Published in Neurobiol Aging on May 01, 2006
Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav Immun (2007) 3.07
Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biol Psychiatry (2008) 2.66
Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia. J Neuroinflammation (2008) 2.53
Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines. Brain Behav Immun (2008) 2.37
Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. Neuropsychopharmacology (2007) 2.20
β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. J Neurosci (2011) 2.15
Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide. Neurobiol Aging (2007) 2.03
Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol (2008) 1.94
Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci (2009) 1.89
Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav Immun (2008) 1.82
Review: microglia of the aged brain: primed to be activated and resistant to regulation. Neuropathol Appl Neurobiol (2013) 1.82
Neurogenesis, inflammation and behavior. Brain Behav Immun (2012) 1.58
Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment. J Neurosci (2009) 1.52
Microglial dysfunction in brain aging and Alzheimer's disease. Biochem Pharmacol (2014) 1.52
Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: a potential mechanism leading to chronic inflammation. Exp Neurol (2008) 1.44
Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation (2008) 1.43
Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge. Brain Behav Immun (2010) 1.43
Microglia and memory: modulation by early-life infection. J Neurosci (2011) 1.37
The immune system and developmental programming of brain and behavior. Front Neuroendocrinol (2012) 1.36
Microglia during development and aging. Pharmacol Ther (2013) 1.30
Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice. Psychoneuroendocrinology (2008) 1.29
Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice. Brain Behav Immun (2011) 1.27
Microglia activation and anti-inflammatory regulation in Alzheimer's disease. Mol Neurobiol (2010) 1.22
Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation. Front Cell Neurosci (2013) 1.20
Aging-dependent changes in the radiation response of the adult rat brain. Int J Radiat Oncol Biol Phys (2007) 1.20
Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes. J Neurosci (2011) 1.19
IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats. Brain Behav Immun (2009) 1.15
Microglial M1/M2 polarization and metabolic states. Br J Pharmacol (2015) 1.14
Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease. Neuropharmacology (2014) 1.12
Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation. Exp Neurol (2010) 1.12
Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo. J Neuroimmunol (2010) 1.12
Imaging microglial activation during neuroinflammation and Alzheimer's disease. J Neuroimmune Pharmacol (2008) 1.11
Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice. Brain Behav Immun (2011) 1.11
Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1. J Neurosci (2010) 1.11
Age related changes in microglial phenotype vary between CNS regions: grey versus white matter differences. Brain Behav Immun (2011) 1.09
Memory impairments in healthy aging: Role of aging-induced microglial sensitization. Aging Dis (2010) 1.09
Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline. Neurobiol Learn Mem (2010) 1.08
Microglia in the developing brain: a potential target with lifetime effects. Neurotoxicology (2012) 1.07
Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment. J Neuroinflammation (2011) 1.05
Characterization of the sickness response in young and aging rats following E. coli infection. Brain Behav Immun (2009) 1.04
Neuroinflammation and memory: the role of prostaglandins. Mol Neurobiol (2009) 1.02
Microglia across the lifespan: from origin to function in brain development, plasticity and cognition. J Physiol (2016) 1.02
A lifespan approach to neuroinflammatory and cognitive disorders: a critical role for glia. J Neuroimmune Pharmacol (2011) 1.00
Osteopetrotic (op/op) mice have reduced microglia, no Abeta deposition, and no changes in dopaminergic neurons. J Neuroinflammation (2007) 0.99
Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J Nutr (2010) 0.99
Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia. Biol Psychiatry (2013) 0.98
T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease. PLoS One (2010) 0.96
Immune and behavioral consequences of microglial reactivity in the aged brain. Integr Comp Biol (2009) 0.95
Neuroinflammation in the normal aging hippocampus. Neuroscience (2015) 0.95
Priming the Inflammatory Pump of the CNS after Traumatic Brain Injury. Trends Neurosci (2015) 0.91
Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition. Horm Behav (2012) 0.89
Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury. Exp Neurol (2015) 0.89
Insulin-like growth factor-1 in CNS and cerebrovascular aging. Front Aging Neurosci (2013) 0.88
Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand. Neurobiol Aging (2013) 0.88
Effects of minocycline on spatial learning, hippocampal neurogenesis and microglia in aged and adult mice. Behav Brain Res (2012) 0.88
Changes in oxidative damage, inflammation and [NAD(H)] with age in cerebrospinal fluid. PLoS One (2014) 0.88
Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity. Neuropharmacology (2014) 0.87
Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice. J Neuroinflammation (2013) 0.86
Immune responses in Parkinson's disease: interplay between central and peripheral immune systems. Biomed Res Int (2014) 0.86
Understanding the neurobiology of CD200 and the CD200 receptor: a therapeutic target for controlling inflammation in human brains? Future Neurol (2013) 0.85
Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector. Front Aging Neurosci (2014) 0.84
Distribution and expression of CD200 in the rat respiratory system under normal and endotoxin-induced pathological conditions. J Anat (2010) 0.84
Interleukin-10 protects against aging-induced endothelial dysfunction. Physiol Rep (2013) 0.83
Traumatic brain injury and aging: is a combination of progesterone and vitamin D hormone a simple solution to a complex problem? Neurotherapeutics (2010) 0.83
Aging- and injury-related differential apoptotic response in the dentate gyrus of the hippocampus in rats following brain trauma. Front Aging Neurosci (2013) 0.83
Differential sensitivity to endotoxin exposure in young and middle-age mice. Brain Behav Immun (2009) 0.82
Progesterone and vitamin d hormone as a biologic treatment of traumatic brain injury in the aged. PM R (2011) 0.82
Coordinated gene expression of neuroinflammatory and cell signaling markers in dorsolateral prefrontal cortex during human brain development and aging. PLoS One (2014) 0.81
Neuroinflammation: the devil is in the details. J Neurochem (2016) 0.80
Microglia Priming with Aging and Stress. Neuropsychopharmacology (2016) 0.80
Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia. Neurobiol Aging (2014) 0.80
Decline in Proliferation and Immature Neuron Markers in the Human Subependymal Zone during Aging: Relationship to EGF- and FGF-Related Transcripts. Front Aging Neurosci (2016) 0.80
Influence of age on behavioral, immune and endocrine responses to the T-cell superantigen staphylococcal enterotoxin A. Eur J Neurosci (2009) 0.79
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming. J Neurosci (2016) 0.79
Alzheimer's Disease: Mechanism and Approach to Cell Therapy. Int J Mol Sci (2015) 0.79
Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. J Neuroinflammation (2012) 0.79
Ovariectomy and subsequent treatment with estrogen receptor agonists tune the innate immune system of the hippocampus in middle-aged female rats. PLoS One (2014) 0.78
Differential rescue of spatial memory deficits in aged rats by L-type voltage-dependent calcium channel and ryanodine receptor antagonism. Neuroscience (2014) 0.78
Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation. Curr Opin Pharmacol (2015) 0.78
Impaired Spatial Learning Memory after Isoflurane Anesthesia or Appendectomy in Aged Mice is Associated with Microglia Activation. J Cell Death (2015) 0.78
Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice. Rejuvenation Res (2016) 0.76
Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence. Front Aging Neurosci (2016) 0.75
Fate of microglia during HIV-1 infection: From activation to senescence? Glia (2016) 0.75
Age-dependent differences in microglial responses to systemic inflammation are evident as early as middle age. Physiol Genomics (2016) 0.75
Old Maids: Aging and Its Impact on Microglia Function. Int J Mol Sci (2017) 0.75
The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats. Brain Behav Immun (2014) 0.75
Minocycline attenuates post-operative cognitive impairment in aged mice by inhibiting microglia activation. J Cell Mol Med (2016) 0.75
Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system. Curr Pharm Des (2014) 0.75
Disparate Changes in Plasma and Brainstem Cytokine Levels in Adult and Ageing Rats Associated with Age-Related Changes in Facial Motor Neuron Number, Snout Muscle Morphology, and Exploratory Behavior. Front Neurol (2016) 0.75
Anti-aging effects of guanosine in glial cells. Purinergic Signal (2016) 0.75
Microglial Function across the Spectrum of Age and Gender. Int J Mol Sci (2017) 0.75
Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans? Front Pharmacol (2016) 0.75
Indomethacin Increases Neurogenesis across Age Groups and Improves Delayed Probe Trial Difference Scores in Middle-Aged Rats. Front Aging Neurosci (2017) 0.75
High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory. Neurobiol Aging (2017) 0.75
Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson's Disease. Front Aging Neurosci (2017) 0.75
Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci (2009) 5.53
Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch Neurol (2003) 3.80
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain (2005) 3.34
Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci Biobehav Rev (2005) 3.25
The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci (2009) 3.06
Separate neural substrates for skill learning and performance in the ventral and dorsal striatum. Nat Neurosci (2006) 2.93
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun (2006) 2.89
Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci (2003) 2.87
Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev (2002) 2.75
Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov (2003) 2.71
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci (2008) 2.65
PKMzeta maintains spatial, instrumental, and classically conditioned long-term memories. PLoS Biol (2008) 2.58
Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. ScientificWorldJournal (2007) 2.43
Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiol Aging (2006) 2.37
"Brain-specific" nutrients: a memory cure? Nutrition (2003) 2.29
The role of the dorsal hippocampus in the acquisition and retrieval of context memory representations. J Neurosci (2004) 2.25
Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun (2009) 2.19
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci (2004) 2.14
Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci (2004) 2.11
Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex. J Neurosci (2006) 2.07
Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun (2006) 2.00
Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. J Neurosci (2012) 1.93
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun (2008) 1.92
Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. J Neurosci (2003) 1.91
Glia: novel counter-regulators of opioid analgesia. Trends Neurosci (2005) 1.86
Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol (2003) 1.84
Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav Immun (2008) 1.82
Prior stressor exposure sensitizes LPS-induced cytokine production. Brain Behav Immun (2002) 1.82
Hippocampal formation supports conditioning to memory of a context. Behav Neurosci (2002) 1.81
Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A (2012) 1.80
Glial activation and pathological pain. Neurochem Int (2004) 1.80
Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10. Eur J Neurosci (2005) 1.73
Toll-like receptor 4 in CNS pathologies. J Neurochem (2010) 1.68
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun (2006) 1.67
Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Mol Pain (2005) 1.66
Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev (2011) 1.66
Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain (2006) 1.66
"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev (2007) 1.62
Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. J Neurosci Methods (2005) 1.61
Context preexposure prevents forgetting of a contextual fear memory: implication for regional changes in brain activation patterns associated with recent and remote memory tests. Learn Mem (2007) 1.59
Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain Behav Immun (2008) 1.58
Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus. Behav Brain Res (2002) 1.58
Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide. Brain Behav Immun (2009) 1.58
Behavioral control, the medial prefrontal cortex, and resilience. Dialogues Clin Neurosci (2006) 1.56
5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress. Biol Psychiatry (2009) 1.55
Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. J Neurosci (2003) 1.53
Neonatal infection induces memory impairments following an immune challenge in adulthood. Behav Neurosci (2005) 1.53
Role of the medial prefrontal cortex in coping and resilience. Brain Res (2010) 1.52
Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. J Comp Neurol (2004) 1.52
Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opin Investig Drugs (2007) 1.45
Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress. Behav Neurosci (2004) 1.44
The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain. Neuron Glia Biol (2006) 1.43
Peripheral and central proinflammatory cytokine response to a severe acute stressor. Brain Res (2003) 1.42
Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. J Neurosci (2005) 1.41
Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav Immun (2009) 1.36
Spinal gap junctions: potential involvement in pain facilitation. J Pain (2004) 1.36
The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration. Behav Brain Res (2008) 1.36
Amygdala regulation of immediate-early gene expression in the hippocampus induced by contextual fear conditioning. J Neurosci (2006) 1.35
The role of dorsal hippocampus and basolateral amygdala NMDA receptors in the acquisition and retrieval of context and contextual fear memories. Behav Neurosci (2007) 1.34