A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PubWeight™: 4.25‹?› | Rank: Top 1%

🔗 View Article (PMID 10380929)

Published in Cell on June 11, 1999

Authors

Q Wu1, T Maniatis

Author Affiliations

1: Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Articles citing this

(truncated to the top 100)

Comparative genomics of the eukaryotes. Science (2000) 26.62

Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron (2009) 5.46

Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F. Am J Hum Genet (2001) 3.42

Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model. Genes Dev (2002) 3.14

Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell (2004) 3.10

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Res (2001) 2.66

CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell (2015) 2.59

Protocadherins mediate dendritic self-avoidance in the mammalian nervous system. Nature (2012) 2.52

miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis. Cancer Cell (2011) 2.30

Agglomerative epigenetic aberrations are a common event in human breast cancer. Cancer Res (2008) 2.22

Chromosomal variation in neurons of the developing and adult mammalian nervous system. Proc Natl Acad Sci U S A (2001) 2.20

Microtubule-associated protein 1A is a modifier of tubby hearing (moth1). Nat Genet (2002) 1.97

Gamma protocadherins are required for synaptic development in the spinal cord. Proc Natl Acad Sci U S A (2004) 1.95

X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment. Nat Genet (2008) 1.95

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc Natl Acad Sci U S A (2000) 1.90

gamma-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina. Development (2008) 1.85

Dscam-mediated cell recognition regulates neural circuit formation. Annu Rev Cell Dev Biol (2008) 1.80

Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Genome Res (2003) 1.71

Genetics and cell biology of building specific synaptic connectivity. Annu Rev Neurosci (2010) 1.71

Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta. EMBO J (2000) 1.70

Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases. Neuron (2007) 1.58

Functional cis-heterodimers of N- and R-cadherins. J Cell Biol (2000) 1.57

Identification of long-range regulatory elements in the protocadherin-alpha gene cluster. Proc Natl Acad Sci U S A (2006) 1.55

Assessing long-distance RNA sequence connectivity via RNA-templated DNA-DNA ligation. Elife (2015) 1.50

Molecular heterogeneity in the choroid plexus epithelium: the 22-member γ-protocadherin family is differentially expressed, apically localized, and implicated in CSF regulation. J Neurochem (2011) 1.48

Non-clustered protocadherin. Cell Adh Migr (2011) 1.44

Gene conversion and the evolution of protocadherin gene cluster diversity. Genome Res (2004) 1.42

Deep molecular diversity of mammalian synapses: why it matters and how to measure it. Nat Rev Neurosci (2012) 1.40

CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice. Proc Natl Acad Sci U S A (2012) 1.39

T-cadherin structures reveal a novel adhesive binding mechanism. Nat Struct Mol Biol (2010) 1.37

Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev (2001) 1.35

γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway. Neuron (2012) 1.35

Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res (2013) 1.33

Clustered protocadherins. Development (2013) 1.32

Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes. Genetics (2005) 1.31

Functional significance of isoform diversification in the protocadherin gamma gene cluster. Neuron (2012) 1.30

Single-cell identity generated by combinatorial homophilic interactions between α, β, and γ protocadherins. Cell (2014) 1.29

Coelacanth genome sequence reveals the evolutionary history of vertebrate genes. Genome Res (2004) 1.29

Control of CNS synapse development by {gamma}-protocadherin-mediated astrocyte-neuron contact. J Neurosci (2009) 1.29

Dscam mediates remodeling of glutamate receptors in Aplysia during de novo and learning-related synapse formation. Neuron (2009) 1.29

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. Proc Natl Acad Sci U S A (2000) 1.28

Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of protocadherin-α gene expression. Proc Natl Acad Sci U S A (2012) 1.26

Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing. Proc Natl Acad Sci U S A (2014) 1.26

Gamma-protocadherin homophilic interaction and intracellular trafficking is controlled by the cytoplasmic domain in neurons. Mol Cell Neurosci (2008) 1.24

Regulatory elements required for the activation and repression of the protocadherin-alpha gene cluster. Proc Natl Acad Sci U S A (2011) 1.21

Proteomics analysis reveals overlapping functions of clustered protocadherins. Mol Cell Proteomics (2009) 1.21

Estrogen effects on cognition and hippocampal transcription in middle-aged mice. Neurobiol Aging (2007) 1.19

Inactivation status of PCDH11X: sexual dimorphisms in gene expression levels in brain. Hum Genet (2006) 1.14

alpha- and gamma-Protocadherins negatively regulate PYK2. J Biol Chem (2008) 1.14

Identification of the cluster control region for the protocadherin-beta genes located beyond the protocadherin-gamma cluster. J Biol Chem (2011) 1.13

Protocadherin X ( PCDHX) and Y ( PCDHY) genes; multiple mRNA isoforms encoding variant signal peptides and cytoplasmic domains. Mamm Genome (2004) 1.10

Genome architecture of the human beta-globin locus affects developmental regulation of gene expression. Mol Cell Biol (2005) 1.09

Molecular codes for neuronal individuality and cell assembly in the brain. Front Mol Neurosci (2012) 1.09

Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer. Cancer Med (2014) 1.08

Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret. Proc Natl Acad Sci U S A (2010) 1.08

Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9. J Mol Cell Biol (2015) 1.07

Identification of CTCF as a master regulator of the clustered protocadherin genes. Nucleic Acids Res (2011) 1.07

Extensive linkage disequilibrium, a common 16.7-kilobase deletion, and evidence of balancing selection in the human protocadherin alpha cluster. Am J Hum Genet (2003) 1.06

Protocadherin-19 and N-cadherin interact to control cell movements during anterior neurulation. J Cell Biol (2010) 1.06

Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems. Front Mol Neurosci (2012) 1.04

Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1. PLoS One (2009) 1.04

Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions. Cell (2015) 1.02

Assessment of the developmental totipotency of neural cells in the cerebral cortex of mouse embryo by nuclear transfer. Proc Natl Acad Sci U S A (2001) 1.01

LC3-dependent intracellular membrane tubules induced by gamma-protocadherins A3 and B2: a role for intraluminal interactions. J Biol Chem (2010) 1.01

Combinatorial expression of alpha- and gamma-protocadherins alters their presenilin-dependent processing. Mol Cell Biol (2007) 1.01

The gentle art of gene arrangement: the meaning of gene clusters. Genome Biol (2002) 0.99

Elephant shark sequence reveals unique insights into the evolutionary history of vertebrate genes: A comparative analysis of the protocadherin cluster. Proc Natl Acad Sci U S A (2008) 0.99

Direct and Indirect Regulation of Spinal Cord Ia Afferent Terminal Formation by the γ-Protocadherins. Front Mol Neurosci (2011) 0.99

Sorting out a promiscuous superfamily: towards cadherin connectomics. Trends Cell Biol (2014) 0.97

Adhesion molecules in establishing retinal circuitry. Curr Opin Neurobiol (2009) 0.96

Regulation of protocadherin gene expression by multiple neuron-restrictive silencer elements scattered in the gene cluster. Nucleic Acids Res (2010) 0.96

Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing. EMBO J (2013) 0.96

Complex alternative splicing. Adv Exp Med Biol (2007) 0.94

Synaptogenesis in the CNS: an odyssey from wiring together to firing together. J Physiol (2003) 0.93

Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice. Dev Biol (2009) 0.93

The variable transmembrane domain of Drosophila N-cadherin regulates adhesive activity. Mol Cell Biol (2006) 0.93

Cell adhesion molecules in the central nervous system. Cell Adh Migr (2009) 0.92

γ-protocadherins are enriched and transported in specialized vesicles associated with the secretory pathway in neurons. Eur J Neurosci (2010) 0.92

Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes. BMC Evol Biol (2007) 0.92

The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain. Mol Cell Biol (2009) 0.91

Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. PLoS One (2007) 0.91

Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression. Sci Rep (2013) 0.90

PDCD10/CCM3 acts downstream of {gamma}-protocadherins to regulate neuronal survival. J Biol Chem (2010) 0.90

Protocadherins, not prototypical: a complex tale of their interactions, expression, and functions. Front Mol Neurosci (2013) 0.90

Total expression and dual gene-regulatory mechanisms maintained in deletions and duplications of the Pcdha cluster. J Biol Chem (2009) 0.90

Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia. Schizophr Res (2008) 0.90

Specification of synaptic connectivity by cell surface interactions. Nat Rev Neurosci (2015) 0.89

Sequencing and comparative analysis of fugu protocadherin clusters reveal diversity of protocadherin genes among teleosts. BMC Evol Biol (2007) 0.89

Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia. PLoS One (2011) 0.89

Postnatal development- and age-related changes in DNA-methylation patterns in the human genome. Nucleic Acids Res (2012) 0.89

Constitutively expressed Protocadherin-α regulates the coalescence and elimination of homotypic olfactory axons through its cytoplasmic region. Front Mol Neurosci (2012) 0.89

hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3. Cancer Cell Int (2014) 0.89

Heritability and genetic association analysis of cognition in the Diabetes Heart Study. Neurobiol Aging (2014) 0.88

Molecular and functional interaction between protocadherin-γC5 and GABAA receptors. J Neurosci (2012) 0.88

Whole exome sequencing in females with autism implicates novel and candidate genes. Int J Mol Sci (2015) 0.87

Microarray data integration for genome-wide analysis of human tissue-selective gene expression. BMC Genomics (2010) 0.87

Synaptic and nonsynaptic localization of protocadherin-gammaC5 in the rat brain. J Comp Neurol (2010) 0.87

Genetic basis of neuronal individuality in the mammalian brain. J Neurogenet (2013) 0.86

Protocadherin α (PCDHA) as a novel susceptibility gene for autism. J Psychiatry Neurosci (2013) 0.86

Protocadherins branch out: Multiple roles in dendrite development. Cell Adh Migr (2015) 0.85

Articles by these authors

(truncated to the top 100)

Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res (1984) 86.56

Nucleotide sequence of the rightward operator of phage lambda. Proc Natl Acad Sci U S A (1975) 56.75

The isolation of structural genes from libraries of eucaryotic DNA. Cell (1978) 37.13

The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA. Cell (1978) 22.88

Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis. Biochemistry (1975) 22.00

The structure and evolution of the human beta-globin gene family. Cell (1980) 21.24

Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15

Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. Cell (1983) 17.60

Regulation of inducible and tissue-specific gene expression. Science (1987) 15.04

Amplification and characterization of a beta-globin gene synthesized in vitro. Cell (1976) 14.99

Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell (1984) 12.30

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell (1994) 11.62

The primary structure of rabbit beta-globin mRNA as determined from cloned DNA. Cell (1977) 11.05

Detection and localization of single base changes by denaturing gradient gel electrophoresis. Methods Enzymol (1987) 10.90

Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system. Cell (1981) 9.81

Human beta-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei. Cell (1983) 9.77

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell (1984) 9.13

The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions. Cell (1980) 9.13

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature (1990) 8.79

Transcriptional activation: a complex puzzle with few easy pieces. Cell (1994) 8.63

The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing. Nature (1987) 8.28

The nucleotide sequence of the human beta-globin gene. Cell (1980) 8.11

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell (1993) 8.07

Molecular cloning and characterization of the human beta-like globin gene cluster. Cell (1980) 7.77

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev (1995) 7.36

NF-kappa B: a lesson in family values. Cell (1995) 7.33

Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products. Cell (1983) 7.22

Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell (1995) 7.17

Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell (1998) 7.01

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85

Structure of the lambda operators. Nature (1973) 6.66

Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. Nucleic Acids Res (1985) 6.52

Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes. Nature (1983) 6.48

A role for exon sequences and splice-site proximity in splice-site selection. Cell (1986) 6.41

Fine structure genetic analysis of a beta-globin promoter. Science (1986) 6.36

Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes. Science (1985) 6.35

Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell (2000) 6.32

Sequence of a repressor-binding site in the DNA of bacteriophage lamda. Nature (1974) 6.22

Detection of single base substitutions in total genomic DNA. Nature (1985) 5.99

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell (1996) 5.91

The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene. Cell (1992) 5.85

The human beta-interferon gene enhancer is under negative control. Cell (1986) 5.61

Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J (1995) 5.59

The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell (1989) 5.50

Enzymatic in vitro synthesis of globin genes. Cell (1976) 5.31

Intron sequences involved in lariat formation during pre-mRNA splicing. Cell (1985) 5.30

Multiple repressor binding at the operators in bacteriophage lambda. Proc Natl Acad Sci U S A (1973) 5.15

Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell (1984) 5.12

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell (1993) 4.82

NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev (2001) 4.70

Bovine papillomavirus vector that propagates as a plasmid in both mouse and bacterial cells. Proc Natl Acad Sci U S A (1982) 4.69

Human beta-interferon gene expression is regulated by an inducible enhancer element. Cell (1985) 4.68

The molecular genetics of human hemoglobins. Annu Rev Genet (1980) 4.67

Structure and in vitro transcription of human globin genes. Science (1980) 4.65

cis and trans activation of globin gene transcription in transient assays. Proc Natl Acad Sci U S A (1983) 4.41

Activation of the human beta-interferon gene requires an interferon-inducible factor. Mol Cell Biol (1986) 4.38

Associations between distinct pre-mRNA splicing components and the cell nucleus. EMBO J (1991) 4.38

Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda. Cell (1975) 4.28

Tuberculosis as a manifestation of the acquired immunodeficiency syndrome (AIDS). JAMA (1986) 4.25

Control elements in the DNA of bacteriophage lambda. Cold Spring Harb Symp Quant Biol (1974) 4.23

A single-base change at a splice site in a beta 0-thalassemic gene causes abnormal RNA splicing. Cell (1982) 4.22

Characterisation of deletions which affect the expression of fetal globin genes in man. Nature (1979) 4.18

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. Proc Natl Acad Sci U S A (1995) 4.16

The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication. Cell (1980) 4.15

The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. Cell (1982) 4.13

Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell (1993) 4.01

General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc Natl Acad Sci U S A (1992) 3.97

A general method for saturation mutagenesis of cloned DNA fragments. Science (1985) 3.94

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell (1997) 3.91

Full length and discrete partial reverse transcripts of globin and chorion mRNAs. Cell (1975) 3.83

Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the Drosophila germ line. Cell (1983) 3.83

GAL4 activates transcription in Drosophila. Nature (1988) 3.73

The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. Genes Dev (1996) 3.63

Overlapping positive and negative regulatory domains of the human beta-interferon gene. Proc Natl Acad Sci U S A (1988) 3.54

Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proc Natl Acad Sci U S A (1979) 3.53

Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. Science (1992) 3.52

Selection and characterization of pre-mRNA splicing enhancers: identification of novel SR protein-specific enhancer sequences. Mol Cell Biol (1999) 3.36

Detection of factors that interact with the human beta-interferon regulatory region in vivo by DNAase I footprinting. Cell (1986) 3.35

A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. Genes Dev (1990) 3.26

Generation of p50 subunit of NF-kappa B by processing of p105 through an ATP-dependent pathway. Nature (1991) 3.26

The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2. Cell (1994) 3.18

The role of the mammalian branchpoint sequence in pre-mRNA splicing. Genes Dev (1988) 3.14

Positive control of pre-mRNA splicing in vitro. Science (1992) 3.05

The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site. Proc Natl Acad Sci U S A (1992) 3.04

2-Aminopurine selectively inhibits the induction of beta-interferon, c-fos, and c-myc gene expression. Science (1988) 2.97

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. Cell (1991) 2.95

The mechanism of transcriptional synergy of an in vitro assembled interferon-beta enhanceosome. Mol Cell (1997) 2.94

Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. Genes Dev (1996) 2.90

Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis. Nucleic Acids Res (1985) 2.90

Rapid reprogramming of globin gene expression in transient heterokaryons. Cell (1986) 2.90

The linkage arrangement of four rabbit beta-like globin genes. Cell (1979) 2.90

Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter. Mol Cell (1999) 2.89

The structure and transcription of four linked rabbit beta-like globin genes. Cell (1979) 2.81

The regulated expression of beta-globin genes introduced into mouse erythroleukemia cells. Cell (1983) 2.75

Tissue-specific DNA methylation in a cluster of rabbit beta-like globin genes. Proc Natl Acad Sci U S A (1980) 2.74

Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA. Mol Cell Biol (1999) 2.72

A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev (2000) 2.72

A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers. EMBO J (1998) 2.71

Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science (1996) 2.66

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Res (2001) 2.66