Published in Brain Behav Immun on August 01, 2002
Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci U S A (2003) 5.26
An inflammatory review of glucocorticoid actions in the CNS. Brain Behav Immun (2006) 2.31
The stressed CNS: when glucocorticoids aggravate inflammation. Neuron (2009) 1.66
Depressive symptoms, omega-6:omega-3 fatty acids, and inflammation in older adults. Psychosom Med (2007) 1.54
Immune dysregulation and chronic stress among older adults: a review. Neuroimmunomodulation (2008) 1.51
Stress-induced extracellular Hsp72 is a functionally significant danger signal to the immune system. Cell Stress Chaperones (2003) 1.47
Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation (2008) 1.43
Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice. Psychoneuroendocrinology (2008) 1.29
Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice. Psychoneuroendocrinology (2012) 1.25
Depressive symptoms predict exaggerated inflammatory responses to an in vivo immune challenge among pregnant women. Brain Behav Immun (2009) 1.22
Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome. J Biol Chem (2011) 1.14
Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation. Exp Neurol (2010) 1.12
Psychoneuroimmunology in pregnancy: immune pathways linking stress with maternal health, adverse birth outcomes, and fetal development. Neurosci Biobehav Rev (2011) 1.04
Depressive symptoms enhance stress-induced inflammatory responses. Brain Behav Immun (2012) 1.04
Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in humans. Brain Behav Immun (2008) 1.03
The HPA - Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain. Front Immunol (2014) 1.02
The inflammation hypothesis in geriatric depression. Int J Geriatr Psychiatry (2011) 1.01
Enhanced cytokine-induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to unpredictable sound stress. Eur J Pain (2011) 1.00
Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation. J Neuroinflammation (2014) 0.99
Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus. Psychoneuroendocrinology (2013) 0.99
Biobehavioral influences on recovery following hematopoietic stem cell transplantation. Brain Behav Immun (2012) 0.99
Lower subjective social status exaggerates interleukin-6 responses to a laboratory stressor. Psychoneuroendocrinology (2013) 0.99
Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine. J Neurochem (2012) 0.98
Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. J Neurosci (2015) 0.97
Acute and chronic stress-induced disturbances of microglial plasticity, phenotype and function. Curr Drug Targets (2013) 0.97
Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation. Brain Behav Immun (2011) 0.96
Periodontal innate immune mechanisms relevant to atherosclerosis and obesity. Periodontol 2000 (2010) 0.95
Neuroinflammation in the normal aging hippocampus. Neuroscience (2015) 0.95
Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats. Psychoneuroendocrinology (2008) 0.94
A biological substrate for somatoform disorders: importance of pathophysiology. Psychosom Med (2007) 0.93
Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue. Brain Behav Immun (2011) 0.92
Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge. Brain Behav Immun (2013) 0.91
Interleukin-6 as a mechanism for the adverse effects of social stress on acute Theiler's virus infection. Brain Behav Immun (2007) 0.90
Chronic intermittent cold stress sensitizes neuro-immune reactivity in the rat brain. Psychoneuroendocrinology (2011) 0.90
Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition. Horm Behav (2012) 0.89
The intestinal microbiota are necessary for stressor-induced enhancement of splenic macrophage microbicidal activity. Brain Behav Immun (2011) 0.89
Persistent neuroinflammatory effects of serial exposure to stress and methamphetamine on the blood-brain barrier. J Neuroimmune Pharmacol (2012) 0.89
Examination of the bovine leukocyte environment using immunogenetic biomarkers to assess immunocompetence following exposure to weaning stress. BMC Vet Res (2011) 0.87
Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy. Brain Behav Immun (2012) 0.87
Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming. Brain Behav Immun (2015) 0.87
Glucocorticoids regulate natural killer cell function epigenetically. Cell Immunol (2014) 0.87
Cerebrospinal fluid cortisol and progesterone profiles and outcomes prognostication after severe traumatic brain injury. J Neurotrauma (2014) 0.86
Influenza, immune system, and pregnancy. Reprod Sci (2014) 0.86
Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. J Neuroimmunol (2011) 0.85
Inflammatory cytokine-associated depression. Brain Res (2014) 0.84
The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome. Brain Behav Immun (2015) 0.84
Inflammation at the intersection of behavior and somatic symptoms. Psychiatr Clin North Am (2011) 0.83
Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain. Neuroscience (2014) 0.83
Neuroimmune mechanisms of stress: sex differences, developmental plasticity, and implications for pharmacotherapy of stress-related disease. Stress (2015) 0.82
Irritable bowel syndrome and inflammatory bowel disease overlap syndrome: pieces of the puzzle are falling into place. Intest Res (2016) 0.82
Relevance of chronic stress and the two faces of microglia in Parkinson's disease. Front Cell Neurosci (2015) 0.81
Systemic lipopolysaccharide administration impairs retrieval of context-object discrimination, but not spatial, memory: Evidence for selective disruption of specific hippocampus-dependent memory functions during acute neuroinflammation. Brain Behav Immun (2014) 0.81
Divergent effects of repeated restraint versus chronic variable stress on prefrontal cortical immune status after LPS injection. Brain Behav Immun (2016) 0.80
Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia. Neurobiol Aging (2014) 0.80
Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits. Transl Psychiatry (2014) 0.80
Immunity, aging, and geriatric depression. Psychiatr Clin North Am (2011) 0.80
Febrile response induced by cecal ligation and puncture (CLP) in rats: involvement of prostaglandin E2 and cytokines. Med Microbiol Immunol (2011) 0.78
Glucocorticoids can arm macrophages for innate immune battle. Brain Behav Immun (2009) 0.78
Stress-induced neuroinflammatory priming is time of day dependent. Psychoneuroendocrinology (2016) 0.78
Behavioral and endocrine consequences of simultaneous exposure to two different stressors in rats: interaction or independence? PLoS One (2011) 0.77
Altered functional connectivity in an aged rat model of postoperative cognitive dysfunction: a study using resting-state functional MRI. PLoS One (2013) 0.77
Behavioral Symptoms after Breast Cancer Treatment: A Biobehavioral Approach. J Pers Med (2015) 0.77
Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1. eNeuro (2016) 0.77
Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior. Brain Behav Immun (2016) 0.77
Social disruption induced priming of CNS inflammatory response to Theiler's virus is dependent upon stress induced IL-6 release. J Neuroimmunol (2011) 0.77
Periodontal innate immune mechanisms relevant to atherosclerosis. Mol Oral Microbiol (2014) 0.76
A pre-conditioning stress accelerates increases in mouse plasma inflammatory cytokines induced by stress. BMC Neurosci (2015) 0.76
Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders. Neurobiol Stress (2015) 0.76
Disrupted glucocorticoid-Immune interactions during stress response in schizophrenia. Psychoneuroendocrinology (2015) 0.75
Physical versus psychological social stress in male rats reveals distinct cardiovascular, inflammatory and behavioral consequences. PLoS One (2017) 0.75
Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice. J Neuroinflammation (2016) 0.75
Association between serum C-reactive protein and DSM-IV generalized anxiety disorder in adolescence: Findings from the ALSPAC cohort. Neurobiol Stress (2016) 0.75
Social disruption alters pain and cognition in an animal model of multiple sclerosis. J Neuroimmunol (2015) 0.75
The Pro-inflammatory Effects of Glucocorticoids in the Brain. Front Endocrinol (Lausanne) (2016) 0.75
Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Activation of the Alpha-7 Nicotinic Acetylcholine Receptor. Front Immunol (2017) 0.75
Enriched environment and stress exposure influence splenic B lymphocyte composition. PLoS One (2017) 0.75
Assessment of social behavior directed toward sick partners and its relation to central cytokine expression in rats. Physiol Behav (2017) 0.75
Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci (2009) 5.53
Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch Neurol (2003) 3.80
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain (2005) 3.34
Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci Biobehav Rev (2005) 3.25
The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci (2009) 3.06
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun (2006) 2.89
Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci (2003) 2.87
Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev (2002) 2.75
Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov (2003) 2.71
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci (2008) 2.65
Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. ScientificWorldJournal (2007) 2.43
Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiol Aging (2006) 2.37
"Brain-specific" nutrients: a memory cure? Nutrition (2003) 2.29
Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun (2009) 2.19
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci (2004) 2.14
Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci (2004) 2.11
Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex. J Neurosci (2006) 2.07
mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Neurobiol Aging (2006) 2.06
Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun (2006) 2.00
Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. J Neurosci (2012) 1.93
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun (2008) 1.92
Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. J Neurosci (2003) 1.91
Glia: novel counter-regulators of opioid analgesia. Trends Neurosci (2005) 1.86
Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol (2003) 1.84
Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav Immun (2008) 1.82
Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A (2012) 1.80
Glial activation and pathological pain. Neurochem Int (2004) 1.80
Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10. Eur J Neurosci (2005) 1.73
Toll-like receptor 4 in CNS pathologies. J Neurochem (2010) 1.68
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun (2006) 1.67
Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Mol Pain (2005) 1.66
Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev (2011) 1.66
Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain (2006) 1.66
"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev (2007) 1.62
Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. J Neurosci Methods (2005) 1.61
Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain Behav Immun (2008) 1.58
Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus. Behav Brain Res (2002) 1.58
Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide. Brain Behav Immun (2009) 1.58
Behavioral control, the medial prefrontal cortex, and resilience. Dialogues Clin Neurosci (2006) 1.56
5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress. Biol Psychiatry (2009) 1.55
Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. J Neurosci (2003) 1.53
Neonatal infection induces memory impairments following an immune challenge in adulthood. Behav Neurosci (2005) 1.53
Role of the medial prefrontal cortex in coping and resilience. Brain Res (2010) 1.52
Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. J Comp Neurol (2004) 1.52
Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opin Investig Drugs (2007) 1.45
Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress. Behav Neurosci (2004) 1.44
The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain. Neuron Glia Biol (2006) 1.43
Peripheral and central proinflammatory cytokine response to a severe acute stressor. Brain Res (2003) 1.42
Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. J Neurosci (2005) 1.41
Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav Immun (2009) 1.36
Spinal gap junctions: potential involvement in pain facilitation. J Pain (2004) 1.36
The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration. Behav Brain Res (2008) 1.36
Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids. J Neurosci (2010) 1.34
Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain Behav Immun (2008) 1.34
Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects. Cytokine (2003) 1.30
Central proinflammatory cytokines and pain enhancement. Neurosignals (2005) 1.30
Toll-like receptors in chronic pain. Exp Neurol (2011) 1.29
Effects of prior stress on LPS-induced cytokine and sickness responses. Am J Physiol Regul Integr Comp Physiol (2002) 1.26
A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats. Behav Brain Res (2006) 1.25
The cortical innate immune response increases local neuronal excitability leading to seizures. Brain (2009) 1.25
Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment. Brain Behav Immun (2003) 1.24