Mutational analysis of the chicken beta-globin enhancer reveals two positive-acting domains.

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Published in Proc Natl Acad Sci U S A on September 01, 1988

Authors

M Reitman1, G Felsenfeld

Author Affiliations

1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.

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Histone H3 disulfide dimers and nucleosome structure. Proc Natl Acad Sci U S A (1977) 1.29

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The developmental switch in embryonic rho-globin expression is correlated with erythroid lineage-specific differences in transcription factor levels. Development (1992) 1.19

DNA. Sci Am (1985) 1.18

A simple model of DNA superhelices in solution. Proc Natl Acad Sci U S A (1978) 1.17

Properties of BGP1, a poly(dG)-binding protein from chicken erythrocytes. Nucleic Acids Res (1990) 1.16

Association of arginine-rich histones with G-C-rich regions of DNA in chromatin. Nat New Biol (1972) 1.14

Histone hyperacetylation has little effect on the higher order folding of chromatin. Nucleic Acids Res (1983) 1.13

Transcription of histone-covered T7 DNA by Escherichia coli RNA polymerase. Biochemistry (1978) 1.13