Published in Nat Struct Biol on August 01, 2003
Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system. PLoS Biol (2008) 4.34
Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. Nat Biotechnol (2009) 3.44
RBPDB: a database of RNA-binding specificities. Nucleic Acids Res (2010) 2.42
Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression. EMBO J (2003) 2.03
Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation. RNA (2010) 1.51
Quantitative approaches to monitor protein-nucleic acid interactions using fluorescent probes. RNA (2010) 1.40
Structural evolution of C-terminal domains in the p53 family. EMBO J (2007) 1.32
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Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse. BMC Genomics (2007) 1.26
Discovering structural cis-regulatory elements by modeling the behaviors of mRNAs. Mol Syst Biol (2009) 1.17
Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein. Genome Biol (2014) 1.15
Smaug assembles an ATP-dependent stable complex repressing nanos mRNA translation at multiple levels. EMBO J (2010) 1.07
Identifying polymer-forming SAM domains. Proteins (2009) 1.06
Drosophila maternal Hsp83 mRNA destabilization is directed by multiple SMAUG recognition elements in the open reading frame. Mol Cell Biol (2008) 1.04
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Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation. J Cell Biol (2011) 1.00
S. cerevisiae Vts1p induces deadenylation-dependent transcript degradation and interacts with the Ccr4p-Pop2p-Not deadenylase complex. RNA (2008) 0.99
microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein. EMBO Rep (2012) 0.99
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Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells. Genome Biol (2012) 0.95
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p73alpha isoforms drive opposite transcriptional and post-transcriptional regulation of MYCN expression in neuroblastoma cells. Nucleic Acids Res (2008) 0.92
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Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation. Biochemistry (2005) 0.88
Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3. BMC Struct Biol (2014) 0.86
Dispensability of nanos mRNA localization for abdominal patterning but not for germ cell development. Mech Dev (2007) 0.86
Loss of Bicc1 impairs tubulomorphogenesis of cultured IMCD cells by disrupting E-cadherin-based cell-cell adhesion. Eur J Cell Biol (2010) 0.84
SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum. Cell Mol Life Sci (2010) 0.84
The Bic-C family of developmental translational regulators. Comp Funct Genomics (2012) 0.83
Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. Mol Oncol (2015) 0.83
Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina. PLoS One (2013) 0.82
Involvement of Vts1, a structure-specific RNA-binding protein, in Okazaki fragment processing in yeast. Nucleic Acids Res (2009) 0.80
SASH1 inhibits proliferation and invasion of thyroid cancer cells through PI3K/Akt signaling pathway. Int J Clin Exp Pathol (2015) 0.80
The eIF4E-binding protein Eap1p functions in Vts1p-mediated transcript decay. PLoS One (2012) 0.79
SAM breaks its stereotype. Nat Struct Biol (2003) 0.78
The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.78
Clinical Significance of SASH1 Expression in Glioma. Dis Markers (2015) 0.78
[NSI+] determinant has a pleiotropic phenotypic manifestation that is modulated by SUP35, SUP45, and VTS1 genes. Curr Genet (2012) 0.78
Structural insights into SAM domain-mediated tankyrase oligomerization. Protein Sci (2016) 0.77
Snf1-Dependent Transcription Confers Glucose-Induced Decay upon the mRNA Product. Mol Cell Biol (2015) 0.75
Plant-Specific Preprotein and Amino Acid Transporter Proteins Are Required for tRNA Import into Mitochondria. Plant Physiol (2016) 0.75
Smaug variants in neural and non-neuronal cells. Commun Integr Biol (2016) 0.75
Comprehensive and quantitative mapping of RNA-protein interactions across a transcribed eukaryotic genome. Proc Natl Acad Sci U S A (2017) 0.75
ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain. Sci Rep (2017) 0.75
RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression. Cell Discov (2017) 0.75
Expression and localization of sterile alpha motif domain containing 5 is associated with cell type and malignancy of biliary tree. PLoS One (2017) 0.75
Smaug: an unexpected journey into the mechanisms of post-transcriptional regulation. Fly (Austin) (2013) 0.75
Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance. Oncoimmunology (2016) 0.75
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Cell (2003) 5.72
A dimerization-dependent mechanism drives RAF catalytic activation. Nature (2009) 5.39
Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell (2008) 4.59
Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell (2005) 4.41
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell (2005) 3.38
Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J Virol (2007) 2.88
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol Cell (2010) 2.74
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Cell (2007) 2.69
Formin leaky cap allows elongation in the presence of tight capping proteins. Curr Biol (2003) 2.69
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature (2013) 2.64
SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase. Dev Cell (2007) 2.64
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol Cell Proteomics (2008) 2.56
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell (2007) 2.53
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature (2010) 2.47
MicroRNA-155 is an Epstein-Barr virus-induced gene that modulates Epstein-Barr virus-regulated gene expression pathways. J Virol (2008) 2.45
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell (2011) 2.35
Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature (2003) 2.35
Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase. Structure (2010) 2.33
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Mol Cell (2005) 2.29
Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo. Curr Biol (2005) 2.18
Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression. EMBO J (2003) 2.03
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor. Proc Natl Acad Sci U S A (2008) 2.00
An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat Biotechnol (2010) 1.88
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell (2011) 1.83
Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation. Mol Cell (2008) 1.78
The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization. Nat Struct Biol (2002) 1.76
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature (2013) 1.70
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal (2013) 1.69
High rates of sustained smoking cessation in women hospitalized with cardiovascular disease: the Women's Initiative for Nonsmoking (WINS). Circulation (2004) 1.68
Epstein-Barr virus growth/latency III program alters cellular microRNA expression. Virology (2008) 1.63
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Mol Cell (2012) 1.58
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. J Biol Chem (2011) 1.58
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Mol Cell (2008) 1.51
Problems with co-funding in Canada. Science (2005) 1.48
Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p. Nat Struct Mol Biol (2006) 1.45
A strategy for modulation of enzymes in the ubiquitin system. Science (2013) 1.43
Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity: implications for possible immune adjuvant therapy. PLoS Pathog (2013) 1.43
Transcriptome and targetome analysis in MIR155 expressing cells using RNA-seq. RNA (2010) 1.39
Mechanisms of translational regulation in Drosophila. Biol Cell (2005) 1.38
Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9. J Biol Chem (2007) 1.32
An essential role for the RNA-binding protein Smaug during the Drosophila maternal-to-zygotic transition. Development (2009) 1.31
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. EMBO J (2006) 1.30
Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. J Biol Chem (2011) 1.26
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proc Natl Acad Sci U S A (2009) 1.24
MicroRNA miR-155 inhibits bone morphogenetic protein (BMP) signaling and BMP-mediated Epstein-Barr virus reactivation. J Virol (2010) 1.23
X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition. Mol Cell (2002) 1.18
Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase. Proc Natl Acad Sci U S A (2012) 1.15
Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein. Genome Biol (2014) 1.15
Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis. Mol Biol Cell (2010) 1.14
The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates. J Biol Chem (2009) 1.10
Cleavage furrow organization requires PIP(2)-mediated recruitment of anillin. Curr Biol (2011) 1.10
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nat Chem Biol (2013) 1.10
PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha. Mol Cell Biol (2005) 1.09
Choosing SNPs using feature selection. Proc IEEE Comput Syst Bioinform Conf (2005) 1.09
Novel protein interactors of urokinase-type plasminogen activator receptor. Biochem Biophys Res Commun (2010) 1.07
Mechanistic principles of RAF kinase signaling. Cell Mol Life Sci (2010) 1.07
Confidentiality in genome research. Science (2006) 1.06
Identification of new viral genes and transcript isoforms during Epstein-Barr virus reactivation using RNA-Seq. J Virol (2011) 1.06
CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization. J Biol Chem (2011) 1.05
Drosophila maternal Hsp83 mRNA destabilization is directed by multiple SMAUG recognition elements in the open reading frame. Mol Cell Biol (2008) 1.04
Genome-wide analysis of Staufen-associated mRNAs identifies secondary structures that confer target specificity. Nucleic Acids Res (2013) 1.04
Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK. J Biol Chem (2007) 1.02
Allosteric protein kinase regulation by pseudokinases: insights from STRAD. Sci Signal (2010) 1.00
Autologous tenocyte therapy for experimental Achilles tendinopathy in a rabbit model. Tissue Eng Part A (2011) 1.00
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Nucleic Acids Res (2013) 1.00
microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein. EMBO Rep (2012) 0.99
S. cerevisiae Vts1p induces deadenylation-dependent transcript degradation and interacts with the Ccr4p-Pop2p-Not deadenylase complex. RNA (2008) 0.99
CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. Proc Natl Acad Sci U S A (2008) 0.99
Species independence in brain tissue binding using brain homogenates. Drug Metab Dispos (2011) 0.97
Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. EMBO J (2011) 0.97
Structural and functional analysis of Saccharomyces cerevisiae Mob1. J Mol Biol (2006) 0.96
Determination of the Plk4/Sak consensus phosphorylation motif using peptide spots arrays. FEBS Lett (2006) 0.95
Epstein-Barr virus and human herpesvirus 6 detection in a non-Hodgkin's diffuse large B-cell lymphoma cohort by using RNA sequencing. J Virol (2013) 0.95
Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases. Methods Enzymol (2005) 0.94
Differentiation of rodent bone marrow mesenchymal stem cells into intervertebral disc-like cells following coculture with rat disc tissue. Tissue Eng Part A (2009) 0.94
Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. Proc Natl Acad Sci U S A (2007) 0.94
A multiprotein complex that mediates translational enhancement in Drosophila. J Biol Chem (2007) 0.93
Global bidirectional transcription of the Epstein-Barr virus genome during reactivation. J Virol (2013) 0.93
The Epstein-Barr virus latent membrane protein 1 and transforming growth factor--β1 synergistically induce epithelial--mesenchymal transition in lung epithelial cells. Am J Respir Cell Mol Biol (2010) 0.92
Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation. J Mol Biol (2009) 0.92
Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein. Proc Natl Acad Sci U S A (2008) 0.91
Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cells. Virology (2011) 0.91
Prevention of wear particle-induced osteolysis by a novel V-ATPase inhibitor saliphenylhalamide through inhibition of osteoclast bone resorption. PLoS One (2012) 0.90
Rapid identification of linear protein domain binding motifs using peptide SPOT arrays. Methods Mol Biol (2009) 0.90
Sequencing, annotation, and characterization of the influenza ferret infectome. J Virol (2012) 0.89
Versatile roles of V-ATPases accessory subunit Ac45 in osteoclast formation and function. PLoS One (2011) 0.89
Conserved structural mechanisms for autoinhibition in IpaH ubiquitin ligases. J Biol Chem (2011) 0.89
SCFCdc4 enables mating type switching in yeast by cyclin-dependent kinase-mediated elimination of the Ash1 transcriptional repressor. Mol Cell Biol (2010) 0.88
Comparative profiling of miRNA expression of lung adenocarcinoma cells in two-dimensional and three-dimensional cultures. Gene (2012) 0.87
The structural basis of modified nucleosome recognition by 53BP1. Nature (2016) 0.86
Autologous tenocyte injection for the treatment of severe, chronic resistant lateral epicondylitis: a pilot study. Am J Sports Med (2013) 0.86
Sanguinarine inhibits osteoclast formation and bone resorption via suppressing RANKL-induced activation of NF-κB and ERK signaling pathways. Biochem Biophys Res Commun (2012) 0.85
Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase. Mol Cell Biol (2013) 0.85
Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase. Cell Signal (2012) 0.85
Bioreactor design for tendon/ligament engineering. Tissue Eng Part B Rev (2012) 0.85
Polybrominated diphenyl ethers in road and farmland soils from an e-waste recycling region in Southern China: concentrations, source profiles, and potential dispersion and deposition. Sci Total Environ (2008) 0.85
Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays. J Mol Biol (2009) 0.84