Published in Cancer Res on May 01, 1999
The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes Dev (2001) 4.82
Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol (2002) 4.50
BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res (2006) 3.29
Aurora kinase inhibitors--rising stars in cancer therapeutics? Mol Cancer Ther (2010) 1.91
Regulation of aurora B expression by the bromodomain protein Brd4. Mol Cell Biol (2009) 1.60
Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell (2007) 1.59
Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol Cell Biol (2005) 1.54
Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats. Proc Natl Acad Sci U S A (2004) 1.50
The aurora kinase A regulates GSK-3beta in gastric cancer cells. Oncogene (2008) 1.41
The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis. Mol Biol Cell (2002) 1.33
Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors. Am J Pathol (2007) 1.28
Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion. Proc Natl Acad Sci U S A (2004) 1.27
HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks. Cell Cycle (2006) 1.25
Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships. Breast Cancer Res (2005) 1.20
Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer. Mol Cancer (2010) 1.15
Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells. J Transl Med (2008) 1.15
Aurora A kinase activity influences calcium signaling in kidney cells. J Cell Biol (2011) 1.10
Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability. Br J Cancer (2005) 1.07
Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer. PLoS One (2007) 1.07
Genetic variation in the chromosome 17q23 amplicon and breast cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 1.05
Conditional transgenic system for mouse aurora a kinase: degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein. Mol Cell Biol (2005) 1.04
Essential roles of mTOR/Akt pathway in Aurora-A cell transformation. Int J Biol Sci (2009) 1.02
Association of genetic variation in mitotic kinases with breast cancer risk. Breast Cancer Res Treat (2009) 1.02
Aurora-A identifies early recurrence and poor prognosis and promises a potential therapeutic target in triple negative breast cancer. PLoS One (2013) 1.01
Analysis of Aurora kinase A expression in CD34(+) blast cells isolated from patients with myelodysplastic syndromes and acute myeloid leukemia. J Hematop (2008) 1.01
Rapid calcium-dependent activation of Aurora-A kinase. Nat Commun (2010) 0.98
Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation. J Transl Med (2011) 0.98
Physiological and oncogenic Aurora-A pathway. Int J Biol Sci (2009) 0.97
Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype. BMC Cancer (2007) 0.97
Astrin regulates Aurora-A localization. Biochem Biophys Res Commun (2008) 0.97
Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients. BMC Cancer (2012) 0.97
Cdk1, Plks, Auroras, and Neks: the mitotic bodyguards. Adv Exp Med Biol (2008) 0.96
A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2. J Biol Chem (2009) 0.95
Transcriptional regulation of serine/threonine kinase-15 (STK15) expression by hypoxia and HIF-1. Mol Biol Cell (2008) 0.94
The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1. Nucleic Acids Res (2002) 0.94
NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors. Cancer Res (2013) 0.93
Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells. J Cancer Res Clin Oncol (2011) 0.93
Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation. PLoS Pathog (2012) 0.91
Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation. Mol Cancer Ther (2013) 0.91
Aurora kinase A in gastrointestinal cancers: time to target. Mol Cancer (2015) 0.90
Aurora-A contributes to cisplatin resistance and lymphatic metastasis in non-small cell lung cancer and predicts poor prognosis. J Transl Med (2014) 0.90
Aurora Kinase Inhibitors: Current Status and Outlook. Front Oncol (2015) 0.90
Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells. J Med Chem (2013) 0.88
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen. J Cancer Res Clin Oncol (2010) 0.86
Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway. Biochem J (2007) 0.85
The molecular mechanism studies of chirality effect of PHA-739358 on Aurora kinase A by molecular dynamics simulation and free energy calculations. J Comput Aided Mol Des (2011) 0.85
MLN-8237: A dual inhibitor of aurora A and B in soft tissue sarcomas. Oncotarget (2016) 0.84
Cell cycle and no end. Virchows Arch (2004) 0.84
A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer. BMC Cancer (2013) 0.84
Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer. Front Oncol (2015) 0.81
Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells. J Transl Med (2011) 0.80
Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice. Pancreas (2008) 0.80
Differential expression of aurora-A kinase in T-cell lymphomas. Mod Pathol (2013) 0.80
Ashwagandha derived withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activity. PLoS One (2012) 0.79
Effect of Food on the Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237) in Patients with Advanced Solid Tumors. Drugs R D (2016) 0.79
Role of proliferative markers in breast lesions. Indian J Surg (2010) 0.79
Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA. Invest New Drugs (2013) 0.79
Expression of mitotic Aurora/Ipl1p-related kinases in renal cell carcinomas: an immunohistochemical study. Urol Res (2003) 0.79
Correlation of Aurora-A expression with the effect of chemoradiation therapy on esophageal squamous cell carcinoma. BMC Cancer (2015) 0.79
Antitumor effects of calgranulin B internalized in human colon cancer cells. Oncotarget (2016) 0.78
Structural studies of B-type Aurora kinase inhibitors using computational methods. Acta Pharmacol Sin (2010) 0.78
Non-centrosomal TPX2-Dependent Regulation of the Aurora A Kinase: Functional Implications for Healthy and Pathological Cell Division. Front Oncol (2016) 0.77
Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer. Carcinogenesis (2016) 0.77
Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway. BMC Cancer (2009) 0.77
Generation and characterization of novel monoclonal antibodies against human aurora-A. Hybridoma (Larchmt) (2008) 0.77
Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer. Carcinogenesis (2015) 0.76
MYC Deregulation in Primary Human Cancers. Genes (Basel) (2017) 0.75
Integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to Aurora-A kinase inhibitors. PLoS One (2013) 0.75
Inhibition of Aurora kinase B is important for biologic activity of the dual inhibitors of BCR-ABL and Aurora kinases R763/AS703569 and PHA-739358 in BCR-ABL transformed cells. PLoS One (2014) 0.75
Morphometric and histological study of breast lesions with special reference to proliferative activity and invasiveness. Indian J Surg (2012) 0.75
Serine/threonine kinase 15 gene polymorphism and risk of digestive system cancers: A meta-analysis. Exp Ther Med (2014) 0.75
Characterization of Aurora A and Its Impact on the Effect of Cisplatin-Based Chemotherapy in Patients with Non-Small Cell Lung Cancer. Transl Oncol (2017) 0.75
FOXM1 recruits nuclear Aurora kinase A to participate in a positive feedback loop essential for the self-renewal of breast cancer stem cells. Oncogene (2017) 0.75
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