Published in FEBS Lett on December 11, 2006
Autophosphorylation of polo-like kinase 4 and its role in centriole duplication. Mol Biol Cell (2009) 1.45
Plk4 is required for cytokinesis and maintenance of chromosomal stability. Proc Natl Acad Sci U S A (2010) 1.40
The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification. J Cell Biol (2011) 1.16
Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels. Cancer Res (2009) 1.14
Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication. J Cell Biol (2008) 1.09
Polo-like kinase 4: the odd one out of the family. Cell Div (2010) 1.03
Rapid determination of multiple linear kinase substrate motifs by mass spectrometry. Chem Biol (2012) 1.01
Polo-like kinase 4 autodestructs by generating its Slimb-binding phosphodegron. Curr Biol (2013) 0.95
Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4. Endocrinology (2011) 0.82
A novel role for Plk4 in regulating cell spreading and motility. Oncogene (2014) 0.79
Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Cell (2003) 5.72
A dimerization-dependent mechanism drives RAF catalytic activation. Nature (2009) 5.39
Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell (2008) 4.59
Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell (2005) 4.41
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature (2006) 4.05
The myc oncogene: MarvelouslY Complex. Adv Cancer Res (2002) 3.68
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell (2005) 3.38
The alcohol-preferring P rat and animal models of excessive alcohol drinking. Addict Biol (2006) 2.82
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol Cell (2010) 2.74
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Cell (2007) 2.69
Formin leaky cap allows elongation in the presence of tight capping proteins. Curr Biol (2003) 2.69
Improved surface temperature prediction for the coming decade from a global climate model. Science (2007) 2.65
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature (2013) 2.64
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol Cell Proteomics (2008) 2.56
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell (2007) 2.53
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature (2010) 2.47
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell (2011) 2.35
Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature (2003) 2.35
Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase. Structure (2010) 2.33
Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity. Immunity (2012) 2.30
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Mol Cell (2005) 2.29
The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators. Nat Struct Biol (2003) 2.29
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor. Proc Natl Acad Sci U S A (2008) 2.00
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood (2014) 1.97
Nck proteins maintain the adult glomerular filtration barrier. J Am Soc Nephrol (2009) 1.92
An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat Biotechnol (2010) 1.88
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell (2011) 1.83
Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation. Mol Cell (2008) 1.78
The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization. Nat Struct Biol (2002) 1.76
Recent advances in animal models of alcohol craving and relapse. Pharmacol Biochem Behav (2004) 1.72
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature (2013) 1.70
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal (2013) 1.69
Intracranial self-administration of ethanol within the ventral tegmental area of male Wistar rats: evidence for involvement of dopamine neurons. J Neurosci (2004) 1.65
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Mol Cell (2012) 1.58
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. J Biol Chem (2011) 1.58
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Mol Cell (2008) 1.51
Problems with co-funding in Canada. Science (2005) 1.48
Daily patterns of ethanol drinking in peri-adolescent and adult alcohol-preferring (P) rats. Pharmacol Biochem Behav (2006) 1.46
Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p. Nat Struct Mol Biol (2006) 1.45
A strategy for modulation of enzymes in the ubiquitin system. Science (2013) 1.43
Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcohol-preferring (P) rats: involvement of dopamine and serotonin. Neuropsychopharmacology (2005) 1.43
Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays. Mol Cell Biol (2006) 1.41
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat Struct Mol Biol (2013) 1.38
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties. Biochem J (2014) 1.33
Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9. J Biol Chem (2007) 1.32
Effects of repeated alcohol deprivations on operant ethanol self-administration by alcohol-preferring (P) rats. Neuropsychopharmacology (2003) 1.31
Microdialysis of dopamine in the nucleus accumbens of alcohol-preferring (P) rats during anticipation and operant self-administration of ethanol. Alcohol Clin Exp Res (2002) 1.31
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. EMBO J (2006) 1.30
Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. J Biol Chem (2011) 1.26
Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats: I. Periadolescent exposure. Alcohol Clin Exp Res (2002) 1.26
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proc Natl Acad Sci U S A (2009) 1.24
Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats. J Pharmacol Exp Ther (2002) 1.23
The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats. Behav Brain Res (2006) 1.23
Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats: II. Adult exposure. Alcohol Clin Exp Res (2002) 1.22
X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition. Mol Cell (2002) 1.18
Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res (2005) 1.16
Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase. Proc Natl Acad Sci U S A (2012) 1.15
Neuropeptide Y reduces oral ethanol intake in alcohol-preferring (P) rats following a period of imposed ethanol abstinence. Alcohol Clin Exp Res (2003) 1.15
Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis. Mol Biol Cell (2010) 1.14
Adolescent alcohol drinking and its long-range consequences. Studies with animal models. Recent Dev Alcohol (2005) 1.11
Intracranial self-administration of cocaine within the posterior ventral tegmental area of Wistar rats: evidence for involvement of serotonin-3 receptors and dopamine neurons. J Pharmacol Exp Ther (2005) 1.11
Cleavage furrow organization requires PIP(2)-mediated recruitment of anillin. Curr Biol (2011) 1.10
The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates. J Biol Chem (2009) 1.10
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nat Chem Biol (2013) 1.10
Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood (2010) 1.09
PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha. Mol Cell Biol (2005) 1.09
Comparison of intracranial self-administration of ethanol within the posterior ventral tegmental area between alcohol-preferring and Wistar rats. Alcohol Clin Exp Res (2004) 1.09
Ethanol is self-administered into the nucleus accumbens shell, but not the core: evidence of genetic sensitivity. Alcohol Clin Exp Res (2009) 1.09
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL. Biochem J (2014) 1.07
Mechanistic principles of RAF kinase signaling. Cell Mol Life Sci (2010) 1.07
The long journey of cancer biomarkers from the bench to the clinic. Clin Chem (2012) 1.05
CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization. J Biol Chem (2011) 1.05
Prolonged increase in the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol following repeated exposure to cycles of ethanol access and deprivation. J Pharmacol Exp Ther (2005) 1.04
A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants. J Mol Biol (2005) 1.03
Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK. J Biol Chem (2007) 1.02
Effects of concurrent access to a single concentration or multiple concentrations of ethanol on ethanol intake by periadolescent high-alcohol-drinking rats. Alcohol (2004) 1.01
Chronic ethanol drinking by alcohol-preferring rats increases the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol. Alcohol Clin Exp Res (2005) 1.01
Extracellular dopamine levels are lower in the medial prefrontal cortex of alcohol-preferring rats compared to Wistar rats. Alcohol (2006) 1.01
Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats. Psychopharmacology (Berl) (2002) 1.00
Allosteric protein kinase regulation by pseudokinases: insights from STRAD. Sci Signal (2010) 1.00
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Nucleic Acids Res (2013) 1.00
CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. Proc Natl Acad Sci U S A (2008) 0.99
Serotonin-3 receptors in the actions of alcohol, alcohol reinforcement, and alcoholism. Alcohol Clin Exp Res (2004) 0.98
In vivo time-course changes in ethanol levels sampled with subcutaneous microdialysis. Alcohol Clin Exp Res (2008) 0.98
Effects of multiple alcohol deprivations on operant ethanol self-administration by high-alcohol-drinking replicate rat lines. Alcohol (2006) 0.98
Effects of concurrent access to a single concentration or multiple concentrations of ethanol on the intake of ethanol by male and female periadolescent alcohol-preferring (P) rats. Alcohol (2003) 0.98
Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats. Addict Biol (2008) 0.97
Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. EMBO J (2011) 0.97
False biomarker discovery due to reactivity of a commercial ELISA for CUZD1 with cancer antigen CA125. Clin Chem (2013) 0.96
Structural and functional analysis of Saccharomyces cerevisiae Mob1. J Mol Biol (2006) 0.96
Effects of short deprivation and re-exposure intervals on the ethanol drinking behavior of selectively bred high alcohol-consuming rats. Alcohol (2008) 0.96
Strategies for discovering novel pancreatic cancer biomarkers. J Proteomics (2012) 0.96
Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice. Blood (2008) 0.95
Alcohol stimulates the release of dopamine in the ventral pallidum but not in the globus pallidus: a dual-probe microdialysis study. Neuropsychopharmacology (2003) 0.95
Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases. Methods Enzymol (2005) 0.94
Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. Proc Natl Acad Sci U S A (2007) 0.94
Pediatric reference intervals for 28 chemistries and immunoassays on the Roche cobas 6000 analyzer--a CALIPER pilot study. Clin Biochem (2010) 0.93
Sensitized effects of neuropeptide Y on multiple ingestive behaviors in P rats following ethanol abstinence. Pharmacol Biochem Behav (2005) 0.92
Effects of long-term episodic access to ethanol on the expression of an alcohol deprivation effect in low alcohol-consuming rats. Alcohol Clin Exp Res (2004) 0.92