Published in Cells on December 17, 2012
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A (1993) 20.33
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature (2010) 18.63
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell (2010) 15.58
Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94
Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol (2000) 12.41
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature (2011) 9.33
Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. Cell Stem Cell (2010) 7.16
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature (2010) 7.05
Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell (2011) 6.82
Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature (2012) 6.65
Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature (2011) 6.51
iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51
Embryonic stem cells alone are able to support fetal development in the mouse. Development (1990) 6.37
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature (2011) 6.21
BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol (2002) 6.20
Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19
MicroRNA-mediated conversion of human fibroblasts to neurons. Nature (2011) 5.59
Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med (2009) 5.50
Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell (2008) 5.40
Direct conversion of human fibroblasts to multilineage blood progenitors. Nature (2010) 5.35
Retracted Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons. Cell (2011) 5.09
Direct conversion of human fibroblasts to dopaminergic neurons. Proc Natl Acad Sci U S A (2011) 4.81
Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell (2011) 4.65
Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell (2012) 4.28
Adult mice generated from induced pluripotent stem cells. Nature (2009) 4.21
iPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell (2009) 4.04
Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature (2012) 3.96
Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell (2012) 3.85
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc Natl Acad Sci U S A (2006) 3.85
Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell (2011) 3.73
MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. Circ Res (2012) 3.53
Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell (2012) 3.52
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell (2012) 3.30
Differences between human and mouse embryonic stem cells. Dev Biol (2004) 3.30
Stem cells: The promises and perils of p53. Nature (2009) 3.01
Gene function in mouse embryogenesis: get set for gastrulation. Nat Rev Genet (2007) 2.95
Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. Cell Stem Cell (2012) 2.94
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo. Nat Rev Mol Cell Biol (2009) 2.86
Birth of parthenogenetic mice that can develop to adulthood. Nature (2004) 2.75
Wnt signaling mediates self-organization and axis formation in embryoid bodies. Cell Stem Cell (2008) 2.64
Methods for making induced pluripotent stem cells: reprogramming à la carte. Nat Rev Genet (2011) 2.60
Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J Biol Chem (2010) 2.59
Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells (2009) 2.48
Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature (2010) 2.46
Self-formation of functional adenohypophysis in three-dimensional culture. Nature (2011) 2.34
Isolation of epiblast stem cells from preimplantation mouse embryos. Cell Stem Cell (2011) 2.16
Trophoblast differentiation in embryoid bodies derived from human embryonic stem cells. Endocrinology (2003) 2.15
Mouse embryonic chimeras: tools for studying mammalian development. Development (2003) 2.06
Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev (2007) 2.01
Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells. Nat Biotechnol (2012) 2.00
Pluripotency in the embryo and in culture. Cold Spring Harb Perspect Biol (2012) 1.93
Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells. Cell Stem Cell (2012) 1.79
Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of the same coin. Biochem Soc Trans (2005) 1.78
Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. Proc Natl Acad Sci U S A (2012) 1.72
Pluripotent cell lines derived from common marmoset (Callithrix jacchus) blastocysts. Biol Reprod (1996) 1.70
From teratocarcinomas to embryonic stem cells. Philos Trans R Soc Lond B Biol Sci (2002) 1.56
Primate embryonic stem cells. Curr Top Dev Biol (1998) 1.56
Lessons from human teratomas to guide development of safe stem cell therapies. Nat Biotechnol (2012) 1.43
Commentary: is totipotency of a human cell a sufficient reason to exclude its patentability under the European law? Stem Cells (2007) 1.42
Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Rep (2012) 1.40
Genetic and epigenetic stability of human pluripotent stem cells. Nat Rev Genet (2012) 1.38
Self-renewal vs. differentiation of mouse embryonic stem cells. Biol Reprod (2004) 1.37
Cell fate decisions and axis determination in the early mouse embryo. Development (2012) 1.28
BMP4 induction of trophoblast from mouse embryonic stem cells in defined culture conditions on laminin. In Vitro Cell Dev Biol Anim (2009) 1.25
Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium. FASEB J (2008) 1.24
Distinct developmental ground states of epiblast stem cell lines determine different pluripotency features. Stem Cells (2011) 1.21
Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions. PLoS Genet (2011) 1.20
Induced pluripotent stem cells: how to deal with the developmental potential. Reprod Biomed Online (2009) 1.15
Epithelial-mesenchymal transition in colonies of rhesus monkey embryonic stem cells: a model for processes involved in gastrulation. Stem Cells (2005) 1.09
Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states. Development (2012) 1.04
Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells. PLoS Biol (2011) 1.02
Production of mice using iPS cells and tetraploid complementation. Nat Protoc (2010) 1.01
Deficient DNA damage response and cell cycle checkpoints lead to accumulation of point mutations in human embryonic stem cells. Stem Cells (2012) 0.98
Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning. Cell Stem Cell (2010) 0.91
Germline development from human pluripotent stem cells toward disease modeling of infertility. Fertil Steril (2012) 0.89
Potentiality of embryonic stem cells: an ethical problem even with alternative stem cell sources. J Med Ethics (2006) 0.88
Self-organization phenomena in embryonic stem cell-derived embryoid bodies: axis formation and breaking of symmetry during cardiomyogenesis. Cells Tissues Organs (2011) 0.86
Embryonic stem cells: An exciting field for basic research and tissue engineering, but also an ethical dilemma? Cells Tissues Organs (1999) 0.86
Induced pluripotent stem cells: will they be safe? Curr Opin Mol Ther (2009) 0.86
Ethical concerns over use of new cloning technique in humans. Nature (2009) 0.84
Global transcriptional profiling of neural and mesenchymal progenitors derived from human embryonic stem cells reveals alternative developmental signaling pathways. Stem Cells Dev (2011) 0.81
The Janus face of pluripotent stem cells--connection between pluripotency and tumourigenicity. Bioessays (2010) 0.80
Early human development: new data raise important embryological and ethical questions relevant for stem cell research. Naturwissenschaften (2003) 0.80
Human embryonic stem cells: the real challenge for research as well as for bioethics is still ahead of us. Cells Tissues Organs (2008) 0.78
Epithelial-mesenchymal transition in rhesus monkey embryonic stem cell colonies: the role of culturing conditions. In Vitro Cell Dev Biol Anim (2010) 0.77
Totipotency/pluripotency and patentability. Stem Cells (2008) 0.76