Published in Nucleic Acids Res on July 11, 1985
The lysozyme enhancer: cell-specific activation of the chicken lysozyme gene by a far-upstream DNA element. EMBO J (1986) 2.19
Sequence-specific and general transcriptional activation by the bovine papillomavirus-1 E2 trans-activator require an N-terminal amphipathic helix-containing E2 domain. EMBO J (1988) 1.79
Interaction of distinct nuclear proteins with sequences controlling the expression of polyomavirus early genes. Mol Cell Biol (1986) 1.69
Modifications of the E.coli Lac repressor for expression in eukaryotic cells: effects of nuclear signal sequences on protein activity and nuclear accumulation. Nucleic Acids Res (1992) 1.51
Nucleotides in the polyomavirus enhancer that control viral transcription and DNA replication. Mol Cell Biol (1987) 1.48
Nuclear factors binding specific sequences within the immunoglobulin enhancer interact differentially with other enhancer elements. EMBO J (1986) 1.45
The polyomavirus enhancer comprises multiple functional elements. J Virol (1988) 1.14
Functional analysis of the individual enhancer core sequences of polyomavirus: cell-specific uncoupling of DNA replication from transcription. Mol Cell Biol (1988) 1.08
Multiple domains in the polyomavirus B enhancer are required for productive infection of F9 embryonal carcinoma cells. J Virol (1988) 1.02
Negative regulation of early polyomavirus expression in mouse embryonal carcinoma cells. J Virol (1986) 0.98
Expression and amplification in transgenic mice of a polyoma virus mutant regulatory region. Nucleic Acids Res (1988) 0.95
New class of polyomavirus mutant that can persist as free copies in F9 embryonal carcinoma cells. Mol Cell Biol (1986) 0.93
Establishment of composite DNA derived from L factor as a plasmid in mouse embryonal carcinoma (F9) cells. Mol Cell Biol (1988) 0.86
Unique requirement for the PyF441 mutation for polyomavirus infection of F9 embryonal carcinoma cells. J Virol (1988) 0.86
Biological activities of oligonucleotides spanning the F9 point mutation within the enhancer region of polyomavirus DNA. J Virol (1988) 0.85
Enhancer and promoter elements from simian virus 40 and polyomavirus can substitute for an upstream activation sequence in Saccharomyces cerevisiae. Mol Cell Biol (1990) 0.81
A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol (1982) 116.75
Transcriptional control signals of a eukaryotic protein-coding gene. Science (1982) 25.38
In vivo sequence requirements of the SV40 early promotor region. Nature (1981) 25.00
Enchancement of the infectivity of simian virus 40 deoxyribonucleic acid with diethylaminoethyl-dextran. J Natl Cancer Inst (1968) 21.44
Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences. Nature (1981) 13.89
Simian virus 40 tandem repeated sequences as an element of the early promoter. Proc Natl Acad Sci U S A (1981) 13.67
Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1982) 12.30
Coding potential and regulatory signals of the polyoma virus genome. Nature (1980) 11.24
Deletion mapping of DNA regions required for SV40 early region promoter function in vivo. J Mol Appl Genet (1982) 10.71
Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma. Cell (1984) 9.47
Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes. Nature (1984) 8.65
Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus. J Virol (1984) 7.80
A small segment of polyoma virus DNA enhances the expression of a cloned beta-globin gene over a distance of 1400 base pairs. Nucleic Acids Res (1981) 7.57
Specific interaction between enhancer-containing molecules and cellular components. Cell (1984) 6.96
A region of the polyoma virus genome between the replication origin and late protein coding sequences is required in cis for both early gene expression and viral DNA replication. Nucleic Acids Res (1981) 6.11
Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus. Nature (1982) 6.02
The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter. Nucleic Acids Res (1983) 4.93
Teratocarcinomas and mammalian embryogenesis. Science (1980) 4.72
Bovine papilloma virus contains an activator of gene expression at the distal end of the early transcription unit. Mol Cell Biol (1983) 4.56
Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells. Nature (1984) 4.52
Polyoma virus DNA replication requires an enhancer. Nature (1984) 4.32
Polyomavirus enhancer contains multiple redundant sequence elements that activate both DNA replication and gene expression. Mol Cell Biol (1985) 3.91
Expression of polyoma early functions in mouse embryonal carcinoma cells depends on sequence rearrangements in the beginning of the late region. Cell (1980) 3.63
Mutation near the polyoma DNA replication origin permits productive infection of F9 embryonal carcinoma cells. Cell (1981) 3.61
Isolation and characterization of polyoma host range mutants that replicate in nullipotential embryonal carcinoma cells. Proc Natl Acad Sci U S A (1981) 3.55
Polyoma DNA sequences involved in control of viral gene expression in murine embryonal carcinoma cells. Nature (1981) 3.47
Polyomavirus origin for DNA replication comprises multiple genetic elements. J Virol (1983) 2.89
DNA fragments from F9 PyEC mutants increase expression of heterologous genes in transfected F9 cells. Cell (1983) 2.64
Mutational dissection of the 21 bp repeat region of the SV40 early promoter reveals that it contains overlapping elements of the early-early and late-early promoters. Nucleic Acids Res (1984) 2.52
JC virus enhancer-promoter active in human brain cells. Science (1984) 2.36
Effect of the 21-bp repeat upstream element on in vitro transcription from the early and late SV40 promoters. EMBO J (1984) 2.03
An enhancer sequence from bovine papilloma virus DNA consists of two essential regions. Nucleic Acids Res (1984) 1.98
Cloning of randomly sheared DNA fragments from a phi 105 lysogen of Bacillus subtilis identification of prophage-containing clones. Gene (1980) 1.91
5' termini of polyoma virus early region transcripts synthesized in vivo by wild-type virus and viable deletion mutants. J Mol Biol (1982) 1.82
Isolation of cDNA clones for basal lamina components: type IV procollagen. Nucleic Acids Res (1983) 1.65
Location of sequences in polyomavirus DNA that are required for early gene expression in vivo and in vitro. Mol Cell Biol (1984) 1.49
Physical and biological features of polyoma virus mutants able to infect embryonal carcinoma cell lines. J Virol (1982) 1.39
Isolation and characterization of polyoma virus mutants which grow in murine embryonal carcinoma and trophoblast cells. EMBO J (1982) 1.38
Structure and topology of 16S ribosomal RNA. An analysis of the pattern of psoralen crosslinking. Nucleic Acids Res (1980) 0.86
Identification of mRNA species that code for extra-embryonic endodermal cytoskeletal proteins in differentiated derivatives of murine embryonal carcinoma cells. J Biol Chem (1982) 0.83
Multiple point mutations affecting the simian virus 40 enhancer. Science (1983) 13.69
Simian virus 40 tandem repeated sequences as an element of the early promoter. Proc Natl Acad Sci U S A (1981) 13.67
Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1982) 12.30
Enhancer elements. Cell (1983) 10.41
Pax7 is required for the specification of myogenic satellite cells. Cell (2000) 9.88
Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus. J Virol (1984) 7.80
Specific interaction between enhancer-containing molecules and cellular components. Cell (1984) 6.96
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature (1985) 6.86
Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature (1999) 6.23
Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus. Nature (1982) 6.02
Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci U S A (1994) 5.71
New type of POU domain in germ line-specific protein Oct-4. Nature (1990) 5.65
Pax-6, a murine paired box gene, is expressed in the developing CNS. Development (1991) 5.49
Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res (1997) 4.89
HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene. Science (1988) 4.77
Bovine papilloma virus deoxyribonucleic acid: a novel eucaryotic cloning vector. Mol Cell Biol (1981) 4.75
The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature (1997) 4.69
Pax6 is required for the multipotent state of retinal progenitor cells. Cell (2001) 4.65
Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature (1997) 4.58
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell (1998) 4.53
A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J (1989) 4.47
Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J (1990) 4.42
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development (1995) 3.90
Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40. Proc Natl Acad Sci U S A (1979) 3.89
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev (2000) 3.85
Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J (1991) 3.85
Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell (1991) 3.71
Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature (1992) 3.63
Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression. Science (1989) 3.48
Pax-2 controls multiple steps of urogenital development. Development (1995) 3.42
BK viral enhancer element and a human cellular homolog. Science (1983) 3.36
A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Cell (1987) 3.09
Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet (1999) 3.01
Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes. Proc Natl Acad Sci U S A (1989) 3.00
Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination. Nature (1989) 2.94
Identification of a precursor in the biosynthesis of the p21 transforming protein of harvey murine sarcoma virus. J Virol (1982) 2.89
Processing and expression of early SV40 mRNA: a role for RNA conformation in splicing. Cell (1979) 2.80
Pax6 controls radial glia differentiation in the cerebral cortex. Neuron (1998) 2.78
Expression of simian virus 40-rat preproinsulin recombinants in monkey kidney cells: use of preproinsulin RNA processing signals. Proc Natl Acad Sci U S A (1981) 2.76
Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet (1998) 2.75
Post-transcriptional control of myc and p53 expression during differentiation of the embryonal carcinoma cell line F9. Nature (1985) 2.75
Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development (1990) 2.72
Murine developmental control genes. Science (1990) 2.71
Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors. EMBO J (1985) 2.70
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev Biol (1999) 2.70
Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO J (1989) 2.70
Pax: a murine multigene family of paired box-containing genes. Genomics (1991) 2.60
Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development (1994) 2.45
Homeobox genes and connective tissue patterning. Development (1995) 2.43
Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development (1990) 2.42
Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression. Development (2001) 2.37
Pax2 contributes to inner ear patterning and optic nerve trajectory. Development (1996) 2.33
Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice. Development (1996) 2.31
Origin of DNA replication in papovavirus chromatin is recognized by endogenous endonuclease. Proc Natl Acad Sci U S A (1978) 2.24
Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev (1993) 2.21
Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain. EMBO J (1990) 2.19
Roles of Pax-genes in developing and adult brain as suggested by expression patterns. J Neurosci (1994) 2.19
A nexus between Oct-4 and E1A: implications for gene regulation in embryonic stem cells. Cell (1991) 2.18
Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell (1995) 2.15
The molecular basis of the undulated/Pax-1 mutation. Cell (1991) 2.14
The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech Dev (1990) 2.12
Interdigital cell death can occur through a necrotic and caspase-independent pathway. Curr Biol (1999) 2.11
Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development. Cell (1988) 2.05
An alpha-E-catenin gene trap mutation defines its function in preimplantation development. Proc Natl Acad Sci U S A (1997) 2.05
Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells. Nature (1985) 2.01
Spatially and temporally restricted expression of Pax2 during murine neurogenesis. Development (1990) 2.01
undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1. Cell (1988) 2.01
A viral enhancer element specifically active in human haematopoietic cells. Nature (1985) 1.95
Forebrain patterning defects in Small eye mutant mice. Development (1996) 1.95
Magic enhancers? DNA (1984) 1.95
Efficient FLP recombination in mouse ES cells and oocytes. Genesis (2001) 1.94
Classification and treatment of zygomatic fractures: a review of 1,025 cases. J Oral Maxillofac Surg (1992) 1.89
The oncogenic potential of Pax genes. EMBO J (1993) 1.88
Mice lacking HSP90beta fail to develop a placental labyrinth. Development (2000) 1.83
HIV-1, HTLV-1 and normal T-cell growth: transcriptional strategies and surprises. Immunol Today (1989) 1.82
Clustered homeo boxes are differentially expressed during murine development. Cell (1985) 1.80
Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice. Cell (1990) 1.79
Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6. Development (2000) 1.77
PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. Development (1992) 1.77
Resorbable plate fixation in pediatric craniofacial surgery: long-term outcome. Arch Facial Plast Surg (2001) 1.74
Pax6 modulates the dorsoventral patterning of the mammalian telencephalon. J Neurosci (2000) 1.74
Pax6 lights-up the way for eye development. Curr Opin Cell Biol (2001) 1.74
Regulation of interleukin 2 receptor alpha subunit (Tac or CD25 antigen) gene expression: binding of inducible nuclear proteins to discrete promoter sequences correlates with transcriptional activation. Proc Natl Acad Sci U S A (1988) 1.74
Rescue of a splicing defective mutant by insertion of an heterologous intron. Nature (1980) 1.74
Pax genes and their roles in cell differentiation and development. Curr Opin Cell Biol (1996) 1.72
Interaction of distinct nuclear proteins with sequences controlling the expression of polyomavirus early genes. Mol Cell Biol (1986) 1.69