Published in Proc Natl Acad Sci U S A on March 20, 2014
Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape. Proc Natl Acad Sci U S A (2014) 1.42
Metabostemness: a new cancer hallmark. Front Oncol (2014) 1.05
Oncometabolic Nuclear Reprogramming of Cancer Stemness. Stem Cell Reports (2016) 0.83
Effects of Collective Histone State Dynamics on Epigenetic Landscape and Kinetics of Cell Reprogramming. Sci Rep (2015) 0.77
Reprogramming by lineage specifiers: blurring the lines between pluripotency and differentiation. Curr Opin Genet Dev (2014) 0.75
Increased robustness of early embryogenesis through collective decision-making by key transcription factors. BMC Syst Biol (2015) 0.75
Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells. Cell Rep (2016) 0.75
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat Biotechnol (2008) 10.63
Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science (2008) 10.55
Direct cell reprogramming is a stochastic process amenable to acceleration. Nature (2009) 8.71
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell (2010) 7.51
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell (2011) 7.30
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature (2009) 6.85
Cells of origin in cancer. Nature (2011) 6.85
Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature (2010) 6.20
Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell (2011) 6.11
Pioneer transcription factors: establishing competence for gene expression. Genes Dev (2011) 6.01
Deterministic direct reprogramming of somatic cells to pluripotency. Nature (2013) 5.18
Cancer stem cells: current status and evolving complexities. Cell Stem Cell (2012) 5.07
Elite and stochastic models for induced pluripotent stem cell generation. Nature (2009) 5.06
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol (2011) 4.64
A molecular roadmap of reprogramming somatic cells into iPS cells. Cell (2012) 4.41
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A (2011) 3.93
Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome. Cell (2012) 3.80
Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell (2012) 3.52
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell (2012) 3.30
Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell (2009) 3.12
miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol (2011) 2.79
Cancer stem cells: the challenges ahead. Nat Cell Biol (2013) 2.78
Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell (2013) 2.69
Direct lineage conversions: unnatural but useful? Nat Biotechnol (2011) 2.69
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat Rev Mol Cell Biol (2011) 2.52
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet (2012) 2.47
A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol (2010) 2.32
Mechanisms and models of somatic cell reprogramming. Nat Rev Genet (2013) 2.09
Quantifying the Waddington landscape and biological paths for development and differentiation. Proc Natl Acad Sci U S A (2011) 2.00
Origins and implications of pluripotent stem cell variability and heterogeneity. Nat Rev Mol Cell Biol (2013) 1.91
Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods (2012) 1.91
Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency. Cell Rep (2012) 1.84
A dynamical-systems view of stem cell biology. Science (2012) 1.82
The potential landscape of genetic circuits imposes the arrow of time in stem cell differentiation. Biophys J (2010) 1.76
A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network. Cell Stem Cell (2012) 1.72
Genetic and epigenetic variations in iPSCs: potential causes and implications for application. Cell Stem Cell (2013) 1.63
Lineage conversion methodologies meet the reprogramming toolbox. Nat Cell Biol (2012) 1.56
Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies. Nat Rev Mol Cell Biol (2013) 1.52
Reprogramming of human fibroblasts to pluripotency with lineage specifiers. Cell Stem Cell (2013) 1.45
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier. Philos Trans R Soc Lond B Biol Sci (2013) 1.26
Quasi-potential landscape in complex multi-stable systems. J R Soc Interface (2012) 1.23
Potential and flux landscapes quantify the stability and robustness of budding yeast cell cycle network. Proc Natl Acad Sci U S A (2010) 1.17
Statistical mechanics of pluripotency. Cell (2013) 1.16
Stem cells and reprogramming: breaking the epigenetic barrier? Trends Pharmacol Sci (2011) 1.12
Quantifying cell fate decisions for differentiation and reprogramming of a human stem cell network: landscape and biological paths. PLoS Comput Biol (2013) 1.08
Cancer stem cell dynamics in tumor progression and metastasis: is the microenvironment to blame? Cancer Lett (2012) 1.06
Predicting rates of cell state change caused by stochastic fluctuations using a data-driven landscape model. Proc Natl Acad Sci U S A (2012) 0.89
Understanding impediments to cellular conversion to pluripotency by assessing the earliest events in ectopic transcription factor binding to the genome. Cell Cycle (2013) 0.83
First passage time distribution in stochastic processes with moving and static absorbing boundaries with application to biological rupture experiments. J Chem Phys (2010) 0.80
Reprogramming somatic cells to pluripotency: a fresh look at Yamanaka's model. Cell Cycle (2013) 0.79
Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50
Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell (2011) 6.82
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature (2002) 3.67
Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature (2011) 3.56
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature (2012) 3.38
Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell (2011) 3.32
Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A (2005) 3.13
Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell (2009) 3.12
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat Rev Mol Cell Biol (2011) 2.52
Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector. Proc Natl Acad Sci U S A (2009) 2.44
A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol (2010) 2.32
A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques (2009) 2.30
The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. Cell Res (2011) 2.30
Visual adaptation: neural, psychological and computational aspects. Vision Res (2007) 2.23
Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell (2008) 2.21
Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells. Nat Cell Biol (2013) 2.20
The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell (2009) 2.11
Transcriptomics approach to investigate zebrafish heart regeneration. J Cardiovasc Med (Hagerstown) (2010) 2.00
CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site. Immunity (2010) 1.91
Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods (2012) 1.91
Cooperative nonlinearities in auditory cortical neurons. Neuron (2008) 1.90
Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development. Development (2011) 1.88
LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells. Nat Cell Biol (2011) 1.76
Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 1.69
Mitochondrial regulation in pluripotent stem cells. Cell Metab (2013) 1.67
Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev (2003) 1.57
Lineage conversion methodologies meet the reprogramming toolbox. Nat Cell Biol (2012) 1.56
Concise review: Induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart? Stem Cells (2012) 1.50
A cut above the rest: targeted genome editing technologies in human pluripotent stem cells. J Biol Chem (2013) 1.47
Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs. Cell Res (2011) 1.47
Reprogramming of human fibroblasts to pluripotency with lineage specifiers. Cell Stem Cell (2013) 1.45
Associative learning enhances population coding by inverting interneuronal correlation patterns. Neuron (2013) 1.36
Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell (2012) 1.34
Hierarchical computation in the canonical auditory cortical circuit. Proc Natl Acad Sci U S A (2009) 1.34
A histone demethylase is necessary for regeneration in zebrafish. Proc Natl Acad Sci U S A (2009) 1.31
Hypoxia induces myocardial regeneration in zebrafish. Circulation (2012) 1.30
Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning. Neural Dev (2007) 1.30
BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. Biochemistry (2007) 1.27
p53: guardian of reprogramming. Cell Cycle (2010) 1.24
iPSCs: induced back to controversy. Cell Stem Cell (2011) 1.24
Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1. Genes Dev (2010) 1.23
Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A (2012) 1.22
Characterization of pluripotent stem cells. Nat Protoc (2013) 1.14
Reprogramming toward heart regeneration: stem cells and beyond. Cell Stem Cell (2013) 1.14
Preserving information in neural transmission. J Neurosci (2009) 1.12
Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. Nat Commun (2013) 1.12
Re: Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. J Natl Cancer Inst (2014) 1.10
iPSC technology to study human aging and aging-related disorders. Curr Opin Cell Biol (2012) 1.09
The cell cycle inhibitor p27Kip¹ controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist. Cell Cycle (2011) 1.09
The fine structure of shape tuning in area V4. Neuron (2013) 1.07
Simple generation of human induced pluripotent stem cells using poly-beta-amino esters as the non-viral gene delivery system. J Biol Chem (2011) 1.06
Predictable irregularities in retinal receptive fields. Proc Natl Acad Sci U S A (2009) 1.05
Receptive field dimensionality increases from the auditory midbrain to cortex. J Neurophysiol (2012) 1.05
Second order dimensionality reduction using minimum and maximum mutual information models. PLoS Comput Biol (2011) 1.02
Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities. Development (2009) 1.02
Autophagic control of cell 'stemness'. EMBO Mol Med (2013) 1.01
Development and validation of an automated high-throughput system for zebrafish in vivo screenings. PLoS One (2012) 1.01
Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds. Hum Mol Genet (2012) 1.01
Navigating the epigenetic landscape of pluripotent stem cells. Nat Rev Mol Cell Biol (2012) 0.99
Rapid and highly efficient generation of induced pluripotent stem cells from human umbilical vein endothelial cells. PLoS One (2011) 0.99
Defining rhythmic locomotor burst patterns using a continuous wavelet transform. Ann N Y Acad Sci (2010) 0.98
Macrohistone variants preserve cell identity by preventing the gain of H3K4me2 during reprogramming to pluripotency. Cell Rep (2013) 0.98
Estimating linear-nonlinear models using Renyi divergences. Network (2009) 0.98
Minimal models of multidimensional computations. PLoS Comput Biol (2011) 0.97
Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med (2013) 0.97
Generation of feeder-free pig induced pluripotent stem cells without Pou5f1. Cell Transplant (2011) 0.97
Emergence of learned categorical representations within an auditory forebrain circuit. J Neurosci (2011) 0.96
Post-translational modulation of pluripotency. J Mol Cell Biol (2012) 0.96
Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors. Protein Cell (2014) 0.96
Generation of induced pluripotent stem cells from human renal proximal tubular cells with only two transcription factors, OCT4 and SOX2. J Biol Chem (2012) 0.93
Isolation and in vitro culture of primary cardiomyocytes from adult zebrafish hearts. Nat Protoc (2013) 0.93
Analyzing multicomponent receptive fields from neural responses to natural stimuli. Network (2011) 0.92
p38α MAPK regulates myocardial regeneration in zebrafish. Cell Cycle (2012) 0.92
Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice. Development (2011) 0.92
Induced neural stem cells: a new tool for studying neural development and neurological disorders. Cell Res (2012) 0.91
Cut and paste: restoring cellular function by gene correction. Cell Res (2011) 0.90
Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein. J Bone Joint Surg Am (2003) 0.90
Bone morphogenetic protein-2 and -6 heterodimer illustrates the nature of ligand-receptor assembly. Mol Endocrinol (2010) 0.90
Activin/BMP2 chimeric ligands direct adipose-derived stem cells to chondrogenic differentiation. Stem Cell Res (2013) 0.89
MicroRNAs contribute to induced pluripotent stem cell somatic donor memory. J Biol Chem (2013) 0.88
Maximally informative pairwise interactions in networks. Phys Rev E Stat Nonlin Soft Matter Phys (2009) 0.87
Rem2 GTPase controls proliferation and apoptosis of neurons during embryo development. Cell Cycle (2010) 0.87
iPS cells forgive but do not forget. Nat Cell Biol (2011) 0.87
Encoding of temporal information by timing, rate, and place in cat auditory cortex. PLoS One (2010) 0.87
Characterizing responses of translation-invariant neurons to natural stimuli: maximally informative invariant dimensions. Neural Comput (2012) 0.87
Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev (2012) 0.87
Concealing cellular defects in pluripotent stem cells. Trends Cell Biol (2013) 0.87
Anaerobicizing into pluripotency. Cell Metab (2011) 0.86
Regenerating the epigenome. EMBO Rep (2011) 0.86
The cell cycle and pluripotency: Is there a direct link? Cell Cycle (2010) 0.86