Published in Cell Adh Migr on January 01, 2014
Cancer metastases: challenges and opportunities. Acta Pharm Sin B (2015) 1.22
Mechanical interplay between invadopodia and the nucleus in cultured cancer cells. Sci Rep (2015) 0.89
The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells. Exp Cell Res (2016) 0.76
Persistent Morbillivirus Infection Leads to Altered Cortactin Distribution in Histiocytic Sarcoma Cells with Decreased Cellular Migration Capacity. PLoS One (2016) 0.75
Cortactin enhances exosome secretion without altering cargo. J Cell Biol (2016) 0.75
LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis. Nat Commun (2017) 0.75
Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00
Tissue cells feel and respond to the stiffness of their substrate. Science (2005) 23.42
Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer (2003) 13.01
Local force and geometry sensing regulate cell functions. Nat Rev Mol Cell Biol (2006) 11.29
Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56
The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc Natl Acad Sci U S A (1998) 9.33
Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev (2006) 7.92
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol (2003) 7.89
Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27
Functional atlas of the integrin adhesome. Nat Cell Biol (2007) 6.89
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat Cell Biol (2007) 6.15
Adhesion-dependent cell mechanosensitivity. Annu Rev Cell Dev Biol (2003) 6.08
The ARP2/3 complex: an actin nucleator comes of age. Nat Rev Mol Cell Biol (2006) 6.04
Nanoscale architecture of integrin-based cell adhesions. Nature (2010) 5.88
Mechanism of filopodia initiation by reorganization of a dendritic network. J Cell Biol (2003) 5.47
Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc Natl Acad Sci U S A (1990) 5.25
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol (2005) 4.75
Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science (1998) 4.74
Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol (2003) 4.51
Life at the leading edge. Cell (2011) 4.42
Targeting proteases: successes, failures and future prospects. Nat Rev Drug Discov (2006) 4.39
Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38
Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta (2006) 4.27
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol (2011) 4.24
The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol (2007) 4.23
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol (2001) 4.16
Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res (2006) 3.83
Identification and characterization of a novel cytoskeleton-associated pp60src substrate. Mol Cell Biol (1991) 3.83
The integrins. Genome Biol (2007) 3.72
Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes. Exp Cell Res (1985) 3.41
MT1-MMP: a potent modifier of pericellular microenvironment. J Cell Physiol (2006) 3.37
The interplay between Src family kinases and receptor tyrosine kinases. Oncogene (2004) 3.36
Interaction of cortactin and N-WASp with Arp2/3 complex. Curr Biol (2002) 3.34
Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia. Cancer Res (2007) 3.30
Altered distributions of the cytoskeletal proteins vinculin and alpha-actinin in cultured fibroblasts transformed by Rous sarcoma virus. Proc Natl Acad Sci U S A (1980) 3.29
Assembly and biological role of podosomes and invadopodia. Curr Opin Cell Biol (2008) 3.26
Hierarchical assembly of cell-matrix adhesion complexes. Biochem Soc Trans (2004) 3.15
Exploring the neighborhood: adhesion-coupled cell mechanosensors. Cell (2002) 3.15
Paxillin: a focal adhesion-associated adaptor protein. Oncogene (2001) 3.03
Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia. J Cell Sci (2009) 2.94
Mechanotransduction - a field pulling together? J Cell Sci (2008) 2.94
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol (2002) 2.92
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J Cell Biol (2009) 2.90
An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation. Oncogene (1999) 2.86
Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol (2011) 2.82
Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell (2011) 2.77
Roles of fascin in cell adhesion and motility. Curr Opin Cell Biol (2004) 2.74
IQGAP1 in cellular signaling: bridging the GAP. Trends Cell Biol (2006) 2.63
Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia. J Cell Biol (2010) 2.62
Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells. J Exp Zool (1989) 2.48
Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker? Int J Biochem Cell Biol (2005) 2.39
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA. J Cell Biol (2008) 2.39
Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion. Proc Natl Acad Sci U S A (1997) 2.35
A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol (2011) 2.34
Degrading devices: invadosomes in proteolytic cell invasion. Annu Rev Cell Dev Biol (2011) 2.33
Extracellular matrix rigidity promotes invadopodia activity. Curr Biol (2008) 2.31
The integrin-actin connection, an eternal love affair. EMBO J (2003) 2.26
Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res (2007) 2.26
The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. Curr Biol (2010) 2.23
Dynamin participates in focal extracellular matrix degradation by invasive cells. Mol Biol Cell (2003) 2.19
WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat Cell Biol (2001) 2.18
MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. EMBO J (2007) 2.16
Src phosphorylation of cortactin enhances actin assembly. Proc Natl Acad Sci U S A (2007) 2.16
Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions. J Cell Sci (2009) 2.13
The switchable integrin adhesome. J Cell Sci (2010) 2.12
Organization of pp60src and selected cytoskeletal proteins within adhesion plaques and junctions of Rous sarcoma virus-transformed rat cells. J Cell Biol (1981) 2.09
Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation. J Cell Sci (2008) 2.06
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. J Cell Biol (2009) 1.97
Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells. J Biol Chem (1985) 1.95
Integration of signals to the Arp2/3 complex. Curr Opin Cell Biol (2003) 1.95
Functions of cofilin in cell locomotion and invasion. Nat Rev Mol Cell Biol (2013) 1.95
CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells. J Cell Physiol (1998) 1.93
Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells. Curr Biol (2004) 1.91
Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia. J Biol Chem (1998) 1.87
Invadopodia: specialized tumor cell structures for the focal degradation of the extracellular matrix. Cancer Metastasis Rev (2009) 1.85
Cortactin potentiates bone metastasis of breast cancer cells. Cancer Res (2001) 1.85
N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors. J Cell Sci (2012) 1.84
An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Res (2011) 1.75
The leukocyte podosome. Eur J Cell Biol (2005) 1.72
Migrating fibroblasts perform polarized, microtubule-dependent exocytosis towards the leading edge. J Cell Sci (2003) 1.64
Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells. Cancer Res (2009) 1.63
A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells. Cancer Res (1994) 1.63
Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages. J Cell Sci (2000) 1.62
A novel protease-docking function of integrin at invadopodia. J Biol Chem (1999) 1.58
Dynamic regulation of the structure and functions of integrin adhesions. Dev Cell (2013) 1.57
Local degradation of fibronectin at sites of expression of the transforming gene product pp60src. Nature (1985) 1.55
N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. Cell Motil Cytoskeleton (2009) 1.54
Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia. J Cell Sci (2010) 1.53
A new role for cortactin in invadopodia: regulation of protease secretion. Eur J Cell Biol (2008) 1.52
Integrating the actin and vimentin cytoskeletons. adhesion-dependent formation of fimbrin-vimentin complexes in macrophages. J Cell Biol (1999) 1.52
Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration. J Biol Chem (2007) 1.50
Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility. EMBO J (2003) 1.45
Hic-5 promotes invadopodia formation and invasion during TGF-β-induced epithelial-mesenchymal transition. J Cell Biol (2012) 1.45
Binding and localization of M(r) 72,000 matrix metalloproteinase at cell surface invadopodia. Cancer Res (1993) 1.41
Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells. Exp Cell Res (2002) 1.40
F-actin aggregates in transformed cells. J Cell Biol (1981) 1.40
Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells. J Cell Biol (1992) 1.39
Invadosome regulation by adhesion signaling. Curr Opin Cell Biol (2011) 1.38
Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway. J Cell Biol (2011) 1.38
Actin dynamics at sites of extracellular matrix degradation. Eur J Cell Biol (2006) 1.36