Published in J Neurosci on August 18, 2004
Pain Modulation in Rheumatoid Arthritis (RA) - Influence of Adalimumab (PARADE) | NCT01197144
Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci (2009) 5.53
The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci (2009) 3.06
Interactions between the immune and nervous systems in pain. Nat Med (2010) 2.91
Glia and pain: is chronic pain a gliopathy? Pain (2013) 2.21
Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun (2009) 2.19
Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun (2006) 2.00
Neuron-glia crosstalk gets serious: role in pain hypersensitivity. Curr Opin Anaesthesiol (2008) 1.99
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun (2008) 1.92
Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. Brain Behav Immun (2006) 1.88
Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain (2007) 1.88
Cytokine and chemokine regulation of sensory neuron function. Handb Exp Pharmacol (2009) 1.70
Chemokines: integrators of pain and inflammation. Nat Rev Drug Discov (2005) 1.68
Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev (2011) 1.66
"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev (2007) 1.62
The narcotic bowel syndrome: clinical features, pathophysiology, and management. Clin Gastroenterol Hepatol (2007) 1.60
Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain Behav Immun (2008) 1.58
Peripheral mechanisms of pain and analgesia. Brain Res Rev (2008) 1.55
Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease. Mol Vis (2010) 1.54
Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats. Exp Neurol (2008) 1.46
The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain. Neuron Glia Biol (2006) 1.43
Glia in pathological pain: a role for fractalkine. J Neuroimmunol (2008) 1.39
Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain Behav Immun (2008) 1.34
Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta. Neuroscience (2010) 1.33
Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences. Neuroscience (2010) 1.22
Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain (2010) 1.19
Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision. Mol Pain (2008) 1.13
Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia. J Clin Invest (2014) 1.11
Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders. Neuroscience (2010) 1.09
Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors. Mol Pain (2009) 1.08
Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision. Pain (2009) 1.07
CXCR4 signaling mediates morphine-induced tactile hyperalgesia. Brain Behav Immun (2010) 1.05
The impact of morphine after a spinal cord injury. Behav Brain Res (2007) 1.05
Intrathecal morphine attenuates recovery of function after a spinal cord injury. J Neurotrauma (2009) 1.02
Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase. J Neuroinflammation (2012) 0.97
Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains. Brain Behav Immun (2011) 0.97
Blockade of Toll-like receptor 4 attenuates morphine tolerance and facilitates the pain relieving properties of morphine. J Neurosci (2013) 0.97
Expression of fractalkine and fractalkine receptor in urinary bladder after cyclophosphamide (CYP)-induced cystitis. Auton Neurosci (2006) 0.95
Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain (2006) 0.95
A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats. J Neurosci Methods (2009) 0.94
An IL-1 receptor antagonist blocks a morphine-induced attenuation of locomotor recovery after spinal cord injury. Brain Behav Immun (2010) 0.93
Lipomatosis-associated inflammation and excess collagen may contribute to lower relative resting energy expenditure in women with adiposis dolorosa. Int J Obes (Lond) (2009) 0.91
Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9. Mol Pain (2012) 0.91
Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain. Brain Behav Immun (2015) 0.88
PEGylation of interleukin-10 for the mitigation of enhanced pain states. J Biomed Mater Res A (2010) 0.88
The role of TNFα in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats. Neuropsychopharmacology (2010) 0.87
Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy. Brain Behav Immun (2012) 0.87
Metaplasticity and behavior: how training and inflammation affect plastic potential within the spinal cord and recovery after injury. Front Neural Circuits (2014) 0.87
Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience (2014) 0.86
Cannabinoid CB(2) receptor attenuates morphine-induced inflammatory responses in activated microglial cells. Br J Pharmacol (2012) 0.86
Peroxynitrite and opiate antinociceptive tolerance: a painful reality. Arch Biochem Biophys (2008) 0.86
Biphasic effect of curcumin on morphine tolerance: a preliminary evidence from cytokine/chemokine protein array analysis. Evid Based Complement Alternat Med (2011) 0.85
CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells. J Gen Virol (2015) 0.85
CCL5 and cytokine expression in the rat brain: differential modulation by chronic morphine and morphine withdrawal. Brain Behav Immun (2013) 0.85
Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance. Pain (2013) 0.84
Lack of effect of chronic dextromethorphan on experimental pain tolerance in methadone-maintained patients. Addict Biol (2008) 0.84
Glial modulators: a novel pharmacological approach to altering the behavioral effects of abused substances. Expert Opin Investig Drugs (2012) 0.83
Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats. Gene Ther (2011) 0.83
Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice. Neuroscience (2013) 0.83
Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death. Mol Neurodegener (2011) 0.83
Gabapentin enhances the morphine anti-nociceptive effect in neuropathic pain via the interleukin-10-heme oxygenase-1 signalling pathway in rats. J Mol Neurosci (2014) 0.83
Exaggerated expression of inflammatory mediators in vasoactive intestinal polypeptide knockout (VIP-/-) mice with cyclophosphamide (CYP)-induced cystitis. J Mol Neurosci (2008) 0.82
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. J Neuroimmunol (2012) 0.82
On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats. Mol Pain (2011) 0.81
The chemokine CX3CL1/fractalkine interferes with the antinociceptive effect induced by opioid agonists in the periaqueductal grey of rats. Brain Res (2007) 0.81
The effects of ibudilast, a glial activation inhibitor, on opioid withdrawal symptoms in opioid-dependent volunteers. Addict Biol (2015) 0.80
Current gene therapy using viral vectors for chronic pain. Mol Pain (2015) 0.79
Involvement of neuronal TGF-β activated kinase 1 in the development of tolerance to morphine-induced antinociception in rat spinal cord. Br J Pharmacol (2015) 0.79
Opioid-induced central immune signaling: implications for opioid analgesia. Headache (2015) 0.79
Persistent pain facilitates response to morphine reward by downregulation of central amygdala GABAergic function. Neuropsychopharmacology (2014) 0.79
Opioid administration following spinal cord injury: implications for pain and locomotor recovery. Exp Neurol (2013) 0.79
Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice. Mol Pain (2012) 0.79
Elevated expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain. Biomed Res Int (2013) 0.78
Pioglitazone prevents morphine antinociception tolerance and withdrawal symptoms in rats. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.78
Interleukin 10 mediated by herpes simplex virus vectors suppresses neuropathic pain induced by human immunodeficiency virus gp120 in rats. Anesth Analg (2014) 0.78
Evaluation of the effects of specific opioid receptor agonists in a rodent model of spinal cord injury. Spinal Cord (2016) 0.77
Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats. Inflammopharmacology (2011) 0.77
NADPH-oxidase 2 activation promotes opioid-induced antinociceptive tolerance in mice. Neuroscience (2013) 0.77
The association between spinal cord trauma-sensitive miRNAs and pain sensitivity, and their regulation by morphine. Neurochem Int (2014) 0.77
Delay of morphine tolerance by palmitoylethanolamide. Biomed Res Int (2015) 0.77
Intrathecal lamotrigine attenuates antinociceptive morphine tolerance and suppresses spinal glial cell activation in morphine-tolerant rats. J Korean Med Sci (2013) 0.77
Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation. Trends Pharmacol Sci (2016) 0.76
Glial TLR4 signaling does not contribute to opioid-induced depression of respiration. J Appl Physiol (1985) (2014) 0.76
An emerging new paradigm in opioid withdrawal: a critical role for glia-neuron signaling in the periaqueductal gray. ScientificWorldJournal (2012) 0.76
Treatment of Cancer Pain by Targeting Cytokines. Mediators Inflamm (2015) 0.76
N-acetyl-cysteine attenuates remifentanil-induced postoperative hyperalgesia via inhibiting matrix metalloproteinase-9 in dorsal root ganglia. Oncotarget (2017) 0.75
IL-4 mediated by HSV vector suppresses morphine withdrawal response and decreases TNFα, NR2B, and pC/EBPβ in the periaqueductal gray in rats. Gene Ther (2017) 0.75
Nor-Binaltorphimine Blocks the Adverse Effects of Morphine after Spinal Cord Injury. J Neurotrauma (2016) 0.75
Cytokine and neuropeptide levels are associated with pain relief in patients with chronically painful total knee arthroplasty: a pilot study. BMC Musculoskelet Disord (2017) 0.75
Plasma levels of eight different mediators and their potential as biomarkers of various clinical malaria conditions in African children. Malar J (2016) 0.75
Neurobiological Effects of Morphine after Spinal Cord Injury. J Neurotrauma (2016) 0.75
Opioids Resistance in Chronic Pain Management. Curr Neuropharmacol (2017) 0.75
Contribution of adrenomedullin to the switch of G protein-coupled μ-opioid receptors from Gi to Gs in the spinal dorsal horn following chronic morphine exposure in rats. Br J Pharmacol (2016) 0.75
Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation. J Neuroinflammation (2016) 0.75
Regulation of Physical Microglia-Neuron Interactions by Fractalkine Signaling after Status Epilepticus. eNeuro (2017) 0.75
Complement factor C5a and C5a receptor contribute to morphine tolerance and withdrawal-induced hyperalgesia in rats. Exp Ther Med (2012) 0.75
Differentially Severe Cognitive Effects of Compromised Cerebral Blood Flow in Aged Mice: Association with Myelin Degradation and Microglia Activation. Front Aging Neurosci (2017) 0.75
Genetic deletion of microglial Panx1 attenuates morphine withdrawal, but not analgesic tolerance or hyperalgesia in mice. Channels (Austin) (2017) 0.75
The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats. J Neuroimmune Pharmacol (2017) 0.75
Attenuation of morphine analgesic tolerance by rosuvastatin in naïve and morphine tolerance rats. Inflammation (2015) 0.75
Spinal CX3CL1/CX3CR1 May Not Directly Participate in the Development of Morphine Tolerance in Rats. Neurochem Res (2017) 0.75
The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res (2012) 15.41
Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci (2009) 5.53
Functional classification of proteins for the prediction of cellular function from a protein-protein interaction network. Genome Biol (2003) 3.80
Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch Neurol (2003) 3.80
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain (2005) 3.37
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain (2005) 3.34
Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci Biobehav Rev (2005) 3.25
The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci (2009) 3.06
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun (2006) 2.89
Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci (2003) 2.87
Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev (2002) 2.75
Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov (2003) 2.71
Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice. J Clin Invest (2004) 2.67
Evaluation of annotation strategies using an entire genome sequence. Bioinformatics (2003) 2.66
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci (2008) 2.65
Context-based tourism information filtering with a semantic rule engine. Sensors (Basel) (2012) 2.51
Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. ScientificWorldJournal (2007) 2.43
Intussusception risk after rotavirus vaccination in U.S. infants. N Engl J Med (2014) 2.41
Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiol Aging (2006) 2.37
"Brain-specific" nutrients: a memory cure? Nutrition (2003) 2.29
Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. Cardiovasc Res (2008) 2.23
Penile length alterations following penile prosthesis surgery. Eur Urol (2006) 2.20
Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation. Hippocampus (1992) 2.19
Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun (2009) 2.19
Overall quality of outcomes framework scores lower in practices in deprived areas. Br J Gen Pract (2006) 2.14
Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci (2004) 2.11
Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution. PLoS Genet (2009) 2.07
Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex. J Neurosci (2006) 2.07
mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Neurobiol Aging (2006) 2.06
Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun (2006) 2.00
A genetic screen identifies novel non-compatible loxP sites. Nucleic Acids Res (2002) 1.99
Low rates of testing and diagnostic codes usage in a commercial clinical laboratory: evidence for lack of physician awareness of chronic kidney disease. J Am Soc Nephrol (2005) 1.98
Ablation for longstanding permanent atrial fibrillation: results from a randomized study comparing three different strategies. Heart Rhythm (2008) 1.96
MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. Gastroenterology (2005) 1.94
Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. J Neurosci (2012) 1.93
Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines. Neuroscience (2005) 1.92
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun (2008) 1.92
Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. J Neurosci (2003) 1.91
Distance, rurality and the need for care: access to health services in South West England. Int J Health Geogr (2004) 1.90
Glia: novel counter-regulators of opioid analgesia. Trends Neurosci (2005) 1.86
Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol (2003) 1.84
Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav Immun (2008) 1.82
Prior stressor exposure sensitizes LPS-induced cytokine production. Brain Behav Immun (2002) 1.82
Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A (2012) 1.80
Glial activation and pathological pain. Neurochem Int (2004) 1.80
Exposure to acute stress induces brain interleukin-1beta protein in the rat. J Neurosci (1998) 1.78
1,25-Dihydroxyvitamin D3 but not cinacalcet HCl (Sensipar/Mimpara) treatment mediates aortic calcification in a rat model of secondary hyperparathyroidism. Nephrol Dial Transplant (2005) 1.76
SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane. J Cell Biol (2004) 1.75
The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nat Struct Mol Biol (2009) 1.75
The role of the vagus nerve in cytokine-to-brain communication. Ann N Y Acad Sci (1998) 1.74
The immune system and memory consolidation: a role for the cytokine IL-1beta. Neurosci Biobehav Rev (2001) 1.74
Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10. Eur J Neurosci (2005) 1.73
Molecular biology of mosquito vitellogenesis: from basic studies to genetic engineering of antipathogen immunity. Insect Biochem Mol Biol (2002) 1.72
Genome-wide identification of in vivo Drosophila Engrailed-binding DNA fragments and related target genes. Development (2003) 1.70
Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor. Circ Res (2012) 1.69
Toll-like receptor 4 in CNS pathologies. J Neurochem (2010) 1.68
Electrical isolation of the superior vena cava: an adjunctive strategy to pulmonary vein antrum isolation improving the outcome of AF ablation. J Cardiovasc Electrophysiol (2007) 1.68
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun (2006) 1.67
Immune globulins and thrombotic adverse events as recorded in a large administrative database in 2008 through 2010. Transfusion (2012) 1.66
Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Mol Pain (2005) 1.66
Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev (2011) 1.66
Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain (2006) 1.66
A phase III equivalence trial of azithromycin versus benzathine penicillin for treatment of early syphilis. J Infect Dis (2010) 1.64
Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J Pharmacol Exp Ther (2003) 1.63