Published in Chem Biol on July 01, 2005
Natural products version 2.0: connecting genes to molecules. J Am Chem Soc (2010) 3.06
Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens. Antimicrob Agents Chemother (2006) 1.14
A comprehensive review of glycosylated bacterial natural products. Chem Soc Rev (2015) 1.13
Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway. Proc Natl Acad Sci U S A (2014) 1.01
Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136. J Nat Prod (2010) 0.92
Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136. Chembiochem (2007) 0.92
On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2). Angew Chem Int Ed Engl (2006) 0.89
Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin. Angew Chem Int Ed Engl (2012) 0.87
Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology. Curr Opin Chem Biol (2012) 0.83
Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.75
Cloning and Heterologous Expression of the Grecocycline Biosynthetic Gene Cluster. PLoS One (2016) 0.75
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat Prod Rep (2006) 2.25
A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. Chem Biol (2013) 1.59
Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin. J Mol Biol (2007) 1.28
Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. J Bacteriol (2006) 1.19
A genomic screening approach to the structure-guided identification of drug candidates from natural sources. Chembiochem (2007) 1.13
The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers. Angew Chem Int Ed Engl (2004) 1.13
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. J Mol Biol (2005) 1.10
Biosynthesis of actinorhodin and related antibiotics: discovery of alternative routes for quinone formation encoded in the act gene cluster. Chem Biol (2009) 1.07
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives. Chem Biol (2006) 1.06
Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. FEMS Microbiol Lett (2008) 1.05
Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem Biol (2002) 1.05
Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem (2009) 1.04
Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides. Mol Biosyst (2005) 1.01
Glycosyltransferases, important tools for drug design. Curr Top Med Chem (2008) 0.99
Generation of novel landomycins M and O through targeted gene disruption. Chembiochem (2005) 0.99
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. Mol Microbiol (2003) 0.98
Genes and enzymes involved in bacterial isoprenoid biosynthesis. Curr Opin Chem Biol (2009) 0.96
Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717. Chembiochem (2003) 0.96
Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern. Curr Top Med Chem (2008) 0.96
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. J Am Chem Soc (2002) 0.96
Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using red/ET recombineering. Chembiochem (2008) 0.94
Functional expression of the Cre recombinase in actinomycetes. Appl Microbiol Biotechnol (2008) 0.93
Isolation of 8'-phosphate ester derivatives of amicoumacins: structure-activity relationship of hydroxy amino acid moiety. J Antibiot (Tokyo) (2007) 0.93
A bacterial glycosyltransferase gene toolbox: generation and applications. Phytochemistry (2009) 0.92
Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136. Chembiochem (2007) 0.92
Site-specific recombination strategies for engineering actinomycete genomes. Appl Environ Microbiol (2012) 0.92
Marker removal from actinomycetes genome using Flp recombinase. Gene (2008) 0.91
Features and applications of bacterial glycosyltransferases: current state and prospects. Appl Microbiol Biotechnol (2008) 0.90
Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis. Chembiochem (2004) 0.90
On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2). Angew Chem Int Ed Engl (2006) 0.89
Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. Chembiochem (2007) 0.89
Biosynthesis of pyranonaphthoquinone polyketides reveals diverse strategies for enzymatic carbon-carbon bond formation. Curr Opin Chem Biol (2013) 0.89
LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis. Chembiochem (2005) 0.89
LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis. Chembiochem (2005) 0.88
The future of natural products as a source of new antibiotics. Curr Opin Investig Drugs (2007) 0.87
Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biol (2013) 0.87
Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae. BMC Genomics (2014) 0.86
The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses. J Am Chem Soc (2003) 0.86
Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase. Chem Biol (2011) 0.86
Chapter 12. The power of glycosyltransferases to generate bioactive natural compounds. Methods Enzymol (2009) 0.86
Function of lanI in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies with Streptomyces antibiotic regulatory proteins encoding genes. Arch Microbiol (2007) 0.85
Differences in the substrate specificity of glycosyltransferases involved in landomycins A and E biosynthesis. Appl Microbiol Biotechnol (2009) 0.85
Actinorhodin biosynthesis: structural requirements for post-PKS tailoring intermediates revealed by functional analysis of ActVI-ORF1 reductase. Biochemistry (2007) 0.85
Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene. FEMS Microbiol Lett (2004) 0.84
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains. Chembiochem (2009) 0.84
Engineering a function into a glycosyltransferase. Chem Biol (2009) 0.83
It works: combinatorial biosynthesis for generating novel glycosylated compounds. Mol Microbiol (2005) 0.82
Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. J Mol Biol (2003) 0.82
Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A. Appl Environ Microbiol (2005) 0.82
Genes encoding enzymes responsible for biosynthesis of L-lyxose and attachment of eurekanate during avilamycin biosynthesis. Chem Biol (2005) 0.81
Development of intergeneric conjugal gene transfer system in Streptomyces diastatochromogenes 1628 and its application for improvement of toyocamycin production. Curr Microbiol (2013) 0.81
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis. Appl Microbiol Biotechnol (2007) 0.81
Novel avilamycin derivatives with improved polarity generated by targeted gene disruption. Chem Biol (2004) 0.81
Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and it's initial characterization. J Antibiot (Tokyo) (2004) 0.81
Functional studies on a ketoreductase gene from Streptomyces sp. AM-7161 to control the stereochemistry in medermycin biosynthesis. Bioorg Med Chem (2005) 0.81
A transposon-based strategy to identify the regulatory gene network responsible for landomycin E biosynthesis. FEMS Microbiol Lett (2013) 0.80
Rational saccharide extension by using the natural product glycosyltransferase LanGT4. Chembiochem (2004) 0.80
Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae. BMC Genomics (2012) 0.80
Overexpression of ribosome recycling factor is responsible for improvement of nucleotide antibiotic-toyocamycin in Streptomyces diastatochromogenes 1628. Appl Microbiol Biotechnol (2014) 0.79
SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors. AMB Express (2012) 0.79
Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tü117. Appl Microbiol Biotechnol (2009) 0.78
SorF: a glycosyltransferase with promiscuous donor substrate specificity in vitro. Chembiochem (2007) 0.78
The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme. J Biol Chem (2006) 0.78
Genome sequence of Streptomyces sp. strain Tü6071. J Bacteriol (2011) 0.78
Preventive effect of Kaempferia parviflora ethyl acetate extract and its major components polymethoxyflavonoid on metabolic diseases. Fitoterapia (2011) 0.78
Novel natural compounds obtained by genome-based screening and genetic engineering. Curr Opin Drug Discov Devel (2005) 0.78
Chemoenzymatic and bioenzymatic synthesis of carbohydrate containing natural products. Top Curr Chem (2010) 0.78
A putative proteinase gene is involved in regulation of landomycin E biosynthesis in Streptomyces globisporus 1912. FEMS Microbiol Lett (2006) 0.77
Distinct intraspecific variations of garlic (Allium sativum L.) revealed by the exon-intron sequences of the alliinase gene. J Nat Med (2013) 0.77
Insights into the bioactivity of mensacarcin and epoxide formation by MsnO8. Chembiochem (2014) 0.77
Combinatorial and synthetic biosynthesis in actinomycetes. Fortschr Chem Org Naturst (2010) 0.76
Cloning and heterologous expression of three type II PKS gene clusters from Streptomyces bottropensis. Chembiochem (2011) 0.76
Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity. Appl Microbiol Biotechnol (2008) 0.76
Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2. Angew Chem Int Ed Engl (2015) 0.75
Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis. Appl Environ Microbiol (2013) 0.75
Functions of genes and enzymes involved in phenalinolactone biosynthesis. Chembiochem (2010) 0.75
Design, Synthesis, Biological Evaluation, and Antioxidant and Cytotoxic Activity of Heteroatom-Substituted 1,4-Naphtho- and Benzoquinones. Chem Pharm Bull (Tokyo) (2015) 0.75
Enantioselective reduction of beta-keto acids with engineered Streptomyces coelicolor. Angew Chem Int Ed Engl (2005) 0.75
Synthesis and microbiological evaluation of new 2- and 2,3-diphenoxysubstituted naphthalene-1,4-diones with 5-oxopyrrolidine moieties. Molecules (2012) 0.75
Synthesis and biological evaluation of novel nitrogen- and sulfur-containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. Eur J Med Chem (2011) 0.75
Production of avilamycin A is regulated by AviC1 and AviC2, two transcriptional activators. J Antibiot (Tokyo) (2009) 0.75