The Mre11 complex is required for ATM activation and the G2/M checkpoint.

PubWeight™: 3.91‹?› | Rank: Top 1%

🔗 View Article (PMC 291825)

Published in EMBO J on December 15, 2003

Authors

Christian T Carson1, Rachel A Schwartz, Travis H Stracker, Caroline E Lilley, Darwin V Lee, Matthew D Weitzman

Author Affiliations

1: Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Articles citing this

(truncated to the top 100)

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A (2005) 4.24

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev (2006) 4.18

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev (2004) 3.76

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol (2005) 3.25

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J (2004) 3.20

A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol (2008) 3.07

Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem (2006) 2.76

Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol (2005) 2.64

ATM and ataxia telangiectasia. EMBO Rep (2004) 2.31

Involvement of human MOF in ATM function. Mol Cell Biol (2005) 2.30

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J (2006) 2.25

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol (2004) 2.23

Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation. PLoS Pathog (2009) 2.21

DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A (2005) 2.20

Nbs1 is required for ATR-dependent phosphorylation events. EMBO J (2004) 1.95

Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex. Oncogene (2006) 1.93

DNA repair deficiency and neurological disease. Nat Rev Neurosci (2009) 1.91

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway. Mol Cell Biol (2004) 1.83

Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation. J Virol (2007) 1.80

Mre11 assembles linear DNA fragments into DNA damage signaling complexes. PLoS Biol (2004) 1.79

MRE11/RAD50/NBS1: complex activities. Chromosoma (2004) 1.79

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. EMBO J (2010) 1.75

Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J (2004) 1.75

Common mechanisms of PIKK regulation. DNA Repair (Amst) (2009) 1.73

Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling. Genes Dev (2005) 1.71

Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proc Natl Acad Sci U S A (2005) 1.69

MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A (2008) 1.63

Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. Genes Dev (2005) 1.61

Induction and utilization of an ATM signaling pathway by polyomavirus. J Virol (2005) 1.53

The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett (2010) 1.53

Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes. J Virol (2005) 1.50

RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites. Cancer Lett (2008) 1.50

Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53. Mol Cell Biol (2004) 1.48

The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication. J Virol (2007) 1.46

Adenovirus exploits the cellular aggresome response to accelerate inactivation of the MRN complex. J Virol (2005) 1.46

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol Cell (2005) 1.39

MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem (2009) 1.39

The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A. Mol Cell Biol (2007) 1.38

The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0. PLoS Pathog (2011) 1.37

Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export. J Virol (2006) 1.37

The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev (2005) 1.37

Viral manipulation of DNA repair and cell cycle checkpoints. DNA Repair (Amst) (2009) 1.37

Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks. EMBO J (2006) 1.36

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev (2009) 1.36

A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner. Mol Biol Cell (2008) 1.34

DNA end resection by CtIP and exonuclease 1 prevents genomic instability. EMBO Rep (2010) 1.33

Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins. J Virol (2005) 1.33

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J Exp Med (2007) 1.32

Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol (2005) 1.31

Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell (2008) 1.30

Structural and functional analysis of Mre11-3. Nucleic Acids Res (2004) 1.28

DNA strand breaks, neurodegeneration and aging in the brain. Mech Ageing Dev (2008) 1.27

Active role for nibrin in the kinetics of atm activation. Mol Cell Biol (2006) 1.27

Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. EMBO J (2009) 1.24

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol (2008) 1.24

Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase. J Virol (2009) 1.24

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. J Cell Biol (2012) 1.21

Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response. Mol Cell (2008) 1.21

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation. Proc Natl Acad Sci U S A (2010) 1.17

Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol (2010) 1.16

N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair. J Biol Chem (2009) 1.15

The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. J Virol (2010) 1.15

Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation. J Virol (2009) 1.14

Genetic identification of adenovirus type 5 genes that influence viral spread. J Virol (2006) 1.14

A role for E1B-AP5 in ATR signaling pathways during adenovirus infection. J Virol (2008) 1.11

MRE11 complex links RECQ5 helicase to sites of DNA damage. Nucleic Acids Res (2009) 1.11

Control of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activity. J Virol (2008) 1.11

Distinct roles of the ATR kinase and the Mre11-Rad50-Nbs1 complex in the maintenance of chromosomal stability in Arabidopsis. Plant Cell (2010) 1.10

Pharmacologic and chemical adjuvants in tumor virotherapy. Chem Rev (2009) 1.10

The ATM signaling network in development and disease. Front Genet (2013) 1.09

Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection. J Virol (2011) 1.09

Small-scale extracts for the study of nucleotide excision repair and non-homologous end joining. Nucleic Acids Res (2007) 1.08

Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. J Virol (2008) 1.08

Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53. J Virol (2006) 1.07

Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain. Mol Cell (2012) 1.06

Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery. Hum Mol Genet (2010) 1.06

An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus. PLoS Pathog (2011) 1.04

Bocavirus infection induces a DNA damage response that facilitates viral DNA replication and mediates cell death. J Virol (2010) 1.03

Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication. PLoS Pathog (2010) 1.03

Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia. Genes Dev (2008) 1.03

Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies. J Virol (2010) 1.01

Bacillus subtilis RecN binds and protects 3'-single-stranded DNA extensions in the presence of ATP. Nucleic Acids Res (2005) 1.01

Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates. J Virol (2008) 1.01

The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair. Mol Cell Biol (2006) 1.01

H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistence. J Virol (2013) 1.00

What's the damage? The impact of pathogens on pathways that maintain host genome integrity. Cell Host Microbe (2014) 1.00

DNA double-strand break signaling and human disorders. Genome Integr (2010) 1.00

Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response. J Virol (2008) 0.98

Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection. J Virol (2010) 0.98

Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors. Cell Cycle (2010) 0.98

Chromatin at the intersection of viral infection and DNA damage. Biochim Biophys Acta (2009) 0.97

Competition effect in DNA damage response. Radiat Environ Biophys (2008) 0.97

Molecular cross-talk among chromosome fragility syndromes. Genes Dev (2004) 0.96

The ATM kinase signaling induced by the low-energy β-particles emitted by (33)P is essential for the suppression of chromosome aberrations and is greater than that induced by the energetic β-particles emitted by (32)P. Mutat Res (2011) 0.93

Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viral DNA is important for inhibiting DNA replication. Virology (2008) 0.93

Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. J Virol (2009) 0.93

Expression of the adenovirus E4 34k oncoprotein inhibits repair of double strand breaks in the cellular genome of a 293-based inducible cell line. Nucleic Acids Res (2004) 0.93

Mouse models of DNA double-strand break repair and neurological disease. DNA Repair (Amst) (2008) 0.92

Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage. Redox Biol (2014) 0.92

Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability. Mol Cell Biol (2008) 0.92

Articles cited by this

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29

ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer (2003) 16.06

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol (2000) 13.46

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol (2003) 8.55

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res (1999) 7.82

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell (1998) 6.58

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat Rev Mol Cell Biol (2002) 6.44

Requirement of the MRN complex for ATM activation by DNA damage. EMBO J (2003) 6.23

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature (2000) 5.55

The many substrates and functions of ATM. Nat Rev Mol Cell Biol (2000) 5.46

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell (1999) 5.44

Interfaces between the detection, signaling, and repair of DNA damage. Science (2002) 5.33

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J (1998) 5.25

In situ visualization of DNA double-strand break repair in human fibroblasts. Science (1998) 4.53

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol (2002) 4.45

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev (2003) 4.40

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol (2001) 4.35

Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol (2002) 4.27

Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature (2002) 3.99

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature (2000) 3.96

DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol Cell Biol (2001) 3.78

Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Genes Dev (2001) 3.67

Human Rad50/Mre11 is a flexible complex that can tether DNA ends. Mol Cell (2001) 3.66

A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol Cell (2001) 3.65

ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet (2000) 3.49

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature (2000) 3.48

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet (2002) 2.97

The yeast Xrs2 complex functions in S phase checkpoint regulation. Genes Dev (2001) 2.75

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci U S A (2001) 2.75

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. Mol Cell (2001) 2.65

Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence. EMBO J (1997) 2.44

Nuclear retention of ATM at sites of DNA double strand breaks. J Biol Chem (2001) 2.43

Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery. J Virol (2002) 2.31

A murine model of Nijmegen breakage syndrome. Curr Biol (2002) 1.96

Localization of the E1B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies. Virology (1985) 1.94

Chk2 activation dependence on Nbs1 after DNA damage. Mol Cell Biol (2001) 1.85

Interaction of adenoviral E4 and E1b products in late gene expression. Virology (1990) 1.84

The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response. Am J Hum Genet (1999) 1.73

Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells. J Virol (1996) 1.65

Structural analysis of the adenovirus type 5 E1B 55-kilodalton-E4orf6 protein complex. J Virol (1997) 1.44

Dissection of functional domains in the adenovirus 2 early 1B 55K polypeptide by suppressor-linker insertional mutagenesis. Virology (1990) 1.32

Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex. J Virol (2001) 1.31

A functional complex of adenovirus proteins E1B-55kDa and E4orf6 is necessary to modulate the expression level of p53 but not its transcriptional activity. J Virol (2000) 1.24

Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein. J Virol (2001) 1.16

Articles by these authors

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell (2008) 8.41

Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature (2002) 3.99

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. Curr Biol (2006) 3.57

Custom zinc-finger nucleases for use in human cells. Mol Ther (2005) 3.04

Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors. Nat Biotechnol (2003) 3.01

Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature (2012) 2.98

The cellular response to DNA double-strand breaks: defining the sensors and mediators. Trends Cell Biol (2003) 2.95

Gene therapy: twenty-first century medicine. Annu Rev Biochem (2005) 2.59

DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A (2005) 2.20

A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell (2006) 2.20

Using or abusing: viruses and the cellular DNA damage response. Trends Microbiol (2007) 2.12

APOBEC3A can activate the DNA damage response and cause cell-cycle arrest. EMBO Rep (2011) 2.07

Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks. Mol Cell Biol (2003) 2.01

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. EMBO J (2010) 1.75

Interactions of viruses with the cellular DNA repair machinery. DNA Repair (Amst) (2004) 1.72

Genomes in conflict: maintaining genome integrity during virus infection. Annu Rev Microbiol (2010) 1.72

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Mol Cell (2009) 1.70

Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase. PLoS Pathog (2009) 1.65

The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett (2010) 1.53

Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes. J Virol (2005) 1.50

PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication. Mol Cell (2013) 1.50

The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication. J Virol (2007) 1.46

Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. J Virol (2010) 1.40

Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production. J Virol (2004) 1.39

The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0. PLoS Pathog (2011) 1.37

Viral manipulation of DNA repair and cell cycle checkpoints. DNA Repair (Amst) (2009) 1.37

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev (2009) 1.36

Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins. J Virol (2005) 1.33

Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy. J Virol (2003) 1.31

Structural and functional analysis of Mre11-3. Nucleic Acids Res (2004) 1.28

Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. EMBO J (2009) 1.24

Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase. J Virol (2009) 1.24

The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication. J Virol (2004) 1.17

The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. J Virol (2010) 1.15

The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest (2003) 1.14

Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins. J Cell Sci (2008) 1.13

Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors. Mol Ther (2004) 1.09

SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication. J Virol (2013) 1.09

Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. J Virol (2008) 1.08

Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain. Mol Cell (2012) 1.06

Direct comparison of efficiency and stability of gene transfer into the mammalian heart using adeno-associated virus versus adenovirus vectors. J Thorac Cardiovasc Surg (2003) 1.03

Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication. PLoS Pathog (2010) 1.03

Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates. J Virol (2008) 1.01

OncomiR addiction is generated by a miR-155 feedback loop in Theileria-transformed leukocytes. PLoS Pathog (2013) 0.98

Chromatin at the intersection of viral infection and DNA damage. Biochim Biophys Acta (2009) 0.97

A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes. PLoS One (2007) 0.94

USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism. Mol Cell Biol (2014) 0.94

A new animal model for pulmonary hypertension based on the overexpression of a single gene, angiopoietin-1. Ann Thorac Surg (2004) 0.93

Cep63 and cep152 cooperate to ensure centriole duplication. PLoS One (2013) 0.92

APOBEC3 proteins and genomic stability: the high cost of a good defense. Cell Cycle (2012) 0.88

Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression. Proc Natl Acad Sci U S A (2012) 0.86

Changing the ubiquitin landscape during viral manipulation of the DNA damage response. FEBS Lett (2011) 0.86

Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection. J Virol (2011) 0.81

Caveolin-1 mediates inflammatory breast cancer cell invasion via the Akt1 pathway and RhoC GTPase. J Cell Biochem (2015) 0.81

Characterization of a nuclear localization signal in the C-terminus of the adeno-associated virus Rep68/78 proteins. Virology (2004) 0.79

A core viral protein binds host nucleosomes to sequester immune danger signals. Nature (2016) 0.78

Enhancement of green fluorescent protein expression in adeno-associated virus with the woodchuck hepatitis virus post-transcriptional regulatory element. Methods Mol Biol (2002) 0.78

Keeping viruses in Chk: DNA damage signaling puts the brakes on transformation. Cell Host Microbe (2010) 0.77

Breaking the barriers to global gene delivery. Nat Biotechnol (2005) 0.75

Gene delivery to the mammalian heart using AAV vectors. Methods Mol Biol (2004) 0.75

Caveolin-1 Mediates Inflammatory Breast Cancer Cell Invasion via the Akt1 Pathway and RhoC GTPase. J Cell Biochem (2017) 0.75