populations: rewards and challenges. Eur J Clin Nutr (2013) 0.82
A missing link in body weight homeostasis: the catabolic signal of the overfed state. Cell Metab (2014) 0.82
Metabolic vs. hedonic obesity: a conceptual distinction and its clinical implications. Obes Rev (2015) 0.82
Energetic adaptations persist after bariatric surgery in severely obese adolescents. Obesity (Silver Spring) (2015) 0.81
Persistent Chromatin Modifications Induced by High Fat Diet. J Biol Chem (2016) 0.81
Repletion of TNFα or leptin in calorically restricted mice suppresses post-restriction hyperphagia. Dis Model Mech (2011) 0.80
Addressing weight loss recidivism: a clinical focus on metabolic rate and the psychological aspects of obesity. ISRN Obes (2012) 0.80
A Review of Natural Stimulant and Non-stimulant Thermogenic Agents. Phytother Res (2016) 0.78
An inconvenient truth about obesity. Mol Metab (2012) 0.78
Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss. Mol Metab (2016) 0.78
Models of energy homeostasis in response to maintenance of reduced body weight. Obesity (Silver Spring) (2016) 0.78
Chromatin Modifications Associated With Diabetes and Obesity. Arterioscler Thromb Vasc Biol (2015) 0.77
Shedding pounds after going under the knife: guts over glory-why diets fail. Nat Med (2012) 0.77
Protein-Pacing Caloric-Restriction Enhances Body Composition Similarly in Obese Men and Women during Weight Loss and Sustains Efficacy during Long-Term Weight Maintenance. Nutrients (2016) 0.77
Nutrigenomics of body weight regulation: a rationale for careful dissection of individual contributors. Nutrients (2014) 0.76
Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity. Front Physiol (2016) 0.75
Long-term weight loss maintenance in obesity: Possible insights from anorexia nervosa? Int J Eat Disord (2017) 0.75
Changes in Energy Expenditure with Weight Gain and Weight Loss in Humans. Curr Obes Rep (2016) 0.75
Brown adipose tissue: endocrine determinants of function and therapeutic manipulation as a novel treatment strategy for obesity. BMC Obes (2014) 0.75
Effects of a novel potent melanin-concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs. Br J Pharmacol (2016) 0.75
Baseline characteristics associated with different BMI trajectories in weight loss trials: a case for better targeting of interventions. Eur J Clin Nutr (2015) 0.75
Defense of Elevated Body Weight Setpoint in Diet-Induced Obese Rats on Low Energy Diet Is Mediated by Loss of Melanocortin Sensitivity in the Paraventricular Hypothalamic Nucleus. PLoS One (2015) 0.75
Assessment of acute and chronic pharmacological effects on energy expenditure and macronutrient oxidation in humans: responses to ephedrine. J Obes (2010) 0.75
Diet Versus Exercise in Weight Loss and Maintenance: Focus on Tryptophan. Int J Tryptophan Res (2016) 0.75
Medical devices for the treatment of obesity. Nat Rev Gastroenterol Hepatol (2017) 0.75
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44
The long-term stability of the human gut microbiota. Science (2013) 5.15
Human oocytes reprogram somatic cells to a pluripotent state. Nature (2011) 4.03
Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol (2008) 3.49
Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43
Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest (2005) 3.10
Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab (2010) 2.79
Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab (2002) 2.76
Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2010) 2.45
Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest (2008) 2.44
Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am J Physiol Regul Integr Comp Physiol (2003) 2.28
Is the energy homeostasis system inherently biased toward weight gain? Diabetes (2003) 2.14
11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med (2009) 1.99
Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Obesity (Silver Spring) (2007) 1.87
Responses of gut microbiota to diet composition and weight loss in lean and obese mice. Obesity (Silver Spring) (2011) 1.73
To eat or not to eat - how the gut talks to the brain. N Engl J Med (2003) 1.68
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest (2011) 1.55
Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun (2011) 1.49
Dietary fat is not a major determinant of body fat. Am J Med (2002) 1.46
Determinants of leptin gene expression in fat depots of lean mice. Am J Physiol Regul Integr Comp Physiol (2002) 1.45
Body fat redistribution after weight gain in women with anorexia nervosa. Am J Clin Nutr (2005) 1.34
Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys. Am J Physiol Endocrinol Metab (2006) 1.27
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem (2010) 1.26
iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2013) 1.23
Energy intake in weight-reduced humans. Brain Res (2010) 1.21
Challenges and opportunities of defining clinical leptin resistance. Cell Metab (2012) 1.21
Leptin reverses declines in satiation in weight-reduced obese humans. Am J Clin Nutr (2012) 1.19
β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes (2013) 1.19
Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice. Am J Physiol Regul Integr Comp Physiol (2004) 1.17
Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss. Metabolism (2011) 1.17
Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine. J Endocrinol (2008) 1.13
Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2. Neurobiol Dis (2008) 1.12
Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects. Am J Physiol Regul Integr Comp Physiol (2009) 1.12
Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet (2008) 1.10
Reproducibility and accuracy of body composition assessments in mice by dual energy x-ray absorptiometry and time domain nuclear magnetic resonance. Int J Body Compos Res (2009) 1.03
Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice. Am J Physiol Regul Integr Comp Physiol (2012) 1.01
Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arterioscler Thromb Vasc Biol (2004) 1.00
Considerations regarding the genetics of obesity. Obesity (Silver Spring) (2008) 1.00
The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest (2002) 0.97
Effects of weight loss and leptin on skeletal muscle in human subjects. Am J Physiol Regul Integr Comp Physiol (2011) 0.97
In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J (2009) 0.96
Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell (2011) 0.96
Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny. Obesity (Silver Spring) (2010) 0.96
Functional consequences of the human leptin receptor (LEPR) Q223R transversion. Obesity (Silver Spring) (2008) 0.96
Roles of the placenta in fetal brain development. Proc Natl Acad Sci U S A (2011) 0.93
Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein. J Biol Chem (2011) 0.93
Differentiation of hypothalamic-like neurons from human pluripotent stem cells. J Clin Invest (2015) 0.93
Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. Hum Hered (2008) 0.89
Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro. Mol Endocrinol (2012) 0.89
Molecular physiology of syndromic obesities in humans. Trends Endocrinol Metab (2005) 0.88
The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects. J Nutr Biochem (2007) 0.87
TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism. Endocrinology (2012) 0.85
The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity. Am J Physiol Endocrinol Metab (2006) 0.84
Fat cell size and adipokine expression in relation to gender, depot, and metabolic risk factors in morbidly obese adolescents. Obesity (Silver Spring) (2013) 0.84
Whole-exome sequencing identifies novel LEPR mutations in individuals with severe early onset obesity. Obesity (Silver Spring) (2013) 0.83
Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study). Front Genet (2011) 0.82
Hypomorphism of Fto and Rpgrip1l causes obesity in mice. J Clin Invest (2016) 0.81
Diabetes and oral disease: implications for health professionals. Ann N Y Acad Sci (2012) 0.81
Energy in, energy out, and the effects of obesity-related genes. N Engl J Med (2008) 0.81
Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring) (2014) 0.80
Measuring activity of the autonomic nervous system in humans. Obes Res (2003) 0.80
Location, location, location... Cell Metab (2008) 0.80
Haplotype analysis of the growth hormone releasing hormone receptor locus in three apparently unrelated kindreds from the indian subcontinent with the identical mutation in the GHRH receptor. Am J Med Genet A (2003) 0.80
Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome. J Clin Invest (2016) 0.79
Effects of a novel MC4R agonist on maintenance of reduced body weight in diet-induced obese mice. Obesity (Silver Spring) (2014) 0.78
The links between obesity, leptin, and prostate cancer. Cancer J (2006) 0.78
An apparent role for Alox15 in the pathogenesis of diabetes in the NOD mouse: parsing the supporting genetic data. Diabetes (2008) 0.77
Does diet composition have structural consequences in the hypothalamus? Mol Metab (2013) 0.77
FTO gains function. Nat Genet (2010) 0.76
ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis. PLoS One (2013) 0.76
Brain reorganization following weight loss. Nestle Nutr Inst Workshop Ser (2012) 0.76
Identifying functional relationships among human genes by systematic analysis of biological literature. BMC Bioinformatics (2002) 0.75
One thing leads to another. J Clin Invest (2004) 0.75
Toward optimal health: the experts discuss advances in diabetes management in women. Interview by Jodi Godfrey. J Womens Health (Larchmt) (2004) 0.75
iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2017) 0.75
Straight talk with...Jules Hirsch. Interview by Roxanne Palmer. Nat Med (2010) 0.75
Corrigendum: MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature (2017) 0.75