Published in Nature on May 10, 1979
Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer. Proc Natl Acad Sci U S A (1981) 6.03
Molecular structure and evolutionary origin of human cardiac muscle actin gene. Proc Natl Acad Sci U S A (1982) 4.97
Unusual nucleotide sequences at the 5' end of actin genes in Dictyostelium discoideum. Proc Natl Acad Sci U S A (1979) 2.64
The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer. Nucleic Acids Res (1981) 2.26
Genetic organization of the region around UNC-15 (I), a gene affecting paramyosin in Caenorhabditis elegans. Genetics (1980) 2.11
Differential nuclease sensitivity of the ovalbumin and beta-globin chromatin regions in erythrocytes and oviduct cells of laying hen. Nucleic Acids Res (1980) 1.91
Physical analysis of the CYC1-sup4 interval in Saccharomyces cerevisiae. Mol Cell Biol (1981) 1.68
Arrangement of coding and intervening sequences of chicken lysozyme gene. Proc Natl Acad Sci U S A (1979) 1.53
Termination of the ovalbumin gene transcription. EMBO J (1984) 1.53
Organization and expression of multiple actin genes in the sea urchin. Mol Cell Biol (1981) 1.52
DNA sequence preference of the progesterone receptor. Proc Natl Acad Sci U S A (1983) 1.45
Isolation and characterization of genomic DNA coding for alpha 2 type I collagen. Nucleic Acids Res (1980) 1.43
Linkage of the four gamma subclass heavy chain genes. Proc Natl Acad Sci U S A (1981) 1.38
Localization of the casein gene family to a single mouse chromosome. J Cell Biol (1982) 1.33
A 45-kb DNA domain with two divergently orientated genes is the unit of organisation of the murine major urinary protein genes. EMBO J (1984) 1.21
The association of transcriptionally active genes with the nuclear matrix of the chicken oviduct. Nucleic Acids Res (1983) 1.17
The ovalbumin gene family: complete sequence and structure of the Y gene. Nucleic Acids Res (1982) 1.16
Vitellogenin B2 gene in Xenopus laevis: isolation, in vitro transcription and relation to other vitellogenin genes. Nucleic Acids Res (1983) 1.13
The William Allan Memorial Award Address: Gene clusters, Genome organization, and complex phenotypes. When the sequence is known, what will it mean? Am J Hum Genet (1981) 1.11
Isolation and characterisation of genes for androgen-responsive secretory proteins of rat seminal vesicles. Nucleic Acids Res (1983) 1.07
Steroid hormone dependence of four DNase I-hypersensitive regions located within the 7000-bp 5'-flanking segment of the ovalbumin gene. EMBO J (1986) 1.06
DNA organisation in the chicken lysozyme gene region. Nucleic Acids Res (1981) 1.01
Evidence for evolutionary duplication of genes in the dopa decarboxylase region of Drosophila. Genetics (1986) 0.97
Hormonally induced alterations of chromatin structure in the polyadenylation and transcription termination regions of the chicken ovalbumin gene. EMBO J (1986) 0.96
A detailed comparison of the 5'-end of the ovalbumin gene cloned from chicken oviduct and erythrocyte DNA. Nucleic Acids Res (1980) 0.95
Simultaneous analysis of conformation and transcription of A and B groups of vitellogenin genes in male and female Xenopus during primary and secondary activation by estrogen. Nucleic Acids Res (1983) 0.87
Analysis of DNA attached to the chromosome scaffold. J Cell Biol (1982) 0.79
Synthesis of apoprotein B of very low density lipoprotein in embryonic-chick liver. Development of responsiveness of oestrogen. Biochem J (1980) 0.75
Organization and expression of eucaryotic split genes coding for proteins. Annu Rev Biochem (1981) 49.46
In vivo sequence requirements of the SV40 early promotor region. Nature (1981) 25.00
The nuclear receptor superfamily: the second decade. Cell (1995) 24.99
Isolation of high-molecular-weight DNA from mammalian cells. Eur J Biochem (1973) 24.38
Promoter sequences of eukaryotic protein-coding genes. Science (1980) 19.96
The ovalbumin gene-sequence of putative control regions. Nucleic Acids Res (1980) 18.04
A reliable method for the recovery of DNA fragments from agarose and acrylamide gels. Anal Biochem (1981) 15.38
The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants. Nucleic Acids Res (1981) 15.12
Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc Natl Acad Sci U S A (1978) 14.82
Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion. Science (1996) 11.59
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature (1986) 11.35
Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence. Proc Natl Acad Sci U S A (1980) 10.27
Specific in vitro initiation of transcription on conalbumin and ovalbumin genes and comparison with adenovirus-2 early and late genes. Nature (1980) 10.22
DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. Science (1993) 9.94
Folding of the DNA double helix in chromatin-like structures from simian virus 40. Proc Natl Acad Sci U S A (1975) 9.70
A new dominant hybrid selective marker for higher eukaryotic cells. J Mol Biol (1981) 9.51
The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product. Cell (1990) 9.37
Organisation and sequences at the 5' end of a cloned complete ovalbumin gene. Nature (1979) 9.30
A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature (1988) 9.07
Electron microscopic and biochemical evidence that chromatin structure is a repeating unit. Cell (1975) 8.90
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A (2000) 8.34
Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem Biophys Res Commun (1997) 7.87
Deletions covering the putative promoter region of early mRNAs of simian virus 40 do not abolish T-antigen expression. Proc Natl Acad Sci U S A (1980) 7.77
Multiple sequence motifs are involved in SV40 enhancer function. EMBO J (1986) 7.76
Cloning of the active thymidine kinase gene of herpes simplex virus type 1 in Escherichia coli K-12. Proc Natl Acad Sci U S A (1979) 7.24
Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequences. Nature (1983) 7.22
Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome. Science (1991) 7.16
Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription. Nature (1985) 7.14
Ovalbumin gene is split in chicken DNA. Nature (1977) 7.05
A direct estimate of the human alphabeta T cell receptor diversity. Science (1999) 6.85
The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell (1988) 6.59
Clinical and genetic abnormalities in patients with Friedreich's ataxia. N Engl J Med (1996) 6.57
Functional domains of the human estrogen receptor. Cell (1987) 6.52
Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci U S A (1996) 6.48
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science (1995) 6.37
Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res (1999) 6.35
The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell (1989) 6.24
A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol Cell (2000) 6.14
Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor. EMBO J (1986) 6.08
Bone formation and inflammation in cardiac valves. Circulation (2001) 6.01
Nuclear receptors enhance our understanding of transcription regulation. Trends Genet (1988) 5.95
The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements. Cell (1983) 5.67
Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science (1996) 5.55
Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor. Nature (1987) 5.47
The SV40 early region TATA box is required for accurate in vitro initiation of transcription. Nature (1981) 5.43
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature (1995) 5.40
Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression. Cell (1986) 5.39
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat Genet (1999) 5.31
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A (1997) 5.24
Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Res (1982) 5.14
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature (1991) 5.13
Identification of a second human retinoic acid receptor. Nature (1988) 5.11
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J (1990) 5.05
Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters. Nature (1993) 5.05
Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development (2000) 5.03
Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions. Science (1985) 5.00
The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc Natl Acad Sci U S A (1993) 4.97
TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J (1996) 4.96
The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter. Nucleic Acids Res (1983) 4.93
DNA methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes. Nucleic Acids Res (1979) 4.81
Fusion of bacterial protoplasts. Proc Natl Acad Sci U S A (1976) 4.79
Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. Nature (1995) 4.79
Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter. Nature (1986) 4.77
The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J (1995) 4.72
A canonical structure for the ligand-binding domain of nuclear receptors. Nat Struct Biol (1996) 4.69
A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J (1996) 4.65
Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell (1995) 4.64
The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation. Nat Genet (1993) 4.57
The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors. EMBO J (1986) 4.47
Organization and sequence studies of the 17-piece chicken conalbumin gene. Nature (1979) 4.36
Sequences upstream from the T-A-T-A box are required in vivo and in vitro for efficient transcription from the adenovirus serotype 2 major late promoter. Proc Natl Acad Sci U S A (1982) 4.30
Stimulation of in vitro transcription from the SV40 early promoter by the enhancer involves a specific trans-acting factor. EMBO J (1984) 4.28
The yeast UASG is a transcriptional enhancer in human HeLa cells in the presence of the GAL4 trans-activator. Cell (1988) 4.22
Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms. Proc Natl Acad Sci U S A (1984) 4.22
The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell (1988) 4.17
Alpha-amanitin: a specific inhibitor of one of two DNA-pendent RNA polymerase activities from calf thymus. Biochem Biophys Res Commun (1970) 4.16
Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J Biol Chem (2000) 4.15
The ovalbumin gene family: structure of the X gene and evolution of duplicated split genes. Cell (1980) 4.14
The 16s/23s ribosomal spacer region as a target for DNA probes to identify eubacteria. PCR Methods Appl (1991) 4.10