Published in Proc Natl Acad Sci U S A on November 09, 1999
Nomenclature for factors of the HLA system, 2010. Tissue Antigens (2010) 3.22
Comparative genomics of major histocompatibility complexes. Immunogenetics (2004) 2.31
Single haplotype analysis demonstrates rapid evolution of the killer immunoglobulin-like receptor (KIR) loci in primates. Genome Res (2005) 1.56
Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence. Proc Natl Acad Sci U S A (2003) 1.43
Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. Genetics (2006) 1.37
Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P. RNA (2001) 1.25
Primate-specific regulation of natural killer cells. J Med Primatol (2010) 1.14
The human Major Histocompatibility Complex as a paradigm in genomics research. Brief Funct Genomic Proteomic (2009) 1.11
Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis. Am J Hum Genet (2002) 1.11
The genomic sequence and comparative analysis of the rat major histocompatibility complex. Genome Res (2004) 1.11
Comparative genome organization of human, murine, and feline MHC class II region. Genome Res (2003) 1.09
Genomic evolution of MHC class I region in primates. Proc Natl Acad Sci U S A (2005) 1.08
Gene duplication and gene conversion in class II MHC genes of New Zealand robins (Petroicidae). Immunogenetics (2004) 1.05
Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6. BMC Genomics (2008) 1.03
Genomic anatomy of a premier major histocompatibility complex paralogous region on chromosome 1q21-q22. Genome Res (2001) 0.98
The major histocompatibility complex (Mhc) class IIB region has greater genomic structural flexibility and diversity in the quail than the chicken. BMC Genomics (2006) 0.95
Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1. Nat Immunol (2016) 0.94
Species-specific class I gene expansions formed the telomeric 1 mb of the mouse major histocompatibility complex. Genome Res (2003) 0.92
Analysis of a marsupial MHC region containing two recently duplicated class I loci. Mamm Genome (2004) 0.90
Nucleotide sequencing analysis of the swine 433-kb genomic segment located between the non-classical and classical SLA class I gene clusters. Immunogenetics (2003) 0.90
Genetics of inflammatory bowel disease: the role of the HLA complex. World J Gastroenterol (2006) 0.89
The orthology of HLA-E and H2-Qa1 is hidden by their concerted evolution with other MHC class I molecules. Biol Direct (2006) 0.88
The tammar wallaby major histocompatibility complex shows evidence of past genomic instability. BMC Genomics (2011) 0.88
Sequencing and comparative analysis of the gorilla MHC genomic sequence. Database (Oxford) (2013) 0.85
Isolation of major histocompatibility complex Class I genes from the tammar wallaby (Macropus eugenii). Immunogenetics (2006) 0.84
Evolutionary relationships of major histocompatibility complex class I genes in simian primates. Genetics (2004) 0.84
The phylogenetic history of the MHC class I gene families in pig, including a fossil gene predating mammalian radiation. J Mol Evol (2003) 0.81
Comparative genome analysis of the major histocompatibility complex (MHC) class I B/C segments in primates elucidated by genomic sequencing in common marmoset (Callithrix jacchus). Immunogenetics (2011) 0.80
Comparative genome analyses reveal distinct structure in the saltwater crocodile MHC. PLoS One (2014) 0.79
MICA polymorphisms and cancer risk: a meta-analysis. Int J Clin Exp Med (2015) 0.78
Human endogenous retrovirus (HERVK9) structural polymorphism with haplotypic HLA-A allelic associations. Genetics (2008) 0.78
High levels of genetic variation at MHC class II DBB loci in the tammar wallaby (Macropus eugenii). Immunogenetics (2008) 0.77
The opossum MHC genomic region revisited. Immunogenetics (2015) 0.77
Role of HLA, KIR, MICA, and cytokines genes in leprosy. Biomed Res Int (2013) 0.76
Evolutionary relations of Hexanchiformes deep-sea sharks elucidated by whole mitochondrial genome sequences. Biomed Res Int (2013) 0.75
Random subcloning of sonicated DNA: application to shotgun DNA sequence analysis. Anal Biochem (1983) 13.88
Direct repeats flank three small nuclear RNA pseudogenes in the human genome. Cell (1981) 4.53
Structure, function, and diversity of class I major histocompatibility complex molecules. Annu Rev Biochem (1990) 4.02
The impact of L1 retrotransposons on the human genome. Nat Genet (1998) 3.56
A second lineage of mammalian major histocompatibility complex class I genes. Proc Natl Acad Sci U S A (1994) 3.33
Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents. Proc Natl Acad Sci U S A (1990) 3.09
Survey of human and rat microsatellites. Genomics (1992) 2.92
Implications for immunosurveillance of altered HLA class I phenotypes in human tumours. Immunol Today (1997) 2.89
Alu: structure, origin, evolution, significance and function of one-tenth of human DNA. Prog Nucleic Acid Res Mol Biol (1996) 2.29
Gene duplication and nucleotide substitution in evolution. Nature (1969) 1.85
Second-generation approach to the construction of yeast artificial-chromosome libraries. Genomics (1990) 1.36
Precise switching of DNA replication timing in the GC content transition area in the human major histocompatibility complex. Mol Cell Biol (1997) 1.20
Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region. Genomics (1998) 1.15
Nucleotide sequence analysis of the HLA class I region spanning the 237-kb segment around the HLA-B and -C genes. Genomics (1997) 1.13
An integrated map with cosmid/PAC contigs of a 4-Mb Down syndrome critical region. Genomics (1996) 1.11
Examination of four HLA class I pseudogenes. Common events in the evolution of HLA genes and pseudogenes. J Immunol (1992) 0.93
New polymorphic microsatellite markers in the human MHC class I region. Tissue Antigens (1999) 0.90
Cloning the human major histocompatibility complex in YACs. Genomics (1994) 0.88
Physical mapping between the S and HLA-E genes in the human MHC class I region: construction of a BAC, PAC, and cosmid contig. Immunogenetics (1998) 0.80
A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol (1980) 113.75
Evolutionary rate at the molecular level. Nature (1968) 33.15
The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations. Genetics (1969) 22.59
Loop-mediated isothermal amplification of DNA. Nucleic Acids Res (2000) 19.30
A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. Genet Res (1973) 13.08
Nucleotide sequence of the kanamycin resistance transposon Tn903. J Mol Biol (1981) 12.25
Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes. J Mol Biol (1981) 11.87
Coding potential and regulatory signals of the polyoma virus genome. Nature (1980) 11.24
The DNA sequence of human chromosome 21. Nature (2000) 10.66
Boron nitride substrates for high-quality graphene electronics. Nat Nanotechnol (2010) 9.72
A stochastic model concerning the maintenance of genetic variability in quantitative characters. Proc Natl Acad Sci U S A (1965) 9.20
Obesity, cigarette smoking, and telomere length in women. Lancet (2005) 8.59
A dipole mode in the tropical Indian Ocean. Nature (1999) 8.42
Codon usage tabulated from international DNA sequence databases: status for the year 2000. Nucleic Acids Res (2000) 7.88
Artemisinins target the SERCA of Plasmodium falciparum. Nature (2003) 7.72
The substitutional load in a finite population. Heredity (Edinb) (1969) 7.56
Linkage disequilibrium at steady state determined by random genetic drift and recurrent mutation. Genetics (1969) 7.33
The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell (2006) 6.80
Protein polymorphism as a phase of molecular evolution. Nature (1971) 6.68
Theoretical foundation of population genetics at the molecular level. Theor Popul Biol (1971) 6.38
Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates. J Biol Chem (1968) 6.28
Small ribonucleic acids of Escherichia coli. I. Characterization by polyacrylamide gel electrophoresis and fingerprint analysis. J Biol Chem (1973) 6.10
The probability of consanguineous marriages. Genetics (1966) 5.85
Purification and properties of bacterial chondroitinases and chondrosulfatases. J Biol Chem (1968) 5.66
Estimation of evolutionary distances between homologous nucleotide sequences. Proc Natl Acad Sci U S A (1981) 5.34
Specific inactivation of 16S ribosomal RNA induced by colicin E3 in vivo. Proc Natl Acad Sci U S A (1971) 5.28
On the stochastic model for estimation of mutational distance between homologous proteins. J Mol Evol (1972) 5.16
Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat Med (2000) 4.99
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell (1999) 4.98
On some principles governing molecular evolution. Proc Natl Acad Sci U S A (1974) 4.97
Multilayer white light-emitting organic electroluminescent device. Science (1995) 4.86
Nucleotide sequence of Escherichia coli K-12 replication origin. Proc Natl Acad Sci U S A (1979) 4.85
Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoalleles. Genet Res (1968) 4.83
Codon usage tabulated from the GenBank genetic sequence data. Nucleic Acids Res (1986) 4.83
The rate of molecular evolution considered from the standpoint of population genetics. Proc Natl Acad Sci U S A (1969) 4.75
Mobilization of transposons by a mutation abolishing full DNA methylation in Arabidopsis. Nature (2001) 4.71
Pattern of neutral polymorphism in a geographically structured population. Genet Res (1971) 4.65
On the constancy of the evolutionary rate of cistrons. J Mol Evol (1971) 4.49
The age of a neutral mutant persisting in a finite population. Genetics (1973) 4.44
Genetic variability and effective population size when local extinction and recolonization of subpopulations are frequent. Proc Natl Acad Sci U S A (1980) 4.37
Recent evidence for evolution of the genetic code. Microbiol Rev (1992) 4.32
Nucleotide sequence of small ColE1 derivatives: structure of the regions essential for autonomous replication and colicin E1 immunity. Mol Gen Genet (1979) 4.30
The basal ganglia and adaptive motor control. Science (1994) 4.27
Codon usage tabulated from the GenBank Genetic Sequence Data. Nucleic Acids Res (1988) 4.26
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol (2011) 4.22
Diversity in G + C content at the third position of codons in vertebrate genes and its cause. Nucleic Acids Res (1986) 4.17
Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension (2001) 4.07
Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution. Nature (1977) 4.00
Replication origin of the Escherichia coli K-12 chromosome: the size and structure of the minimum DNA segment carrying the information for autonomous replication. Mol Gen Genet (1980) 3.99
Development of a pertussis component vaccine in Japan. Lancet (1984) 3.94
Cleavage map of colicin E1 plasmid. Nature (1976) 3.85
Prevalence of serum and salivary antibodies to HTLV-1 in Sjögren's syndrome. Lancet (1994) 3.83
Massive Dirac fermions and Hofstadter butterfly in a van der Waals heterostructure. Science (2013) 3.79
Massive outbreak of Escherichia coli O157:H7 infection in schoolchildren in Sakai City, Japan, associated with consumption of white radish sprouts. Am J Epidemiol (1999) 3.75
Effects of insulin, glucagon, and insuling/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs. Lancet (1976) 3.74
Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles. Proc Natl Acad Sci U S A (1975) 3.64
Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. Nature (2000) 3.61
Codon usage tabulated from the GenBank genetic sequence data. Nucleic Acids Res (1990) 3.54
Expansive open-door laminoplasty for cervical spinal stenotic myelopathy. Spine (Phila Pa 1976) (1983) 3.53
Application of typing by pulsed-field gel electrophoresis to the study of Clostridium difficile in a neonatal intensive care unit. J Clin Microbiol (1994) 3.51
Linkage disequilibrium between two segregating nucleotide sites under the steady flux of mutations in a finite population. Genetics (1971) 3.51
The average number of generations until extinction of an individual mutant gene in a finite population. Genetics (1969) 3.49
Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell (2006) 3.44
Effect of overall phenotypic selection on genetic change at individual loci. Proc Natl Acad Sci U S A (1978) 3.41
1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proc Natl Acad Sci U S A (1994) 3.37
Identification of toxin A-negative, toxin B-positive Clostridium difficile by PCR. J Clin Microbiol (1998) 3.34
Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension (2000) 3.32
Sequence from early region of polyoma virus DNA containing viral replication origin and encoding small, middle and (part of) large T antigens. Cell (1979) 3.29
Stepwise mutation model and distribution of allelic frequencies in a finite population. Proc Natl Acad Sci U S A (1978) 3.29
The structure of a transcriptional unit on colicin E1 plasmid. Eur J Biochem (1979) 3.26
Isolation and characterization of transducing coliphage fd carrying a kanamycin resistance gene. Gene (1978) 3.25
Genetic and biochemical studies on cell wall peptidoglycan synthesis in Escherichia coli K-12. Biochem Biophys Res Commun (1969) 3.13
Codon usage and transfer RNA contents: organism-specific codon-choice patterns in reference to the isoacceptor contents. Cold Spring Harb Symp Quant Biol (1983) 3.12
Distribution of bifidobacterial species in human intestinal microflora examined with 16S rRNA-gene-targeted species-specific primers. Appl Environ Microbiol (1999) 3.06
Codon usage tabulated from the GenBank genetic sequence data. Nucleic Acids Res (1991) 3.01
Codon usage tabulated from the GenBank genetic sequence data. Nucleic Acids Res (1992) 2.95
Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae. Nat Genet (1995) 2.88
One-dimensional electrical contact to a two-dimensional material. Science (2013) 2.87
The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle. J Cell Biol (1999) 2.82
Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling. EMBO J (1994) 2.81
Mutation and evolution at the molecular level. Genetics (1973) 2.79
Effects of statin therapy on abdominal aortic aneurysm growth: a meta-analysis and meta-regression of observational comparative studies. Eur J Vasc Endovasc Surg (2012) 2.72
5'-Terminal nucleotide sequences of the double-stranded RNA of silkworm cytoplasmic polyhedrosis virus. J Mol Biol (1974) 2.71
Role of matrix in an early postentry step in the human immunodeficiency virus type 1 life cycle. J Virol (1998) 2.62
Loop-mediated isothermal amplification reaction using a nondenatured template. Clin Chem (2001) 2.61
Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10. Nat Genet (2000) 2.60
FILAMENTOUS FLOWER, a meristem and organ identity gene of Arabidopsis, encodes a protein with a zinc finger and HMG-related domains. Genes Dev (1999) 2.58
Identification of spacer tRNA genes in individual ribosomal RNA transcription units of Escherichia coli. Proc Natl Acad Sci U S A (1977) 2.51
Fixation of a deleterious allele at one of two "duplicate" loci by mutation pressure and random drift. Proc Natl Acad Sci U S A (1979) 2.51
ARR1, a transcription factor for genes immediately responsive to cytokinins. Science (2001) 2.50
Scanning tunnelling microscopy and spectroscopy of ultra-flat graphene on hexagonal boron nitride. Nat Mater (2011) 2.48
Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci U S A (2000) 2.43
Nucleotide sequence of the asnA gene coding for asparagine synthetase of E. coli K-12. Nucleic Acids Res (1981) 2.42
Combination therapy with fluconazole and flucytosine for cryptococcal meningitis in Ugandan patients with AIDS. Clin Infect Dis (1998) 2.40
Vitamin D and intact PTH status in patients with hip fracture. Osteoporos Int (2006) 2.37
Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing. J Bone Miner Res (2001) 2.37