Dual promoter activation by the human beta-globin locus control region.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMC 43148)

Published in Proc Natl Acad Sci U S A on February 15, 1994

Authors

E H Bresnick1, G Felsenfeld

Author Affiliations

1: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Laboratory of Molecular Biology, Bethesda, MD 20892.

Articles cited by this

Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell (1987) 15.79

Gene regulation by proteins acting nearby and at a distance. Nature (1986) 9.71

The "beta-like-globin" gene domain in human erythroid cells. Proc Natl Acad Sci U S A (1985) 8.35

The molecular genetics of human hemoglobin. Prog Nucleic Acid Res Mol Biol (1984) 5.50

A developmentally stable chromatin structure in the human beta-globin gene cluster. Proc Natl Acad Sci U S A (1986) 5.47

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice. Genes Dev (1989) 4.60

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice. Nature (1990) 4.53

A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Genes Dev (1990) 4.30

A dominant control region from the human beta-globin locus conferring integration site-independent gene expression. Nature (1989) 4.17

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes. Proc Natl Acad Sci U S A (1989) 4.11

Detailed analysis of the site 3 region of the human beta-globin dominant control region. EMBO J (1990) 4.05

Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus. Proc Natl Acad Sci U S A (1983) 4.05

Human gamma- to beta-globin gene switching in transgenic mice. Genes Dev (1990) 4.04

The beta-globin dominant control region: hypersensitive site 2. EMBO J (1990) 3.75

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression. EMBO J (1990) 3.72

The 5'HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites. EMBO J (1991) 3.28

Importance of globin gene order for correct developmental expression. Genes Dev (1991) 2.85

Inducible transcription of five globin genes in K562 human leukemia cells. Proc Natl Acad Sci U S A (1983) 2.35

Transcription of the hypersensitive site HS2 enhancer in erythroid cells. Proc Natl Acad Sci U S A (1992) 2.20

The transcriptionally-active MMTV promoter is depleted of histone H1. Nucleic Acids Res (1992) 2.16

Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region. Genes Dev (1992) 1.84

The reprogramming of transcriptional competence. Cell (1992) 1.77

Synthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers. EMBO J (1993) 1.77

Evidence that the transcription factor USF is a component of the human beta-globin locus control region heteromeric protein complex. J Biol Chem (1993) 1.46

Structure and function of the murine beta-globin locus control region 5' HS-3. Nucleic Acids Res (1992) 1.17

Articles by these authors

(truncated to the top 100)

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature (2000) 14.91

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell (1999) 9.74

Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC). Proc Natl Acad Sci U S A (1981) 8.07

A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell (1993) 8.05

Nucleosome structure. Annu Rev Biochem (1980) 7.16

A 200 base pair region at the 5' end of the chicken adult beta-globin gene is accessible to nuclease digestion. Cell (1981) 6.43

The erythroid-specific transcription factor Eryf1: a new finger protein. Cell (1989) 6.14

Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Science (2001) 6.00

Chromatin. Nature (1978) 5.89

Insulators and boundaries: versatile regulatory elements in the eukaryotic genome. Science (2001) 5.37

An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. Proc Natl Acad Sci U S A (1988) 5.29

Structure of chromatin. Nat New Biol (1971) 5.23

The organization of histones and DNA in chromatin: evidence for an arginine-rich histone kernel. Cell (1976) 4.31

Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci. EMBO J (2001) 4.28

A new method for the purification and identification of covalently closed circular DNA molcules. Nucleic Acids Res (1978) 4.09

Specific factor conferring nuclease hypersensitivity at the 5' end of the chicken adult beta-globin gene. Proc Natl Acad Sci U S A (1984) 4.03

Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult beta-globin gene: nature of the binding domain. Cell (1985) 3.99

Synthesis of globin ribonucleic acid from duck-reticulocyte chromatin in vitro. Proc Natl Acad Sci U S A (1973) 3.93

NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. Science (1993) 3.74

Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. Genes Dev (1998) 3.70

A new procedure for purifying histone pairs H2A + H2B and H3 + H4 from chromatin using hydroxylapatite. Nucleic Acids Res (1979) 3.62

Characterization of the chicken beta-globin insulator. Proc Natl Acad Sci U S A (1997) 3.57

A comparison of the digestion of nuclei and chromatin by staphylococcal nuclease. Biochemistry (1975) 3.52

Conformation of polyribouridylic acid in solution. J Mol Biol (1970) 3.28

Specific sites of interaction between histones and DNA in chromatin. Proc Natl Acad Sci U S A (1974) 3.25

A neighbor-interaction analysis of the hypochromism and spectra of DNA. J Mol Biol (1965) 3.24

Regulated gene expression in transfected primary chicken erythrocytes. Proc Natl Acad Sci U S A (1986) 3.17

A study of polyadenylic acid at neutral pH. J Mol Biol (1966) 2.99

Supercoiling energy and nucleosome formation: the role of the arginine-rich histone kernel. Nucleic Acids Res (1977) 2.94

Structural and functional conservation at the boundaries of the chicken beta-globin domain. EMBO J (2000) 2.88

Mechanism of transcription through the nucleosome by eukaryotic RNA polymerase. Science (1997) 2.81

Mutational analysis of the chicken beta-globin enhancer reveals two positive-acting domains. Proc Natl Acad Sci U S A (1988) 2.80

An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene. EMBO J (1999) 2.68

The solution structure of a specific GAGA factor-DNA complex reveals a modular binding mode. Nat Struct Biol (1997) 2.67

A histone octamer can step around a transcribing polymerase without leaving the template. Cell (1994) 2.48

DNAase I, DNAase II and staphylococcal nuclease cut at different, yet symmetrically located, sites in the nucleosome core. Cell (1978) 2.48

Structure and evolution of a human erythroid transcription factor. Nature (1990) 2.47

Tissue-specific factors additively increase the probability of the all-or-none formation of a hypersensitive site. EMBO J (1996) 2.45

The binding of small cations to deoxyribonucleic acid. Nucleotide specificity. Biochemistry (1969) 2.44

Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A (1999) 2.39

DNA conformation at the 5' end of the chicken adult beta-globin gene. Cell (1983) 2.37

Analysis of the tissue-specific enhancer at the 3' end of the chicken adult beta-globin gene. Proc Natl Acad Sci U S A (1987) 2.30

Chromatin structure as probed by nucleases and proteases: evidence for the central role of histones H3 and H4. Cell (1976) 2.24

Stopped at the border: boundaries and insulators. Curr Opin Genet Dev (1999) 2.15

The preferential interactions of polylysine and polyarginine with specific base sequences in DNA. Proc Natl Acad Sci U S A (1966) 2.13

Developmental regulation of topoisomerase II sites and DNase I-hypersensitive sites in the chicken beta-globin locus. Mol Cell Biol (1990) 2.13

Determination of DNA composition and concentration by spectral analysis. J Mol Biol (1966) 2.12

Control of globin gene transcription. Annu Rev Cell Biol (1990) 2.10

Changes in the helical repeat of poly(dG-m5dC) . poly(dG-m5dC) and poly(dG-dC) . poly(dG-dC) associated with the B-Z transition. Nature (1981) 2.06

A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction. Mol Cell Biol (1996) 2.05

trans-Activation of a globin promoter in nonerythroid cells. Mol Cell Biol (1991) 2.02

The interaction of high mobility proteins HMG14 and 17 with nucleosomes. Nucleic Acids Res (1980) 2.00

Higher order structure of chromatin: orientation of nucleosomes within the 30 nm chromatin solenoid is independent of species and spacer length. Cell (1983) 1.99

Isolation and characterization of recombinant clones containing the chicken adult beta-globin gene. J Biol Chem (1979) 1.96

An enhancer/locus control region is not sufficient to open chromatin. Mol Cell Biol (1993) 1.93

Structure of the 30 nm chromatin fiber. Cell (1986) 1.93

Transcription of chromatin in vitro. J Mol Biol (1973) 1.84

An erythrocyte-specific protein that binds to the poly(dG) region of the chicken beta-globin gene promoter. Genes Dev (1988) 1.82

Site-independent expression of the chicken beta A-globin gene in transgenic mice. Nature (1991) 1.82

The single Cys2-His2 zinc finger domain of the GAGA protein flanked by basic residues is sufficient for high-affinity specific DNA binding. Proc Natl Acad Sci U S A (1996) 1.82

Overcoming a nucleosomal barrier to transcription. Cell (1995) 1.81

Chemical probes of chromatin structure. Biochemistry (1974) 1.79

Structure and promoter activity of the gene for the erythroid transcription factor GATA-1. Proc Natl Acad Sci U S A (1991) 1.77

Studies of the temperature-dependent conformation and phase separation of polyriboadenylic acid solutions at neutral pH. J Mol Biol (1967) 1.75

Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. Proc Natl Acad Sci U S A (2000) 1.74

A nucleosome core is transferred out of the path of a transcribing polymerase. Cell (1992) 1.72

Another potential artifact in the study of nucleosome phasing by chromatin digestion with micrococcal nuclease. Cell (1983) 1.72

Orientation of the nucleosome within the higher order structure of chromatin. Cell (1980) 1.72

Methylation and gene control. Nature (1982) 1.70

Pancreatic DNAase cleavage sites in nuclei. Cell (1977) 1.69

A method for mapping intranuclear protein-DNA interactions and its application to a nuclease hypersensitive site. Proc Natl Acad Sci U S A (1985) 1.64

Chromatin structure of the chicken beta-globin gene region. Sensitivity to DNase I, micrococcal nuclease, and DNase II. J Biol Chem (1982) 1.61

Deoxyribonucleic acid-polylysine complexes. Structure and nucleotide specificity. Biochemistry (1969) 1.59

Bidirectional control of the chicken beta- and epsilon-globin genes by a shared enhancer. Proc Natl Acad Sci U S A (1988) 1.59

A 145-base pair DNA sequence that positions itself precisely and asymmetrically on the nucleosome core. EMBO J (1984) 1.57

Positional enhancer-blocking activity of the chicken beta-globin insulator in transiently transfected cells. Proc Natl Acad Sci U S A (1999) 1.56

Protein-binding sites within the 5' DNase I-hypersensitive region of the chicken alpha D-globin gene. Mol Cell Biol (1987) 1.53

The mechanism of osmotic transfection of avian embryonic erythrocytes: analysis of a system for studying developmental gene expression. J Cell Biol (1987) 1.51

Formation of nucleosomes on positively supercoiled DNA. EMBO J (1991) 1.50

Developmental modulation of protein binding to beta-globin gene regulatory sites within chicken erythrocyte nuclei. Genes Dev (1989) 1.48

Effect of the B--Z transition in poly(dG-m5dC) . poly(dG-m5dC) on nucleosome formation. Proc Natl Acad Sci U S A (1982) 1.46

Evidence that the transcription factor USF is a component of the human beta-globin locus control region heteromeric protein complex. J Biol Chem (1993) 1.46

Reaction of nucleosome DNA with dimethyl sulfate. Proc Natl Acad Sci U S A (1979) 1.43

A small single-"finger" peptide from the erythroid transcription factor GATA-1 binds specifically to DNA as a zinc or iron complex. Proc Natl Acad Sci U S A (1993) 1.43

The conformation of single-strand polynucleotides in solution: sedimentation studies of apurinic acid. Biopolymers (1971) 1.41

Nucleosome structure, DNA folding, and gene activity. Cold Spring Harb Symp Quant Biol (1978) 1.32

Identification and characterization of a chicken alpha-globin enhancer. Mol Cell Biol (1989) 1.31

Histone H3 disulfide dimers and nucleosome structure. Proc Natl Acad Sci U S A (1977) 1.29

The conformation of polyriboadenylic acid at low temperature and neutral pH. A single-stranded rodlike structure. Biopolymers (1975) 1.28

Effect of Z-DNA on nucleosome placement. J Mol Biol (1987) 1.24

Use of mercury-substituted ribonucleoside triphosphates can lead to artefacts in the analysis of in vitro chromatin transcrits. Biochem Biophys Res Commun (1977) 1.24

A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse beta -globin locus. Proc Natl Acad Sci U S A (2000) 1.23

An octamer of histones H3 and H4 forms a compact complex with DNA of nucleosome size. Nucleic Acids Res (1978) 1.22

Analysis of in vitro transcription of duck reticulocyte chromatin using mercury-substituted ribonucleoside triphosphates. Biochemistry (1977) 1.21

The developmental switch in embryonic rho-globin expression is correlated with erythroid lineage-specific differences in transcription factor levels. Development (1992) 1.19

DNA. Sci Am (1985) 1.18

A simple model of DNA superhelices in solution. Proc Natl Acad Sci U S A (1978) 1.17

Properties of BGP1, a poly(dG)-binding protein from chicken erythrocytes. Nucleic Acids Res (1990) 1.16

Association of arginine-rich histones with G-C-rich regions of DNA in chromatin. Nat New Biol (1972) 1.14

Histone hyperacetylation has little effect on the higher order folding of chromatin. Nucleic Acids Res (1983) 1.13