Published in Cell on July 01, 1978
High-resolution mapping and characterization of open chromatin across the genome. Cell (2008) 15.93
Precise location of DNase I cutting sites in the nucleosome core determined by high resolution gel electrophoresis. Nucleic Acids Res (1979) 2.85
Protein/DNA architecture of the DNase I hypersensitive region of the Drosophila hsp26 promoter. EMBO J (1988) 2.62
Nucleosome cores reconstituted from poly (dA-dT) and the octamer of histones. Nucleic Acids Res (1979) 2.50
Contacts between DNA gyrase and its binding site on DNA: features of symmetry and asymmetry revealed by protection from nucleases. Proc Natl Acad Sci U S A (1981) 2.02
Transcription-induced nucleosome 'splitting': an underlying structure for DNase I sensitive chromatin. EMBO J (1991) 1.93
Presence of double-strand breaks with single-base 3' overhangs in cells undergoing apoptosis but not necrosis. J Cell Biol (1996) 1.85
Organization of spacer DNA in chromatin. Proc Natl Acad Sci U S A (1979) 1.76
The helical periodicity of DNA on the nucleosome. Nucleic Acids Res (1981) 1.60
Salt induced transitions of chromatin core particles studied by tyrosine fluorescence anisotropy. Nucleic Acids Res (1980) 1.54
Nucleosome-like structural subunits of intranuclear parental adenovirus type 2 DNA. J Virol (1979) 1.54
Asymmetric lateral distribution of unshielded phosphate groups in nucleosomal DNA and its role in DNA bending. Proc Natl Acad Sci U S A (1979) 1.49
Effect of the B--Z transition in poly(dG-m5dC) . poly(dG-m5dC) on nucleosome formation. Proc Natl Acad Sci U S A (1982) 1.46
Reaction of nucleosome DNA with dimethyl sulfate. Proc Natl Acad Sci U S A (1979) 1.43
Nucleosome depletion at yeast terminators is not intrinsic and can occur by a transcriptional mechanism linked to 3'-end formation. Proc Natl Acad Sci U S A (2010) 1.37
Biotin-labeled hairpin oligonucleotides: probes to detect double-strand breaks in DNA in apoptotic cells. Am J Pathol (1998) 1.24
Core nucleosomes by digestion of reconstructed histone-DNA complexes. Nucleic Acids Res (1979) 1.21
Specific chemical labeling of DNA fragments. Nucleic Acids Res (1979) 1.13
DNase II digestion of the nucleosome core: precise locations and relative exposures of sites. Nucleic Acids Res (1981) 1.12
The chromatin structure of an actively expressed, single copy yeast gene. Nucleic Acids Res (1983) 1.09
DNA strand breaks alter histone ADP-ribosylation. Proc Natl Acad Sci U S A (1989) 1.00
Early necrotic DNA degradation: presence of blunt-ended DNA breaks, 3' and 5' overhangs in apoptosis, but only 5' overhangs in early necrosis. Am J Pathol (2003) 0.98
Role of chromatin states in transcriptional memory. Biochim Biophys Acta (2009) 0.94
A correlation between nucleosome spacer region susceptibility to DNase I and histone acetylation. Nucleic Acids Res (1979) 0.88
Transcriptional mapping of the ribosomal RNA region of mouse L-cell mitochondrial DNA. Nucleic Acids Res (1980) 0.87
Simultaneous analysis of conformation and transcription of A and B groups of vitellogenin genes in male and female Xenopus during primary and secondary activation by estrogen. Nucleic Acids Res (1983) 0.87
Alternative DNA-protein interactions in variable-length internucleosomal regions associated with Drosophila Adh distal promoter expression. Nucleic Acids Res (1990) 0.86
Nucleosome structure and conformational changes. Biophys J (1980) 0.81
Subnuclear fractionation by mild micrococcal-nuclease treatment of nuclei of different transcriptional activities causes a partition of expressed and non-expressed genes. Biochem J (1980) 0.81
DNase-seq predicts regions of rotational nucleosome stability across diverse human cell types. Genome Res (2013) 0.80
Small DNA pieces in C. elegans are intermediates of DNA fragmentation during apoptosis. PLoS One (2010) 0.79
DNA repeat length in chromatin from murine bone marrow and L1210 leukaemia cells. Br J Cancer (1985) 0.75
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature (2000) 14.91
The nucleotide sequence of the initiation and termination sites for ribosomal RNA transcription in X. laevis. Cell (1979) 11.64
High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment. Nucleic Acids Res (1984) 10.40
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell (1999) 9.74
Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC). Proc Natl Acad Sci U S A (1981) 8.07
A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell (1993) 8.05
Nucleosome structure. Annu Rev Biochem (1980) 7.16
A 200 base pair region at the 5' end of the chicken adult beta-globin gene is accessible to nuclease digestion. Cell (1981) 6.43
The erythroid-specific transcription factor Eryf1: a new finger protein. Cell (1989) 6.14
Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Science (2001) 6.00
Chromatin. Nature (1978) 5.89
The U3 small nucleolar ribonucleoprotein functions in the first step of preribosomal RNA processing. Cell (1990) 5.39
Insulators and boundaries: versatile regulatory elements in the eukaryotic genome. Science (2001) 5.37
An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. Proc Natl Acad Sci U S A (1988) 5.29
Structure of chromatin. Nat New Biol (1971) 5.23
Transcription of mouse rRNA genes by RNA polymerase I: in vitro and in vivo initiation and processing sites. Cell (1981) 4.97
The organization of histones and DNA in chromatin: evidence for an arginine-rich histone kernel. Cell (1976) 4.31
Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci. EMBO J (2001) 4.28
A new method for the purification and identification of covalently closed circular DNA molcules. Nucleic Acids Res (1978) 4.09
Specific factor conferring nuclease hypersensitivity at the 5' end of the chicken adult beta-globin gene. Proc Natl Acad Sci U S A (1984) 4.03
Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult beta-globin gene: nature of the binding domain. Cell (1985) 3.99
Synthesis of globin ribonucleic acid from duck-reticulocyte chromatin in vitro. Proc Natl Acad Sci U S A (1973) 3.93
NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. Science (1993) 3.74
Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. Genes Dev (1998) 3.70
A new procedure for purifying histone pairs H2A + H2B and H3 + H4 from chromatin using hydroxylapatite. Nucleic Acids Res (1979) 3.62
Characterization of the chicken beta-globin insulator. Proc Natl Acad Sci U S A (1997) 3.57
A comparison of the digestion of nuclei and chromatin by staphylococcal nuclease. Biochemistry (1975) 3.52
Transcription of cloned eukaryotic ribosomal RNA genes. Annu Rev Biochem (1986) 3.30
Conformation of polyribouridylic acid in solution. J Mol Biol (1970) 3.28
Specific sites of interaction between histones and DNA in chromatin. Proc Natl Acad Sci U S A (1974) 3.25
A neighbor-interaction analysis of the hypochromism and spectra of DNA. J Mol Biol (1965) 3.24
Regulated gene expression in transfected primary chicken erythrocytes. Proc Natl Acad Sci U S A (1986) 3.17
A study of polyadenylic acid at neutral pH. J Mol Biol (1966) 2.99
Supercoiling energy and nucleosome formation: the role of the arginine-rich histone kernel. Nucleic Acids Res (1977) 2.94
Purification of a functional enzymatic editing complex from Trypanosoma brucei mitochondria. EMBO J (1997) 2.94
Structural and functional conservation at the boundaries of the chicken beta-globin domain. EMBO J (2000) 2.88
Mechanism of transcription through the nucleosome by eukaryotic RNA polymerase. Science (1997) 2.81
Mutational analysis of the chicken beta-globin enhancer reveals two positive-acting domains. Proc Natl Acad Sci U S A (1988) 2.80
An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene. EMBO J (1999) 2.68
The solution structure of a specific GAGA factor-DNA complex reveals a modular binding mode. Nat Struct Biol (1997) 2.67
A histone octamer can step around a transcribing polymerase without leaving the template. Cell (1994) 2.48
Structure and evolution of a human erythroid transcription factor. Nature (1990) 2.47
Tissue-specific factors additively increase the probability of the all-or-none formation of a hypersensitive site. EMBO J (1996) 2.45
The binding of small cations to deoxyribonucleic acid. Nucleotide specificity. Biochemistry (1969) 2.44
A transcriptional terminator is a novel element of the promoter of the mouse ribosomal RNA gene. Cell (1986) 2.42
RNA editing involves indiscriminate U changes throughout precisely defined editing domains. Cell (1990) 2.40
Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A (1999) 2.39
DNA conformation at the 5' end of the chicken adult beta-globin gene. Cell (1983) 2.37
Trypanosome U-deletional RNA editing involves guide RNA-directed endonuclease cleavage, terminal U exonuclease, and RNA ligase activities. Proc Natl Acad Sci U S A (1996) 2.34
Reduction of the diagnostic window with a new combined p24 antigen and human immunodeficiency virus antibody screening assay. J Virol Methods (1998) 2.31
Analysis of the tissue-specific enhancer at the 3' end of the chicken adult beta-globin gene. Proc Natl Acad Sci U S A (1987) 2.30
Primary processing of mammalian rRNA involves two adjacent cleavages and is not species specific. Mol Cell Biol (1987) 2.28
Chromatin structure as probed by nucleases and proteases: evidence for the central role of histones H3 and H4. Cell (1976) 2.24
A complex control region of the mouse rRNA gene directs accurate initiation by RNA polymerase I. Mol Cell Biol (1985) 2.24
Transcription of mouse rDNA is regulated by an activated subform of RNA polymerase I. Cell (1987) 2.18
Stopped at the border: boundaries and insulators. Curr Opin Genet Dev (1999) 2.15
Developmental regulation of topoisomerase II sites and DNase I-hypersensitive sites in the chicken beta-globin locus. Mol Cell Biol (1990) 2.13
The preferential interactions of polylysine and polyarginine with specific base sequences in DNA. Proc Natl Acad Sci U S A (1966) 2.13
Determination of DNA composition and concentration by spectral analysis. J Mol Biol (1966) 2.12
Control of globin gene transcription. Annu Rev Cell Biol (1990) 2.10
Changes in the helical repeat of poly(dG-m5dC) . poly(dG-m5dC) and poly(dG-dC) . poly(dG-dC) associated with the B-Z transition. Nature (1981) 2.06
A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction. Mol Cell Biol (1996) 2.05
The two RNA ligases of the Trypanosoma brucei RNA editing complex: cloning the essential band IV gene and identifying the band V gene. Mol Cell Biol (2001) 2.05
Factors and nucleotide sequences that direct ribosomal DNA transcription and their relationship to the stable transcription complex. Mol Cell Biol (1986) 2.04
trans-Activation of a globin promoter in nonerythroid cells. Mol Cell Biol (1991) 2.02
The interaction of high mobility proteins HMG14 and 17 with nucleosomes. Nucleic Acids Res (1980) 2.00
Nested control regions promote Xenopus ribosomal RNA synthesis by RNA polymerase I. Cell (1983) 1.99
Higher order structure of chromatin: orientation of nucleosomes within the 30 nm chromatin solenoid is independent of species and spacer length. Cell (1983) 1.99
Mapping of transcription initiation and termination signals on Xenopus laevis ribosomal DNA. Proc Natl Acad Sci U S A (1982) 1.99
Isolation and characterization of recombinant clones containing the chicken adult beta-globin gene. J Biol Chem (1979) 1.96
Sites of transcription initiation in vivo on Xenopus laevis ribosomal DNA. Proc Natl Acad Sci U S A (1977) 1.95
An enhancer/locus control region is not sufficient to open chromatin. Mol Cell Biol (1993) 1.93
Structure of the 30 nm chromatin fiber. Cell (1986) 1.93
Transcription of chromatin in vitro. J Mol Biol (1973) 1.84
Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation. Mol Cell Biol (1987) 1.83
An erythrocyte-specific protein that binds to the poly(dG) region of the chicken beta-globin gene promoter. Genes Dev (1988) 1.82
Site-independent expression of the chicken beta A-globin gene in transgenic mice. Nature (1991) 1.82
The single Cys2-His2 zinc finger domain of the GAGA protein flanked by basic residues is sufficient for high-affinity specific DNA binding. Proc Natl Acad Sci U S A (1996) 1.82
Overcoming a nucleosomal barrier to transcription. Cell (1995) 1.81
The terminal balls characteristic of eukaryotic rRNA transcription units in chromatin spreads are rRNA processing complexes. Genes Dev (1993) 1.81
Chemical probes of chromatin structure. Biochemistry (1974) 1.79
T. brucei RNA editing: adenosine nucleotides inversely affect U-deletion and U-insertion reactions at mRNA cleavage. Mol Cell (1998) 1.78
Structure and promoter activity of the gene for the erythroid transcription factor GATA-1. Proc Natl Acad Sci U S A (1991) 1.77
Stable integrative transformation of Trypanosoma brucei that occurs exclusively by homologous recombination. Proc Natl Acad Sci U S A (1991) 1.75
Studies of the temperature-dependent conformation and phase separation of polyriboadenylic acid solutions at neutral pH. J Mol Biol (1967) 1.75
Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. Proc Natl Acad Sci U S A (2000) 1.74
A nucleosome core is transferred out of the path of a transcribing polymerase. Cell (1992) 1.72
Another potential artifact in the study of nucleosome phasing by chromatin digestion with micrococcal nuclease. Cell (1983) 1.72
Trypanosome RNA editing: simple guide RNA features enhance U deletion 100-fold. Mol Cell Biol (2001) 1.72
Orientation of the nucleosome within the higher order structure of chromatin. Cell (1980) 1.72
Roles for ligases in the RNA editing complex of Trypanosoma brucei: band IV is needed for U-deletion and RNA repair. EMBO J (2001) 1.70
Methylation and gene control. Nature (1982) 1.70
Pancreatic DNAase cleavage sites in nuclei. Cell (1977) 1.69
A method for mapping intranuclear protein-DNA interactions and its application to a nuclease hypersensitive site. Proc Natl Acad Sci U S A (1985) 1.64