Differential transformation of mammary epithelial cells by Wnt genes.

PubWeight™: 2.37‹?› | Rank: Top 2%

🔗 View Article (PMC 359154)

Published in Mol Cell Biol on September 01, 1994

Authors

G T Wong1, B J Gavin, A P McMahon

Author Affiliations

1: Roche Institute of Molecular Biology, Nutley, New Jersey 07110.

Articles citing this

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 7.36

WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer (2013) 6.64

Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A (2000) 4.71

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev (1998) 4.51

WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci U S A (1998) 3.73

The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol (2003) 3.53

Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol (1998) 3.09

Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J Cell Biol (1996) 3.01

A Wnt survival guide: from flies to human disease. J Invest Dermatol (2009) 2.91

Signal transduction by the Wnt family of ligands. Biochem J (1998) 2.66

Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. Proc Natl Acad Sci U S A (2006) 2.60

Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol (2001) 2.52

Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos. Mol Cell Biol (1995) 2.21

Wnt-1 induces growth, cytosolic beta-catenin, and Tcf/Lef transcriptional activation in Rat-1 fibroblasts. Mol Cell Biol (1998) 1.98

SARPs: a family of secreted apoptosis-related proteins. Proc Natl Acad Sci U S A (1997) 1.84

WNT7a induces E-cadherin in lung cancer cells. Proc Natl Acad Sci U S A (2003) 1.78

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol (2002) 1.75

Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. J Cell Biol (2001) 1.59

When pathways collide: collaboration and connivance among signalling proteins in development. Nat Rev Mol Cell Biol (2010) 1.57

Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol (2008) 1.56

Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos. J Anat (2004) 1.55

Winding through the WNT pathway during cellular development and demise. Histol Histopathol (2006) 1.50

Wnt5a is essential for intestinal elongation in mice. Dev Biol (2008) 1.41

Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. Dev Biol (2012) 1.39

Differential inhibition of Wnt-3a by Sfrp-1, Sfrp-2, and Sfrp-3. Dev Dyn (2006) 1.38

Plakoglobin suppresses epithelial proliferation and hair growth in vivo. J Cell Biol (2000) 1.30

ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo. Mol Cell Biol (2009) 1.28

Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells. BMC Dev Biol (2003) 1.22

Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts. J Biol Chem (2012) 1.14

Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. Br J Cancer (1997) 1.13

Evolution of the Wnt pathways. Methods Mol Biol (2008) 1.13

Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis. J Immunol (2008) 1.11

Noncanonical Wnt signaling promotes apoptosis in thymocyte development. J Exp Med (2007) 1.10

Alternative Wnt pathways and receptors. Cold Spring Harb Perspect Biol (2012) 1.09

To beta or not to beta: canonical beta-catenin signaling pathway and ovarian development. Dev Dyn (2008) 1.09

Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex. J Cell Biol (2000) 1.05

Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling. Cold Spring Harb Perspect Biol (2012) 1.05

Wnt signaling pathways in urological cancers: past decades and still growing. Mol Cancer (2012) 1.03

Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin Cancer Res (2009) 1.03

Genomic insights into WNT/β-catenin signaling. Trends Pharmacol Sci (2013) 1.00

Loss of Wnt8b has no overt effect on hippocampus development but leads to altered Wnt gene expression levels in dorsomedial telencephalon. Dev Dyn (2010) 1.00

Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways. Annu Rev Pharmacol Toxicol (2011) 0.97

Small molecule antagonists of the Wnt/β-catenin signaling pathway target breast tumor-initiating cells in a Her2/Neu mouse model of breast cancer. PLoS One (2012) 0.96

WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer. Neoplasia (2013) 0.96

Identification of Wnt responsive genes using a murine mammary epithelial cell line model system. BMC Dev Biol (2004) 0.96

Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization. J Cell Biochem (2013) 0.94

Wnt signalling via the epidermal growth factor receptor: a role in breast cancer? Breast Cancer Res (2003) 0.93

The Wnt-dependent signaling pathways as target in oncology drug discovery. Invest New Drugs (2006) 0.93

High expression of Wnt7b in human superficial bladder cancer vs invasive bladder cancer. Br J Cancer (1998) 0.92

Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain. Neural Dev (2009) 0.92

Activation of intracellular calcium by multiple Wnt ligands and translocation of β-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/β-catenin pathways. J Biol Chem (2013) 0.92

A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration. Cell Tissue Res (2014) 0.91

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways. J Bone Miner Res (2015) 0.90

WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis. Oncotarget (2015) 0.89

Wnts in adult brain: from synaptic plasticity to cognitive deficiencies. Front Cell Neurosci (2013) 0.88

Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther (2010) 0.87

Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation. J Neuroinflammation (2012) 0.86

Challenging role of Wnt5a and its signaling pathway in cancer metastasis (Review). Exp Ther Med (2014) 0.86

Canonical WNT signaling inhibits follicle stimulating hormone mediated steroidogenesis in primary cultures of rat granulosa cells. PLoS One (2014) 0.85

Wnt4 is not sufficient to induce lobuloalveolar mammary development. BMC Dev Biol (2009) 0.85

WNT5A expression in ameloblastoma and its roles in regulating enamel epithelium tumorigenic behaviors. Am J Pathol (2009) 0.85

The p53 transcriptional target gene wnt7b contributes to NGF-inducible neurite outgrowth in neuronal PC12 cells. Differentiation (2008) 0.83

The roles of Wnt5a, JNK and paxillin in the occurrence of metastasis of pancreatic adenocarcinoma. Int J Clin Oncol (2013) 0.82

Frizzled 7 maintains the undifferentiated state of human limbal stem/progenitor cells. Stem Cells (2014) 0.81

AurkA controls self-renewal of breast cancer-initiating cells promoting wnt3a stabilization through suppression of miR-128. Sci Rep (2016) 0.79

The role of WNT signaling in adult ovarian folliculogenesis. Reproduction (2015) 0.78

Upregulation of the expression of Wnt5a promotes the proliferation of pancreatic cancer cells in vitro and in a nude mouse model. Mol Med Rep (2015) 0.77

The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the arm-like domain-containing protein Alex3. PLoS One (2013) 0.77

Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling. J Cell Biol (2016) 0.75

Molecular mechanisms of asymmetric divisions in mammary stem cells. EMBO Rep (2016) 0.75

4-HPR impairs bladder cancer cell migration and invasion by interfering with the Wnt5a/JNK and Wnt5a/MMP-2 signaling pathways. Oncol Lett (2016) 0.75

Multiple Roles of WNT5A in Breast Cancer. Med Sci Monit (2016) 0.75

Articles cited by this

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19

Mutations affecting segment number and polarity in Drosophila. Nature (1980) 18.72

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell (1991) 14.89

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell (1982) 9.29

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell (1988) 6.48

Cadherins: a molecular family important in selective cell-cell adhesion. Annu Rev Biochem (1990) 6.13

A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Science (1991) 5.71

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature (1984) 5.53

Wnt genes. Cell (1992) 4.55

Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell (1990) 4.05

TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell (1990) 3.86

The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell (1987) 3.78

Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. Cell (1989) 3.42

Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules. Eur J Cell Biol (1990) 2.77

Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell (1991) 2.75

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. Cell (1991) 2.72

Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. Cell (1990) 2.63

Distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell communication. Cell (1989) 2.61

Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis. Development (1993) 2.58

p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. Oncogene (1992) 2.49

Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact. Cell (1984) 2.44

A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line. Cell (1986) 2.32

The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix. EMBO J (1990) 2.25

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev (1990) 1.97

Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain. Proc Natl Acad Sci U S A (1990) 1.94

Secreted int-1 protein is associated with the cell surface. Mol Cell Biol (1990) 1.88

Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. Mol Cell Biol (1992) 1.88

The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Mol Cell Biol (1992) 1.75

Demonstration of an adhering-junction molecule (plakoglobin) in the autoantigens of pemphigus foliaceus and pemphigus vulgaris. N Engl J Med (1989) 1.72

Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity. EMBO J (1987) 1.69

Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO J (1988) 1.67

TGF-beta 1-induced inhibition of mouse mammary ductal growth: developmental specificity and characterization. Dev Biol (1989) 1.67

Murine mammary tumor virus (MuMTV) infection of an epithelial cell line established from C57BL/6 mouse mammary glands. Virology (1978) 1.54

Secretion and movement of wingless protein in the epidermis of the Drosophila embryo. Mech Dev (1991) 1.52

The development of wingless, a homeotic mutation of Drosophila. Dev Biol (1977) 1.51

Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis. Cell (1987) 1.48

Overlapping expression of Xwnt-3A and Xwnt-1 in neural tissue of Xenopus laevis embryos. Dev Biol (1993) 1.45

Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line. Mol Biol Cell (1992) 1.39

The biochemical properties and transforming potential of human Wnt-2 are similar to Wnt-1. Oncogene (1992) 1.36

Epidermal growth factor requirement for development of cultured mammary gland. Nature (1980) 1.26

Desmoglein shows extensive homology to the cadherin family of cell adhesion molecules. Biochem Biophys Res Commun (1990) 1.24

Epidermal growth factor stimulates cell proliferation and inhibits functional differentiation of mouse mammary epithelial cells in culture. Endocrinology (1983) 1.23

Localization and quantification of Wnt-2 gene expression in mouse mammary development. Dev Biol (1993) 1.16

Local effects of EGF, alpha-TGF, and EGF-like growth factors on lobuloalveolar development of the mouse mammary gland in vivo. J Cell Physiol (1987) 1.15

Changes in insulin responsiveness during development of mammary epithelium. J Cell Biol (1974) 1.06

The segment polarity phenotype of Drosophila involves differential tendencies toward transformation and cell death. Dev Biol (1989) 1.05

Hyperplasia of mouse mammary epithelium induced by expression of the Wnt-1 (int-1) oncogene in reconstituted mammary gland. Oncogene (1992) 1.03

Analysis of Xwnt-4 in embryos of Xenopus laevis: a Wnt family member expressed in the brain and floor plate. Development (1992) 1.03

Insulin is essential for accumulation of casein mRNA in mouse mammary epithelial cells. Proc Natl Acad Sci U S A (1981) 1.02

Growth control and differentiation in mammary epithelial cells. Environ Health Perspect (1989) 0.99

Inhibition of mouse mammary ductal morphogenesis and down-regulation of the EGF receptor by epidermal growth factor. Dev Biol (1990) 0.96

Changes in Scatchard plots for insulin binding to mammary epithelial cells from cycling, pregnant, and lactating mice. Endocrinology (1982) 0.83

Articles by these authors

(truncated to the top 100)

Hedgehog signaling in animal development: paradigms and principles. Genes Dev (2001) 14.75

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol (1998) 10.58

Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development (2001) 9.00

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev (1999) 8.43

Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development (2000) 8.07

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41

Fate of the mammalian cardiac neural crest. Development (2000) 6.79

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature (1994) 6.57

Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science (2003) 6.35

A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85

Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58

Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol (1995) 5.36

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development (2001) 4.89

Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science (1998) 4.72

Sonic hedgehog regulates growth and morphogenesis of the tooth. Development (2000) 4.71

Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron (2000) 4.17

Female development in mammals is regulated by Wnt-4 signalling. Nature (1999) 4.13

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature (1999) 3.87

Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev (1994) 3.77

Hedgehog signals regulate multiple aspects of gastrointestinal development. Development (2000) 3.77

Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development (1993) 3.66

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46

Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30

Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol (1998) 3.29

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell (1987) 3.29

T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev (1999) 3.13

Wnt signalling required for expansion of neural crest and CNS progenitors. Nature (1997) 3.11

Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99

Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature (1996) 2.98

Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development (1998) 2.90

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell (2001) 2.84

The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature (2000) 2.78

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell (1998) 2.77

A local Wnt-3a signal is required for development of the mammalian hippocampus. Development (2000) 2.75

Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature (1995) 2.73

Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development (1994) 2.73

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature (1999) 2.69

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell (2001) 2.65

Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol (1996) 2.59

The world according to hedgehog. Trends Genet (1997) 2.52

Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron (1999) 2.50

Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest (2001) 2.49

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature (1995) 2.46

A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. Development (1987) 2.44

Regulation of pancreas development by hedgehog signaling. Development (2000) 2.43

Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development (2000) 2.39

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development (2001) 2.37

Introduction of cloned DNA into sea urchin egg cytoplasm: replication and persistence during embryogenesis. Dev Biol (1985) 2.23

Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev (1995) 2.22

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse. EMBO J (1988) 2.08

The zebrafish organizer requires chordino. Nature (1997) 2.06

Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev (1998) 2.02

Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci (1999) 2.02

Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol (1997) 2.02

Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development (1991) 2.02

Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development (1996) 1.99

Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development (1992) 1.99

The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol (2001) 1.98

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev (1990) 1.97

Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev (1996) 1.94

Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature (1998) 1.94

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev (1996) 1.92

Wnt5 is required for tail formation in the zebrafish embryo. Cold Spring Harb Symp Quant Biol (1997) 1.91

Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature (1996) 1.91

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell (2001) 1.88

Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. Mol Cell Biol (1992) 1.88

Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol (2001) 1.77

Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol (1998) 1.73

Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res (1994) 1.72

Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor. Genes Dev (1996) 1.65

Hedgehog signaling is required for pituitary gland development. Development (2001) 1.62

Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development. Development (1989) 1.60

GDNF induces branching and increased cell proliferation in the ureter of the mouse. Dev Biol (1997) 1.56

Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development (1996) 1.55

Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Development (1997) 1.54

Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms. Development (1999) 1.52

Persistence and integration of cloned DNA in postembryonic sea urchins. Dev Biol (1985) 1.50

Proteolytic processing yields two secreted forms of sonic hedgehog. Mol Cell Biol (1995) 1.50

Wnt-1-dependent regulation of local E-cadherin and alpha N-catenin expression in the embryonic mouse brain. Development (1994) 1.45

Wnt family proteins are secreted and associated with the cell surface. Mol Biol Cell (1993) 1.43

A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling. Development (2000) 1.41

Negative feedback mechanisms and their roles during pattern formation. Cell (1999) 1.37

Wnt7b regulates placental development in mice. Dev Biol (2001) 1.37

Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development (1995) 1.36

Wnt genes and vertebrate development. Curr Opin Genet Dev (1994) 1.35

Wnt expression patterns in chick embryo nervous system. Mech Dev (1995) 1.33

Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development (1994) 1.27

Transcriptional analysis of minute virus of mice P4 promoter mutants. J Virol (1989) 1.27

FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse. Development (1991) 1.25

Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence that governs Wnt-1 expression in the murine neural plate. Development (1998) 1.17

Dorsalization of the neural tube by the non-neural ectoderm. Development (1995) 1.16

The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in hedgehog signaling. Dev Biol (1998) 1.15

Biochemical analysis of murine Wnt proteins reveals both shared and distinct properties. Exp Cell Res (1995) 1.15

Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein. Nat Med (1995) 1.14

Inducible expression of a cloned heat shock fusion gene in sea urchin embryos. Proc Natl Acad Sci U S A (1984) 1.10

A single homeodomain binding site restricts spatial expression of Wnt-1 in the developing brain. Mech Dev (1995) 1.10

Separation of mouse testis cells on a Celsep (TM) apparatus and their usefulness as a source of high molecular weight DNA or RNA. Gamete Res (1985) 1.10

Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin. J Biol Chem (1990) 1.08

Recent advances in hedgehog signalling. Trends Cell Biol (1997) 1.08

cDNA cloning, sequencing and chromosome mapping of a non-erythroid spectrin, human alpha-fodrin. Differentiation (1987) 1.08