Published in Proc Natl Acad Sci U S A on May 28, 1996
Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. EMBO J (2000) 2.22
RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity (1998) 2.15
Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J (1997) 2.09
Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells. Mol Cell Biol (2003) 1.78
Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis. J Exp Med (2005) 1.72
Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting. Mol Cell Biol (2004) 1.40
B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching. J Exp Med (1996) 1.34
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor. EMBO J (2003) 1.31
Nur77 as a survival factor in tumor necrosis factor signaling. Proc Natl Acad Sci U S A (2003) 1.12
Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosis. Proc Natl Acad Sci U S A (2002) 1.12
The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells. J Exp Med (1998) 0.98
Expression of constitutively active IkappaB beta in T cells of transgenic mice: persistent NF-kappaB activity is required for T-cell immune responses. Mol Cell Biol (1998) 0.95
Resistance of Foxp3+ regulatory T cells to Nur77-induced apoptosis promotes allograft survival. PLoS One (2008) 0.89
Proteasome regulation of activation-induced T cell death. Proc Natl Acad Sci U S A (1997) 0.88
Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K2 is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei. J Cancer Res Clin Oncol (2008) 0.87
Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes. Proc Natl Acad Sci U S A (1999) 0.85
Fas apoptosis inhibitory molecule regulates T cell receptor-mediated apoptosis of thymocytes by modulating Akt activation and Nur77 expression. J Biol Chem (2010) 0.82
Local interstitial delivery of z-butylidenephthalide by polymer wafers against malignant human gliomas. Neuro Oncol (2011) 0.81
Thymocyte apoptosis. J Clin Immunol (1999) 0.81
Down-regulation of NR4A1 in follicular thyroid carcinomas is restored following lithium treatment. Clin Endocrinol (Oxf) (2008) 0.80
Apoptosis with FasL+ cell infiltration in the periphery and thymus of corrected autoimmune mice. Immunology (1997) 0.79
Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes. Cell Death Differ (2016) 0.75
Analysis of 20alpha-hydroxysteroid dehydrogenase expression in the corpus luteum of the buffalo cow: effect of prostaglandin F2-alpha treatment on circulating 20alpha-hydroxyprogesterone levels. Reprod Biol Endocrinol (2013) 0.75
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol (1992) 34.17
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods (1991) 16.64
The Fas death factor. Science (1995) 13.81
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (1992) 12.92
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95) Nature (1995) 8.23
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature (1995) 7.52
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell (1994) 7.23
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol (1991) 6.89
Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature (1995) 6.85
Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature (1989) 6.70
T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature (1994) 6.20
Induction of apoptosis in mature T cells by tumour necrosis factor. Nature (1995) 5.26
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature (1995) 4.95
Genetic disease detection and DNA amplification using cloned thermostable ligase. Proc Natl Acad Sci U S A (1991) 4.89
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell (1995) 4.70
The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity (1994) 4.26
A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc Natl Acad Sci U S A (1988) 3.77
Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell (1995) 3.70
Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science (1991) 3.41
Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron (1988) 3.39
Positive selection of lymphocytes. Cell (1994) 2.86
Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature (1994) 2.78
Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol (1994) 2.74
Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature (1994) 2.69
The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity (1994) 2.59
Expression of the Fas ligand in cells of T cell lineage. J Immunol (1995) 2.54
A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev (1995) 2.50
A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity (1995) 2.31
Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol (1992) 2.11
In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J Immunol (1991) 2.00
Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor. EMBO J (1989) 1.98
The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol Cell Biol (1993) 1.98
Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77). Science (1995) 1.93
Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation. J Immunol (1989) 1.85
Tolerance-related V beta clonal deletions in normal CD4-8-, TCR-alpha/beta + and abnormal lpr and gld cell populations. J Exp Med (1989) 1.83
Functional dissection of the lck proximal promoter. Mol Cell Biol (1992) 1.78
TCR/CD3 coupling to Fas-based cytotoxicity. J Exp Med (1995) 1.64
Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen. Oncogene (1994) 1.59
Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody. J Exp Med (1995) 1.57
Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice. Eur J Immunol (1992) 1.44
Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice. J Immunol (1991) 1.32
Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. Biochem Biophys Res Commun (1994) 1.25
Interleukin 4 expressed in situ selectively alters thymocyte development. J Exp Med (1991) 1.25
Overexpression of RelA in transgenic mouse thymocytes: specific increase in levels of the inhibitor protein I kappa B alpha. Mol Cell Biol (1995) 1.16
Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice. Mol Cell Biol (1995) 1.07
Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77. Proc Natl Acad Sci U S A (1995) 1.03
The onset of Fas expression parallels the acquisition of CD8 and CD4 in fetal and adult alpha beta thymocytes. Int Immunol (1994) 1.01
Deletion analysis of the human CD2 gene locus control region in transgenic mice. Nucleic Acids Res (1991) 0.97
Overexpression of RelB in transgenic mice does not affect I kappa B alpha levels: differential regulation of RelA and RelB by the inhibitor protein. Oncogene (1996) 0.87
The sequence of the human genome. Science (2001) 101.55
A whole-genome assembly of Drosophila. Science (2000) 38.48
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med (1999) 16.91
Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature (1985) 9.73
Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature (1987) 8.28
The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90
Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci U S A (1994) 5.74
Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med (1997) 5.72
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J (1999) 5.49
Complexity of the early genetic response to growth factors in mouse fibroblasts. Mol Cell Biol (1988) 5.21
Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts. Nature (1988) 5.04
NF-AT components define a family of transcription factors targeted in T-cell activation. Nature (1994) 4.90
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell (1995) 4.70
The Human Connectome Project: a data acquisition perspective. Neuroimage (2012) 4.64
Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J Exp Med (1997) 4.57
The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. EMBO J (1989) 4.27
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol (2001) 4.10
Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc Natl Acad Sci U S A (1988) 4.08
A transcriptional hierarchy involved in mammalian cell-type specification. Nature (1992) 4.08
RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. Mol Cell Biol (1992) 4.03
A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J (1988) 3.98
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med (1997) 3.89
A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A (1996) 3.89
A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site. Mol Cell Biol (1992) 3.63
Characterization of junD: a new member of the jun proto-oncogene family. EMBO J (1989) 3.55
Rad23 links DNA repair to the ubiquitin/proteasome pathway. Nature (1998) 3.54
A search for differential polypeptide synthesis throughout the cell cycle of HeLa cells. J Cell Biol (1980) 3.50
Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res (1998) 3.44
c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins. Oncogene (1991) 3.41
Establishment and characterization of a cell line of human breast carcinoma origin. Eur J Cancer (1979) 3.37
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30
Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Genes Dev (1997) 3.23
TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol (2001) 3.22
The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell (1995) 3.17
The jun and fos protein families are both required for cell cycle progression in fibroblasts. Mol Cell Biol (1991) 3.08
Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins. Proc Natl Acad Sci U S A (1987) 3.05
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A (2001) 2.93
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. Proc Natl Acad Sci U S A (1994) 2.91
The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation. Cell (1989) 2.84
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci U S A (1999) 2.81
An enzymatic assay reveals that proteins destined for the apical or basolateral domains of an epithelial cell line share the same late Golgi compartments. EMBO J (1985) 2.78
Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses. J Exp Med (1998) 2.78
Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol (1994) 2.75
Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers. Br J Cancer (2006) 2.67
ATP is essential for protein translocation into Escherichia coli membrane vesicles. Proc Natl Acad Sci U S A (1985) 2.65
Mutation of the Bacillus subtilis alkyl hydroperoxide reductase (ahpCF) operon reveals compensatory interactions among hydrogen peroxide stress genes. J Bacteriol (1996) 2.57
Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot. Nat Struct Biol (1999) 2.57
A prospective 4-year follow-up study of attention-deficit hyperactivity and related disorders. Arch Gen Psychiatry (1996) 2.55
Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children? Am J Psychiatry (1996) 2.54
Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1. J Immunol (1995) 2.47
The complete DNA sequence of myxoma virus. Virology (1999) 2.44
Xa21D encodes a receptor-like molecule with a leucine-rich repeat domain that determines race-specific recognition and is subject to adaptive evolution. Plant Cell (1998) 2.43
A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol (1994) 2.42
SecA protein is required for secretory protein translocation into E. coli membrane vesicles. Cell (1988) 2.41
A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene (1998) 2.39
Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex. Science (1995) 2.35
Primitive deuterostomes from the Chengjiang Lagerstätte (Lower Cambrian, China). Nature (2001) 2.31
Seventh cervical nerve root transfer from the contralateral healthy side for treatment of brachial plexus root avulsion. J Hand Surg Br (1992) 2.30
Changes in the nuclear distribution of cyclin (PCNA) but not its synthesis depend on DNA replication. EMBO J (1985) 2.28
LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J Immunol (2000) 2.27
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol (2000) 2.27
Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex. Mol Cell Biol (1992) 2.27
Survival time comparison between Hawley and clear overlay retainers: a randomized trial. J Dent Res (2011) 2.26
Predictors of persistence and remission of ADHD into adolescence: results from a four-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry (1996) 2.24
Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts. Oncogene (1996) 2.20
Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse. Nature (1989) 2.18
Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat Med (2000) 2.18
Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China. Infection (2013) 2.18
Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2. J Exp Med (1997) 2.13
Architecture and polypeptide composition of HeLa cytoskeletons. Modification of cytoarchitectural polypeptides during mitosis. J Mol Biol (1982) 2.13
NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol (1998) 2.11
Effect of ADP and ionic strength on the kinetic and motile properties of recombinant mouse myosin V. J Biol Chem (2000) 2.09
ADHD is associated with early initiation of cigarette smoking in children and adolescents. J Am Acad Child Adolesc Psychiatry (1997) 2.09
The DNA repair protein rad23 is a negative regulator of multi-ubiquitin chain assembly. Nat Cell Biol (2000) 2.07
RNA recognition by an isolated alpha helix. Cell (1993) 2.05
PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney Int (2006) 2.05
The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments. J Toxicol Environ Health A (2005) 2.05
Characterization of a mouse multigene family that encodes zinc finger structures. Mol Cell Biol (1988) 2.05
Rapid angiographic progression of coronary artery disease in patients with angina pectoris. The role of complex stenosis morphology. Circulation (1995) 2.04
MDM2 suppresses p73 function without promoting p73 degradation. Mol Cell Biol (1999) 2.00
Identification of a nuclear and of a cytoplasmic polypeptide whose relative proportions are sensitive to changes in the rate of cell proliferation. Exp Cell Res (1981) 1.99
Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor. EMBO J (1989) 1.98
Epitope mapping of human anti-adeno-associated virus type 2 neutralizing antibodies: implications for gene therapy and virus structure. J Virol (2000) 1.98
Chinese Hemophilia Joint Health Score 2.1 reliability study. Haemophilia (2013) 1.98
Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy. J Exp Med (1997) 1.96
Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities. Diabetologia (2006) 1.96
Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC. J Biol Chem (1996) 1.94
The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. Mol Cell Biol (1993) 1.94
Role of RNA structure in arginine recognition of TAR RNA. Proc Natl Acad Sci U S A (1993) 1.94
Synthesis of the nuclear protein cyclin (PCNA) and its relationship with DNA replication. Exp Cell Res (1986) 1.92
Nucleotide sequence of a multiple-copy gene for the B protein of photosystem II of a cyanobacterium. Proc Natl Acad Sci U S A (1984) 1.92
Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor. J Immunol (1998) 1.92