9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels.

PubWeight™: 0.84‹?›

🔗 View Article (PMID 25573456)

Published in Br J Pharmacol on March 24, 2015

Authors

Sarah K Burris1, Qian Wang, Simon Bulley, Zachary P Neeb, Jonathan H Jaggar

Author Affiliations

1: Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.

Articles cited by this

Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol (2010) 17.30

Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol (2010) 13.76

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Res (2013) 9.61

TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science (2008) 8.74

TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature (2008) 8.40

Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell (2008) 7.79

Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone. Am J Physiol (1990) 4.71

The vitelliform macular dystrophy protein defines a new family of chloride channels. Proc Natl Acad Sci U S A (2002) 3.73

Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol Cell Biol (2005) 3.28

The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol (2013) 3.03

Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. Circ Res (2004) 2.47

Protein kinase C regulates vascular myogenic tone through activation of TRPM4. Am J Physiol Heart Circ Physiol (2007) 2.35

The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. EMBO J (2006) 2.22

Regulation of TMEM16A chloride channel properties by alternative splicing. J Biol Chem (2009) 2.16

Ion channels and vascular tone. Hypertension (2000) 2.14

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A (2012) 1.97

Cellular mechanisms involved in the vascular myogenic response. Am J Physiol (1992) 1.86

Intravascular pressure regulates local and global Ca(2+) signaling in cerebral artery smooth muscle cells. Am J Physiol Cell Physiol (2001) 1.85

Invited review: arteriolar smooth muscle mechanotransduction: Ca(2+) signaling pathways underlying myogenic reactivity. J Appl Physiol (1985) (2001) 1.74

TRPM4 regulates calcium oscillations after T cell activation. Science (2004) 1.74

9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br J Pharmacol (2008) 1.48

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J (2011) 1.45

Pharmacological inhibition of TRPM4 hyperpolarizes vascular smooth muscle. Am J Physiol Cell Physiol (2010) 1.35

TMEM16A channels generate Ca²⁺-activated Cl⁻ currents in cerebral artery smooth muscle cells. Am J Physiol Heart Circ Physiol (2011) 1.29

Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow. Clin Exp Pharmacol Physiol (2008) 1.29

Transient receptor potential channels and vascular function. Clin Sci (Lond) (2010) 1.28

Volume sensitivity of the bestrophin family of chloride channels. J Physiol (2004) 1.26

TMEM16A/ANO1 channels contribute to the myogenic response in cerebral arteries. Circ Res (2012) 1.23

Inhibition of cell proliferation by a selective inhibitor of the Ca(2+)-activated Cl(-) channel, Ano1. Biochem Biophys Res Commun (2012) 1.20

Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension by promoting basilar smooth muscle cell proliferation. Circulation (2012) 1.20

Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01. Br J Pharmacol (2013) 1.18

Decavanadate modulates gating of TRPM4 cation channels. J Physiol (2004) 1.05

Smooth muscle cell transient receptor potential polycystin-2 (TRPP2) channels contribute to the myogenic response in cerebral arteries. J Physiol (2013) 0.97

Endogenous cytosolic Ca(2+) buffering is necessary for TRPM4 activity in cerebral artery smooth muscle cells. Cell Calcium (2011) 0.96

Expression and physiological roles of TRP channels in smooth muscle cells. Adv Exp Med Biol (2011) 0.94

Molecular evolution and functional divergence of the bestrophin protein family. BMC Evol Biol (2008) 0.86

Effects of transient receptor potential channel blockers on pacemaker activity in interstitial cells of Cajal from mouse small intestine. Mol Cells (2011) 0.86

Biochemical, single-channel, whole-cell patch clamp, and pharmacological analyses of endogenous TRPM4 channels in HEK293 cells. Neurosci Lett (2013) 0.85

Articles by these authors

Ballistic carbon nanotube field-effect transistors. Nature (2003) 4.35

Fluorescence visualization of newly synthesized proteins in mammalian cells. Angew Chem Int Ed Engl (2006) 2.96

Severe fever with thrombocytopenia syndrome virus, Shandong Province, China. Emerg Infect Dis (2012) 2.77

Polarization-controlled tunable directional coupling of surface plasmon polaritons. Science (2013) 2.73

Improvement of Fat Graft Survival with Autologous Bone Marrow Aspirate and Bone Marrow Concentrate: A One-Step Method. Plast Reconstr Surg (2016) 2.59

A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes. Org Lett (2004) 2.57

Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation (2006) 2.50

Cilium-generated signaling and cilia-related disorders. Lab Invest (2005) 2.42

Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. J Neurosci (2004) 2.40

Mitochondria-derived reactive oxygen species dilate cerebral arteries by activating Ca2+ sparks. Circ Res (2005) 2.29

GFOLD: a generalized fold change for ranking differentially expressed genes from RNA-seq data. Bioinformatics (2012) 2.21

High-kappa dielectrics for advanced carbon-nanotube transistors and logic gates. Nat Mater (2002) 2.18

Modeling elastic properties in finite-element analysis: how much precision is needed to produce an accurate model? Anat Rec A Discov Mol Cell Evol Biol (2005) 2.01

An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices. J Am Chem Soc (2004) 1.98

Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: a double-blinded, randomized, controlled, cross-over intervention trial. Int J Cardiol (2012) 1.98

OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY IN CENTRAL SEROUS CHORIORETINOPATHY. Retina (2016) 1.93

Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell (2007) 1.90

Impaired function of coronary BK(Ca) channels in metabolic syndrome. Am J Physiol Heart Circ Physiol (2009) 1.89

Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors. Clin Cancer Res (2010) 1.89

Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J Neurosci (2005) 1.89

Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev Cell (2007) 1.88

Electron transport in very clean, as-grown suspended carbon nanotubes. Nat Mater (2005) 1.86

Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial. J Clin Oncol (2012) 1.84

Selective dye-labeling of newly synthesized proteins in bacterial cells. J Am Chem Soc (2005) 1.77

Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disorders. Cell (2004) 1.76

ABSORB: Atlas Building by Self-organized Registration and Bundling. Neuroimage (2010) 1.75

An aurora kinase is essential for flagellar disassembly in Chlamydomonas. Dev Cell (2004) 1.75

Thermal conductance of an individual single-wall carbon nanotube above room temperature. Nano Lett (2006) 1.73

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood (2010) 1.72

Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells. J Gen Physiol (2010) 1.71

Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9. Hepatol Res (2009) 1.70

TNF-alpha dilates cerebral arteries via NAD(P)H oxidase-dependent Ca2+ spark activation. Am J Physiol Cell Physiol (2005) 1.70

High-field quasiballistic transport in short carbon nanotubes. Phys Rev Lett (2004) 1.68

The feeding biomechanics and dietary ecology of Australopithecus africanus. Proc Natl Acad Sci U S A (2009) 1.66

A comprehensive view of nuclear receptor cancer cistromes. Cancer Res (2011) 1.64

Self-directed self-assembly of nanoparticle/copolymer mixtures. Nature (2005) 1.62

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J Clin Invest (2002) 1.56

Clinical presentation and management of mTOR inhibitor-associated stomatitis. Oral Oncol (2011) 1.54

Systemic trafficking of plant virus nanoparticles in mice via the oral route. Virology (2005) 1.53

A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions. J Cell Biol (2007) 1.53

Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats. J Trauma Acute Care Surg (2012) 1.50

Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation. J Appl Physiol (1985) (2006) 1.49

Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis (2006) 1.49

The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem (2010) 1.48

An experimental design to study adipocyte stem cells for reconstruction of calvarial defects. J Craniofac Surg (2009) 1.47

Genome-scale transcriptome analysis of the desert poplar, Populus euphratica. Tree Physiol (2011) 1.47

Prioritizing risk pathways: a novel association approach to searching for disease pathways fusing SNPs and pathways. Bioinformatics (2008) 1.46

A cone-beam computed tomography study of maxillary first permanent molar root and canal morphology in a Chinese population. J Endod (2010) 1.45

Surface modification of tobacco mosaic virus with "click" chemistry. Chembiochem (2008) 1.43

Exercise training decreases store-operated Ca2+entry associated with metabolic syndrome and coronary atherosclerosis. Cardiovasc Res (2009) 1.43

Bead-based microarray analysis of microRNA expression in hepatocellular carcinoma: miR-338 is downregulated. Hepatol Res (2009) 1.42

Hybrid virus-polymer materials. 1. Synthesis and properties of PEG-decorated cowpea mosaic virus. Biomacromolecules (2003) 1.42

Global impairment of brachial, carotid, and aortic vascular function in young smokers: direct quantification by high-resolution magnetic resonance imaging. J Am Coll Cardiol (2004) 1.41

Co-delivery of HIV-1 entry inhibitor and nonnucleoside reverse transcriptase inhibitor shuttled by nanoparticles: cocktail therapeutic strategy for antiviral therapy. AIDS (2016) 1.40

Carbon nanotube DNA sensor and sensing mechanism. Nano Lett (2006) 1.39

Preparation of superhydrophobic polymeric film on aluminum plates by electrochemical polymerization. Molecules (2009) 1.38

The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis. Ann Neurol (2008) 1.38

Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease. Ann Neurol (2012) 1.37

SharpMean: groupwise registration guided by sharp mean image and tree-based registration. Neuroimage (2011) 1.37

Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs). Proc Natl Acad Sci U S A (2006) 1.35

Astrocyte-derived ATP modulates depressive-like behaviors. Nat Med (2013) 1.35

IP3 constricts cerebral arteries via IP3 receptor-mediated TRPC3 channel activation and independently of sarcoplasmic reticulum Ca2+ release. Circ Res (2008) 1.34

Characteristics of long non-coding RNA and its relation to hepatocellular carcinoma. Carcinogenesis (2013) 1.33

Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome. Am J Physiol Heart Circ Physiol (2008) 1.32

Carbon monoxide activates KCa channels in newborn arteriole smooth muscle cells by increasing apparent Ca2+ sensitivity of alpha-subunits. Am J Physiol Heart Circ Physiol (2003) 1.32

Electromechanical properties of metallic, quasimetallic, and semiconducting carbon nanotubes under stretching. Phys Rev Lett (2003) 1.32

Genomic insights into salt adaptation in a desert poplar. Nat Commun (2013) 1.30

TMEM16A channels generate Ca²⁺-activated Cl⁻ currents in cerebral artery smooth muscle cells. Am J Physiol Heart Circ Physiol (2011) 1.29

A sequence-based genetic linkage map as a reference for Brassica rapa pseudochromosome assembly. BMC Genomics (2011) 1.29

Essential role for smooth muscle BK channels in alcohol-induced cerebrovascular constriction. Proc Natl Acad Sci U S A (2004) 1.29

miR-338-3p suppresses invasion of liver cancer cell by targeting smoothened. J Pathol (2011) 1.28

Clustering methods for microarray gene expression data. OMICS (2006) 1.28

Negative differential conductance and hot phonons in suspended nanotube molecular wires. Phys Rev Lett (2005) 1.28

Stress hormone and male reproductive function. Cell Tissue Res (2005) 1.27

PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosis. Ann Neurol (2004) 1.27

Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins. Proc Natl Acad Sci U S A (2007) 1.27

The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity. J Immunol (2010) 1.26

MicroRNA-9 reduces cell invasion and E-cadherin secretion in SK-Hep-1 cell. Med Oncol (2009) 1.26

Fluorogenic click reaction. Chem Soc Rev (2009) 1.26

Transmission ecology of Echinococcus multilocularis: what are the ranges of parasite stability among various host communities in China? Parasitol Int (2005) 1.25

Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries. J Physiol (2004) 1.25

Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer. Carcinogenesis (2012) 1.25

Carbon monoxide as an endogenous vascular modulator. Am J Physiol Heart Circ Physiol (2011) 1.23

TMEM16A/ANO1 channels contribute to the myogenic response in cerebral arteries. Circ Res (2012) 1.23

Extensive chromatin fragmentation improves enrichment of protein binding sites in chromatin immunoprecipitation experiments. Nucleic Acids Res (2008) 1.23

Head-to-tail peptide cyclodimerization by copper-catalyzed azide-alkyne cycloaddition. Angew Chem Int Ed Engl (2005) 1.23

Clustering of Ti on a C60 surface and its effect on hydrogen storage. J Am Chem Soc (2005) 1.23

Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor. Nat Immunol (2007) 1.22

Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution. J Mol Biol (2005) 1.22

Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition. Immunity (2009) 1.22

PATJ regulates directional migration of mammalian epithelial cells. EMBO Rep (2007) 1.22

Smooth muscle cell alpha2delta-1 subunits are essential for vasoregulation by CaV1.2 channels. Circ Res (2009) 1.21

Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors. FEBS Lett (2003) 1.21

Identification of a G(2) arrest domain in the E1 wedge E4 protein of human papillomavirus type 16. J Virol (2002) 1.21

Severe fever with thrombocytopenia syndrome, Shandong Province, China, 2011. Emerg Infect Dis (2014) 1.21

Evaluation of the root and canal morphology of mandibular first permanent molars in a western Chinese population by cone-beam computed tomography. J Endod (2010) 1.20