Published in Curr Biol on June 04, 2002
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol (2003) 9.27
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol (2003) 8.32
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol (2005) 4.80
The life and miracles of kinetochores. EMBO J (2009) 4.59
Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell (2003) 4.28
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol (2010) 3.50
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99
Sensing centromere tension: Aurora B and the regulation of kinetochore function. Trends Cell Biol (2010) 2.88
Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol (2009) 2.61
Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell (2004) 2.51
Kinetochore localization of spindle checkpoint proteins: who controls whom? Mol Biol Cell (2004) 2.50
Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal. J Cell Sci (2010) 2.05
CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1. Mol Cell Biol (2005) 2.00
A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism. Curr Biol (2009) 1.95
Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly. J Cell Biol (2008) 1.91
Sli15(INCENP) dephosphorylation prevents mitotic checkpoint reengagement due to loss of tension at anaphase onset. Curr Biol (2010) 1.82
A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension. Cell (2006) 1.79
Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation. Nat Cell Biol (2011) 1.69
Spindle assembly checkpoint: the third decade. Philos Trans R Soc Lond B Biol Sci (2011) 1.68
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction. EMBO J (2011) 1.62
Protein phosphatase 1 regulates exit from the spindle checkpoint in budding yeast. Curr Biol (2009) 1.61
Regulation of aurora B expression by the bromodomain protein Brd4. Mol Cell Biol (2009) 1.60
The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation. Chromosome Res (2004) 1.60
Both midzone and astral microtubules are involved in the delivery of cytokinesis signals: insights from the mobility of aurora B. J Cell Biol (2002) 1.60
C. elegans mitotic cyclins have distinct as well as overlapping functions in chromosome segregation. Cell Cycle (2009) 1.59
Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nat Commun (2011) 1.59
Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol (2008) 1.44
Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin. Proc Natl Acad Sci U S A (2006) 1.43
Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts. Mol Biol Cell (2004) 1.43
Making an effective switch at the kinetochore by phosphorylation and dephosphorylation. Chromosoma (2013) 1.39
Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase. Curr Biol (2003) 1.37
Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation. J Cell Biol (2012) 1.36
Aurora-C kinase deficiency causes cytokinesis failure in meiosis I and production of large polyploid oocytes in mice. Mol Biol Cell (2010) 1.35
Cell division: control of the chromosomal passenger complex in time and space. Chromosoma (2013) 1.34
Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. Chromosoma (2004) 1.30
Kinetochore-microtubule interactions: steps towards bi-orientation. EMBO J (2010) 1.30
Chromosome dynamics: new light on Aurora B kinase function. Curr Biol (2002) 1.30
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol (2012) 1.27
Changing roles of aurora-B kinase in two life cycle stages of Trypanosoma brucei. Eukaryot Cell (2006) 1.22
Linking kinetochore-microtubule binding to the spindle checkpoint. Dev Cell (2008) 1.21
Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis. PLoS One (2009) 1.16
Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells. J Transl Med (2008) 1.15
Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. Nucleic Acids Res (2002) 1.15
Identification and dynamics of two classes of aurora-like kinases in Arabidopsis and other plants. Plant Cell (2005) 1.15
Aurora kinase B modulates chromosome alignment in mouse oocytes. Mol Reprod Dev (2009) 1.12
The chromosomal passenger complex and a mitotic kinesin interact with the Tousled-like kinase in trypanosomes to regulate mitosis and cytokinesis. PLoS One (2008) 1.10
A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proc Natl Acad Sci U S A (2009) 1.06
Evolutionary relationships of Aurora kinases: implications for model organism studies and the development of anti-cancer drugs. BMC Evol Biol (2004) 1.04
Phosphoserines on maize CENTROMERIC HISTONE H3 and histone H3 demarcate the centromere and pericentromere during chromosome segregation. Plant Cell (2005) 1.03
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. J Biol Chem (2009) 1.02
Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells. Mol Biol Cell (2008) 1.02
The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond. Cell Div (2008) 0.99
Essential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit. Biochem J (2005) 0.98
The current view for the silencing of the spindle assembly checkpoint. Cell Cycle (2014) 0.95
RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. J Cell Biol (2007) 0.95
Perturbation of Incenp function impedes anaphase chromatid movements and chromosomal passenger protein flux at centromeres. Chromosoma (2008) 0.94
In-silico modeling of the mitotic spindle assembly checkpoint. PLoS One (2008) 0.94
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes. EMBO J (2002) 0.94
Kinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components. J Cell Biol (2015) 0.93
Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis. J Cell Biol (2008) 0.92
A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. Cancer Res (2009) 0.91
Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol Biol Cell (2012) 0.91
The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling. Front Oncol (2015) 0.91
Overexpression of active Aurora-C kinase results in cell transformation and tumour formation. PLoS One (2011) 0.90
EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B. J Cell Biol (2014) 0.89
Identification of an Aurora kinase inhibitor specific for the Aurora B isoform. Cancer Res (2012) 0.89
Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality. PLoS One (2014) 0.88
Additive effects of vorinostat and MLN8237 in pediatric leukemia, medulloblastoma, and neuroblastoma cell lines. Invest New Drugs (2012) 0.88
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells. Oncogene (2014) 0.88
CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status. J Cell Biol (2014) 0.88
Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint. Chromosoma (2015) 0.87
KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis. Nucleic Acids Res (2014) 0.85
Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. Biochem J (2010) 0.85
Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint. Nat Commun (2015) 0.84
Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis. Mol Biol Cell (2012) 0.81
Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis. Proc Natl Acad Sci U S A (2015) 0.80
The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B. Mol Biol Cell (2014) 0.79
Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. Mol Biol Cell (2009) 0.78
Excess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivo. Br J Cancer (2014) 0.78
Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53. Mol Biol Cell (2016) 0.78
Mitotic Kinases and p53 Signaling. Biochem Res Int (2012) 0.78
Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments. Biology (Basel) (2017) 0.78
A cell-based assay for screening spindle checkpoint inhibitors. Assay Drug Dev Technol (2012) 0.77
Dynamical scenarios for chromosome bi-orientation. Biophys J (2013) 0.77
'Signalling' between chromosomes in crane-fly spermatocytes studied using ultraviolet microbeam irradiation. Chromosome Res (2003) 0.77
Cell division: righting the check. Curr Biol (2009) 0.75
A Centromere-Signaling Network Underlies the Coordination among Mitotic Events. Trends Biochem Sci (2015) 0.75
Dual recognition of chromatin and microtubules by INCENP is important for mitotic progression. J Cell Biol (2017) 0.75
PRKAR2B plays an oncogenic role in the castration-resistant prostate cancer. Oncotarget (2017) 0.75
Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells. Nat Commun (2017) 0.75
Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells. PLoS One (2017) 0.75
GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms. J Cell Biol (2017) 0.75
Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae. Nat Biotechnol (2002) 8.37
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol (2004) 6.61
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr Biol (2004) 4.20
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature (2008) 3.77
Protein architecture of the human kinetochore microtubule attachment site. Cell (2009) 3.68
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol Cell (2002) 3.65
Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy. Blood (2002) 3.45
Aurora B is enriched at merotelic attachment sites, where it regulates MCAK. Curr Biol (2006) 3.22
Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Mol Cell (2005) 3.14
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science (2010) 3.13
The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev (2003) 3.04
Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell (2002) 2.56
Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1). Curr Biol (2008) 2.38
The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr Biol (2004) 2.31
Phosphorylation regulates SIRT1 function. PLoS One (2008) 2.30
Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation. Science (2008) 2.28
The reversibility of mitotic exit in vertebrate cells. Nature (2006) 2.16
Developmental control of late replication and S phase length. Curr Biol (2010) 2.10
Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell (2007) 1.97
Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells. J Cell Biol (2002) 1.95
Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly. J Cell Biol (2008) 1.91
Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis. Curr Biol (2009) 1.90
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Curr Biol (2005) 1.88
Regulation of microtubule stability and mitotic progression by survivin. Cancer Res (2002) 1.74
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila. Dev Cell (2006) 1.71
Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited. Mol Biol Cell (2011) 1.68
Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function. Mol Biol Cell (2007) 1.66
The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis. Cell Cycle (2002) 1.63
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62
Cohesion fatigue induces chromatid separation in cells delayed at metaphase. Curr Biol (2011) 1.60
Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochore. Mol Biol Cell (2005) 1.52
Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. Proc Natl Acad Sci U S A (2004) 1.51
Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity. J Cell Sci (2004) 1.51
Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit. Mol Biol Cell (2009) 1.49
Complement activation on B lymphocytes opsonized with rituximab or ofatumumab produces substantial changes in membrane structure preceding cell lysis. J Immunol (2008) 1.46
Rapid exchange of mammalian topoisomerase II alpha at kinetochores and chromosome arms in mitosis. J Cell Biol (2002) 1.42
Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation. J Cell Biol (2012) 1.36
CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency. Cancer Res (2012) 1.35
Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin. Chromosoma (2007) 1.32
Spindle poisons and cell fate: a tale of two pathways. Mol Interv (2011) 1.24
Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae. Eukaryot Cell (2005) 1.24
Linking kinetochore-microtubule binding to the spindle checkpoint. Dev Cell (2008) 1.21
Timing of events in mitosis. Curr Biol (2002) 1.20
Xenopus Cep57 is a novel kinetochore component involved in microtubule attachment. Cell (2007) 1.17
Multimodal microtubule binding by the Ndc80 kinetochore complex. Nat Struct Mol Biol (2012) 1.15
The Ndc80 complex: integrating the kinetochore's many movements. Chromosome Res (2011) 1.11
Spindle checkpoint function and cellular sensitivity to antimitotic drugs. Mol Cancer Ther (2006) 1.08
ICIS and Aurora B coregulate the microtubule depolymerase Kif2a. Curr Biol (2009) 1.08
Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. Cell Cycle (2007) 1.07
The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein. J Cell Biol (2011) 1.07
Cep57, a multidomain protein with unique microtubule and centrosomal localization domains. Biochem J (2008) 1.06
The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement. Mol Biol Cell (2011) 1.05
Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells. Mol Biol Cell (2008) 1.02
Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions. J Biol Chem (2002) 1.01
Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion. Virology (2008) 0.99
Microtubule network is required for insulin signaling through activation of Akt/protein kinase B: evidence that insulin stimulates vesicle docking/fusion but not intracellular mobility. J Biol Chem (2006) 0.98
A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint. Genes Dev (2012) 0.96
Perturbation of Incenp function impedes anaphase chromatid movements and chromosomal passenger protein flux at centromeres. Chromosoma (2008) 0.94
Aurora-A kinase and inhibitor-2 regulate the cyclin threshold for mitotic entry in Xenopus early embryonic cell cycles. Cell Cycle (2006) 0.92
CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest (2016) 0.92
A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. Cancer Res (2009) 0.91
Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol Biol Cell (2012) 0.91
The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit. Mol Biol Cell (2014) 0.90
Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint. Carcinogenesis (2009) 0.90
Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor. Biochemistry (2012) 0.90
The kinetochore NUPtials. Nat Cell Biol (2003) 0.90
A Hec of a microtubule attachment. Nat Struct Mol Biol (2007) 0.89
EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B. J Cell Biol (2014) 0.89
Binding of phosphatase inhibitor-2 to prolyl isomerase Pin1 modifies specificity for mitotic phosphoproteins. Biochemistry (2007) 0.89
Penetration of antibody-opsonized cells by the membrane attack complex of complement promotes Ca(2+) influx and induces streamers. Eur J Immunol (2011) 0.88
Both alpha and beta isoforms of mammalian DNA topoisomerase II associate with chromosomes in mitosis. Cell Growth Differ (2002) 0.86
Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons. Mol Cancer Ther (2006) 0.82
Structural features and chaperone activity of the NudC protein family. J Mol Biol (2011) 0.81
The distinct functions of CENP-C and CENP-T/W in centromere propagation and function in Xenopus egg extracts. Nucleus (2015) 0.81
Expression of HPV16 E5 produces enlarged nuclei and polyploidy through endoreplication. Virology (2010) 0.79
Cell-based expression cloning for identification of polypeptides that hypersensitize mammalian cells to mitotic arrest. Biol Proced Online (2006) 0.79
Purification of the Ndc80 kinetochore subcomplex from Xenopus eggs. Methods Mol Biol (2005) 0.78
Lysed cell models and isolated chromosomes for the study of kinetochore/centromere biochemistry in vitro. Methods (2006) 0.78
Cdt1 throws kinetochore-microtubule attachments for a loop. Nat Cell Biol (2012) 0.77
Probing kinetochore structure and function using Xenopus laevis frog egg extracts. Methods Mol Biol (2009) 0.76
A new histone at the centromere? Cell (2012) 0.75
Xenopus egg extracts as a simplified model system for structure-function studies of dynein regulators. Methods Mol Biol (2014) 0.75
The dynamics of DNA topoisomerase IIalpha in living cells. Methods Mol Biol (2009) 0.75
Live-cell fluorescence imaging for phenotypic analysis of mitosis. Methods Mol Biol (2014) 0.75
The quest for the holy "G" of chromosomal passengers. Dev Cell (2003) 0.75
Cell division: righting the check. Curr Biol (2009) 0.75