Published in J Mol Biol on January 21, 2005
Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases. BMC Bioinformatics (2007) 1.74
Exploring knotting mechanisms in protein folding. Proc Natl Acad Sci U S A (2008) 1.28
The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase. Nucleic Acids Res (2010) 1.16
Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis. BMC Evol Biol (2006) 1.12
pKNOT: the protein KNOT web server. Nucleic Acids Res (2007) 1.08
The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site. Nucleic Acids Res (2008) 1.06
The yfhQ gene of Escherichia coli encodes a tRNA:Cm32/Um32 methyltransferase. BMC Mol Biol (2006) 1.00
Structure of the thiostrepton resistance methyltransferase.S-adenosyl-L-methionine complex and its interaction with ribosomal RNA. J Biol Chem (2009) 0.96
Flexible recognition of the tRNA G18 methylation target site by TrmH methyltransferase through first binding and induced fit processes. J Biol Chem (2010) 0.96
Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.89
The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process. J Biol Chem (2013) 0.86
Binding induced RNA conformational changes control substrate recognition and catalysis by the thiostrepton resistance methyltransferase (Tsr). J Biol Chem (2014) 0.79
Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding. Proc Natl Acad Sci U S A (2016) 0.75
Subcellular localization and RNA interference of an RNA methyltransferase gene from silkworm, Bombyx mori. Comp Funct Genomics (2008) 0.75
Functional roles in S-adenosyl-l-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase. FEBS Lett (2015) 0.75
Crystallization and preliminary crystallographic analysis of nosiheptide-resistance methyltransferase from Streptomyces actuosus in complex with SAM. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.75
The structure of a mycobacterial outer-membrane channel. Science (2004) 2.56
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat Prod Rep (2006) 2.25
Designed protein-protein association. Science (2008) 2.16
The structure of a retinal-forming carotenoid oxygenase. Science (2005) 2.03
Conversion of squalene to the pentacarbocyclic hopene. Chem Biol (2004) 1.72
Binding structure of elastase inhibitor scyptolin A. Chem Biol (2003) 1.71
A binuclear manganese cluster that catalyzes radical-mediated N-oxygenation. Angew Chem Int Ed Engl (2007) 1.69
A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. Chem Biol (2013) 1.59
Self-assembly of proteins into designed networks. Science (2003) 1.53
Structural basis for the function of Clostridium difficile toxin B. J Mol Biol (2005) 1.46
Crystal structure of ethylbenzene dehydrogenase from Aromatoleum aromaticum. Structure (2006) 1.41
Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin. J Mol Biol (2007) 1.28
Structural basis for the entrance into the phenylpropanoid metabolism catalyzed by phenylalanine ammonia-lyase. Plant Cell (2004) 1.22
Structure and action of the binary C2 toxin from Clostridium botulinum. J Mol Biol (2006) 1.20
Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. J Bacteriol (2006) 1.19
Structure and action of the N-oxygenase AurF from Streptomyces thioluteus. J Mol Biol (2007) 1.14
A genomic screening approach to the structure-guided identification of drug candidates from natural sources. Chembiochem (2007) 1.13
The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers. Angew Chem Int Ed Engl (2004) 1.13
Conformational changes and reaction of clostridial glycosylating toxins. J Mol Biol (2008) 1.10
Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba. Biochemistry (2006) 1.09
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives. Chem Biol (2006) 1.06
Autocatalytic peptide cyclization during chain folding of histidine ammonia-lyase. Structure (2002) 1.06
Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem Biol (2002) 1.05
Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. FEMS Microbiol Lett (2008) 1.05
Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat. J Mol Biol (2002) 1.05
Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem (2009) 1.04
Structure and mechanism of the ThDP-dependent benzaldehyde lyase from Pseudomonas fluorescens. FEBS J (2005) 1.01
Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A. Chem Biol (2005) 1.01
Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides. Mol Biosyst (2005) 1.01
The expression of outer membrane proteins for crystallization. Biochim Biophys Acta (2003) 1.00
Preprotein translocase of the outer mitochondrial membrane: reconstituted Tom40 forms a characteristic TOM pore. J Mol Biol (2005) 1.00
Glycosyltransferases, important tools for drug design. Curr Top Med Chem (2008) 0.99
Generation of novel landomycins M and O through targeted gene disruption. Chembiochem (2005) 0.99
Structure and reaction mechanism of L-rhamnulose kinase from Escherichia coli. J Mol Biol (2006) 0.98
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. Mol Microbiol (2003) 0.98
Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells. J Biol Chem (2004) 0.97
Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern. Curr Top Med Chem (2008) 0.96
Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717. Chembiochem (2003) 0.96
Genes and enzymes involved in bacterial isoprenoid biosynthesis. Curr Opin Chem Biol (2009) 0.96
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. J Am Chem Soc (2002) 0.96
Structure of the O-acetylserine sulfhydrylase isoenzyme CysM from Escherichia coli. Biochemistry (2005) 0.95
Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using red/ET recombineering. Chembiochem (2008) 0.94
Structure of a type II thymidine kinase with bound dTTP. FEBS Lett (2005) 0.93
Functional expression of the Cre recombinase in actinomycetes. Appl Microbiol Biotechnol (2008) 0.93
Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136. Chembiochem (2007) 0.92
A bacterial glycosyltransferase gene toolbox: generation and applications. Phytochemistry (2009) 0.92
Crystal structure of 6-hydroxy-D-nicotine oxidase from Arthrobacter nicotinovorans. J Mol Biol (2005) 0.92
Structure and catalytic mechanism of L-rhamnulose-1-phosphate aldolase. Biochemistry (2003) 0.92
Site-specific recombination strategies for engineering actinomycete genomes. Appl Environ Microbiol (2012) 0.92
Marker removal from actinomycetes genome using Flp recombinase. Gene (2008) 0.91
Structure and mode of action of a mosquitocidal holotoxin. J Mol Biol (2008) 0.90
Structure and action of the myxobacterial chondrochloren halogenase CndH: a new variant of FAD-dependent halogenases. J Mol Biol (2008) 0.90
Features and applications of bacterial glycosyltransferases: current state and prospects. Appl Microbiol Biotechnol (2008) 0.90
Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis. Chembiochem (2004) 0.90
Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. Chembiochem (2007) 0.89
On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2). Angew Chem Int Ed Engl (2006) 0.89
Reaction geometry and thermostable variant of pyranose 2-oxidase from the white-rot fungus Peniophora sp. Biochemistry (2006) 0.89
LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis. Chembiochem (2005) 0.89
A putative alpha-helical porin from Corynebacterium glutamicum. J Mol Biol (2008) 0.89
LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis. Chembiochem (2005) 0.88
The future of natural products as a source of new antibiotics. Curr Opin Investig Drugs (2007) 0.87
Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biol (2013) 0.87
Crystal structure of pyranose 2-oxidase from the white-rot fungus Peniophora sp. Biochemistry (2004) 0.87
Binding structure of the leucine aminopeptidase inhibitor microginin FR1. FEBS Lett (2006) 0.86
Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae. BMC Genomics (2014) 0.86
Substrate binding and catalysis of ecto-ADP-ribosyltransferase 2.2 from rat. Biochemistry (2003) 0.86
Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase. Chem Biol (2011) 0.86
Chapter 12. The power of glycosyltransferases to generate bioactive natural compounds. Methods Enzymol (2009) 0.86
Structure of 2,6-dihydroxypyridine 3-hydroxylase from a nicotine-degrading pathway. J Mol Biol (2008) 0.86
The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses. J Am Chem Soc (2003) 0.86
Structure and action of urocanase. J Mol Biol (2004) 0.86
Function of lanI in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies with Streptomyces antibiotic regulatory proteins encoding genes. Arch Microbiol (2007) 0.85
Structure of the mosquitocidal toxin from Bacillus sphaericus. J Mol Biol (2006) 0.85
Change of the donor substrate specificity of Clostridium difficile toxin B by site-directed mutagenesis. J Biol Chem (2005) 0.85
Differences in the substrate specificity of glycosyltransferases involved in landomycins A and E biosynthesis. Appl Microbiol Biotechnol (2009) 0.85
The structure of L-rhamnulose-1-phosphate aldolase (class II) solved by low-resolution SIR phasing and 20-fold NCS averaging. Acta Crystallogr D Biol Crystallogr (2002) 0.85
Catalytic mechanism of CMP:2-keto-3-deoxy-manno-octonic acid synthetase as derived from complexes with reaction educt and product. Biochemistry (2002) 0.84
Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene. FEMS Microbiol Lett (2004) 0.84
Structures of two histidine ammonia-lyase modifications and implications for the catalytic mechanism. Eur J Biochem (2002) 0.84
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains. Chembiochem (2009) 0.84
Covalent and three-dimensional structure of the cyclodextrinase from Flavobacterium sp. no. 92. Eur J Biochem (2003) 0.83
Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase. J Med Chem (2003) 0.83
Engineering a function into a glycosyltransferase. Chem Biol (2009) 0.83
Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. J Mol Biol (2003) 0.82
Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A. Appl Environ Microbiol (2005) 0.82
It works: combinatorial biosynthesis for generating novel glycosylated compounds. Mol Microbiol (2005) 0.82
Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine. FEBS Lett (2008) 0.82
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis. Appl Microbiol Biotechnol (2007) 0.81
Genes encoding enzymes responsible for biosynthesis of L-lyxose and attachment of eurekanate during avilamycin biosynthesis. Chem Biol (2005) 0.81
Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and it's initial characterization. J Antibiot (Tokyo) (2004) 0.81
Novel avilamycin derivatives with improved polarity generated by targeted gene disruption. Chem Biol (2004) 0.81
Development of intergeneric conjugal gene transfer system in Streptomyces diastatochromogenes 1628 and its application for improvement of toyocamycin production. Curr Microbiol (2013) 0.81
Structure and action of a C-C bond cleaving alpha/beta-hydrolase involved in nicotine degradation. J Mol Biol (2006) 0.80
A transposon-based strategy to identify the regulatory gene network responsible for landomycin E biosynthesis. FEMS Microbiol Lett (2013) 0.80
Rational saccharide extension by using the natural product glycosyltransferase LanGT4. Chembiochem (2004) 0.80
Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae. BMC Genomics (2012) 0.80
Structural base for enzymatic cyclodextrin hydrolysis. J Mol Biol (2008) 0.80