Microtubules.

A protein factor essential for microtubule assembly. Proc Natl Acad Sci U S A (1975) 15.35

Behavior of spindles and spindle plaques in the cell cycle and conjugation of Saccharomyces cerevisiae. J Bacteriol (1975) 13.41

Cytoplasmic microtubules in normal and transformed cells in culture: analysis by tubulin antibody immunofluorescence. Proc Natl Acad Sci U S A (1975) 6.08

Antibody against tuberlin: the specific visualization of cytoplasmic microtubules in tissue culture cells. Proc Natl Acad Sci U S A (1975) 5.99

The pericentriolar material in Chinese hamster ovary cells nucleates microtubule formation. J Cell Biol (1977) 4.41

Diffusion of injected macromolecules within the cytoplasm of living cells. Proc Natl Acad Sci U S A (1981) 3.61

Microtubules from mammalian brain: some properties of their depolymerization products and a proposed mechanism of assembly and disassembly. Proc Natl Acad Sci U S A (1974) 3.59

Direct demonstration that receptor crosslinking or aggregation is important in insulin action. Proc Natl Acad Sci U S A (1978) 3.15

Association of mitochondria with microtubules in cultured cells. Proc Natl Acad Sci U S A (1978) 2.85

Microtubular origin of mitotic spindle form birefringence. Demonstration of the applicability of Wiener's equation. J Cell Biol (1975) 2.59

Colchicine inhibition of plasma protein release from rat hepatocytes. J Cell Biol (1975) 2.56

Organization of neuronal microtubules in the nematode Caenorhabditis elegans. J Cell Biol (1979) 2.34

Properties of flagellar "rigor waves" formed by abrupt removal of adenosine triphosphate from actively swimming sea urchin sperm. J Cell Biol (1974) 2.32

BALD-2: a mutation affecting the formation of doublet and triplet sets of microtubules in Chlamydomonas reinhardtii. J Cell Biol (1975) 2.31

Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes. J Cell Biol (1976) 2.08

Organization and energy-dependent growth of microtubules in cells. Proc Natl Acad Sci U S A (1976) 2.02

Pressure-induced depolymerization of spindle microtubules. I. Changes in birefringence and spindle length. J Cell Biol (1975) 1.95

Response of myogenic and fibrogenic cells to cytochalasin B and to colcemid. I. Light microscope observations. J Cell Biol (1975) 1.87

Growth and lability of Chaetopterus oocyte mitotic spindles isolated in the presence of porcine brain tubulin. J Cell Biol (1974) 1.85

Involvement of microtubules and 10-nm filaments in the movement and positioning of nuclei in syncytia. J Cell Biol (1979) 1.78

Aster formation in eggs of Xenopus laevis. Induction by isolated basal bodies. J Cell Biol (1975) 1.73

Cytoskeletal requirements in Chlamydia trachomatis infection of host cells. Infect Immun (1995) 1.61

The basal bodies of Chlamydomonas reinhardtii. Formation from probasal bodies, isolation, and partial characterization. J Cell Biol (1975) 1.60

Identification of tubulin from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1978) 1.57

Bridges between microtubules. J Cell Biol (1974) 1.47

Binding of microtubules to pituitary secretory granules and secretory granule membranes. J Cell Biol (1977) 1.46

A correlation between the effects of anti-mitotic drugs on microtubule assembly in vitro and the inhibition of axonal transport in noradrenergic neurones. J Physiol (1975) 1.41

Translation in vitro of rat brain messenger RNA coding for tubulin and actin. Proc Natl Acad Sci U S A (1975) 1.31

A sensitive method for measuring polymerized and depolymerized forms of tubulin in tissues. J Cell Biol (1977) 1.30

The adherence of human Fc receptor-bearing lymphocytes to antigen-antibody complexes. II. Morphologic alterations induced by the substrate. J Exp Med (1976) 1.29

Promotion of fluorescence upon binding of colchicine to tubulin. Proc Natl Acad Sci U S A (1974) 1.27

Properties of tubulin in unfertilized sea urchin eggs. Quantitation and characterization by the colchicine-binding reaction. J Cell Biol (1976) 1.25

Reversible in vitro polymerization of tubulin from a cultured cell line (rat glial cell clone C6). Proc Natl Acad Sci U S A (1976) 1.25

Cell biology of leukocyte abnormalities--membrane and cytoskeletal function in normal and defective cells. A review. Am J Pathol (1978) 1.23

Kinetochores and disease: keeping microtubule dynamics in check! Curr Opin Cell Biol (2011) 1.19

Mechanical regulation of nuclear structure and function. Annu Rev Biomed Eng (2012) 1.19

Role of microtubules in low density lipoprotein processing by cultured cells. J Clin Invest (1979) 1.18

Microfilaments and microtubules in calcium ionophore-induced secretion of lysosomal enzymes from human polymorphonuclear leukocytes. J Cell Biol (1978) 1.17

Posttranslational processing of alpha-tubulin during axoplasmic transport in CNS axons. J Cell Biol (1982) 1.14

Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. J Clin Invest (1995) 1.13

Pathogenesis of alcohol-induced accumulation of protein in the liver. J Clin Invest (1977) 1.13

Manipulation of fatty acid composition in animal cells grown in culture. Proc Natl Acad Sci U S A (1973) 1.11

Quantitative studies on the polarization optical properties of living cells II. The role of microtubules in birefringence of the spindle of the sea urchin egg. J Cell Biol (1981) 1.09

Microtubule system of isolated fish melanophores as revealed by immunofluorescence microscopy. J Cell Biol (1978) 1.08

Immunological and structural evidence for patterned intussusceptive surface growth in a unicellular organism. A postulated role for submembranous proteins and microtubules. J Cell Biol (1976) 1.08

Inhibition by colchicine of fibrinogen translocation in hepatocytes. J Cell Biol (1975) 1.08

Antisera against electrophoretically purified tubulin stimulate colchicine-binding activity. Proc Natl Acad Sci U S A (1976) 1.07

Crystal-induced neutrophil activation. IV. Specific inhibition of tyrosine phosphorylation by colchicine. J Clin Invest (1993) 1.06

Physiological regulation of total tubulin and polymerized tubulin in tissues. J Cell Biol (1977) 1.03

Further evidence for a two-step model of glucose-transport regulation. Inositol phosphate-oligosaccharides regulate glucose-carrier activity. Biochem J (1989) 0.99

Antibody-induced desensitization of the insulin receptor. Studies of the mechanism of desensitization in 3T3-L1 fatty fibroblasts. J Clin Invest (1980) 0.99

Involvement of microtubules in the link between cell volume and pH of acidic cellular compartments in rat and human hepatocytes. Proc Natl Acad Sci U S A (1994) 0.98

Nerve fibers in culture and their interactions with non-neural cells visualized by immunofluorescence. J Cell Biol (1979) 0.98

Tubulin aggregation and disaggregation: mediation by two distinct vinblastine-binding sites. Proc Natl Acad Sci U S A (1976) 0.97

Microtubular apparates of melanophores. Three-dimensional organization. J Cell Biol (1978) 0.95

Colchicine-binding protein of the liver. Its characterization and relation to microtubules. J Cell Biol (1975) 0.94

Effects of colchicine and vinblastine on the cellular action of vasopressin in mammalian kidney. A possible role of microtubules. J Clin Invest (1974) 0.93

Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents. Proc Natl Acad Sci U S A (1992) 0.93

Ca2+- and calmodulin-stimulated endogenous phosphorylation of neurotubulin. Proc Natl Acad Sci U S A (1981) 0.92

In vitro, rapid assembly of gap junctions is induced by cytoskeleton disruptors. J Cell Biol (1983) 0.92

Association of microfilament bundles with lysosomes in polymorphonuclear leukocytes. J Cell Biol (1976) 0.92

Regulation of three beta-tubulin mRNAs during rat brain development. EMBO J (1985) 0.91

Platelets and microtubules. Effect of colchicine and D2O on platelet aggregation and release induced by calcium ionophore A23187. J Clin Invest (1980) 0.91

Microtubule assembly and function in Chlamydomonas: inhibition of growth and flagellar regeneration by antitubulins and other drugs and isolation of resistant mutants. J Bacteriol (1974) 0.91

Role of the tubulin-microtubule system in lymphocyte activation. J Cell Biol (1977) 0.89

Simian virus 40-host cell interactions. II. Cytoplasmic and nucleolar accumulation of simian virus 40 virion protein. J Virol (1974) 0.88

Factors which disorganize microtubules or microfilaments increase the frequency of cell transformation by polyoma virus. J Virol (1980) 0.88

Regulation of microtubule assembly in cultured fibroblasts. J Cell Biol (1980) 0.88

Cytoskeletal and muscle-like elements in cochlear hair cells. Arch Otorhinolaryngol (1981) 0.87

Motility in Echinosphaerium nucleofilum. II. Cytoplasmic contractility and its molecular basis. J Cell Biol (1975) 0.87

CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions. J Cell Biol (2013) 0.86

Cyclic AMP-induced morphological transformation of cells infected by temperature-sensitive mouse sarcoma virus. Expression of transformation-associated markers. J Cell Biol (1977) 0.85

Stability of neuronal microtubules to high pressure in vivo and in vitro. Proc Natl Acad Sci U S A (1974) 0.85

Evidence for unaltered structure and in vivo assembly of microtubules in transformed cells. Proc Natl Acad Sci U S A (1978) 0.84

Formation of electrical coupling between embryonic Xenopus muscle cells in culture. J Physiol (1984) 0.83

Destruction and reorganization of the receptor membrane in labellar chemosensory cells of the blowfly. Recovery of responses to sugar after destruction. J Gen Physiol (1986) 0.83

The effect of colchicine on human blood platelets under conditions of short-term incubation. Biochem J (1979) 0.83

Effect of colchicine on rat mast cells. J Cell Biol (1976) 0.82

Use of phytohaemagglutinin stimulated lymphocytes to study effects of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency on polynucleotide and protein synthesis in the Lesch-Nyhan syndrome. J Med Genet (1976) 0.80

Insulin release and the microtubular system of the islets of Langerhans. Identification and characterization of tubulin-like protein. Biochem J (1975) 0.78

Human lung tissue and anaphylaxis. Evidence that cyclic nucleotides modulate the immunologic release of mediators through effects on microtubular assembly. J Clin Invest (1977) 0.78

Eosinophil and neutrophil granulocyte exudation in the Chediak-Higashi (beige) mouse. Am J Pathol (1976) 0.78

Describing autophagy via analysis of individual organelles by capillary electrophoresis with laser induced fluorescence detection. Anal Chem (2013) 0.78

Biphasic kinetics of the colchicine-tubulin interaction: role of amino acids surrounding the A ring of bound colchicine molecule. Biochemistry (2005) 0.76

Receptor-mediated gonadotropin action in the ovary. Action of cytoskeletal element-disrupting agents on gonadotropin-induced steroidogenesis in rat luteal cells. Biochem J (1981) 0.76

Expression of microtubule networks in normal cells, transformed cells, and their hybrids. J Cell Biol (1979) 0.75

Living Cells and Dynamic Molecules Observed with the Polarized Light Microscope: the Legacy of Shinya Inoué. Biol Bull (2016) 0.75

Increased elongated and stabilized microtubules in psoriatic keratinocytes. Arch Dermatol Res (1979) 0.75

The colchicine-binding protein of mammalian brain and its relation to microtubules. Biochemistry (1968) 12.96

The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein. J Cell Biol (1967) 9.66

Affinity purification of antibodies from diazotized paper blots of heterogeneous protein samples. J Biol Chem (1981) 9.11

Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia. J Cell Biol (1999) 8.24

The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatus. J Cell Biol (1967) 6.85

Analysis of the actin-myosin II system in fish epidermal keratocytes: mechanism of cell body translocation. J Cell Biol (1997) 6.67

Association of high-molecular-weight proteins with microtubules and their role in microtubule assembly in vitro. Proc Natl Acad Sci U S A (1975) 6.35

Nucleated assembly of microtubules in porcine brain extracts. Science (1972) 6.22

Head-to-tail polymerization of microtubules in vitro. Electron microscope analysis of seeded assembly. J Cell Biol (1980) 5.64

Purification of tubulin and associated high molecular weight proteins from porcine brain and characterization of microtubule assembly in vitro. Ann N Y Acad Sci (1975) 5.26

Structural polarity and directional growth of microtubules of Chlamydomonas flagella. J Mol Biol (1974) 4.80

Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends. J Cell Biol (1987) 4.52

The pericentriolar material in Chinese hamster ovary cells nucleates microtubule formation. J Cell Biol (1977) 4.41

Isolation of microtubule protein from cultured mouse neuroblastoma cells. Proc Natl Acad Sci U S A (1970) 4.20

Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells. J Cell Biol (1982) 4.08

Functional coordination of microtubule-based and actin-based motility in melanophores. Curr Biol (1998) 4.03

Self-polarization and directional motility of cytoplasm. Curr Biol (1999) 3.93

Kinetochore microtubule dynamics and the metaphase-anaphase transition. J Cell Biol (1995) 3.86

Microtubule assembly in vitro. Fed Proc (1974) 3.82

Myosin II filament assemblies in the active lamella of fibroblasts: their morphogenesis and role in the formation of actin filament bundles. J Cell Biol (1995) 3.55

Direct observation of microtubule dynamics in living cells. Nature (1988) 3.47

Cytoplasmic filaments and tubules. Fed Proc (1968) 3.22

Centriole cycle in Chinese hamster ovary cells as determined by whole-mount electron microscopy. J Cell Biol (1981) 3.17

Kinetic analysis of microtubule self-assembly in vitro. J Mol Biol (1977) 3.15

Microtubule release from the centrosome. Proc Natl Acad Sci U S A (1997) 2.97

Isolated flagellar apparatus of Chlamydomonas: characterization of forward swimming and alteration of waveform and reversal of motion by calcium ions in vitro. J Cell Sci (1978) 2.91

Phosphoproteins are components of mitotic microtubule organizing centers. Proc Natl Acad Sci U S A (1984) 2.84

Polarity of microtubules nucleated by centrosomes and chromosomes of Chinese hamster ovary cells in vitro. J Cell Biol (1980) 2.75

Polymerization of tubulin in vivo: direct evidence for assembly onto microtubule ends and from centrosomes. J Cell Biol (1985) 2.72

Characterization of microtubule assembly in porcine brain extracts by viscometry. Biochemistry (1973) 2.68

Comparison of the microtubule proteins of neuroblastoma cells, brain, and Chlamydomonas flagella. Proc Natl Acad Sci U S A (1971) 2.68

On the mechanisms of cytokinesis in animal cells. J Theor Biol (1983) 2.63

Microtubule-associated proteins. Annu Rev Cell Biol (1986) 2.62

Correlative light and electron microscopy of the cytoskeleton of cultured cells. Methods Enzymol (1998) 2.59

Microtubule dynamics in vivo: a test of mechanisms of turnover. J Cell Biol (1987) 2.56

Injection of anticentromere antibodies in interphase disrupts events required for chromosome movement at mitosis. J Cell Biol (1990) 2.46

Microtubule-nucleating activity of centrosomes in Chinese hamster ovary cells is independent of the centriole cycle but coupled to the mitotic cycle. J Cell Biol (1981) 2.43

Dendritic organization of actin comet tails. Curr Biol (2001) 2.43

Ionic and nucleotide requirements for microtubule polymerization in vitro. Biochemistry (1975) 2.43

Role of tubulin-associated proteins in microtubule nucleation and elongation. J Mol Biol (1977) 2.38

The non-tubulin component of microtubule protein oligomers. Effect on self-association and hydrodynamic properties. J Biol Chem (1978) 2.36

Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton. J Cell Biol (1996) 2.35

A rapid procedure for preparing fluorescein-labeled specific antibodies from whole antiserum: its use in analyzing cytoskeletal architecture. J Cell Biol (1983) 2.32

Microtubule dynamics and chromosome motion visualized in living anaphase cells. J Cell Biol (1988) 2.31

Microtuble assembly: some possible regulatory mechanisms. J Supramol Struct (1974) 2.21

Differential turnover of tyrosinated and detyrosinated microtubules. Proc Natl Acad Sci U S A (1987) 2.15

Analysis of MAP 4 function in living cells using green fluorescent protein (GFP) chimeras. J Cell Biol (1995) 2.15

Non-sarcomeric mode of myosin II organization in the fibroblast lamellum. J Cell Biol (1993) 2.10

Mode of centriole duplication and distribution. J Cell Biol (1990) 2.07

Identity and polymerization-stimulatory activity of the nontubulin proteins associated with microtubules. Biochemistry (1977) 2.07

Microtubule treadmilling in vivo. Science (1997) 2.05

Human anticentromere antibodies: distribution, characterization of antigens, and effect on microtubule organization. Cell (1983) 2.04

Polarity of microtubules of the mitotic spindle. J Mol Biol (1978) 2.02

Self-assembly of microtubules in extracts of cultured HeLa cells and the identification of HeLa microtubule-associated proteins. Proc Natl Acad Sci U S A (1979) 1.99

Improved procedures for electron microscopic visualization of the cytoskeleton of cultured cells. J Struct Biol (1996) 1.93

Colcemid inhibition of cell growth and the characterization of a colcemid-binding activity in Saccharomyces cerevisiae. J Cell Biol (1972) 1.89

Microtubule dynamics at the G2/M transition: abrupt breakdown of cytoplasmic microtubules at nuclear envelope breakdown and implications for spindle morphogenesis. J Cell Biol (1996) 1.88

Origin of kinetochore microtubules in Chinese hamster ovary cells. Chromosoma (1980) 1.87

Immunofluorescence localization of HeLa cell microtubule-associated proteins on microtubules in vitro and in vivo. J Cell Biol (1980) 1.87

Microtubules are acetylated in domains that turn over slowly. J Cell Sci (1989) 1.86

Growth and lability of Chaetopterus oocyte mitotic spindles isolated in the presence of porcine brain tubulin. J Cell Biol (1974) 1.85

Analysis of cytoskeletal structures using blot-purified monospecific antibodies. Methods Enzymol (1986) 1.84

Centriole distribution during tripolar mitosis in Chinese hamster ovary cells. J Cell Biol (1984) 1.83

Immunostructural evidence for the template mechanism of microtubule nucleation. Nat Cell Biol (2000) 1.81

Widespread distribution of a 210,000 mol wt microtubule-associated protein in cells and tissues of primates. J Cell Biol (1980) 1.74

A rapid method for quantitative determination of microtubule protein using DEAE-cellulose filters. Anal Biochem (1972) 1.70

Removal of the projections from cytoplasmic microtubules in vitro by digestion with trypsin. J Biol Chem (1977) 1.65

Microtubules of the kinetochore fiber turn over in metaphase but not in anaphase. J Cell Biol (1989) 1.64

Structure of kinetochore fibers: microtubule continuity and inter-microtubule bridges. Chromosoma (1981) 1.64

Centrosomal and non-centrosomal microtubules. Biol Cell (1999) 1.64

The attachment of kinetochores to the pro-metaphase spindle in PtK1 cells. Recovery from low temperature treatment. Chromosoma (1981) 1.64

Two components of actin-based retrograde flow in sea urchin coelomocytes. Mol Biol Cell (1999) 1.63

Speckle microscopic evaluation of microtubule transport in growing nerve processes. Nat Cell Biol (1999) 1.60

Self-organization of a propulsive actin network as an evolutionary process. Proc Natl Acad Sci U S A (2001) 1.60

Steady state dynamics of intermediate filament networks. J Cell Biol (1992) 1.59

Proteins of the mammalian mitotic spindle: phosphorylation/dephosphorylation of MAP-4 during mitosis. J Cell Sci (1991) 1.58

Quantitative determination of the proportion of microtubule polymer present during the mitosis-interphase transition. J Cell Sci (1994) 1.57

Cadherin-mediated regulation of microtubule dynamics. Nat Cell Biol (2000) 1.56

Assembly and turnover of detyrosinated tubulin in vivo. J Cell Biol (1987) 1.55

Quantitative initiation of microtubule assembly by chromosomes from Chinese hamster ovary cells. Exp Cell Res (1978) 1.53

Cytoplasmic assembly of microtubules in cultured cells. J Cell Sci (1997) 1.52

Nucleation of microtubules from mitotic centrosomes is modulated by a phosphorylated epitope. J Cell Sci (1990) 1.48

MAP 4: occurrence in mouse tissues. J Cell Biol (1984) 1.48

Network contraction model for cell translocation and retrograde flow. Biochem Soc Symp (1999) 1.47

Progressive and spatially differentiated stability of microtubules in developing neuronal cells. J Cell Biol (1989) 1.46

Polarity sorting of actin filaments in cytochalasin-treated fibroblasts. J Cell Sci (1997) 1.43

Contribution of plus and minus end pathways to microtubule turnover. J Cell Sci (1999) 1.43

Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics. J Biol Chem (1996) 1.42

A microtubule-associated protein specific to differentiated neuroblastoma cells. J Biol Chem (1981) 1.41

Dynamic aspects of intermediate filament networks in BHK-21 cells. Proc Natl Acad Sci U S A (1989) 1.40

Microtubule-associated proteins from cultured HeLa cells. Analysis of molecular properties and effects on microtubule polymerization. J Biol Chem (1980) 1.39

Tubulin pools in differentiating neuroblastoma cells. J Cell Biol (1981) 1.38

Transgenic AEQUORIN reveals organ-specific cytosolic Ca2+ responses to anoxia and Arabidopsis thaliana seedlings. Plant Physiol (1996) 1.38

Detyrosinated (Glu) microtubules are stabilized by an ATP-sensitive plus-end cap. J Cell Sci (2000) 1.38