Published in Proc Natl Acad Sci U S A on April 11, 1995
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev (1999) 6.56
NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J (2001) 2.94
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation. Mol Cell Biol (2000) 2.72
Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells. J Virol (1999) 2.09
Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes Dev (2001) 1.91
Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. Mol Cell Biol (1996) 1.70
The ubiquitin-proteasome pathway in cancer. Br J Cancer (1998) 1.56
Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes. Mol Cell Biol (1995) 1.48
Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53. Mol Cell Biol (2004) 1.48
Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc. Neoplasia (2006) 1.34
Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9. Nucleic Acids Res (1996) 1.28
Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradation. J Virol (1996) 1.21
Replication and assembly of human papillomaviruses. J Dent Res (2009) 1.20
Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6. Oncogene (2007) 1.08
Human Sug1/p45 is involved in the proteasome-dependent degradation of Sp1. Biochem J (2000) 1.02
HPV infection and p16 expression in carcinomas of the minor salivary glands. Eur Arch Otorhinolaryngol (2011) 0.92
A novel rat homolog of the Saccharomyces cerevisiae ubiquitin-conjugating enzymes UBC4 and UBC5 with distinct biochemical features is induced during spermatogenesis. Mol Cell Biol (1996) 0.89
DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget (2012) 0.88
Evolution of human papillomavirus carcinogenicity. Adv Virus Res (2010) 0.83
Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-κB signaling. Oral Oncol (2013) 0.81
UBE3C promotes growth and metastasis of renal cell carcinoma via activating Wnt/β-catenin pathway. PLoS One (2015) 0.81
Backbone resonance assignment of human UBC4. J Biomol NMR (2000) 0.78
Carcinoma of the lung: warts and all. Thorax (1996) 0.76
Targeted Therapy in Oropharyngeal Squamous Cell Carcinoma: The Implications of HPV for Therapy. Rare Cancers Ther (2015) 0.75
p53 mutations in human cancers. Science (1991) 31.96
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell (1990) 20.60
The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science (1989) 16.54
Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science (1990) 12.88
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell (1993) 12.41
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature (1991) 9.21
p53 function and dysfunction. Cell (1992) 7.73
Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci U S A (1992) 5.94
Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature (1995) 5.89
Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins. EMBO J (1990) 5.31
The N-end rule. Cell (1992) 4.80
The ubiquitin-conjugation system. Annu Rev Genet (1992) 4.79
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature (1994) 4.77
Viruses in human cancers. Science (1991) 4.58
An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53. J Immunol Methods (1992) 3.23
Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. Proc Natl Acad Sci U S A (1994) 3.12
Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. Proc Natl Acad Sci U S A (1991) 2.53
Performance of an automated system for capillary microinjection into living cells. J Biochem Biophys Methods (1988) 2.19
Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins. Proc Natl Acad Sci U S A (1991) 1.71
Dhr6, a Drosophila homolog of the yeast DNA-repair gene RAD6. Proc Natl Acad Sci U S A (1991) 1.43
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1. Proc Natl Acad Sci U S A (1991) 1.38
The ubc-2 gene of Caenorhabditis elegans encodes a ubiquitin-conjugating enzyme involved in selective protein degradation. Mol Cell Biol (1993) 1.25
A human ubiquitin-conjugating enzyme homologous to yeast UBC8. J Biol Chem (1994) 1.07
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol (1999) 9.92
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science (1995) 9.79
Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev (1993) 8.03
Cyclin A is required at two points in the human cell cycle. EMBO J (1992) 7.96
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev (1999) 6.56
Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol (1995) 6.41
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med (1997) 5.10
Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell (1989) 4.68
Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature (2000) 4.52
The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell (1989) 4.43
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J (1993) 4.33
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev (1999) 4.07
Short-term effects of carbon monoxide exposure on the exercise performance of subjects with coronary artery disease. N Engl J Med (1989) 4.02
The F-box protein family. Genome Biol (2000) 4.00
p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. EMBO J (1987) 3.91
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol (2001) 3.87
Viral load and disease progression in infants infected with human immunodeficiency virus type 1. Women and Infants Transmission Study Group. N Engl J Med (1997) 3.71
Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol (2000) 3.65
Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease? The Neonatology Committee for the Developmental Network. Pediatrics (2000) 3.48
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. Oncogene (1999) 3.36
Identification of a family of human F-box proteins. Curr Biol (1999) 3.31
cdc2 phosphorylation is required for its interaction with cyclin. EMBO J (1991) 3.22
Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+. Cell (1987) 3.12
The human Y chromosome: a 43-interval map based on naturally occurring deletions. Science (1992) 3.09
A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell (1989) 3.08
Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer. N Engl J Med (1996) 3.04
CDC25 phosphatases as potential human oncogenes. Science (1995) 2.84
Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J Cell Biol (1993) 2.83
Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. Cell (1990) 2.70
Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition. EMBO J (1994) 2.61
Role of the F-box protein Skp2 in lymphomagenesis. Proc Natl Acad Sci U S A (2001) 2.55
Risk of oral squamous cell carcinoma in 402 patients with oral lichen planus: a follow-up study in an Italian population. Oral Oncol (2004) 2.46
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J (2001) 2.45
Association of cdk2 kinase with the transcription factor E2F during S phase. Science (1992) 2.37
Differential modulation of cyclin gene expression by MYC. Proc Natl Acad Sci U S A (1993) 2.31
A likelihood-based method for real-time estimation of the serial interval and reproductive number of an epidemic. Stat Med (2008) 2.29
Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression. Oncogene (1994) 2.18
Activation of protein kinase C triggers its ubiquitination and degradation. Mol Cell Biol (1998) 2.15
Using treatment failure under effective directly observed short-course chemotherapy programs to identify patients with multidrug-resistant tuberculosis. Int J Tuberc Lung Dis (2000) 2.15
Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene (1994) 2.10
Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. Cancer Res (1997) 2.05
Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest. J Biol Chem (1997) 2.05
Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src. EMBO J (1993) 2.02
Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor. Mol Cell (2000) 2.02
The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. Cancer Res (1997) 2.00
Hunger in children in the United States: potential behavioral and emotional correlates. Pediatrics (1998) 1.99
White matter disorders of prematurity: association with intraventricular hemorrhage and ventriculomegaly. The Developmental Epidemiology Network. J Pediatr (1999) 1.93
Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J (1995) 1.92
Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma. Cancer Res (1998) 1.92
ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation. Cell (1989) 1.90
Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4. Cancer Res (1994) 1.88
Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts. Mol Biol Cell (1993) 1.87
Regulation of the microtubule nucleating activity of centrosomes in Xenopus egg extracts: role of cyclin A-associated protein kinase. J Cell Biol (1992) 1.82
Activation of human CDC2 protein as a histone H1 kinase is associated with complex formation with the p62 subunit. Proc Natl Acad Sci U S A (1989) 1.80
Prevention of heterosexual transmission of human immunodeficiency virus through couple counseling. J Acquir Immune Defic Syndr (1993) 1.79
Leukaemia in young persons in Scotland: a study of its geographical distribution and relationship to nuclear installations. Health Bull (Edinb) (1987) 1.76
Rescue of defective mitogenic signaling by D-type cyclins. Proc Natl Acad Sci U S A (1995) 1.71
Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression. J Cell Biol (2001) 1.69
Corrected group prognostic curves and summary statistics. J Chronic Dis (1982) 1.67
Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest. Mol Cell Biol (1991) 1.66
Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation. Leukemia (1997) 1.64
Oral acanthosis nigricans, tripe palms and sign of leser-trélat in a patient with gastric adenocarcinoma. Int J Dermatol (2004) 1.62
Maternal infection, fetal inflammatory response, and brain damage in very low birth weight infants. Developmental Epidemiology Network Investigators. Pediatr Res (1999) 1.58
Hypocarbia during the first 24 postnatal hours and white matter echolucencies in newborns < or = 28 weeks gestation. Pediatr Res (2001) 1.58
Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. Oncogene (2001) 1.57
A nonparametric scoring algorithm for identifying informative genes from microarray data. Pac Symp Biocomput (2001) 1.51
Screening for carriers of Tay-Sachs disease in the ultraorthodox Ashkenazi Jewish community in Israel. Am J Med Genet (1993) 1.50
Maternal glucocorticoid therapy and reduced risk of bronchopulmonary dysplasia. Pediatrics (1990) 1.49
The Pediatric Symptom Checklist. Support for a role in a managed care environment. Arch Pediatr Adolesc Med (1995) 1.48
Cdc25 protein phosphatases in cell proliferation. Biochim Biophys Acta (1997) 1.47
Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation. J Virol (1994) 1.46
Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells. Oncogene (1992) 1.46
Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas. Cancer (2001) 1.44
Antenatal glucocorticoid treatment does not reduce chronic lung disease among surviving preterm infants. J Pediatr (2001) 1.44
Maternal toxemia and neonatal germinal matrix hemorrhage in intubated infants less than 1751 g. Obstet Gynecol (1988) 1.43
Fission yeast cdc25 is a cell-cycle regulated protein. Biochem Biophys Res Commun (1990) 1.41
E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products. Mol Cell Biol (1991) 1.41
Cyclin A- and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts. EMBO J (1992) 1.41
Pseudomonas cepacia--fatal pulmonary infection in a patient with cystic fibrosis. J Infect (1986) 1.40
Putative transcription activator with alternative isoforms encoded by human ZFX gene. Nature (1989) 1.39
Bivariate method for spatio-temporal syndromic surveillance. MMWR Morb Mortal Wkly Rep (2004) 1.39
Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. J Biol Chem (1999) 1.39
Risk factors for hepatitis C virus seropositivity in heterosexual couples. JAMA (1993) 1.38
Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells. Oncogene (1993) 1.34
Regulation of the G1 to S transition by the ubiquitin pathway. FEBS Lett (2001) 1.30
The ubiquitin-mediated proteolytic pathway as a therapeutic area. J Mol Med (Berl) (1997) 1.29
Role of the Cdc25A phosphatase in human breast cancer. J Clin Invest (2000) 1.25
Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma. Blood (2000) 1.25
Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells. Oncogene (1997) 1.25
Herculaneum victims of Vesuvius in ad 79. Nature (2001) 1.23
The Schizosaccharomyces pombe casein kinase II alpha and beta subunits: evolutionary conservation and positive role of the beta subunit. Mol Cell Biol (1994) 1.22
Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases. Am J Pathol (1998) 1.19