Published in Mol Microbiol on July 01, 2003
Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. Mol Microbiol (2007) 3.47
The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA. RNA (2007) 1.60
Avoidance of suicide in antibiotic-producing microbes. J Ind Microbiol Biotechnol (2010) 1.01
Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain. Antimicrob Agents Chemother (2011) 0.98
Identification of RNA molecules by specific enzyme digestion and mass spectrometry: software for and implementation of RNA mass mapping. Nucleic Acids Res (2009) 0.89
Bioactive oligosaccharide natural products. Nat Prod Rep (2014) 0.89
The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process. J Biol Chem (2013) 0.86
Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A. Appl Environ Microbiol (2005) 0.82
Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. Proc Natl Acad Sci U S A (2016) 0.77
Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding. Proc Natl Acad Sci U S A (2016) 0.75
The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics. Antimicrob Agents Chemother (2006) 3.94
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science (2006) 3.87
The bacterial ribosome as a target for antibiotics. Nat Rev Microbiol (2005) 3.27
A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Mol Microbiol (2005) 2.89
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat Prod Rep (2006) 2.25
Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs. Mol Cell (2006) 2.15
Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates. Mol Microbiol (2004) 2.01
YebU is a m5C methyltransferase specific for 16 S rRNA nucleotide 1407. J Mol Biol (2006) 1.72
Resistance to linezolid caused by modifications at its binding site on the ribosome. Antimicrob Agents Chemother (2011) 1.70
A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. Chem Biol (2013) 1.59
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nat Commun (2011) 1.52
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding. Mol Cell Biol (2010) 1.51
Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria. Nucleic Acids Res (2009) 1.38
A novel partial modification at C2501 in Escherichia coli 23S ribosomal RNA. RNA (2004) 1.33
Resistance to the peptidyl transferase inhibitor tiamulin caused by mutation of ribosomal protein l3. Antimicrob Agents Chemother (2003) 1.32
Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA. Antimicrob Agents Chemother (2002) 1.32
YgdE is the 2'-O-ribose methyltransferase RlmM specific for nucleotide C2498 in bacterial 23S rRNA. Mol Microbiol (2009) 1.30
Identifying modifications in RNA by MALDI mass spectrometry. Methods Enzymol (2007) 1.30
Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin. J Mol Biol (2007) 1.28
The ketolides: a critical review. Drugs (2002) 1.27
YccW is the m5C methyltransferase specific for 23S rRNA nucleotide 1962. J Mol Biol (2008) 1.26
Detection of pseudouridine and other modifications in tRNA by cyanoethylation and MALDI mass spectrometry. Nucleic Acids Res (2002) 1.23
Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometry. Nucleic Acids Res (2003) 1.22
Modifications in Thermus thermophilus 23 S ribosomal RNA are centered in regions of RNA-RNA contact. J Biol Chem (2006) 1.22
Association of the novel aminoglycoside resistance determinant RmtF with NDM carbapenemase in Enterobacteriaceae isolated in India and the UK. J Antimicrob Chemother (2013) 1.20
Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. J Bacteriol (2006) 1.19
Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. Proc Natl Acad Sci U S A (2002) 1.18
YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA. RNA (2008) 1.15
A genomic screening approach to the structure-guided identification of drug candidates from natural sources. Chembiochem (2007) 1.13
The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers. Angew Chem Int Ed Engl (2004) 1.13
The structural basis of macrolide-ribosome binding assessed using mutagenesis of 23S rRNA positions 2058 and 2059. J Mol Biol (2004) 1.12
Interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center. Antimicrob Agents Chemother (2006) 1.12
LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage. J Am Chem Soc (2002) 1.11
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. J Mol Biol (2005) 1.10
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives. Chem Biol (2006) 1.06
The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene. Antimicrob Agents Chemother (2012) 1.05
Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem Biol (2002) 1.05
Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket. Mol Microbiol (2009) 1.05
Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. FEMS Microbiol Lett (2008) 1.05
Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem (2009) 1.04
Ketolide resistance in Streptococcus pyogenes correlates with the degree of rRNA dimethylation by Erm. Mol Microbiol (2005) 1.04
Enzymatic incorporation of LNA nucleotides into DNA strands. Chembiochem (2007) 1.03
Macrolide antibiotic interaction and resistance on the bacterial ribosome. Curr Opin Investig Drugs (2003) 1.02
Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes. J Mol Biol (2008) 1.02
Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A. Chem Biol (2005) 1.01
Identification of 5-hydroxycytidine at position 2501 concludes characterization of modified nucleotides in E. coli 23S rRNA. J Mol Biol (2011) 1.01
Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides. Mol Biosyst (2005) 1.01
The archaeon Haloarcula marismortui has few modifications in the central parts of its 23S ribosomal RNA. J Mol Biol (2005) 1.00
Identification of the RsmG methyltransferase target as 16S rRNA nucleotide G527 and characterization of Bacillus subtilis rsmG mutants. J Bacteriol (2007) 1.00
The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain. J Mol Biol (2006) 1.00
Glycosyltransferases, important tools for drug design. Curr Top Med Chem (2008) 0.99
Generation of novel landomycins M and O through targeted gene disruption. Chembiochem (2005) 0.99
Methyltransferase Erm(37) slips on rRNA to confer atypical resistance in Mycobacterium tuberculosis. J Biol Chem (2005) 0.99
YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors. RNA (2010) 0.99
Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain. Antimicrob Agents Chemother (2011) 0.98
Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates. J Am Chem Soc (2008) 0.97
Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA. Antimicrob Agents Chemother (2004) 0.97
Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern. Curr Top Med Chem (2008) 0.96
Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717. Chembiochem (2003) 0.96
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. J Am Chem Soc (2002) 0.96
Recognition of guanosine by dissimilar tRNA methyltransferases. RNA (2012) 0.96
Genes and enzymes involved in bacterial isoprenoid biosynthesis. Curr Opin Chem Biol (2009) 0.96
Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. Antimicrob Agents Chemother (2010) 0.96
Archease from Pyrococcus abyssi improves substrate specificity and solubility of a tRNA m5C methyltransferase. J Biol Chem (2007) 0.95
Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using red/ET recombineering. Chembiochem (2008) 0.94
The aminoglycoside resistance methyltransferase Sgm impedes RsmF methylation at an adjacent rRNA nucleotide in the ribosomal A site. RNA (2009) 0.94
Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase. Org Biomol Chem (2009) 0.94
Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer. Nucleic Acids Res (2010) 0.94
A single methyltransferase YefA (RlmCD) catalyses both m5U747 and m5U1939 modifications in Bacillus subtilis 23S rRNA. Nucleic Acids Res (2011) 0.94
Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII. EMBO J (2003) 0.93
Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase. Antimicrob Agents Chemother (2013) 0.93
Functional expression of the Cre recombinase in actinomycetes. Appl Microbiol Biotechnol (2008) 0.93
A novel Erm monomethyltransferase in antibiotic-resistant isolates of Mannheimia haemolytica and Pasteurella multocida. Mol Microbiol (2011) 0.93
Mutations in conserved helix 69 of 23S rRNA of Thermus thermophilus that affect capreomycin resistance but not posttranscriptional modifications. J Bacteriol (2008) 0.93
Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. RNA (2010) 0.92
A bacterial glycosyltransferase gene toolbox: generation and applications. Phytochemistry (2009) 0.92
Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136. Chembiochem (2007) 0.92
RNA fragmentation in MALDI mass spectrometry studied by H/D-exchange: mechanisms of general applicability to nucleic acids. J Am Soc Mass Spectrom (2006) 0.92
Site-specific recombination strategies for engineering actinomycete genomes. Appl Environ Microbiol (2012) 0.92
Marker removal from actinomycetes genome using Flp recombinase. Gene (2008) 0.91
The macrolide binding site on the bacterial ribosome. Curr Drug Targets Infect Disord (2002) 0.90
Features and applications of bacterial glycosyltransferases: current state and prospects. Appl Microbiol Biotechnol (2008) 0.90
3-(3-amino-3-carboxypropyl)-5,6-dihydrouridine is one of two novel post-transcriptional modifications in tRNALys(UUU) from Trypanosoma brucei. FEBS J (2011) 0.90
Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis. Chembiochem (2004) 0.90
Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria. Mol Microbiol (2002) 0.90
Aptamers as a model for functional evaluation of LNA and 2'-amino LNA. Bioorg Med Chem Lett (2009) 0.90
Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. Chembiochem (2007) 0.89
On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2). Angew Chem Int Ed Engl (2006) 0.89
LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis. Chembiochem (2005) 0.89
Identification of RNA molecules by specific enzyme digestion and mass spectrometry: software for and implementation of RNA mass mapping. Nucleic Acids Res (2009) 0.89
Capreomycin susceptibility is increased by TlyA-directed 2'-O-methylation on both ribosomal subunits. Mol Microbiol (2012) 0.88
In vitro incorporation of LNA nucleotides. Nucleosides Nucleotides Nucleic Acids (2007) 0.88