Published in EMBO J on December 20, 1987
Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat. Proc Natl Acad Sci U S A (1989) 6.32
Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro. Proc Natl Acad Sci U S A (1988) 4.33
UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol Cell Biol (1989) 3.83
The NF-kappa B binding sites in the human immunodeficiency virus type 1 long terminal repeat are not required for virus infectivity. J Virol (1989) 3.36
Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. EMBO J (1989) 3.01
Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein. Proc Natl Acad Sci U S A (1988) 2.79
Purification of the human immunodeficiency virus type 1 enhancer and TAR binding proteins EBP-1 and UBP-1. EMBO J (1988) 2.74
TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factors. EMBO J (1989) 2.65
Functional domains required for tat-induced transcriptional activation of the HIV-1 long terminal repeat. EMBO J (1988) 2.57
NF-kappa B protein purification from bovine spleen: nucleotide stimulation and binding site specificity. Proc Natl Acad Sci U S A (1988) 2.39
Role of SP1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat. J Virol (1989) 2.14
Identification of cellular proteins that bind to the human immunodeficiency virus type 1 trans-activation-responsive TAR element RNA. Proc Natl Acad Sci U S A (1989) 2.14
Linker-scanning mutational analysis of the transcriptional activity of the human immunodeficiency virus type 1 long terminal repeat. J Virol (1991) 1.84
Hepatitis B virus X gene can transactivate heterologous viral sequences. Proc Natl Acad Sci U S A (1989) 1.77
Hepatitis B virus X gene activates kappa B-like enhancer sequences in the long terminal repeat of human immunodeficiency virus 1. Proc Natl Acad Sci U S A (1989) 1.61
Stimulation of the human immunodeficiency virus type 1 enhancer by the human T-cell leukemia virus type I tax gene product involves the action of inducible cellular proteins. J Virol (1989) 1.49
Variable role of the long terminal repeat Sp1-binding sites in human immunodeficiency virus replication in T lymphocytes. J Virol (1991) 1.45
An in vitro transcription analysis of early responses of the human immunodeficiency virus type 1 long terminal repeat to different transcriptional activators. Mol Cell Biol (1991) 1.42
Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C. EMBO J (1990) 1.29
Interaction of enhancer-binding protein EBP1 (NF-kappa B) with the human immunodeficiency virus type 1 enhancer. J Virol (1990) 1.22
Repeated B motifs in the human immunodeficiency virus type I long terminal repeat enhancer region do not exhibit cooperative factor binding. Proc Natl Acad Sci U S A (1988) 1.19
Negative regulation of human immune deficiency virus replication in monocytes. Distinctions between restricted and latent expression in THP-1 cells. J Exp Med (1990) 1.18
Identification of a region within the human immunodeficiency virus type 1 long terminal repeat that is essential for transactivation by the hepatitis B virus gene X. J Virol (1989) 1.17
Multiple transcriptional regulatory domains in the human immunodeficiency virus type 1 long terminal repeat are involved in basal and E1A/E1B-induced promoter activity. J Virol (1989) 1.07
A single amino acid change in CUP2 alters its mode of DNA binding. Mol Cell Biol (1990) 1.02
cis-acting elements in the U3 region of a simian immunodeficiency virus. J Virol (1990) 1.01
Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. J Clin Invest (1993) 0.99
Rapid activation and subsequent down-regulation of the human immunodeficiency virus type 1 promoter in the presence of Tat: possible mechanisms contributing to latency. J Virol (1991) 0.97
Silencing of human immunodeficiency virus long terminal repeat expression by an adenovirus E1a mutant. Proc Natl Acad Sci U S A (1990) 0.95
Nuclear factors that bind two regions important to transcriptional activity of the simian immunodeficiency virus long terminal repeat. J Virol (1992) 0.92
kappa B elements strongly activate gene expression in non-lymphoid cells and function synergistically with NF1 elements. Nucleic Acids Res (1989) 0.92
Human immunodeficiency virus type 1 Tat-mediated trans activation correlates with the phosphorylation state of a cellular TAR RNA stem-binding factor. J Virol (1992) 0.90
A novel cis-acting element that controls transcription of human immunodeficiency virus type 1 DNA, depending on cell type. J Virol (1991) 0.87
USF-related transcription factor, HIV-TF1, stimulates transcription of human immunodeficiency virus-1. Nucleic Acids Res (1991) 0.83
Identification of transcriptional suppressor proteins that bind to the negative regulatory element of the human immunodeficiency virus type 1. Nucleic Acids Res (1991) 0.79
The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (1984) 28.58
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (1984) 24.45
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell (1987) 20.61
An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature (1987) 19.23
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell (1983) 17.87
Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell (1986) 15.30
Studies and perspectives of protein kinase C. Science (1986) 14.73
Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell (1987) 14.62
Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. Science (1986) 12.58
The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat. Cell (1985) 11.28
Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein. Cell (1987) 11.15
Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism. Cell (1986) 10.71
Tissue-specific in vitro transcription from the mouse albumin promoter. Cell (1986) 10.54
Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III. Science (1985) 10.36
A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication. Cell (1987) 10.22
Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen. Proc Natl Acad Sci U S A (1980) 10.22
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature (1985) 8.36
Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. Science (1986) 8.01
A single polypeptide possesses the binding and transcription activities of the adenovirus major late transcription factor. Mol Cell Biol (1986) 7.49
Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 antigen. J Immunol (1985) 7.35
Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature (1987) 6.76
Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus. Proc Natl Acad Sci U S A (1986) 6.57
Long-term cultures of HTLV-III--infected T cells: a model of cytopathology of T-cell depletion in AIDS. Science (1986) 5.86
Expression and characterization of the trans-activator of HTLV-III/LAV virus. Science (1986) 5.15
A cyclic AMP- and phorbol ester-inducible DNA element. Nature (1986) 4.60
Regulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in activated T lymphocytes. Cell (1986) 3.88
The role of the kappa enhancer and its binding factor NF-kappa B in the developmental regulation of kappa gene transcription. Cell (1987) 3.72
Human immunodeficiency virus long terminal repeat responds to T-cell activation signals. Proc Natl Acad Sci U S A (1987) 3.47
The Saccharomyces and Drosophila heat shock transcription factors are identical in size and DNA binding properties. Cell (1987) 3.28
Susceptibility of normal human lymphocytes to infection with HTLV-III/LAV. J Immunol (1986) 3.12
Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts. Mol Cell Biol (1986) 2.63
Tumor promoter, TPA, enhances replication of HTLV-III/LAV. Virology (1986) 2.51
Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes. J Immunol (1985) 2.39
Transcription of human histone genes in extracts from synchronized HeLa cells. Proc Natl Acad Sci U S A (1984) 2.27
The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer. Cell (1987) 2.24
Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer. Nature (1986) 2.22
A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells. Cell (1987) 2.00
Cell-type-specific transcription of an immunoglobulin kappa light chain gene in vitro. Proc Natl Acad Sci U S A (1986) 1.82
Metallothionein gene expression is regulated by serum factors and activators of protein kinase C. Mol Cell Biol (1987) 1.57
Two different cis-active elements transfer the transcriptional effects of both EGF and phorbol esters. Science (1986) 1.56
In vitro stimulation of specific RNA polymerase II-mediated transcription by the pseudorabies virus immediate early protein. Cell (1985) 1.46
Phorbol ester induces c-sis gene transcription in stem cell line K-562. Mol Cell Biol (1986) 1.32
Activation of adenovirus promoters by the adenovirus E1A protein in cell-free extracts. Science (1987) 1.16
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell (1987) 20.61
Mammalian MAP kinase signalling cascades. Nature (2001) 18.89
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell (1994) 16.30
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med (1997) 14.51
A method for isolation of intact, translationally active ribonucleic acid. DNA (1983) 13.67
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta (1991) 11.78
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science (2001) 11.56
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature (1997) 11.31
Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science (1995) 11.16
Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro. Cell (1985) 11.03
A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication. Cell (1987) 10.22
A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell (1998) 10.14
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev (1993) 10.01
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell (1996) 9.68
Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell (1995) 9.30
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell (1997) 8.74
Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. Science (1986) 8.01
The regulation of transcription by phosphorylation. Cell (1992) 7.99
AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell (2001) 7.79
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell (1988) 7.76
Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell (1987) 7.75
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science (2001) 7.66
Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene. Nature (1984) 7.57
Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature (1988) 7.45
Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene. Nature (1982) 7.05
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell (1991) 6.89
Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell (1990) 6.84
Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature (1987) 6.76
The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell (1988) 6.75
Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol (2001) 6.73
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature (1998) 6.15
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science (1994) 6.07
AP-1 in cell proliferation and survival. Oncogene (2001) 6.07
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science (1999) 5.95
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med (1999) 5.79
Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature (1994) 5.65
Multiple Ras functions can contribute to mammalian cell transformation. Cell (1995) 5.24
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science (1999) 5.15
Inhibition of JNK activation through NF-kappaB target genes. Nature (2001) 5.03
Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells. J Biol Chem (1981) 4.86
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature (1994) 4.77
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature (1991) 4.74
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science (1995) 4.74
Prevention of fat-induced insulin resistance by salicylate. J Clin Invest (2001) 4.74
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature (2000) 4.66
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol Cell Biol (1996) 4.56
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev (1994) 4.50
Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature (1989) 4.42
The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. Genes Dev (1998) 4.38
JNK is involved in signal integration during costimulation of T lymphocytes. Cell (1994) 4.36
A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. Genes Dev (1991) 4.25
Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell (1989) 4.17
Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature (1991) 4.17
The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell (1992) 4.04
Sp1 binds to promoter sequences and activates herpes simplex virus 'immediate-early' gene transcription in vitro. Nature (1985) 3.99
Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters. Nature (1987) 3.94
A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene (2006) 3.89
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest (2001) 3.86
The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Sci STKE (1999) 3.79
Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol (1997) 3.77
Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol (1991) 3.70
Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene. EMBO J (1987) 3.65
p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction. Genes Dev (1993) 3.64
The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell (1988) 3.64
Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science (1996) 3.56
c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell (1996) 3.54
Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev (1999) 3.51
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell (1994) 3.44
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev (1999) 3.41
Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature (1996) 3.37
Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. J Biol Chem (1999) 3.34
Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. Proc Natl Acad Sci U S A (1984) 3.28
Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science (1998) 3.26
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. Science (1993) 3.25
Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A (2001) 3.23
Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J (1995) 3.19
A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1. Genes Dev (1988) 3.13
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell (2001) 3.10
Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. Cell (1984) 3.08
Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. EMBO J (1989) 3.01
Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell (1992) 2.99
p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps. Mol Cell Biol (2000) 2.96
Metallothioneins: proteins in search of function. Cell (1985) 2.95
Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B. Mol Cell Biol (1995) 2.89
Mitogen-activated protein kinase cascades and regulation of gene expression. Curr Opin Immunol (1996) 2.89
Is NF-kappaB the sensor of oxidative stress? FASEB J (1999) 2.86
Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5'-flanking DNA. Cell (1984) 2.78
JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity (1999) 2.74
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell (2000) 2.74
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol (1990) 2.73
Regulation and function of the JNK subgroup of MAP kinases. Biochim Biophys Acta (1997) 2.72
Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell (2000) 2.70
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell (1992) 2.62
IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature (2001) 2.60
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr Biol (1999) 2.60
Essential contact residues within SV40 large T antigen binding sites I and II identified by alkylation-interference. Cell (1984) 2.59