Published in Science on January 19, 2001
Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83
Evidence for large domains of similarly expressed genes in the Drosophila genome. J Biol (2002) 9.31
Long-range control of gene expression: emerging mechanisms and disruption in disease. Am J Hum Genet (2004) 8.85
Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. Genome Biol (2002) 8.59
On schemes of combinatorial transcription logic. Proc Natl Acad Sci U S A (2003) 6.02
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95
Control of globin gene expression during development and erythroid differentiation. Exp Hematol (2005) 3.47
Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities. Proc Natl Acad Sci U S A (2002) 3.46
Finding distal regulatory elements in the human genome. Curr Opin Genet Dev (2009) 3.02
Evolution and functional classification of vertebrate gene deserts. Genome Res (2004) 2.92
The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide. Genome Res (2004) 2.78
Conserved CTCF insulator elements flank the mouse and human beta-globin loci. Mol Cell Biol (2002) 2.69
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A (2002) 2.62
Identification of higher-order functional domains in the human ENCODE regions. Genome Res (2007) 2.62
Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster. EMBO J (2009) 2.56
Differential chromatin structure within a tandem array 100 kb upstream of the maize b1 locus is associated with paramutation. Genes Dev (2002) 2.29
CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. Mol Cell Biol (2008) 2.24
Logic functions of the genomic cis-regulatory code. Proc Natl Acad Sci U S A (2005) 2.24
Protein:protein interactions and the pairing of boundary elements in vivo. Genes Dev (2003) 2.23
Interactions between natural selection, recombination and gene density in the genes of Drosophila. Genetics (2002) 2.20
Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription. J Cell Biol (2002) 2.14
Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function. EMBO J (2001) 2.13
An insulator blocks spreading of histone acetylation and interferes with RNA polymerase II transfer between an enhancer and gene. Nucleic Acids Res (2004) 2.11
Statistical analysis of the genomic distribution and correlation of regulatory elements in the ENCODE regions. Genome Res (2007) 2.03
Visualization of chromatin domains created by the gypsy insulator of Drosophila. J Cell Biol (2003) 1.93
CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators. Nucleic Acids Res (2007) 1.89
Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes. Genes Dev (2001) 1.89
The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation. Genes Dev (2002) 1.89
Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state. PLoS Comput Biol (2012) 1.71
The regulatory content of intergenic DNA shapes genome architecture. Genome Biol (2004) 1.70
Transgene analysis proves mRNA trans-splicing at the complex mod(mdg4) locus in Drosophila. Proc Natl Acad Sci U S A (2001) 1.69
USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier. Mol Cell Biol (2007) 1.68
Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Dev Cell (2012) 1.63
CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery. J Biol Chem (2008) 1.62
Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster. Proc Natl Acad Sci U S A (2001) 1.57
A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb. Genes Dev (2003) 1.57
Identification of clustered YY1 binding sites in imprinting control regions. Genome Res (2006) 1.51
Inter-species differences of co-expression of neighboring genes in eukaryotic genomes. BMC Genomics (2004) 1.50
Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control region. Mol Cell Biol (2002) 1.49
Thyroid hormone-regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor. EMBO J (2003) 1.49
Regulatory mechanisms at the mouse Igf2/H19 locus. Mol Cell Biol (2001) 1.41
Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1. Mol Cell Biol (2007) 1.40
Imprinted silencing of Slc22a2 and Slc22a3 does not need transcriptional overlap between Igf2r and Air. EMBO J (2003) 1.32
Histone H3 lysine 36 methylation antagonizes silencing in Saccharomyces cerevisiae independently of the Rpd3S histone deacetylase complex. Genetics (2006) 1.25
Trans-splicing as a novel mechanism to explain interallelic complementation in Drosophila. Genetics (2002) 1.23
Expression-state boundaries in the mating-type region of fission yeast. Genetics (2002) 1.23
Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting. Mol Cell Biol (2002) 1.19
Local coexpression domains of two to four genes in the genome of Arabidopsis. Plant Physiol (2005) 1.18
Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res (2009) 1.16
Independent and high-level dual-gene expression in adult stem-progenitor cells from a single lentiviral vector. Gene Ther (2009) 1.13
Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome. Genome Res (2013) 1.12
Coexpression of linked genes in Mammalian genomes is generally disadvantageous. Mol Biol Evol (2008) 1.12
Selection conflicts, gene expression, and codon usage trends in yeast. J Mol Evol (2003) 1.12
Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II. J Cell Biol (2011) 1.12
Evidence for RNA synthesis in the intergenic region between enhancer and promoter and its inhibition by insulators in Drosophila melanogaster. Nucleic Acids Res (2008) 1.11
Inactive X chromosome-specific histone H3 modifications and CpG hypomethylation flank a chromatin boundary between an X-inactivated and an escape gene. Nucleic Acids Res (2009) 1.11
Dioxin receptor and SLUG transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch. Genome Res (2011) 1.10
Evidence that DNase I hypersensitive site 5 of the human beta-globin locus control region functions as a chromosomal insulator in transgenic mice. Nucleic Acids Res (2002) 1.09
Many P-element insertions affect wing shape in Drosophila melanogaster. Genetics (2004) 1.08
Investigation of elements sufficient to imprint the mouse Air promoter. Mol Cell Biol (2001) 1.07
The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity. PLoS One (2009) 1.07
The Promoter Targeting Sequence mediates epigenetically heritable transcription memory. Genes Dev (2004) 1.06
Boundary element-associated factor 32B connects chromatin domains to the nuclear matrix. Mol Cell Biol (2007) 0.99
Transcription factor CTF1 acts as a chromatin domain boundary that shields human telomeric genes from silencing. Mol Cell Biol (2009) 0.98
Studying vertebrate topoisomerase 2 function using a conditional knockdown system in DT40 cells. Nucleic Acids Res (2009) 0.95
Nanoparticles for retinal gene therapy. Prog Retin Eye Res (2010) 0.95
Bioluminescence imaging of reporter mice for studies of infection and inflammation. Antiviral Res (2010) 0.95
Insulator-like pairing elements regulate silencing and mutually exclusive expression in the malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A (2012) 0.95
Dynamic regulation of transcription factors by nucleosome remodeling. Elife (2015) 0.94
An insulator with barrier-element activity promotes alpha-spectrin gene expression in erythroid cells. Blood (2008) 0.93
putzig is required for cell proliferation and regulates notch activity in Drosophila. Mol Biol Cell (2007) 0.92
The principles of nuclear structure. Chromosome Res (2003) 0.91
Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma. J Exp Med (2008) 0.90
Viability of X-autosome translocations in mammals: an epigenomic hypothesis from a rodent case-study. Chromosoma (2004) 0.88
A novel locus for maternally inherited human gingival fibromatosis at chromosome 11p15. Hum Genet (2006) 0.88
The gypsy insulator of Drosophila melanogaster, together with its binding protein suppressor of Hairy-wing, facilitate high and precise expression of transgenes in Arabidopsis thaliana. Genetics (2010) 0.87
Two ubiquitin-conjugating enzymes, Rhp6 and UbcX, regulate heterochromatin silencing in Schizosaccharomyces pombe. Mol Cell Biol (2002) 0.86
Kinetics and epigenetics of retroviral silencing in mouse embryonic stem cells defined by deletion of the D4Z4 element. Mol Ther (2013) 0.86
Higher-order chromatin regulation and differential gene expression in the human tumor necrosis factor/lymphotoxin locus in hepatocellular carcinoma cells. Mol Cell Biol (2012) 0.86
Gene therapy in thalassemia and hemoglobinopathies. Mediterr J Hematol Infect Dis (2009) 0.86
Studying human telomerase gene transcription by a chromatinized reporter generated by recombinase-mediated targeting of a bacterial artificial chromosome. Nucleic Acids Res (2009) 0.85
Chromatin domain boundary element search tool for Drosophila. Nucleic Acids Res (2012) 0.84
ArchAlign: coordinate-free chromatin alignment reveals novel architectures. Genome Biol (2010) 0.84
Insulation of the chicken beta-globin chromosomal domain from a chromatin-condensing protein, MENT. Mol Cell Biol (2003) 0.84
New doxycycline-inducible transgenic lines in Xenopus. Dev Dyn (2011) 0.84
Ribosomal RNA gene transcription mediated by the master genome regulator protein CCCTC-binding factor (CTCF) is negatively regulated by the condensin complex. J Biol Chem (2013) 0.84
A BEAF dependent chromatin domain boundary separates myoglianin and eyeless genes of Drosophila melanogaster. Nucleic Acids Res (2011) 0.83
Transvection at the end of the truncated chromosome in Drosophila melanogaster. Genetics (2003) 0.83
Exogenous gypsy insulator sequences modulate transgene expression in the malaria vector mosquito, Anopheles stephensi. Proc Natl Acad Sci U S A (2013) 0.82
A 21(st) Century View of Evolution. J Biol Phys (2002) 0.82
The sea urchin sns5 insulator protects retroviral vectors from chromosomal position effects by maintaining active chromatin structure. Mol Ther (2009) 0.82
Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activity. Nucleic Acids Res (2003) 0.82
Distinct epigenetic domains separated by a CTCF bound insulator between the tandem genes, BLU and RASSF1A. PLoS One (2010) 0.81
The gypsy insulators flanking yellow enhancers do not form a separate transcriptional domain in Drosophila melanogaster: the enhancers can activate an isolated yellow promoter. Genetics (2002) 0.81
Fishing for function: zebrafish BAC transgenics for functional genomics. Mol Biosyst (2011) 0.80
Promoter activity of the sea urchin (Paracentrotus lividus) nucleosomal H3 and H2A and linker H1 {alpha}-histone genes is modulated by enhancer and chromatin insulator. Nucleic Acids Res (2009) 0.80
A mobile insulator system to detect and disrupt cis-regulatory landscapes in vertebrates. Genome Res (2013) 0.80
Systematically Prioritizing Functional Differentially Methylated Regions (fDMRs) by Integrating Multi-omics Data in Colorectal Cancer. Sci Rep (2015) 0.80
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