Published in Oncogene on September 20, 2004
Primary Operation in SYnchronous meTastasized InVasivE Breast Cancer (POSYTIVE) | NCT01015625
Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One (2008) 8.97
Centrosome amplification can initiate tumorigenesis in flies. Cell (2008) 4.62
p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol (2011) 3.85
Drug resistance in cancer: principles of emergence and prevention. Proc Natl Acad Sci U S A (2005) 3.03
Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol (2008) 2.87
Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue. Proc Natl Acad Sci U S A (2005) 2.77
Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck (2010) 2.76
PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell (2010) 2.68
Stem-like cells in bone sarcomas: implications for tumorigenesis. Neoplasia (2005) 2.62
EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling. Cancer Cell (2011) 2.54
Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell (2010) 2.43
Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development. Neural Dev (2008) 2.41
Cancer stem cells: implications for the progression and treatment of metastatic disease. J Cell Mol Med (2007) 2.29
Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors. Cold Spring Harb Symp Quant Biol (2005) 2.18
Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas. Cell Stem Cell (2009) 2.12
IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci U S A (2007) 2.09
Telomere and telomerase in stem cells. Br J Cancer (2007) 2.09
CNTF receptor subunit α as a marker for glioma tumor-initiating cells and tumor grade: laboratory investigation. J Neurosurg (2012) 1.99
Detection and characterization of CD133+ cancer stem cells in human solid tumours. PLoS One (2008) 1.90
p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proc Natl Acad Sci U S A (2009) 1.89
Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer. Nat Rev Gastroenterol Hepatol (2009) 1.80
CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res (2010) 1.78
Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. Prostate (2010) 1.78
Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. PLoS One (2011) 1.67
NF-kappa B-mediated adaptive resistance to ionizing radiation. Free Radic Biol Med (2007) 1.58
From antimicrobial to anticancer peptides. A review. Front Microbiol (2013) 1.56
The origins and implications of intratumor heterogeneity. Cancer Prev Res (Phila) (2010) 1.55
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells. Nature (2015) 1.53
Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers. J Cell Mol Med (2007) 1.48
HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clin Cancer Res (2012) 1.47
Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev (2010) 1.46
Cancer stem cells: the lessons from pre-cancerous stem cells. J Cell Mol Med (2007) 1.38
MicroRNA regulation of cancer stem cells and therapeutic implications. AAPS J (2009) 1.37
Precancerous stem cells have the potential for both benign and malignant differentiation. PLoS One (2007) 1.36
Recent progress on tissue-resident adult stem cell biology and their therapeutic implications. Stem Cell Rev (2008) 1.36
Targeting the Hedgehog pathway in cancer. Ther Adv Med Oncol (2010) 1.35
Characterization of side populations in HNSCC: highly invasive, chemoresistant and abnormal Wnt signaling. PLoS One (2010) 1.33
Identification of DOK genes as lung tumor suppressors. Nat Genet (2010) 1.32
Endothelial cell differentiation of human breast tumour stem/progenitor cells. J Cell Mol Med (2009) 1.30
CXCR4 mediates the proliferation of glioblastoma progenitor cells. Cancer Lett (2008) 1.27
Live-imaging of single stem cells within their niche reveals that a U3snoRNP component segregates asymmetrically and is required for self-renewal in Drosophila. Nat Cell Biol (2009) 1.26
Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation. Breast Cancer Res (2010) 1.26
The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition. J Mol Signal (2010) 1.26
Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies. Clin Pharmacol Ther (2007) 1.25
Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer. Br J Cancer (2010) 1.23
Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells. Mol Cancer (2007) 1.22
From bench to bedside: the growing use of translational research in cancer medicine. Am J Transl Res (2010) 1.22
The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade. Cancer Microenviron (2010) 1.21
Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors. Clin Cancer Res (2013) 1.20
Aldehyde dehydrogenase 1, a potential marker for cancer stem cells in human sarcoma. PLoS One (2012) 1.19
CD44+/CD24- ovarian cancer cells demonstrate cancer stem cell properties and correlate to survival. Clin Exp Metastasis (2012) 1.18
Persistence of side population cells with high drug efflux capacity in pancreatic cancer. World J Gastroenterol (2008) 1.18
A model of cancer stem cells derived from mouse induced pluripotent stem cells. PLoS One (2012) 1.17
The expressions of stem cell markers: Oct4, Nanog, Sox2, nucleostemin, Bmi, Zfx, Tcl1, Tbx3, Dppa4, and Esrrb in bladder, colon, and prostate cancer, and certain cancer cell lines. Anat Cell Biol (2014) 1.15
Wnt/catenin signaling in adult stem cell physiology and disease. Stem Cell Rev (2014) 1.15
Spheres derived from lung adenocarcinoma pleural effusions: molecular characterization and tumor engraftment. PLoS One (2011) 1.14
Colon cancer stem cells: implications for prevention and therapy. Trends Mol Med (2008) 1.12
Stem cells, senescence, neosis and self-renewal in cancer. Cancer Cell Int (2006) 1.11
Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential. PLoS One (2012) 1.10
Pancreatic cancer stem cells: new understanding of tumorigenesis, clinical implications. Langenbecks Arch Surg (2009) 1.10
E-cadherin plasticity in prostate cancer stem cell invasion. Am J Cancer Res (2010) 1.10
TGF-beta and BMP7 interactions in tumour progression and bone metastasis. Clin Exp Metastasis (2007) 1.08
Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice. Neoplasia (2008) 1.07
Pathways to tumorigenesis--modeling mutation acquisition in stem cells and their progeny. Neoplasia (2008) 1.04
Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications. Ageing Res Rev (2008) 1.02
Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells. Cell Res (2011) 1.02
Stacking the DEK: from chromatin topology to cancer stem cells. Cell Cycle (2012) 1.01
Loss of heterozygosity of TRIM3 in malignant gliomas. BMC Cancer (2009) 1.01
SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance. PLoS One (2013) 1.00
Cancer stem cell-like side population cells in clear cell renal cell carcinoma cell line 769P. PLoS One (2013) 1.00
Cancer stem cells: a novel paradigm for cancer prevention and treatment. Mini Rev Med Chem (2010) 0.99
Expressions of putative cancer stem cell markers ABCB1, ABCG2, and CD133 are correlated with the degree of differentiation of gastric cancer. Gastric Cancer (2012) 0.98
Head and neck cancer stem cells: the side population. Laryngoscope (2010) 0.98
Diverse roles for the paxillin family of proteins in cancer. Genes Cancer (2012) 0.98
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation. PLoS One (2011) 0.97
A CD44high/EGFRlow subpopulation within head and neck cancer cell lines shows an epithelial-mesenchymal transition phenotype and resistance to treatment. PLoS One (2012) 0.96
The haemopoietic stem cell: between apoptosis and self renewal. Yale J Biol Med (2009) 0.96
miRNAs in breast cancer tumorigenesis (Review). Oncol Rep (2011) 0.96
Spheroid-forming subpopulation of breast cancer cells demonstrates vasculogenic mimicry via hsa-miR-299-5p regulated de novo expression of osteopontin. J Cell Mol Med (2009) 0.95
Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression. Genes Dev (2013) 0.94
Understanding tumor heterogeneity as functional compartments--superorganisms revisited. J Transl Med (2011) 0.93
New advances on critical implications of tumor- and metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence. Histol Histopathol (2010) 0.93
Specific posttranslational modification regulates early events in mammary carcinoma formation. Proc Natl Acad Sci U S A (2010) 0.93
A short guide to hereditary diffuse gastric cancer. Hered Cancer Clin Pract (2007) 0.93
Identification of cancer stem cells and a strategy for their elimination. Cancer Biol Ther (2014) 0.92
Expression of CD133 in the cytoplasm is associated with cancer progression and poor prognosis in gastric cancer. Gastric Cancer (2013) 0.92
Identification of a population of epidermal squamous cell carcinoma cells with enhanced potential for tumor formation. PLoS One (2013) 0.92
Cancerous stem cells: deviant stem cells with cancer-causing misbehavior. Stem Cell Res Ther (2010) 0.91
Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/β-catenin negative feedback loop. Stem Cell Res Ther (2014) 0.91
Targeting tumor-initiating cancer cells with dCD133KDEL shows impressive tumor reductions in a xenotransplant model of human head and neck cancer. Mol Cancer Ther (2011) 0.91
Skin-derived precursors as a source of progenitors for cutaneous nerve regeneration. Stem Cells (2012) 0.91
Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells. PLoS One (2011) 0.90
Lymphoma stem cells: enough evidence to support their existence? Haematologica (2010) 0.90
Cooperation of cancer stem cell properties and epithelial-mesenchymal transition in the establishment of breast cancer metastasis. J Oncol (2010) 0.90
Distinct population of highly malignant cells in a head and neck squamous cell carcinoma cell line established by xenograft model. J Biomed Sci (2009) 0.90
Cancer cell: using inflammation to invade the host. Mol Cancer (2007) 0.89
Biochemistry of epidermal stem cells. Biochim Biophys Acta (2012) 0.88
Gastric cancer stem cells: therapeutic targets. Gastric Cancer (2013) 0.88
Testicular Germ Cell Tumors: A Paradigm for the Successful Treatment of Solid Tumor Stem Cells. Curr Cancer Ther Rev (2006) 0.88
Tumor-initiating cells are enriched in CD44(hi) population in murine salivary gland tumor. PLoS One (2011) 0.87
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77
Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35
Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58
The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med (2007) 13.39
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature (2003) 11.23
Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31
Applying the principles of stem-cell biology to cancer. Nat Rev Cancer (2003) 8.95
CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer. N Engl J Med (2016) 8.53
Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell (2009) 8.33
Cancer stem cells: models and concepts. Annu Rev Med (2007) 8.06
Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84
The biology of cancer stem cells. Annu Rev Cell Dev Biol (2007) 6.23
Stem cells in normal breast development and breast cancer. Cell Prolif (2003) 4.47
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20
Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One (2008) 3.97
Bmi1, stem cells, and senescence regulation. J Clin Invest (2004) 3.80
Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells (2007) 3.60
DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell (2009) 3.48
Therapeutic implications of cancer stem cells. Curr Opin Genet Dev (2004) 3.04
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A (2010) 2.89
Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors. Nature (2008) 2.82
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A (2009) 2.76
Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. Nat Med (2006) 2.23
Recent advances in cancer stem cells. Curr Opin Genet Dev (2008) 2.17
Cancer stem cells and radiotherapy: new insights into tumor radioresistance. J Natl Cancer Inst (2006) 2.10
Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer. J Clin Invest (2012) 1.92
Differential gene expression profiling of adult murine hematopoietic stem cells. Blood (2002) 1.69
Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells. Stem Cells (2007) 1.57
Therapeutic implications of the cancer stem cell hypothesis. Semin Radiat Oncol (2009) 1.53
Cancer stem cells and tumor metastasis: first steps into uncharted territory. Cell Stem Cell (2007) 1.48
MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun (2013) 1.43
Hematopoietic stem cell self-renewal. Curr Opin Genet Dev (2006) 1.42
A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. J Immunol (2002) 1.41
Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology (2012) 1.32
Effects of time since fire on birds: how informative are generalized fire response curves for conservation management? Ecol Appl (2012) 1.22
Automated microfluidic chromatin immunoprecipitation from 2,000 cells. Lab Chip (2009) 1.17
Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature (2013) 1.13
MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. Breast Cancer Res Treat (2012) 1.07
Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution. Proc Natl Acad Sci U S A (2012) 0.99
New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication. Hum Gene Ther (2002) 0.99
Remodeling of endogenous mammary epithelium by breast cancer stem cells. Stem Cells (2012) 0.88
Optimal fire histories for biodiversity conservation. Conserv Biol (2014) 0.87
The Myc connection: ES cells and cancer. Cell (2010) 0.87
Neurobiology: at the root of brain cancer. Nature (2004) 0.83
Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials. Int J Radiat Oncol Biol Phys (2009) 0.83
Oncogenic miRNAs and the perils of losing control of a stem cell's epigenetic identity. Cell Stem Cell (2013) 0.80
Identifying the metastatic seeds of breast cancer. Nat Biotechnol (2013) 0.78
SLUGging away at cell death. Cancer Cell (2002) 0.77
Removal of lactate dehydrogenase-elevating virus from human-in-mouse breast tumor xenografts by cell-sorting. J Virol Methods (2011) 0.76
CDX2 as a Prognostic Biomarker in Colon Cancer. N Engl J Med (2016) 0.75