Published in Science on January 25, 2008
Polo-like kinases: conservation and divergence in their functions and regulation. Nat Rev Mol Cell Biol (2009) 4.09
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature (2008) 3.77
Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer (2010) 3.74
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science (2010) 3.13
Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B. Science (2010) 3.07
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99
Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol (2009) 2.61
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal (2009) 2.26
Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nat Cell Biol (2010) 2.18
Structure and functional characterization of the atypical human kinase haspin. Proc Natl Acad Sci U S A (2009) 1.85
Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view. Curr Opin Cell Biol (2009) 1.83
Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A (2012) 1.66
Aurora B kinase activation requires survivin priming phosphorylation by PLK1. J Mol Cell Biol (2010) 1.43
A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis. Curr Biol (2011) 1.41
Making an effective switch at the kinetochore by phosphorylation and dephosphorylation. Chromosoma (2013) 1.39
Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation. J Cell Biol (2012) 1.36
Dual detection of chromosomes and microtubules by the chromosomal passenger complex drives spindle assembly. Dev Cell (2010) 1.34
Cell division: control of the chromosomal passenger complex in time and space. Chromosoma (2013) 1.34
Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization. Proc Natl Acad Sci U S A (2009) 1.31
Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis. J Cell Biol (2010) 1.30
Kinetochore-microtubule interactions: steps towards bi-orientation. EMBO J (2010) 1.30
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol (2012) 1.27
INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol (2009) 1.23
Bi-orienting chromosomes: acrobatics on the mitotic spindle. Chromosoma (2008) 1.19
KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1. J Biol Chem (2011) 1.14
Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors. J Cell Biol (2010) 1.13
Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target. Oncotarget (2011) 1.13
Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene (2011) 1.13
Phosphorylation at serine 331 is required for Aurora B activation. J Cell Biol (2011) 1.10
Kinase signaling in the spindle checkpoint. J Biol Chem (2009) 1.09
ICIS and Aurora B coregulate the microtubule depolymerase Kif2a. Curr Biol (2009) 1.08
Understanding cytokinesis failure. Adv Exp Med Biol (2010) 1.06
Epigenetic virtues of chromodomains. Crit Rev Biochem Mol Biol (2011) 1.03
Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells. Mol Biol Cell (2008) 1.02
Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases. J Biol Chem (2009) 1.02
Haspin: a newly discovered regulator of mitotic chromosome behavior. Chromosoma (2009) 1.00
The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond. Cell Div (2008) 0.99
Ipl1/Aurora-dependent phosphorylation of Sli15/INCENP regulates CPC-spindle interaction to ensure proper microtubule dynamics. J Cell Biol (2011) 0.97
Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B. Mol Biol Cell (2009) 0.97
Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex. EMBO J (2012) 0.95
Insights into protein kinase regulation and inhibition by large scale structural comparison. Biochim Biophys Acta (2009) 0.95
Perturbation of Incenp function impedes anaphase chromatid movements and chromosomal passenger protein flux at centromeres. Chromosoma (2008) 0.94
The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis. J Biol Chem (2015) 0.94
Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation. Cell Cycle (2011) 0.94
The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling. Front Oncol (2015) 0.91
EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B. J Cell Biol (2014) 0.89
Self-organization of intracellular gradients during mitosis. Cell Div (2010) 0.89
Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality. PLoS One (2014) 0.88
Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization. J Biol Chem (2012) 0.88
Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. Biochem J (2010) 0.85
Centromere identity: a challenge to be faced. Mol Genet Genomics (2010) 0.85
RNA stimulates Aurora B kinase activity during mitosis. PLoS One (2014) 0.84
A novel role for TPX2 as a scaffold and co-activator protein of the Chromosomal Passenger Complex. Cell Signal (2012) 0.84
Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer development. Protein Cell (2012) 0.83
TD-60 links RalA GTPase function to the CPC in mitosis. Nat Commun (2015) 0.83
Basal aurora kinase B activity is sufficient for histone H3 phosphorylation in prophase. Biol Open (2013) 0.82
Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis. Mol Biol Cell (2012) 0.81
TD-60 is required for interphase cell cycle progression. Cell Cycle (2013) 0.80
Kif2a depletion generates chromosome segregation and pole coalescence defects in animal caps and inhibits gastrulation of the Xenopus embryo. Mol Biol Cell (2015) 0.80
Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex. Biochemistry (2009) 0.79
Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression. Semin Cell Dev Biol (2011) 0.79
New insights into the mechanism for chromosome alignment in metaphase. Int Rev Cell Mol Biol (2013) 0.79
Phosphorylation regulates kinase and microtubule binding activities of the budding yeast chromosomal passenger complex in vitro. J Biol Chem (2013) 0.78
Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules. Dev Cell (2016) 0.77
The Aurora B kinase in Trypanosoma brucei undergoes post-translational modifications and is targeted to various subcellular locations through binding to TbCPC1. Mol Microbiol (2013) 0.77
Formin mDia3: A novel target for Aurora B kinase. Bioarchitecture (2011) 0.77
The Timing of Midzone Stabilization during Cytokinesis Depends on Myosin II Activity and an Interaction between INCENP and Actin. Curr Biol (2016) 0.76
Bistability of a coupled Aurora B kinase-phosphatase system in cell division. Elife (2016) 0.76
The Ska complex promotes Aurora B activity to ensure chromosome biorientation. J Cell Biol (2016) 0.75
A Centromere-Signaling Network Underlies the Coordination among Mitotic Events. Trends Biochem Sci (2015) 0.75
Dynamic Phosphorylation of NudC by Aurora B in Cytokinesis. PLoS One (2016) 0.75
GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms. J Cell Biol (2017) 0.75
Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae. Nat Biotechnol (2002) 8.37
Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail. Science (2002) 8.08
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol (2004) 6.61
Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature (2005) 5.53
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr Biol (2004) 4.20
Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Nat Struct Mol Biol (2007) 4.10
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature (2008) 3.77
Protein architecture of the human kinetochore microtubule attachment site. Cell (2009) 3.68
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol Cell (2002) 3.65
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51
Aurora B is enriched at merotelic attachment sites, where it regulates MCAK. Curr Biol (2006) 3.22
Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis. Curr Biol (2002) 3.17
Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Mol Cell (2005) 3.14
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science (2010) 3.13
The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev (2003) 3.04
Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell (2002) 2.56
Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1). Curr Biol (2008) 2.38
The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr Biol (2004) 2.31
Phosphorylation regulates SIRT1 function. PLoS One (2008) 2.30
The reversibility of mitotic exit in vertebrate cells. Nature (2006) 2.16
Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. J Cell Biol (2010) 2.05
Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell (2010) 2.00
Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell (2007) 1.97
The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation. Nat Struct Mol Biol (2007) 1.93
Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly. J Cell Biol (2008) 1.91
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Curr Biol (2005) 1.88
The active site of the SET domain is constructed on a knot. Nat Struct Biol (2002) 1.78
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila. Dev Cell (2006) 1.71
Recognition of trimethyllysine by a chromodomain is not driven by the hydrophobic effect. Proc Natl Acad Sci U S A (2007) 1.71
Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function. Mol Biol Cell (2007) 1.66
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62
Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochore. Mol Biol Cell (2005) 1.52
Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. Proc Natl Acad Sci U S A (2004) 1.51
Assays for the determination of structure and dynamics of the interaction of the chromodomain with histone peptides. Methods Enzymol (2004) 1.46
Complement activation on B lymphocytes opsonized with rituximab or ofatumumab produces substantial changes in membrane structure preceding cell lysis. J Immunol (2008) 1.46
Structural basis for bile acid binding and activation of the nuclear receptor FXR. Mol Cell (2003) 1.40
Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin. Chromosoma (2007) 1.32
Beyond the double helix: writing and reading the histone code. Novartis Found Symp (2004) 1.25
Spindle poisons and cell fate: a tale of two pathways. Mol Interv (2011) 1.24
Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae. Eukaryot Cell (2005) 1.24
Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs. J Biol Chem (2008) 1.21
Linking kinetochore-microtubule binding to the spindle checkpoint. Dev Cell (2008) 1.21
Timing of events in mitosis. Curr Biol (2002) 1.20
Xenopus Cep57 is a novel kinetochore component involved in microtubule attachment. Cell (2007) 1.17
Multimodal microtubule binding by the Ndc80 kinetochore complex. Nat Struct Mol Biol (2012) 1.15
The Ndc80 complex: integrating the kinetochore's many movements. Chromosome Res (2011) 1.11
Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. Nat Struct Mol Biol (2010) 1.08
ICIS and Aurora B coregulate the microtubule depolymerase Kif2a. Curr Biol (2009) 1.08
Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. Cell Cycle (2007) 1.07
Molecular implications of evolutionary differences in CHD double chromodomains. J Mol Biol (2007) 1.07
The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein. J Cell Biol (2011) 1.07
Cep57, a multidomain protein with unique microtubule and centrosomal localization domains. Biochem J (2008) 1.06
The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement. Mol Biol Cell (2011) 1.05
Epigenetic virtues of chromodomains. Crit Rev Biochem Mol Biol (2011) 1.03
The HP1a disordered C terminus and chromo shadow domain cooperate to select target peptide partners. Chembiochem (2011) 1.02
Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells. Mol Biol Cell (2008) 1.02
A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint. Genes Dev (2012) 0.96
Perturbation of Incenp function impedes anaphase chromatid movements and chromosomal passenger protein flux at centromeres. Chromosoma (2008) 0.94
Aurora-A kinase and inhibitor-2 regulate the cyclin threshold for mitotic entry in Xenopus early embryonic cell cycles. Cell Cycle (2006) 0.92
Centriole duplication: A lesson in self-control. Cell Cycle (2010) 0.92
Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol Biol Cell (2012) 0.91
Understanding nuclear receptor form and function using structural biology. J Mol Endocrinol (2013) 0.91
The kinetochore NUPtials. Nat Cell Biol (2003) 0.90
Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor. Biochemistry (2012) 0.90
A Hec of a microtubule attachment. Nat Struct Mol Biol (2007) 0.89
Binding of phosphatase inhibitor-2 to prolyl isomerase Pin1 modifies specificity for mitotic phosphoproteins. Biochemistry (2007) 0.89
EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B. J Cell Biol (2014) 0.89
Penetration of antibody-opsonized cells by the membrane attack complex of complement promotes Ca(2+) influx and induces streamers. Eur J Immunol (2011) 0.88
Structural features and chaperone activity of the NudC protein family. J Mol Biol (2011) 0.81
The distinct functions of CENP-C and CENP-T/W in centromere propagation and function in Xenopus egg extracts. Nucleus (2015) 0.81
Implications of a histone code mimic in epigenetic signaling. Mol Cell (2007) 0.81
Purification of the Ndc80 kinetochore subcomplex from Xenopus eggs. Methods Mol Biol (2005) 0.78
Cdt1 throws kinetochore-microtubule attachments for a loop. Nat Cell Biol (2012) 0.77
Probing kinetochore structure and function using Xenopus laevis frog egg extracts. Methods Mol Biol (2009) 0.76
The quest for the holy "G" of chromosomal passengers. Dev Cell (2003) 0.75
Xenopus egg extracts as a simplified model system for structure-function studies of dynein regulators. Methods Mol Biol (2014) 0.75
Cell division: righting the check. Curr Biol (2009) 0.75
A new histone at the centromere? Cell (2012) 0.75