Published in Cells on June 20, 2012
Improvement in Mouse iPSC Induction by Rab32 Reveals the Importance of Lipid Metabolism during Reprogramming. Sci Rep (2015) 0.76
Mitochondrial Dysfunction in Lysosomal Storage Disorders. Diseases (2016) 0.75
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81
Autophagy regulates lipid metabolism. Nature (2009) 13.33
Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol (2009) 13.01
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89
Commentary. Lysosomotropic agents. Biochem Pharmacol (1974) 12.28
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol (2010) 12.26
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature (2006) 11.91
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol (2010) 11.85
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature (2006) 11.81
Autophagy in immunity and inflammation. Nature (2011) 11.16
Mechanisms of mitophagy. Nat Rev Mol Cell Biol (2011) 10.66
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J (2007) 9.65
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02
Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell (2010) 8.29
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem (2008) 7.71
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol (2010) 7.62
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell (2010) 7.59
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol (2011) 7.40
Common principles of protein translocation across membranes. Science (1996) 7.00
Essential role for Nix in autophagic maturation of erythroid cells. Nature (2008) 6.49
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature (2011) 6.48
Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev (2010) 6.35
Autophagy in mammalian development and differentiation. Nat Cell Biol (2010) 5.99
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell (2011) 5.98
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol (2010) 5.94
Active caspase-1 is a regulator of unconventional protein secretion. Cell (2008) 5.89
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab (2010) 5.82
Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep (2009) 5.52
ER tubules mark sites of mitochondrial division. Science (2011) 5.45
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood (2008) 5.43
Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol (2006) 5.37
NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A (2007) 5.14
The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein. Nature (1989) 4.63
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet (2011) 4.41
Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells. EMBO J (1989) 4.10
Fat metabolism links germline stem cells and longevity in C. elegans. Science (2008) 3.95
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature (2010) 3.81
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol (2010) 3.68
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy (2010) 3.68
Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta (2006) 3.57
Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology (2010) 3.57
AMP-activated protein kinase and the regulation of autophagic proteolysis. J Biol Chem (2006) 3.53
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem (2010) 3.45
Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci U S A (2009) 3.41
Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J (2012) 3.37
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol (2010) 3.37
A block of autophagy in lysosomal storage disorders. Hum Mol Genet (2007) 3.28
The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid composition. J Biol Chem (2002) 3.24
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochim Biophys Acta (2009) 3.21
Mechanisms of regulated unconventional protein secretion. Nat Rev Mol Cell Biol (2008) 3.17
Biogenesis and cargo selectivity of autophagosomes. Annu Rev Biochem (2011) 3.15
Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β. EMBO J (2011) 3.04
Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria. EMBO J (1999) 3.03
Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A (2009) 2.95
Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem (2010) 2.93
Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis. Cell Cycle (2011) 2.92
Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J Cell Sci (2007) 2.84
ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell (2010) 2.83
Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ (2009) 2.76
The life of lipid droplets. Biochim Biophys Acta (2008) 2.75
The Golgi-associated protein GRASP is required for unconventional protein secretion during development. Cell (2007) 2.73
The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem (2008) 2.72
Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation. J Cell Biol (2010) 2.58
Unconventional secretion of Acb1 is mediated by autophagosomes. J Cell Biol (2010) 2.58
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol (2011) 2.55
Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy. Aging (Albany NY) (2009) 2.45
Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab (2011) 2.41
Altered lipid content inhibits autophagic vesicular fusion. FASEB J (2010) 2.35
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism. Cell Cycle (2010) 2.26
Role of mitochondrial Ca2+ in the regulation of cellular energetics. Biochemistry (2012) 2.26
Autophagy in human type 2 diabetes pancreatic beta cells. Diabetologia (2009) 2.17
Dietary factors and low-grade inflammation in relation to overweight and obesity. Br J Nutr (2011) 2.16
Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. J Biol Chem (2005) 2.15
Autophagosome formation and molecular mechanism of autophagy. Antioxid Redox Signal (2010) 2.11
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. EMBO Rep (2012) 2.08
Cell death by autophagy: facts and apparent artefacts. Cell Death Differ (2011) 2.06
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
DsbA-L alleviates endoplasmic reticulum stress-induced adiponectin downregulation. Diabetes (2010) 2.01
Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet (2012) 2.01
TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. J Biol Chem (2005) 1.96
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. J Neurochem (2011) 1.93
Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance. Cancer Biol Ther (2011) 1.85
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy. FEBS Lett (2010) 1.79
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood (2010) 1.78
The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem Biophys Res Commun (2009) 1.77
Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript. Free Radic Biol Med (2006) 1.73
Unconventional mechanisms of protein transport to the cell surface of eukaryotic cells. Annu Rev Cell Dev Biol (2008) 1.72
Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice. Autophagy (2009) 1.72
Lipophagy: connecting autophagy and lipid metabolism. Int J Cell Biol (2012) 1.69
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy. EMBO J (2011) 1.68
Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy (2009) 1.67
The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis. Mol Cell (2011) 1.66
Autophagy: for better or for worse. Cell Res (2011) 1.65
Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res (2008) 1.59
Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter. FEBS Lett (2003) 1.59
Autophagy, mitochondria and cell death in lysosomal storage diseases. Autophagy (2007) 1.55
Pathways of unconventional protein secretion. Curr Opin Biotechnol (2010) 1.55