Published in Proc Natl Acad Sci U S A on March 18, 1997
Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. Nucleic Acids Res (1998) 3.11
Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. PLoS Genet (2006) 2.99
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol Cell Biol (1999) 2.86
Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis. Proc Natl Acad Sci U S A (1999) 2.58
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat Cell Biol (2010) 2.48
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem J (2002) 2.18
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med (2003) 1.98
The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol Cell Biol (2001) 1.94
DNA damage response in adult stem cells: pathways and consequences. Nat Rev Mol Cell Biol (2011) 1.57
Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle. Proc Natl Acad Sci U S A (2001) 1.45
Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. J Clin Invest (2010) 1.34
Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20. Nucleic Acids Res (1998) 1.30
The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest. Proc Natl Acad Sci U S A (2000) 1.27
Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation. Proc Natl Acad Sci U S A (1998) 1.26
A human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency. J Exp Med (1998) 1.24
The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity. Nucleic Acids Res (2000) 1.19
UV sensitivity and impaired nucleotide excision repair in DNA-dependent protein kinase mutant cells. Nucleic Acids Res (1998) 1.09
XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation. Nucleic Acids Res (1998) 1.04
Omenn syndrome: a disorder of Rag1 and Rag2 genes. J Clin Immunol (1999) 1.03
Formation of coding joints in V(D)J recombination-inducible severe combined immune deficient pre-B cell lines. Proc Natl Acad Sci U S A (1999) 0.96
Use of humanized severe combined immunodeficient mice for human vaccine development. Expert Rev Vaccines (2009) 0.93
Engraftment of peripheral blood mononuclear cells from systemic lupus erythematosus and antiphospholipid syndrome patient donors into BALB-RAG-2-/- IL-2Rγ-/- mice: a promising model for studying human disease. Arthritis Rheum (2011) 0.93
DNA-PK is essential only for coding joint formation in V(D)J recombination. Nucleic Acids Res (1998) 0.88
Potential large animal models for gene therapy of human genetic diseases of immune and blood cell systems. ILAR J (2009) 0.88
Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Mol Cell Biol (2013) 0.88
Quantitative real-time polymerase chain reaction for the core facility using TaqMan and the Perkin-Elmer/Applied Biosystems Division 7700 Sequence Detector. J Biomol Tech (1999) 0.84
Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development. J Immunol (2012) 0.83
The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase. Mol Cell Biol (2000) 0.83
Host-derived pericytes and Sca-1+ cells predominate in the MART-1- stroma fraction of experimentally induced melanoma. J Histochem Cytochem (2011) 0.82
Therapeutic efficacy of human hepatocyte transplantation in a SCID/uPA mouse model with inducible liver disease. PLoS One (2010) 0.81
A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation. Am J Pathol (2009) 0.80
Increased γ-H2A.X intensity in response to chronic medium-dose-rate γ-ray irradiation. PLoS One (2012) 0.80
Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors. Mol Cell Biol (2001) 0.79
Pathogenicity of T helper 2 T-cell clones from T-cell receptor transgenic non-obese diabetic mice is determined by tumour necrosis factor-alpha. Immunology (2007) 0.78
Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model. PLoS Genet (2015) 0.77
The juvenile alopecia mutation (jal) maps to mouse Chromosome 2, and is an allele of GATA binding protein 3 (Gata3). BMC Genet (2013) 0.77
Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice. Histochem Cell Biol (2008) 0.76
Activation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines. Mol Cell Biol (2000) 0.76
Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too? Cell Mol Life Sci (2016) 0.75
Human liver chimeric mouse model based on diphtheria toxin-induced liver injury. World J Gastroenterol (2017) 0.75
Screening lambdagt recombinant clones by hybridization to single plaques in situ. Science (1977) 83.82
Real time quantitative PCR. Genome Res (1996) 35.79
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc Natl Acad Sci U S A (1988) 35.13
A novel method for real time quantitative RT-PCR. Genome Res (1996) 15.83
A severe combined immunodeficiency mutation in the mouse. Nature (1983) 13.99
PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates. Proc Natl Acad Sci U S A (1994) 9.84
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell (1995) 5.58
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell (1986) 4.68
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell (1995) 4.64
DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science (1995) 4.54
The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell (1988) 4.34
The scid mutation in mice causes a general defect in DNA repair. Nature (1990) 3.85
scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci U S A (1991) 3.69
Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc Natl Acad Sci U S A (1995) 2.99
Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc Natl Acad Sci U S A (1996) 2.77
The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell (1988) 2.71
The fidelity of Taq polymerase catalyzing PCR is improved by an N-terminal deletion. Gene (1992) 2.63
When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell (1995) 2.19
Predominance of null mutations in ataxia-telangiectasia. Hum Mol Genet (1996) 2.06
Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol (1996) 2.02
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J (1996) 1.97
Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. EMBO J (1989) 1.86
The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement. Genes Dev (1988) 1.61
The mouse mutation severe combined immune deficiency (scid) is on chromosome 16. Immunogenetics (1989) 1.41
Aberrant immunoglobulin gene rearrangement in scid mouse bone marrow cells. J Immunol (1988) 1.27
Abnormal recombination of Igh D and J gene segments in transformed pre-B cells of scid mice. J Immunol (1988) 1.20
Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. Proc Natl Acad Sci U S A (1995) 1.13
Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8. Proc Natl Acad Sci U S A (1995) 1.11
Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells. EMBO J (1990) 1.06
Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J Immunol (1995) 1.02
A human gene that restores the DNA-repair defect in SCID mice is located on 8p11.1-->q11.1. Hum Genet (1994) 0.96
Complementation of the radiosensitive phenotype in severe combined immunodeficient mice by human chromosome 8. Cancer Res (1993) 0.96
Functional complementation in mouse-human radiation hybrids assigns the putative murine scid gene to the pericentric region of human chromosome 8. Hum Mol Genet (1993) 0.91
CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme. FEBS Lett (1996) 0.87
Complementation of V(D)J recombination defect and X-ray sensitivity of scid mouse cells by human chromosome 8. Mutat Res (1994) 0.87
Cloning and chromosomal mapping of the mouse DNA-dependent protein kinase gene. Immunogenetics (1996) 0.86
Human chromosome 8 (p12-->q22) complements radiosensitivity in the severe combined immune deficiency (SCID) mouse. Radiat Res (1993) 0.85
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Functional annotation of a full-length mouse cDNA collection. Nature (2001) 23.61
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell (1996) 15.19
Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol (1998) 11.26
Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol (1993) 10.65
Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ (2004) 9.96
Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol (2001) 9.62
The complete sequence of the rice (Oryza sativa) chloroplast genome: intermolecular recombination between distinct tRNA genes accounts for a major plastid DNA inversion during the evolution of the cereals. Mol Gen Genet (1989) 9.53
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
Resetting central and peripheral circadian oscillators in transgenic rats. Science (2000) 8.63
Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science (1995) 7.77
Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev (2001) 7.60
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics (1996) 6.83
Hospital-acquired candidemia. The attributable mortality and excess length of stay. Arch Intern Med (1988) 6.78
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature (1986) 6.67
Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays. Proc Natl Acad Sci U S A (2001) 6.07
Chromosomal beta-lactamase of Klebsiella oxytoca, a new class A enzyme that hydrolyzes broad-spectrum beta-lactam antibiotics. Antimicrob Agents Chemother (1989) 5.98
Green revolution: a mutant gibberellin-synthesis gene in rice. Nature (2002) 5.84
Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J Exp Med (1999) 5.55
Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol (1994) 5.01
Thermostabilization and thermoactivation of thermolabile enzymes by trehalose and its application for the synthesis of full length cDNA. Proc Natl Acad Sci U S A (1998) 4.95
Kaplan-Meier, marginal or conditional probability curves in summarizing competing risks failure time data? Stat Med (1993) 4.60
Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill (2013) 4.44
High-efficiency full-length cDNA cloning by biotinylated CAP trapper. Genomics (1996) 4.41
Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve (1995) 3.84
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Genome Res (2000) 3.78
Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma (1984) 3.74
Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol (1998) 3.62
Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex. Cell (1988) 3.59
Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A (2001) 3.49
Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat Genet (1998) 3.38
Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cells. J Cell Sci (1995) 3.27
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature (2001) 3.24
Narrow-band imaging in the diagnosis of colorectal mucosal lesions: a pilot study. Endoscopy (2004) 3.19
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. Proc Natl Acad Sci U S A (1987) 2.99
Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci (1997) 2.97
Risk factors for hospital-acquired candidemia. A matched case-control study. Arch Intern Med (1989) 2.97
Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol (1996) 2.94
Virulence for mice of Klebsiella strains belonging to the O1 group: relationship to their capsular (K) types. Infect Immun (1983) 2.93
Submembranous junctional plaque proteins include potential tumor suppressor molecules. J Cell Biol (1993) 2.87
Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J Cell Biol (1997) 2.82
Function of the 30 kd protein of tobacco mosaic virus: involvement in cell-to-cell movement and dispensability for replication. EMBO J (1987) 2.78
Definitive chemoradiotherapy for T4 and/or M1 lymph node squamous cell carcinoma of the esophagus. J Clin Oncol (1999) 2.77
Development of ductal carcinoma of the pancreas during follow-up of branch duct intraductal papillary mucinous neoplasm of the pancreas. Gut (2008) 2.75
Cloning and complete nucleotide sequence of the Escherichia coli glutamine permease operon (glnHPQ). Mol Gen Genet (1986) 2.73
Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity (1995) 2.70
Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells. Apoptosis (2002) 2.69
Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics (1995) 2.65
Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking. J Exp Med (1996) 2.62
Beta-protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease. Am J Pathol (1989) 2.61
Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. Immunity (1994) 2.61
Functional domains of alpha-catenin required for the strong state of cadherin-based cell adhesion. J Cell Biol (1999) 2.59
Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression. Cell (1998) 2.57
Temperature-induced A-B intersite charge transfer in an A-site-ordered LaCu(3)Fe(4)O(12) perovskite. Nature (2009) 2.57
Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats. Kidney Int (2006) 2.57
Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2. J Cell Biol (1993) 2.56
An extracellular poly(3-hydroxybutyrate) depolymerase from Alcaligenes faecalis. Eur J Biochem (1982) 2.49
Repressor activity of Headless/Tcf3 is essential for vertebrate head formation. Nature (2000) 2.49
Sodium channels SCN1A, SCN2A and SCN3A in familial autism. Mol Psychiatry (2003) 2.48
Mammalian occludin in epithelial cells: its expression and subcellular distribution. Eur J Cell Biol (1997) 2.46
A mouse homolog of the Escherichia coli recA and Saccharomyces cerevisiae RAD51 genes. Proc Natl Acad Sci U S A (1993) 2.38
Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. FEBS Lett (1999) 2.37
The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J (1997) 2.34
FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity (2002) 2.31
Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor. J Exp Med (1991) 2.31
Quantitative isolation of total glycosphingolipids from animal cells. J Lipid Res (1971) 2.29
Antigen-specific suppressive factor produced by a transplantable I-J bearing T-cell hybridoma. Nature (1979) 2.28
Objective system for interviewer performance evaluation for use in epidemiologic studies. Am J Epidemiol (1994) 2.28
A novel membrane antigen selectively expressed on terminally differentiated human B cells. Blood (1994) 2.27
Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Hum Genet (1998) 2.27
Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int Immunol (2000) 2.24
The medium subunits of adaptor complexes recognize distinct but overlapping sets of tyrosine-based sorting signals. J Biol Chem (1998) 2.21
Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. Proc Natl Acad Sci U S A (2000) 2.19
Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL). J Biol Chem (2000) 2.18
Role of Polysulfides in Reduction of Elemental Sulfur by the Hyperthermophilic Archaebacterium Pyrococcus furiosus. Appl Environ Microbiol (1990) 2.16
Structural and signalling molecules come together at tight junctions. Curr Opin Cell Biol (1999) 2.16
Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. Br J Cancer (2008) 2.13
hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ (2004) 2.13
Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes. Nature (1987) 2.11
Clinical outcome after endoscopic mucosal resection for esophageal squamous cell carcinoma invading the muscularis mucosae--a multicenter retrospective cohort study. Endoscopy (2007) 2.11
High efficiency selection of full-length cDNA by improved biotinylated cap trapper. DNA Res (1997) 2.11
Specific phases of root hair attachment in the Rhizobium trifolii-clover symbiosis. Appl Environ Microbiol (1984) 2.10
Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2). J Immunol (2001) 2.09
Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen. Proc Natl Acad Sci U S A (1988) 2.08
Predominance of null mutations in ataxia-telangiectasia. Hum Mol Genet (1996) 2.06
Influence of dentition status on physical disability, mental impairment, and mortality in institutionalized elderly people. J Dent Res (2001) 2.06
Molecular cloning and characterization of a cDNA encoding the gibberellin biosynthetic enzyme ent-kaurene synthase B from pumpkin (Cucurbita maxima L.). Plant J (1996) 2.04
Endoscopic correction of intussusception and removal of a colonic lipoma. Gastrointest Endosc (1990) 2.04
A new method for rapid mapping of the retinal thickness at the posterior pole. Invest Ophthalmol Vis Sci (1996) 2.03
The Dictyostelium developmental cDNA project: generation and analysis of expressed sequence tags from the first-finger stage of development. DNA Res (1998) 2.03
Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease. Nat Genet (2000) 2.02
The discontinuation of life support measures in patients in a permanent vegetative state. Neurol Sci (2002) 2.00
Novel models for RNA splicing that involve a small nuclear RNA. Proc Natl Acad Sci U S A (1981) 2.00
Human soluble IL-6 receptor: its detection and enhanced release by HIV infection. J Immunol (1992) 1.99
Spondyloarthropathies in Japan: nationwide questionnaire survey performed by the Japan Ankylosing Spondylitis Society. J Rheumatol (2001) 1.99