Published in Hum Mol Genet on July 27, 2016
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (2010) 21.21
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Five years of GWAS discovery. Am J Hum Genet (2012) 12.97
Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med (2009) 8.73
Discovery and refinement of loci associated with lipid levels. Nat Genet (2013) 7.86
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Common vs. rare allele hypotheses for complex diseases. Curr Opin Genet Dev (2009) 6.85
LDL-cholesterol concentrations: a genome-wide association study. Lancet (2008) 6.44
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet (2012) 5.55
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet (2009) 4.71
Clan genomics and the complex architecture of human disease. Cell (2011) 4.53
GWAMA: software for genome-wide association meta-analysis. BMC Bioinformatics (2010) 4.11
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56
The inheritance of liability to diseases with variable age of onset, with particular reference to diabetes mellitus. Ann Hum Genet (1967) 2.57
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am J Hum Genet (2014) 2.33
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes (2011) 2.09
A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups. Hum Mol Genet (2004) 1.98
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
zCall: a rare variant caller for array-based genotyping: genetics and population analysis. Bioinformatics (2012) 1.87
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet (2014) 1.86
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet (2013) 1.57
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci. Hum Mol Genet (2015) 1.45
The impact of low-frequency and rare variants on lipid levels. Nat Genet (2015) 1.20
The lipoprotein subfraction profile: heritability and identification of quantitative trait loci. J Lipid Res (2007) 0.92
ABCA6, a novel a subclass ABC transporter. Biochem Biophys Res Commun (2001) 0.88
Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia. Am J Hum Genet (2013) 0.87
Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations. Curr Genomics (2014) 0.87
Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease. Circ Cardiovasc Genet (2014) 0.85
Genetic prediction of quantitative lipid traits: comparing shrinkage models to gene scores. Genet Epidemiol (2013) 0.85
No large-effect low-frequency coding variation found for myocardial infarction. Hum Mol Genet (2014) 0.84
FoxO regulates expression of ABCA6, an intracellular ATP-binding-cassette transporter responsive to cholesterol. Int J Biochem Cell Biol (2013) 0.76
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Origins and functional impact of copy number variation in the human genome. Nature (2009) 23.63
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet (2008) 10.49
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87
Rheumatoid arthritis association at 6q23. Nat Genet (2007) 6.71
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature (2007) 6.67
LDL-cholesterol concentrations: a genome-wide association study. Lancet (2008) 6.44
Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet (2009) 6.13
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet (2014) 5.78
New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet (2008) 4.96
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet (2009) 4.63
Support for the involvement of large copy number variants in the pathogenesis of schizophrenia. Hum Mol Genet (2009) 4.52
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet (2012) 4.46
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet (2014) 3.94
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol Psychiatry (2009) 3.59
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nat Genet (2008) 3.18
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Mol Psychiatry (2008) 3.01
Common variants near TERC are associated with mean telomere length. Nat Genet (2010) 2.98
Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes (2009) 2.85
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nat Genet (2010) 2.73
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature (2012) 2.66
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet (2010) 2.30
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol (2010) 2.17
Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. Gastroenterology (2008) 2.17
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis. Ann Neurol (2012) 2.15
Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia. Arch Gen Psychiatry (2010) 2.11
Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet (2008) 2.08
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet (2015) 1.87
Seven newly identified loci for autoimmune thyroid disease. Hum Mol Genet (2012) 1.57
Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial. Lancet Diabetes Endocrinol (2015) 1.50
Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. Br J Psychiatry (2009) 1.45
Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci. Arthritis Rheum (2011) 1.44
The genetic architecture of type 2 diabetes. Nature (2016) 1.43
Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circ Cardiovasc Genet (2009) 1.41
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet (2015) 1.39
Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease. PLoS Genet (2016) 1.39
Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Hum Mol Genet (2009) 1.37
Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet (2011) 1.30
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet (2015) 1.28
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS One (2009) 1.28
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat Genet (2015) 1.27
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet (2016) 1.24
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet (2016) 1.22
Evidence that duplications of 22q11.2 protect against schizophrenia. Mol Psychiatry (2013) 1.20
A robust clustering algorithm for identifying problematic samples in genome-wide association studies. Bioinformatics (2011) 1.19
CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1. Hum Mol Genet (2013) 1.14
Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity. Nat Genet (2015) 1.13
Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis. Hum Mol Genet (2012) 1.06
Population genetic differentiation of height and body mass index across Europe. Nat Genet (2015) 1.03
Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco. J Infect Dis (2014) 0.93
Bayesian hierarchical mixture modeling to assign copy number from a targeted CNV array. Genet Epidemiol (2011) 0.93
Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease. PLoS One (2013) 0.90
Genome-wide meta-analysis of common variant differences between men and women. Hum Mol Genet (2012) 0.88
Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction. PLoS One (2012) 0.86
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. Arthritis Rheumatol (2014) 0.85
Rare and low-frequency coding variants alter human adult height. Nature (2017) 0.85
Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's disease. PLoS One (2012) 0.84
Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. J Am Coll Cardiol (2017) 0.83
Genetic determinants of long-term changes in blood lipid concentrations: 10-year follow-up of the GLACIER study. PLoS Genet (2014) 0.83
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet (2017) 0.80
Genome-wide association study of receptive language ability of 12-year-olds. J Speech Lang Hear Res (2014) 0.80
Across-cohort QC analyses of GWAS summary statistics from complex traits. Eur J Hum Genet (2016) 0.79
Plasma IL-5 concentration and subclinical carotid atherosclerosis. Atherosclerosis (2014) 0.79
Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosis. Atherosclerosis (2013) 0.79
Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism. Thromb Res (2014) 0.78