Published in Genome Res on September 01, 2012
Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature (2015) 3.64
CTCF: an architectural protein bridging genome topology and function. Nat Rev Genet (2014) 3.64
CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell (2015) 2.59
A genome-wide map of CTCF multivalency redefines the CTCF code. Cell Rep (2013) 1.92
From promises to practical strategies in epigenetic epidemiology. Nat Rev Genet (2013) 1.82
3D Chromosome Regulatory Landscape of Human Pluripotent Cells. Cell Stem Cell (2015) 1.81
Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. Genome Biol (2013) 1.69
Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer. Genome Res (2014) 1.63
RBPJ, the major transcriptional effector of Notch signaling, remains associated with chromatin throughout mitosis, suggesting a role in mitotic bookmarking. PLoS Genet (2014) 1.61
Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci (2015) 1.60
Genomic discovery of potent chromatin insulators for human gene therapy. Nat Biotechnol (2015) 1.56
Chromatin insulators: linking genome organization to cellular function. Mol Cell (2013) 1.51
What does our genome encode? Genome Res (2012) 1.47
Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models. Genome Biol (2015) 1.46
Evolution of transcription factor binding in metazoans - mechanisms and functional implications. Nat Rev Genet (2014) 1.33
CTCF: the protein, the binding partners, the binding sites and their chromatin loops. Philos Trans R Soc Lond B Biol Sci (2013) 1.32
Effects of cytosine methylation on transcription factor binding sites. BMC Genomics (2014) 1.31
Transcription factor binding dynamics during human ES cell differentiation. Nature (2015) 1.30
Global DNA methylation remodeling accompanies CD8 T cell effector function. J Immunol (2013) 1.27
TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway. Oncogene (2014) 1.26
Cross-talk between site-specific transcription factors and DNA methylation states. J Biol Chem (2013) 1.24
A brief review on the Human Encyclopedia of DNA Elements (ENCODE) project. Genomics Proteomics Bioinformatics (2013) 1.22
Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility. Nat Immunol (2014) 1.20
Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat Commun (2014) 1.20
Large-scale identification of sequence variants influencing human transcription factor occupancy in vivo. Nat Genet (2015) 1.16
Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks. Bioessays (2013) 1.13
Architectural proteins: regulators of 3D genome organization in cell fate. Trends Cell Biol (2014) 1.12
CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer. Cell Rep (2014) 1.11
Nucleosome repositioning links DNA (de)methylation and differential CTCF binding during stem cell development. Genome Res (2014) 1.09
Widespread context dependency of microRNA-mediated regulation. Genome Res (2014) 1.08
RNA-mediated toxicity in neurodegenerative disease. Mol Cell Neurosci (2012) 1.07
Epigenetics and the regulation of stress vulnerability and resilience. Neuroscience (2013) 1.06
Editing DNA Methylation in the Mammalian Genome. Cell (2016) 1.04
The role of chromatin insulators in nuclear architecture and genome function. Curr Opin Genet Dev (2013) 1.04
Organization and function of the 3D genome. Nat Rev Genet (2016) 1.03
Characterization of constitutive CTCF/cohesin loci: a possible role in establishing topological domains in mammalian genomes. BMC Genomics (2013) 1.03
"Seq-ing" insights into the epigenetics of neuronal gene regulation. Neuron (2013) 1.03
Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin. Genome Res (2015) 1.02
An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins. Nucleic Acids Res (2014) 1.02
Decoding the human genome. Genome Res (2012) 0.97
DNA methylation and differentiation: silencing, upregulation and modulation of gene expression. Epigenomics (2013) 0.97
Patterning and regulatory associations of DNA methylation are mirrored by histone modifications in insects. Genome Biol Evol (2013) 0.96
Comprehensive genotyping and clinical characterisation reveal 27 novel NKX2-1 mutations and expand the phenotypic spectrum. J Med Genet (2014) 0.94
Co-binding by YY1 identifies the transcriptionally active, highly conserved set of CTCF-bound regions in primate genomes. Genome Biol (2013) 0.93
Intrinsically disordered proteins and conformational noise: implications in cancer. Cell Cycle (2012) 0.92
On the value of intra-motif dependencies of human insulator protein CTCF. PLoS One (2014) 0.92
Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control. Cell (2016) 0.91
Bivalent Regions of Cytosine Methylation and H3K27 Acetylation Suggest an Active Role for DNA Methylation at Enhancers. Mol Cell (2016) 0.91
Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal. Genome Res (2014) 0.91
ENCODE: A Sourcebook of Epigenomes and Chromatin Language. Genomics Inform (2013) 0.91
TFIIH subunit alterations causing xeroderma pigmentosum and trichothiodystrophy specifically disturb several steps during transcription. Am J Hum Genet (2015) 0.90
Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a Northern European family population. BMC Med Genomics (2013) 0.89
Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors. Cell Stem Cell (2015) 0.89
Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions. Genome Biol (2015) 0.88
Subtelomeric CTCF and cohesin binding site organization using improved subtelomere assemblies and a novel annotation pipeline. Genome Res (2014) 0.88
Architectural proteins, transcription, and the three-dimensional organization of the genome. FEBS Lett (2015) 0.87
Modeling the relationship of epigenetic modifications to transcription factor binding. Nucleic Acids Res (2015) 0.86
Role of CTCF protein in regulating FMR1 locus transcription. PLoS Genet (2013) 0.85
A variably occupied CTCF binding site in the ultrabithorax gene in the Drosophila bithorax complex. Mol Cell Biol (2014) 0.84
Accumulation of CTCF-binding sites drives expression divergence between tandemly duplicated genes in humans. BMC Genomics (2014) 0.84
Dynamic reorganization of the AC16 cardiomyocyte transcriptome in response to TNFα signaling revealed by integrated genomic analyses. BMC Genomics (2014) 0.84
Genome-wide DNA methylation map of human neutrophils reveals widespread inter-individual epigenetic variation. Sci Rep (2015) 0.84
A dynamic CTCF chromatin binding landscape promotes DNA hydroxymethylation and transcriptional induction of adipocyte differentiation. Nucleic Acids Res (2014) 0.84
Increased Intragenic IGF2 Methylation is Associated with Repression of Insulator Activity and Elevated Expression in Serous Ovarian Carcinoma. Front Oncol (2013) 0.83
Identification and characterization of enhancer-blocking insulators to reduce retroviral vector genotoxicity. PLoS One (2013) 0.83
Differential DNA methylation identified in the blood and retina of AMD patients. Epigenetics (2015) 0.83
Human-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases. Genome Med (2014) 0.83
Epigenetic-based therapies for Friedreich ataxia. Front Genet (2014) 0.82
Functional interactions between NURF and Ctcf regulate gene expression. Mol Cell Biol (2014) 0.82
CTCF as a multifunctional protein in genome regulation and gene expression. Exp Mol Med (2015) 0.82
The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition. Nucleic Acids Res (2014) 0.81
CTCF-mediated chromatin loops enclose inducible gene regulatory domains. BMC Genomics (2016) 0.81
The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer. Cold Spring Harb Perspect Med (2016) 0.81
Functional diversity of CTCFs is encoded in their binding motifs. BMC Genomics (2015) 0.80
An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1. Elife (2016) 0.80
Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders. Genome Biol (2016) 0.80
Regulation of disease-associated gene expression in the 3D genome. Nat Rev Mol Cell Biol (2016) 0.80
CCCTC-binding factor recruitment to the early region of the human papillomavirus 18 genome regulates viral oncogene expression. J Virol (2015) 0.79
Argonaute 2 Binds Directly to tRNA Genes and Promotes Gene Repression in cis. Mol Cell Biol (2015) 0.79
Systematic identification and annotation of human methylation marks based on bisulfite sequencing methylomes reveals distinct roles of cell type-specific hypomethylation in the regulation of cell identity genes. Nucleic Acids Res (2015) 0.79
A chromatin code for alternative splicing involving a putative association between CTCF and HP1α proteins. BMC Biol (2015) 0.79
Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol (2017) 0.78
A Comparative Analysis of Genetic and Epigenetic Events of Breast and Ovarian Cancer Related to Tumorigenesis. Int J Mol Sci (2016) 0.78
Towards a predictive model of chromatin 3D organization. Semin Cell Dev Biol (2015) 0.78
DNA-Methylation Patterns in Trisomy 21 Using Cells from Monozygotic Twins. PLoS One (2015) 0.78
Longitudinal epigenetic variation of DNA methyltransferase genes is associated with vulnerability to post-traumatic stress disorder. Psychol Med (2014) 0.77
The cancer-associated CTCFL/BORIS protein targets multiple classes of genomic repeats, with a distinct binding and functional preference for humanoid-specific SVA transposable elements. Epigenetics Chromatin (2016) 0.77
Topologically Associating Domains: An invariant framework or a dynamic scaffold? Nucleus (2015) 0.77
High-resolution genome-wide DNA methylation maps of mouse primary female dermal fibroblasts and keratinocytes. Epigenetics Chromatin (2014) 0.77
Toward mapping the biology of the genome. Genome Res (2012) 0.77
Targeting CTCF to Control Virus Gene Expression: A Common Theme amongst Diverse DNA Viruses. Viruses (2015) 0.77
B cell differentiation is associated with reprogramming the CCCTC binding factor-dependent chromatin architecture of the murine MHC class II locus. J Immunol (2014) 0.77
Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol Cell (2017) 0.77
CTCF and CTCFL mRNA expression in 17β-estradiol-treated MCF7 cells. Biomed Rep (2013) 0.76
The Evolution of Epigenetics: From Prokaryotes to Humans and Its Biological Consequences. Genet Epigenet (2016) 0.76
The three-dimensional cancer genome. Curr Opin Genet Dev (2016) 0.76
Recent advances in understanding nuclear size and shape. Nucleus (2016) 0.76
Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines. BMC Cancer (2016) 0.76
YY1 and CTCF orchestrate a 3D chromatin looping switch during early neural lineage commitment. Genome Res (2017) 0.76
Next-generation sequencing identifies major DNA methylation changes during progression of Ph+ chronic myeloid leukemia. Leukemia (2016) 0.75
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol (2009) 235.12
Statistical significance for genomewide studies. Proc Natl Acad Sci U S A (2003) 88.64
Differential expression analysis for sequence count data. Genome Biol (2010) 64.56
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
The epigenomics of cancer. Cell (2007) 30.91
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
The accessible chromatin landscape of the human genome. Nature (2012) 16.86
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature (2000) 14.91
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature (2000) 12.97
Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature (2008) 12.01
Pvclust: an R package for assessing the uncertainty in hierarchical clustering. Bioinformatics (2006) 10.83
Design and analysis of ChIP-seq experiments for DNA-binding proteins. Nat Biotechnol (2008) 10.10
DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature (2011) 8.75
Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell (2008) 7.80
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41
An expansive human regulatory lexicon encoded in transcription factor footprints. Nature (2012) 7.27
Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat Genet (2011) 6.98
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev (2006) 6.32
An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol (1996) 5.74
CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. Mol Cell (2004) 5.51
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. Nature (2011) 5.50
Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr Biol (2000) 5.34
CTCF physically links cohesin to chromatin. Proc Natl Acad Sci U S A (2008) 4.89
Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site. Cell (1990) 4.13
Identification of genetic elements that autonomously determine DNA methylation states. Nat Genet (2011) 4.04
Developmental programming of CpG island methylation profiles in the human genome. Nat Struct Mol Biol (2009) 3.96
Cytosine methylation and mammalian development. Genes Dev (1999) 3.82
Effects of DNA methylation on DNA-binding proteins and gene expression. Curr Opin Genet Dev (1993) 3.64
Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nat Genet (2004) 3.56
CTCF maintains differential methylation at the Igf2/H19 locus. Nat Genet (2002) 3.15
CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus. Nat Genet (2001) 2.93
The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide. Genome Res (2004) 2.78
Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell (2007) 2.69
BEDOPS: high-performance genomic feature operations. Bioinformatics (2012) 2.62
A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature (2011) 2.58
The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta-protein precursor promoter. Evidence for a role in transcriptional activation. J Biol Chem (1997) 2.55
Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci. J Biol Chem (2007) 2.49
The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. Nature (2009) 2.40
CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity (2009) 2.24
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. Mol Cell Biol (2004) 2.24
Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell (2009) 2.21
DNA methylation and chromatin structure: a view from below. Trends Biochem Sci (1990) 2.11
CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide. Mol Cell Biol (2007) 2.07
Does CTCF mediate between nuclear organization and gene expression? Bioessays (2010) 2.02
Control of embryonic stem cell lineage commitment by core promoter factor, TAF3. Cell (2011) 2.00
CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proc Natl Acad Sci U S A (2008) 1.90
The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription. Mol Cell (2008) 1.81
A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers. Genes Chromosomes Cancer (1998) 1.79
An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA. EMBO J (1998) 1.74
Widespread site-dependent buffering of human regulatory polymorphism. PLoS Genet (2012) 1.72
General transcription factor binding at CpG islands in normal cells correlates with resistance to de novo DNA methylation in cancer cells. Cancer Res (2010) 1.64
Antagonism between DNA hypermethylation and enhancer-blocking activity at the H19 DMD is uncovered by CpG mutations. Nat Genet (2004) 1.60
Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF. Mol Cell Biol (2001) 1.48
Cell growth inhibition by the multifunctional multivalent zinc-finger factor CTCF. Cancer Res (2001) 1.42
VEZF1 elements mediate protection from DNA methylation. PLoS Genet (2010) 1.42
DXZ4 chromatin adopts an opposing conformation to that of the surrounding chromosome and acquires a novel inactive X-specific role involving CTCF and antisense transcripts. Genome Res (2008) 1.40
DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. J Exp Med (2010) 1.39
The CTCF insulator protein is posttranslationally modified by SUMO. Mol Cell Biol (2008) 1.37
Modulation of DNA binding protein affinity directly affects target site demethylation. Mol Cell Biol (2000) 1.31
Heightened expression of CTCF in breast cancer cells is associated with resistance to apoptosis. Cancer Res (2005) 1.26
DNA binding sites for putative methylation boundaries in the unmethylated region of the BRCA1 promoter. Int J Cancer (2004) 1.25
Epigenetic regulation of the human p53 gene promoter by the CTCF transcription factor in transformed cell lines. Oncogene (2010) 1.16
DNA methylation: a secondary event in globin gene switching? Genes Dev (1988) 1.04
Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter. BMC Cancer (2011) 0.92
CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR. Hum Mol Genet (2010) 0.86
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Genome-wide mapping of in vivo protein-DNA interactions. Science (2007) 64.92
Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63
Mapping and sequencing of structural variation from eight human genomes. Nature (2008) 30.28
Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83
Fine-scale structural variation of the human genome. Nat Genet (2005) 24.31
Worldwide human relationships inferred from genome-wide patterns of variation. Science (2008) 22.44
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A (2002) 20.48
Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res (2005) 17.58
The accessible chromatin landscape of the human genome. Nature (2012) 16.86
Systematic localization of common disease-associated variation in regulatory DNA. Science (2012) 14.47
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
An integrated software system for analyzing ChIP-chip and ChIP-seq data. Nat Biotechnol (2008) 13.96
Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data. Nat Methods (2008) 11.61
Comprehensive transposon mutant library of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2003) 10.63
Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles. Science (2005) 10.46
Global mapping of protein-DNA interactions in vivo by digital genomic footprinting. Nat Methods (2009) 10.17
Quantifying similarity between motifs. Genome Biol (2007) 9.27
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res (2004) 9.18
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res (2012) 9.13
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci U S A (2006) 8.85
Genome-scale mapping of DNase I sensitivity in vivo using tiling DNA microarrays. Nat Methods (2006) 8.52
Signals of recent positive selection in a worldwide sample of human populations. Genome Res (2009) 8.38
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Sequence census methods for functional genomics. Nat Methods (2007) 7.38
An expansive human regulatory lexicon encoded in transcription factor footprints. Nature (2012) 7.27
Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat Genet (2011) 6.98
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. Nature (2010) 6.87
Population analysis of large copy number variants and hotspots of human genetic disease. Am J Hum Genet (2009) 6.79
Identification and functional analysis of human transcriptional promoters. Genome Res (2003) 6.23
An abundance of bidirectional promoters in the human genome. Genome Res (2004) 5.90
Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer. Science (2009) 5.64
Power of deep, all-exon resequencing for discovery of human trait genes. Proc Natl Acad Sci U S A (2009) 5.61
Characterization of missing human genome sequences and copy-number polymorphic insertions. Nat Methods (2010) 5.44
The genomic basis of adaptive evolution in threespine sticklebacks. Nature (2012) 5.20
Nucleosome positioning signals in genomic DNA. Genome Res (2007) 4.99
A validated regulatory network for Th17 cell specification. Cell (2012) 4.82
Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors. Genome Res (2012) 4.80
Candidate-gene approaches for studying complex genetic traits: practical considerations. Nat Rev Genet (2002) 4.76
Sequencing newly replicated DNA reveals widespread plasticity in human replication timing. Proc Natl Acad Sci U S A (2009) 4.76
Coding potential of laboratory and clinical strains of human cytomegalovirus. Proc Natl Acad Sci U S A (2003) 4.37
Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Genome Res (2007) 4.33
Closing gaps in the human genome with fosmid resources generated from multiple individuals. Nat Genet (2007) 4.30
An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol (2012) 4.15
Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. Genome Res (2009) 4.11
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet (2008) 4.02
Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome. Genome Res (2005) 3.85
Human mutation rate associated with DNA replication timing. Nat Genet (2009) 3.81
Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma. Nat Immunol (2007) 3.72
Direct isolation and identification of promoters in the human genome. Genome Res (2005) 3.68
Quantification of rare allelic variants from pooled genomic DNA. Nat Methods (2009) 3.66
Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1. Nat Genet (2013) 3.64
Dynamic DNA methylation across diverse human cell lines and tissues. Genome Res (2013) 3.61
Discovery of functional noncoding elements by digital analysis of chromatin structure. Proc Natl Acad Sci U S A (2004) 3.59
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci U S A (2009) 3.49
A comprehensive transposon mutant library of Francisella novicida, a bioweapon surrogate. Proc Natl Acad Sci U S A (2007) 3.49