Published in Purinergic Signal on January 27, 2011
Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms. Front Pharmacol (2013) 0.97
The P2X7 receptor supports both life and death in fibrogenic pancreatic stellate cells. PLoS One (2012) 0.86
Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release. Immunity (2015) 0.84
The second transmembrane domain of P2X7 contributes to dilated pore formation. PLoS One (2013) 0.83
Emerging key roles for P2X receptors in the kidney. Front Physiol (2013) 0.82
P2X7 receptors and Fyn kinase mediate ATP-induced oligodendrocyte progenitor cell migration. Purinergic Signal (2015) 0.81
Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view. Purinergic Signal (2011) 0.79
Trophic activity of human P2X7 receptor isoforms A and B in osteosarcoma. PLoS One (2014) 0.78
Molecular characterization and expression analysis of ATP-gated P2X7 receptor involved in Japanese flounder (Paralichthys olivaceus) innate immune response. PLoS One (2014) 0.77
Pathophysiological role of extracellular purinergic mediators in the control of intestinal inflammation. Mediators Inflamm (2015) 0.77
Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function. PLoS One (2016) 0.75
Extracellular ATP and other nucleotides-ubiquitous triggers of intercellular messenger release. Purinergic Signal (2015) 0.75
The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition. Elife (2017) 0.75
Potential contribution of alveolar epithelial type I cells to pulmonary fibrosis. Biosci Rep (2017) 0.75
Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol (1999) 15.63
Molecular physiology of P2X receptors. Physiol Rev (2002) 13.61
NPS@: network protein sequence analysis. Trends Biochem Sci (2000) 9.68
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J (2006) 8.12
Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence. Proteomics (2004) 7.76
Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature (2009) 4.18
Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. J Biol Chem (2006) 3.36
Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J Immunol (2007) 3.06
Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol Sci (2007) 3.01
Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J Immunol (1997) 2.81
P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol (2008) 2.72
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem (2001) 2.65
Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Am J Physiol Cell Physiol (2003) 2.61
Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis. J Immunol (2005) 2.49
P2X7 receptor-Pannexin1 complex: pharmacology and signaling. Am J Physiol Cell Physiol (2008) 2.49
Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proc Natl Acad Sci U S A (2009) 2.42
Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X7 receptor. J Physiol (1999) 2.37
Proteomic and functional evidence for a P2X7 receptor signalling complex. EMBO J (2001) 2.34
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem (2009) 2.12
Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem (2008) 2.08
The birth and postnatal development of purinergic signalling. Acta Physiol (Oxf) (2010) 2.06
Connexin and pannexin mediated cell-cell communication. Neuron Glia Biol (2007) 1.86
A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP. Am J Physiol Cell Physiol (2008) 1.86
A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor. J Biol Chem (2001) 1.77
Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor. J Immunol (2002) 1.65
ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion. J Immunol (2001) 1.60
The P2X7 receptor channel pore dilates under physiological ion conditions. J Gen Physiol (2008) 1.57
P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide. J Neurosci (2010) 1.55
Pannexins, distant relatives of the connexin family with specific cellular functions? Bioessays (2009) 1.50
Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells. Mol Biol Cell (2003) 1.49
P2 receptors: intracellular signaling. Pflugers Arch (2006) 1.48
P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region. J Biol Chem (2002) 1.48
A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study. Lancet (2002) 1.48
A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages. J Biol Chem (2005) 1.47
CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages. Blood (2008) 1.47
Gap junctional proteins of animals: the innexin/pannexin superfamily. Prog Biophys Mol Biol (2007) 1.41
Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol (2009) 1.39
Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide. J Immunol (2001) 1.37
Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors. J Biol Chem (2003) 1.34
Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding. J Neurosci (2008) 1.33
The double life of ATP. Sci Am (2009) 1.31
An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor. J Biol Chem (2003) 1.31
Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation. Immunity (2003) 1.31
A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization. J Biol Chem (2006) 1.30
Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus. Best Pract Res Clin Endocrinol Metab (2007) 1.30
Neuropathic pain: emerging treatments. Br J Anaesth (2008) 1.28
Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age. Endocrinology (2006) 1.26
Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment. Pharmacogenet Genomics (2007) 1.23
Cloning and functional characterisation of the mouse P2X7 receptor. FEBS Lett (1998) 1.21
Modulation of P2Z/P2X(7) receptor activity in macrophages infected with Chlamydia psittaci. Am J Physiol Cell Physiol (2001) 1.20
Genetics of the P2X7 receptor and human disease. Purinergic Signal (2009) 1.19
Purinergic receptor modulation of lipopolysaccharide signaling and inducible nitric-oxide synthase expression in RAW 264.7 macrophages. J Biol Chem (1998) 1.17
The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes. J Biol Chem (2004) 1.17
Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. J Biol Chem (2002) 1.17
Retracted Extracellular ATP induces cytokine expression and apoptosis through P2X7 receptor in murine mast cells. J Immunol (2005) 1.16
The role of Gads in hematopoietic cell signalling. Oncogene (2001) 1.15
Purinergic signalling: past, present and future. Braz J Med Biol Res (2008) 1.14
Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts. FASEB J (2008) 1.13
P2X7 receptor activates extracellular signal-regulated kinases ERK1 and ERK2 independently of Ca2+ influx. Biochem J (2003) 1.13
The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling. Immunol Lett (2005) 1.12
P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C. Biochem J (2002) 1.10
A role for P2X7 in microglial proliferation. J Neurochem (2006) 1.10
Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function. J Immunol (2003) 1.10
A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death. J Biol Chem (2005) 1.10
ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor. Am J Physiol Cell Physiol (2005) 1.08
Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis. Diabetes (2002) 1.07
Glu496Ala polymorphism of human P2X7 receptor does not affect its electrophysiological phenotype. Am J Physiol Cell Physiol (2002) 1.06
The P2X7 receptor as a therapeutic target. Expert Opin Ther Targets (2008) 1.05
P2X7 receptor signaling pathway as a therapeutic target for neurodegenerative diseases. Arch Immunol Ther Exp (Warsz) (2010) 1.04
ATP-induced P2X7-associated uptake of large molecules involves distinct mechanisms for cations and anions in macrophages. J Cell Sci (2008) 1.03
A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain. Br J Pharmacol (2010) 1.02
Activation by P2X7 agonists of two phospholipases A2 (PLA2) in ductal cells of rat submandibular gland. Coupling of the calcium-independent PLA2 with kallikrein secretion. J Biol Chem (1998) 1.01
The P2X7 carboxyl tail is a regulatory module of P2X7 receptor channel activity. J Biol Chem (2008) 1.01
Coupling of two pools of P2X7 receptors to distinct intracellular signaling pathways in rat submandibular gland. J Lipid Res (2006) 1.01
Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival. Diabetologia (2009) 1.00
Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts. J Cell Sci (2008) 0.99
Neural progenitor cell death is induced by extracellular ATP via ligation of P2X7 receptor. J Neurochem (2009) 0.99
P2X7 receptor-dependent cell death is modulated during murine T cell maturation and mediated by dual signaling pathways. J Immunol (2006) 0.99
Extracellular ATP dissociates nonmuscle myosin from P2X(7) complex: this dissociation regulates P2X(7) pore formation. Am J Physiol Cell Physiol (2009) 0.96
Activation of P2X7 purinoceptor-stimulated TGF-beta 1 mRNA expression involves PKC/MAPK signalling pathway in a rat brain-derived type-2 astrocyte cell line, RBA-2. Cell Signal (2003) 0.96
P2X(7) receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators. Biochem Soc Trans (2007) 0.96
Extracellular ATP induces cell death in CD4+/CD8+ double-positive thymocytes in mice infected with Trypanosoma cruzi. Microbes Infect (2003) 0.95
Identification of Thr283 as a key determinant of P2X7 receptor function. Br J Pharmacol (2006) 0.95
P2X7 receptor-dependent ATP-induced shedding of CD27 in mouse lymphocytes. Immunol Lett (2005) 0.93
Extracellular ATP in the lymphohematopoietic system: P2Z purinoceptors off membrane permeabilization. Braz J Med Biol Res (1998) 0.91
P2X7, NMDA and BDNF receptors converge on GSK3 phosphorylation and cooperate to promote survival in cerebellar granule neurons. Cell Mol Life Sci (2010) 0.91
Mutation of putative N-linked glycosylation sites on the human nucleotide receptor P2X7 reveals a key residue important for receptor function. Biochemistry (2010) 0.91
P2X7 receptor activation amplifies lipopolysaccharide-induced vascular hyporeactivity via interleukin-1 beta release. J Pharmacol Exp Ther (2008) 0.90
Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells. Mol Cell Biol (2003) 0.90
Involvement of chloride in apoptotic cell death induced by activation of ATP-sensitive P2X7 purinoceptor. J Biol Chem (2004) 0.89
An ATP-gated cation channel with some P2Z-like characteristics in gastric smooth muscle cells of toad. J Physiol (1997) 0.89
Modulation of P2X(7) purinergic receptor in macrophages by Leishmania amazonensis and its role in parasite elimination. Microbes Infect (2009) 0.88
C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation. J Biol Chem (2010) 0.88
Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors. J Cell Sci (2004) 0.88
P2X7 nucleotide receptor is coupled to GSK-3 inhibition and neuroprotection in cerebellar granule neurons. Neurotox Res (2009) 0.86
Endogenously expressed truncated P2X7 receptor lacking the C-terminus is preferentially upregulated in epithelial cancer cells and fails to mediate ligand-induced pore formation and apoptosis. Nucleosides Nucleotides Nucleic Acids (2006) 0.85
ATP-induced apoptosis involves a Ca2+-independent phospholipase A2 and 5-lipoxygenase in macrophages. Prostaglandins Other Lipid Mediat (2008) 0.84
Regulation of phospholipase D by P2X7 receptors in submandibular ductal cells. Cell Signal (2003) 0.81
Characterization of P2Z purinergic receptors on phagocytic cells of the thymic reticulum in culture. Biochim Biophys Acta (1996) 0.80
Grb2 associated binder 2 couples B-cell receptor to cell survival. Cell Signal (2008) 0.80
Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation. Br J Pharmacol (2006) 1.08
Activation of the P2X(7) receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophages. Microbes Infect (2010) 1.03
Host-cell lipid rafts: a safe door for micro-organisms? Biol Cell (2010) 1.02
Lipopolysaccharide-induced lung injury: role of P2X7 receptor. Respir Physiol Neurobiol (2011) 0.97
Extracellular ATP induces cell death in CD4+/CD8+ double-positive thymocytes in mice infected with Trypanosoma cruzi. Microbes Infect (2003) 0.95
Modulation of P2X(7) purinergic receptor in macrophages by Leishmania amazonensis and its role in parasite elimination. Microbes Infect (2009) 0.88
Implication of purinergic P2X7 receptor in M. tuberculosis infection and host interaction mechanisms: a mouse model study. Immunobiology (2013) 0.88
Extracellular ATP induces cell death in human intestinal epithelial cells. Biochim Biophys Acta (2012) 0.88
Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors. J Cell Sci (2004) 0.88
Expression of purinergic receptors and modulation of P2X7 function by the inflammatory cytokine IFNgamma in human epithelial cells. Biochim Biophys Acta (2009) 0.88
Characterization of ATP-induced cell death in the GL261 mouse glioma. J Cell Biochem (2010) 0.87
Gap junction reduction in cardiomyocytes following transforming growth factor-beta treatment and Trypanosoma cruzi infection. Mem Inst Oswaldo Cruz (2009) 0.87
Characterizing the presence and sensitivity of the P2X7 receptor in different compartments of the gut. J Innate Immun (2012) 0.86
Prophylactic systemic P2X7 receptor blockade prevents experimental colitis. Biochim Biophys Acta (2013) 0.86
Leukotriene B4 modulates P2X7 receptor-mediated Leishmania amazonensis elimination in murine macrophages. J Immunol (2014) 0.86
Overexpression of ATP-activated P2X7 receptors in the intestinal mucosa is implicated in the pathogenesis of Crohn's disease. Inflamm Bowel Dis (2014) 0.83
Differential modulation of ATP-induced P2X7-associated permeabilities to cations and anions of macrophages by infection with Leishmania amazonensis. PLoS One (2011) 0.83
Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages. Immunobiology (2010) 0.83
Porphyromonas gingivalis fimbriae dampen P2X7-dependent interleukin-1β secretion. J Innate Immun (2014) 0.82
P2X7 receptor is required for neutrophil accumulation in a mouse model of irritant contact dermatitis. Exp Dermatol (2013) 0.81
Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis. Cell Microbiol (2011) 0.81
Reversible inhibition of Chlamydia trachomatis infection in epithelial cells due to stimulation of P2X(4) receptors. Infect Immun (2012) 0.81
The P2X7 Receptor Contributes to the Development of the Exacerbated Inflammatory Response Associated with Sepsis. J Innate Immun (2015) 0.80
Early expression of adenosine 5'-triphosphate-gated P2X7 receptors in the developing rat pancreas. Pancreas (2007) 0.79
Endothelial P2X7 receptors' expression is reduced by schistosomiasis. Purinergic Signal (2012) 0.79
Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view. Purinergic Signal (2011) 0.79
Pharmacological and molecular characterization of functional P2 receptors in rat embryonic cardiomyocytes. Purinergic Signal (2014) 0.79
Modulation of P2X7 receptor expression in macrophages from mineral oil-injected mice. Immunobiology (2008) 0.78
Presence of the P2X(7) purinergic receptor on immune cells that invade the rat endometrium during oestrus. J Reprod Immunol (2005) 0.77
Cellular alarms and whispers contribute to the polyphonic melody of danger signals required for immunity. Microbes Infect (2012) 0.77
Effect of extracellular ATP on the human leukaemic cell line K562 and its multidrug counterpart. Mol Cell Biochem (2006) 0.76