Published in Chem Biol on April 01, 2006
Natural products version 2.0: connecting genes to molecules. J Am Chem Soc (2010) 3.06
Natural-product sugar biosynthesis and enzymatic glycodiversification. Angew Chem Int Ed Engl (2008) 2.69
A streamlined metabolic pathway for the biosynthesis of moenomycin A. Chem Biol (2007) 1.47
Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis. Curr Opin Chem Biol (2012) 1.15
The TetR family of regulators. Microbiol Mol Biol Rev (2013) 1.14
Bioactive compounds from marine actinomycetes. Indian J Microbiol (2009) 1.14
Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. Proc Natl Acad Sci U S A (2013) 1.12
Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes. Appl Environ Microbiol (2011) 1.03
Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia. J Bacteriol (2013) 0.95
Site-specific recombination strategies for engineering actinomycete genomes. Appl Environ Microbiol (2012) 0.92
Building a better bacillus: the emergence of Mycobacterium tuberculosis. Front Microbiol (2014) 0.85
A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat Chem Biol (2011) 0.82
Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis. Medchemcomm (2012) 0.82
Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster. J Biol Chem (2010) 0.81
Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase. J Am Chem Soc (2016) 0.79
Exploration of geosmin synthase from Streptomyces peucetius ATCC 27952 by deletion of doxorubicin biosynthetic gene cluster. J Ind Microbiol Biotechnol (2009) 0.78
Genome sequence of Streptomyces sp. strain Tü6071. J Bacteriol (2011) 0.78
Characterization of an orphan diterpenoid biosynthetic operon from Salinispora arenicola. J Nat Prod (2014) 0.77
Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine. Biochem Pharmacol (2016) 0.76
Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis. Appl Environ Microbiol (2013) 0.75
Biogenetic Relationships of Bioactive Sponge Merotriterpenoids. Mar Drugs (2017) 0.75
DasR positively controls monensin production at two-level regulation in Streptomyces cinnamonensis. J Ind Microbiol Biotechnol (2016) 0.75
Genomic mining for Aspergillus natural products. Chem Biol (2006) 3.22
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat Prod Rep (2006) 2.25
A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. Chem Biol (2013) 1.59
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide. Chem Biol (2005) 1.58
Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin. J Mol Biol (2007) 1.28
Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA. Fungal Genet Biol (2007) 1.23
Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. J Bacteriol (2006) 1.19
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus. Chem Biol (2004) 1.17
A genomic screening approach to the structure-guided identification of drug candidates from natural sources. Chembiochem (2007) 1.13
The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers. Angew Chem Int Ed Engl (2004) 1.13
DNA methylation markers predict outcome in node-positive, estrogen receptor-positive breast cancer with adjuvant anthracycline-based chemotherapy. Clin Cancer Res (2009) 1.12
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. J Mol Biol (2005) 1.10
Molecular analysis of the kirromycin biosynthetic gene cluster revealed beta-alanine as precursor of the pyridone moiety. Chem Biol (2008) 1.05
Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem Biol (2002) 1.05
Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. FEMS Microbiol Lett (2008) 1.05
Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem (2009) 1.04
Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes. Appl Environ Microbiol (2011) 1.03
Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides. Mol Biosyst (2005) 1.01
Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A. Chem Biol (2005) 1.01
Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. J Med Chem (2004) 1.00
Glycosyltransferases, important tools for drug design. Curr Top Med Chem (2008) 0.99
A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones. Chem Biol (2007) 0.99
Generation of novel landomycins M and O through targeted gene disruption. Chembiochem (2005) 0.99
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. Mol Microbiol (2003) 0.98
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. J Am Chem Soc (2002) 0.96
Genes and enzymes involved in bacterial isoprenoid biosynthesis. Curr Opin Chem Biol (2009) 0.96
Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern. Curr Top Med Chem (2008) 0.96
Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717. Chembiochem (2003) 0.96
Actinomycetes biosynthetic potential: how to bridge in silico and in vivo? J Ind Microbiol Biotechnol (2013) 0.95
Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using red/ET recombineering. Chembiochem (2008) 0.94
Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes. Metab Eng (2013) 0.93
Isolation of the lysolipin gene cluster of Streptomyces tendae Tü 4042. Gene (2010) 0.93
Functional expression of the Cre recombinase in actinomycetes. Appl Microbiol Biotechnol (2008) 0.93
The Aspergillus nidulans enzyme TdiB catalyzes prenyltransfer to the precursor of bioactive asterriquinones. Fungal Genet Biol (2007) 0.92
A bacterial glycosyltransferase gene toolbox: generation and applications. Phytochemistry (2009) 0.92
Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136. Chembiochem (2007) 0.92
Site-specific recombination strategies for engineering actinomycete genomes. Appl Environ Microbiol (2012) 0.92
Marker removal from actinomycetes genome using Flp recombinase. Gene (2008) 0.91
Features and applications of bacterial glycosyltransferases: current state and prospects. Appl Microbiol Biotechnol (2008) 0.90
Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis. Chembiochem (2004) 0.90
Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells. Bioorg Med Chem (2005) 0.90
Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. Chembiochem (2007) 0.89
On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2). Angew Chem Int Ed Engl (2006) 0.89
LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis. Chembiochem (2005) 0.89
LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis. Chembiochem (2005) 0.88
The future of natural products as a source of new antibiotics. Curr Opin Investig Drugs (2007) 0.87
Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biol (2013) 0.87
Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae. BMC Genomics (2014) 0.86
The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses. J Am Chem Soc (2003) 0.86
Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase. Chem Biol (2011) 0.86
Chapter 12. The power of glycosyltransferases to generate bioactive natural compounds. Methods Enzymol (2009) 0.86
Function of lanI in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies with Streptomyces antibiotic regulatory proteins encoding genes. Arch Microbiol (2007) 0.85
Catechin derivatives from Parapiptadenia rigida with in vitro wound-healing properties. J Nat Prod (2010) 0.85
I-SceI endonuclease: a new tool for DNA repair studies and genetic manipulations in streptomyces. Appl Microbiol Biotechnol (2010) 0.85
Differences in the substrate specificity of glycosyltransferases involved in landomycins A and E biosynthesis. Appl Microbiol Biotechnol (2009) 0.85
Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle. Phytochemistry (2005) 0.85
Regio- and stereoselective intermolecular oxidative phenol coupling in Streptomyces. J Am Chem Soc (2014) 0.84
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains. Chembiochem (2009) 0.84
Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene. FEMS Microbiol Lett (2004) 0.84
Actinomycetes genome engineering approaches. Antonie Van Leeuwenhoek (2012) 0.84
Insights into the pamamycin biosynthesis. Angew Chem Int Ed Engl (2014) 0.83
Engineering a function into a glycosyltransferase. Chem Biol (2009) 0.83
Hopane-type saponins from the seeds of Glinus lotoides. J Nat Prod (2005) 0.82
Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A. Appl Environ Microbiol (2005) 0.82
In vivo Tn5-based transposon mutagenesis of Streptomycetes. Appl Microbiol Biotechnol (2009) 0.82
It works: combinatorial biosynthesis for generating novel glycosylated compounds. Mol Microbiol (2005) 0.82
Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. J Mol Biol (2003) 0.82
The pathway-specific regulatory genes, tei15* and tei16*, are the master switches of teicoplanin production in Actinoplanes teichomyceticus. Appl Microbiol Biotechnol (2014) 0.82
Human pharmacokinetics and safety profile of finafloxacin, a new fluoroquinolone antibiotic, in healthy volunteers. Antimicrob Agents Chemother (2011) 0.81
Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and it's initial characterization. J Antibiot (Tokyo) (2004) 0.81
Development of a BAC vector for integration-independent and tight regulation of transgenes in rodents via the Tet system. Transgenic Res (2010) 0.81