Dynamics of p53: A Master Decider of Cell Fate.

miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A (2005) 21.51

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell (1992) 16.53

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell (1995) 14.90

A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell (2010) 12.27

The p53 pathway: positive and negative feedback loops. Oncogene (2005) 9.75

mdm2 expression is induced by wild type p53 activity. EMBO J (1993) 8.01

The first 30 years of p53: growing ever more complex. Nat Rev Cancer (2009) 8.00

DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev (1998) 7.78

Roles for microRNAs in conferring robustness to biological processes. Cell (2012) 6.32

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol (2008) 6.02

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23

Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23

Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59

p53 enters the microRNA world. Cancer Cell (2007) 3.78

Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci U S A (2000) 3.74

The expanding universe of p53 targets. Nat Rev Cancer (2009) 3.49

p53 dynamics control cell fate. Science (2012) 3.30

USP10 regulates p53 localization and stability by deubiquitinating p53. Cell (2010) 3.17

The mitochondrial p53 pathway. Biochim Biophys Acta (2008) 2.98

Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96

Transcription-independent pro-apoptotic functions of p53. Curr Opin Cell Biol (2005) 2.88

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell (2008) 2.70

In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol (2004) 2.50

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A (2008) 2.30

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell (2005) 2.17

Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol Cell Biol (1998) 2.13

The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer (2009) 2.13

Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02

miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress. EMBO J (2011) 1.98

Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol (2007) 1.75

The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage. Proc Natl Acad Sci U S A (2007) 1.73

Two-phase dynamics of p53 in the DNA damage response. Proc Natl Acad Sci U S A (2011) 1.65

Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor. J Biol Chem (1993) 1.61

Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop. Oncogene (2012) 1.58

Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. Cell (2016) 1.55

Cell fate decision mediated by p53 pulses. Proc Natl Acad Sci U S A (2009) 1.53

Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging. Cancer Res (2006) 1.34

Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D. Cell Cycle (2005) 1.26

The strength of indecisiveness: oscillatory behavior for better cell fate determination. Sci STKE (2004) 1.12

The role of ubiquitin modification in the regulation of p53. Biochim Biophys Acta (2013) 1.12

Limiting the power of p53 through the ubiquitin proteasome pathway. Genes Dev (2014) 1.10

MDM2-p53 pathway in hepatocellular carcinoma. Cancer Res (2014) 1.09

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters. Nucleic Acids Res (2014) 1.07

Lysine-specific modifications of p53: a matter of life and death? Oncotarget (2013) 1.03

Direct transactivation of c-Ha-Ras gene by p53: evidence for its involvement in p53 transactivation activity and p53-mediated apoptosis. Oncogene (2000) 1.03

WIP1 phosphatase as a potential therapeutic target in neuroblastoma. PLoS One (2015) 0.93

Mechanisms that enhance sustainability of p53 pulses. PLoS One (2013) 0.91

A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities. PLoS One (2012) 0.88

Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. Cell Death Dis (2014) 0.85

Nerve growth factor- and epidermal growth factor-regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma cells. Eur J Cell Biol (2000) 0.84

p28, a first in class peptide inhibitor of cop1 binding to p53. Br J Cancer (2013) 0.84

p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response. Cell Cycle (2014) 0.84

Ubiquitin-specific peptidase 42 (USP42) functions to deubiquitylate histones and regulate transcriptional activity. J Biol Chem (2014) 0.83

Finally, An Apoptosis-Targeting Therapeutic for Cancer. Cancer Res (2016) 0.83

p53 Reactivation by PRIMA-1(Met) (APR-246) sensitises (V600E/K)BRAF melanoma to vemurafenib. Eur J Cancer (2016) 0.82

Apoptosis: A lipid trigger of MOMP. Nat Rev Mol Cell Biol (2012) 0.80

A novel regulator (USP10) of p53: Implications for tumor suppression and therapeutic targeting. Cancer Biol Ther (2010) 0.77

Involvement of miR-605 and miR-34a in the DNA damage response promotes apoptosis induction. Biophys J (2014) 0.77

Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth. Cell Death Differ (2016) 0.77

STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation. Oncotarget (2015) 0.77

Modulation of the p53/MDM2 interplay by HAUSP inhibitors. J Mol Cell Biol (2016) 0.76

Influence of microRNA‑34a on proliferation, invasion and metastasis of HCT116 cells. Mol Med Rep (2016) 0.76

Full-length p53 tetramer bound to DNA and its quaternary dynamics. Oncogene (2016) 0.76