c-myc and c-fos expression in differentiating mouse primary keratinocytes.

An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation. Mol Cell Biol (1988) 4.08

Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta. Mol Cell Biol (1988) 2.20

Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells. Mol Cell Biol (1988) 2.00

Malignant transformation of mouse primary keratinocytes by Harvey sarcoma virus and its modulation by surrounding normal cells. Proc Natl Acad Sci U S A (1988) 1.66

Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C. J Cell Biol (1993) 1.54

The human cut homeodomain protein represses transcription from the c-myc promoter. Mol Cell Biol (1994) 1.40

Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment. J Cell Biol (1989) 1.32

The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins. Mol Cell Biol (1991) 1.22

Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene. Proc Natl Acad Sci U S A (1988) 1.12

Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma. Proc Natl Acad Sci U S A (1990) 1.11

Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation. Mol Cell Biol (1990) 1.07

Role of PI3K-AKT-mTOR and Wnt Signaling Pathways in Transition of G1-S Phase of Cell Cycle in Cancer Cells. Front Oncol (2013) 1.02

Cell cycle regulation of the c-Myc transcriptional activation domain. Mol Cell Biol (1993) 1.01

Constitutive expression of growth-related mRNAs in proliferating and nonproliferating lung epithelial cells in primary culture: evidence for growth-dependent translational control. Proc Natl Acad Sci U S A (1990) 0.94

The calcium signal for BALB/MK keratinocyte terminal differentiation counteracts epidermal growth factor (EGF) very early in the EGF-induced proliferative pathway. Mol Cell Biol (1988) 0.94

Retroviral transduction of the human c-Ha-ras-1 oncogene into midgestation mouse embryos promotes rapid epithelial hyperplasia. Mol Cell Biol (1989) 0.90

Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2. Mol Cell Biol (1993) 0.89

Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation. Nucleic Acids Res (2007) 0.88

Response modification in carcinogenesis. Environ Health Perspect (1989) 0.86

The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors. Proc Natl Acad Sci U S A (1989) 0.84

Developmentally regulated alternative splicing in the Xenopus laevis c-Myc gene creates an intron-1 containing c-Myc RNA present only in post-midblastula embryos. Nucleic Acids Res (1991) 0.79

Changes in oncogene mRNA expression during human keratinocyte differentiation. Arch Dermatol Res (1994) 0.78

The involvement of protein kinase C in proliferation and differentiation of human keratinocytes--an investigation using inhibitors of protein kinase C. Arch Dermatol Res (1994) 0.75

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95

Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res (1984) 86.56

The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (1984) 28.58

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (1984) 24.45

A simple, rapid, and sensitive DNA assay procedure. Anal Biochem (1980) 23.88

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell (1983) 17.87

Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature (1985) 9.73

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature (1985) 8.36

Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell (1980) 8.10

Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation. Cell (1984) 6.53

Expression of cellular homologues of retroviral onc genes in human hematopoietic cells. Proc Natl Acad Sci U S A (1982) 5.80

Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini. Cell (1983) 5.79

Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription. Mol Cell Biol (1986) 5.07

Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor. Science (1984) 4.87

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J Biol Chem (1985) 4.87

Transcriptional and posttranscriptional control of c-myc during myogenesis: its mRNA remains inducible in differentiated cells and does not suppress the differentiated phenotype. Mol Cell Biol (1986) 4.46

Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation. Cell (1985) 3.81

Differentiation of the epidermal keratinocyte in cell culture: formation of the cornified envelope. Cell (1976) 3.30

Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines. Science (1985) 3.15

Induction of the proto-oncogene fos by nerve growth factor. Proc Natl Acad Sci U S A (1985) 2.74

Induction of c-fos during myelomonocytic differentiation and macrophage proliferation. Nature (1985) 2.34

Mouse skin cells resistant to terminal differentiation associated with initiation of carcinogenesis. Nature (1981) 1.96

Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro. Exp Cell Res (1974) 1.94

c-fos expression is neither sufficient nor obligatory for differentiation of monomyelocytes to macrophages. Cell (1986) 1.87

Differential expression of c-fos in hematopoietic cells: correlation with differentiation of monomyelocytic cells in vitro. EMBO J (1984) 1.63

Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Cancer Res (1982) 1.44

Growth and differentiation characteristics of transformed keratinocytes from mouse and human skin in vitro and in vivo. J Invest Dermatol (1983) 1.36

Quantitative assay for carcinogen altered differentiation in mouse epidermal cells. Carcinogenesis (1980) 1.17

Proto-oncogene expression during two-stage carcinogenesis in mouse skin. Carcinogenesis (1985) 1.05

Differential effects of complete and second-stage tumour promoters in normal but not transformed human and mouse keratinocytes. Carcinogenesis (1984) 0.89

Transformation of epidermal cells in culture. J Invest Dermatol (1983) 0.86

Correlation of initiating potency of skin carcinogens with potency to induce resistance to terminal differentiation in cultured mouse keratinocytes. Cancer Res (1985) 0.84

The hallmarks of cancer. Cell (2000) 113.05

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature (1983) 19.76

Tumor spectrum analysis in p53-mutant mice. Curr Biol (1994) 16.60

Creation of human tumour cells with defined genetic elements. Nature (1999) 16.47

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature (1986) 13.96

Mechanism of activation of a human oncogene. Nature (1982) 12.09

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev (2001) 11.25

Effects of an Rb mutation in the mouse. Nature (1992) 11.06

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature (1988) 10.98

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell (1988) 9.04

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 8.74

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell (1992) 7.61

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature (1993) 7.20

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature (1985) 7.07

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell (1986) 7.06

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression. Mol Cell Biol (1986) 7.06

Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell (1982) 6.93

Cellular oncogenes and multistep carcinogenesis. Science (1983) 6.52

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature (1985) 6.23

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell (1989) 6.11

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature (1982) 6.09

Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell (1995) 6.08

The integrated genome of murine leukemia virus. Cell (1978) 5.84

The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature (1986) 5.77

Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc Natl Acad Sci U S A (1979) 5.32

Physical interaction of the retinoblastoma protein with human D cyclins. Cell (1993) 5.31

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol (2000) 5.28

Developmental and genetic regulation of Bacillus subtilis genes transcribed by sigma 28-RNA polymerase. Cell (1983) 5.25

Acrylamide gel electrophoresis of HeLa cell nucleolar RNA. Proc Natl Acad Sci U S A (1967) 5.06

Small molecular weight monodisperse nuclear RNA. J Mol Biol (1968) 4.96

Inhibition of telomerase limits the growth of human cancer cells. Nat Med (1999) 4.96

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts. Nature (1981) 4.72

Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell (1992) 4.68

A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science (1993) 4.65

Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol (1998) 4.54

DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster. Proc Natl Acad Sci U S A (1981) 4.17

Suppression of intestinal neoplasia by DNA hypomethylation. Cell (1995) 4.16

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci U S A (1998) 4.11

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering. Cell (1987) 4.10

Isolation and characterization of simian virus 40 ribonucleic acid. J Virol (1972) 4.09

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc Natl Acad Sci U S A (1990) 4.06

Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature (1996) 4.05

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci U S A (1993) 4.05

Restriction endonuclease cleavage of linear and closed circular murine leukemia viral DNAs: discovery of a smaller circular form. Cell (1979) 4.04

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet (1994) 3.97

A defined subgenomic fragment of in vitro synthesized Moloney sarcoma virus DNA can induce cell transformation upon transfection. Cell (1979) 3.74

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature (1993) 3.73

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. Proc Natl Acad Sci U S A (1987) 3.72

Identification of DNA fragments carrying ecotropic proviruses of AKR mice. Proc Natl Acad Sci U S A (1979) 3.64

The action of oncogenes in the cytoplasm and nucleus. Science (1985) 3.62

Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature (1997) 3.57

Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp Cell Res (2001) 3.48

Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev (1993) 3.41

Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology (1993) 3.37

Functional analysis of bacteriophage f1 intergenic region. Virology (1981) 3.37

Point mutational inactivation of the retinoblastoma antioncogene. Science (1989) 3.37

Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30

Characterization of a human colon/lung carcinoma oncogene. Nature (1983) 3.26

A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci U S A (1998) 3.23

Replication of a plasmid containing two origins of bacteriophage. J Mol Biol (1981) 3.21

Proposal for naming host cell-derived inserts in retrovirus genomes. J Virol (1981) 3.18

Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol Cell Biol (1996) 3.15

Infectious viral DNA of murine leukemia virus. Proc Natl Acad Sci U S A (1975) 3.09

Growth suppression by p16ink4 requires functional retinoblastoma protein. Proc Natl Acad Sci U S A (1995) 3.08

Murine leukemia virus: detection of unintegrated double-stranded DNA forms of the provirus. Proc Natl Acad Sci U S A (1975) 3.07

The pathway to signal achievement. Nature (1993) 3.03

The HL-60 transforming sequence: a ras oncogene coexisting with altered myc genes in hematopoietic tumors. Cell (1983) 3.00

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci U S A (1995) 2.99

Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor. Science (1992) 2.99

Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc Natl Acad Sci U S A (1997) 2.97

Structure of the intermediates leading to the integrated provirus. Biochim Biophys Acta (1977) 2.96

Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene (1996) 2.96

Association between GTPase activators for Rho and Ras families. Nature (1992) 2.92

Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus. Cell (1992) 2.90

Expression cloning and characterization of the TGF-beta type III receptor. Cell (1991) 2.89

Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science (1998) 2.88

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment. Cell (1991) 2.87

Function of a human cyclin gene as an oncogene. Proc Natl Acad Sci U S A (1994) 2.87

Association of Cdk-activating kinase subunits with transcription factor TFIIH. Nature (1995) 2.87

Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts. Mol Cell Biol (1986) 2.86

The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. Science (1985) 2.80

DNA bending and orientation-dependent function of YY1 in the c-fos promoter. Genes Dev (1993) 2.80

Three different human tumor cell lines contain different oncogenes. Cell (1981) 2.77

Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies. Cell (1985) 2.75

The catalytic subunit of yeast telomerase. Proc Natl Acad Sci U S A (1997) 2.72

Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proc Natl Acad Sci U S A (1995) 2.70

Heterogeneity of RNA polymerase in Bacillus subtilis: evidence for an additional sigma factor in vegetative cells. Proc Natl Acad Sci U S A (1981) 2.69

Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Oncogene (1993) 2.67

The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression. Genes Dev (1996) 2.61

Processing of 45 s nucleolar RNA. J Mol Biol (1970) 2.60

Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion. EMBO J (1988) 2.59

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J (1994) 2.57

Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. Nat Genet (1998) 2.56

Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene (1998) 2.56

Rescue of cyclin D1 deficiency by knockin cyclin E. Cell (1999) 2.54

Generation of novel, biologically active Harvey sarcoma viruses via apparent illegitimate recombination. J Virol (1981) 2.53