Langerhans cells renew in the skin throughout life under steady-state conditions.

PubWeight™: 7.03‹?› | Rank: Top 1%

🔗 View Article (PMID 12415265)

Published in Nat Immunol on November 04, 2002

Authors

Miriam Merad1, Markus G Manz, Holger Karsunky, Amy Wagers, Wendy Peters, Israel Charo, Irving L Weissman, Jason G Cyster, Edgar G Engleman

Author Affiliations

1: Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA. meradm@stanford.edu

Articles citing this

(truncated to the top 100)

Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science (2011) 8.53

Monocyte recruitment during infection and inflammation. Nat Rev Immunol (2011) 7.55

Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity (2013) 5.47

Langerhans cells arise from monocytes in vivo. Nat Immunol (2006) 5.46

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med (2006) 4.91

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol (2013) 4.75

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant. J Exp Med (2009) 4.27

Identification of a novel population of Langerin+ dendritic cells. J Exp Med (2007) 4.13

Tissue-resident macrophages. Nat Immunol (2013) 4.09

Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol (2005) 3.75

Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med (2003) 3.74

Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state. J Exp Med (2007) 3.64

Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity (2007) 3.58

Dendritic cell and macrophage heterogeneity in vivo. Immunity (2011) 3.41

IRF8 mutations and human dendritic-cell immunodeficiency. N Engl J Med (2011) 3.29

The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med (2007) 3.24

Dendritic cell homeostasis. Blood (2009) 3.18

Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med (2004) 3.17

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med (2009) 2.77

Dendritic cell subsets in primary and secondary T cell responses at body surfaces. Nat Immunol (2009) 2.76

CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med (2009) 2.75

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med (2012) 2.69

Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med (2004) 2.68

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol (2012) 2.62

Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev (2010) 2.44

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin. Nat Immunol (2012) 2.40

Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages. Blood (2007) 2.37

Plasmacytoid dendritic cells: linking innate and adaptive immunity. J Virol (2005) 2.28

Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci U S A (2008) 2.26

Mechanisms and consequences of dendritic cell migration. Immunity (2008) 2.25

Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men. J Exp Med (2006) 2.18

Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci U S A (2009) 2.12

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation. Front Immunol (2014) 2.03

Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med (2007) 2.00

Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells. Immunity (2008) 1.95

Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia. Immunity (2012) 1.95

Studying the mononuclear phagocyte system in the molecular age. Nat Rev Immunol (2011) 1.93

Immunopathogenic mechanisms in psoriasis. Clin Exp Immunol (2004) 1.82

Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proc Natl Acad Sci U S A (2004) 1.80

CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation. Nat Immunol (2015) 1.73

Resident and "inflammatory" dendritic cells in human skin. J Invest Dermatol (2008) 1.72

In vivo function of Langerhans cells and dermal dendritic cells. Trends Immunol (2010) 1.71

Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis. J Invest Dermatol (2009) 1.59

Early immune events in the induction of allergic contact dermatitis. Nat Rev Immunol (2012) 1.54

The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis. Blood (2013) 1.54

GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization. J Exp Med (2010) 1.52

Whole-body UVB irradiation during allogeneic hematopoietic cell transplantation is safe and decreases acute graft-versus-host disease. J Invest Dermatol (2011) 1.51

CD1c+ blood dendritic cells have Langerhans cell potential. Blood (2014) 1.47

Langerhans cells are precommitted to immune tolerance induction. Proc Natl Acad Sci U S A (2011) 1.47

TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity. J Invest Dermatol (2012) 1.47

Ionizing radiation: the good, the bad, and the ugly. J Invest Dermatol (2012) 1.44

Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J Exp Med (2005) 1.39

Solitary langerhans histiocytosis of the thyroid gland: a case report and literature review. Head Neck Pathol (2011) 1.39

Renal dendritic cells ameliorate nephrotoxic acute kidney injury. J Am Soc Nephrol (2009) 1.39

The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Blood (2007) 1.37

Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair. Front Cell Neurosci (2013) 1.34

Specialized role of migratory dendritic cells in peripheral tolerance induction. J Clin Invest (2013) 1.33

Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling. J Allergy Clin Immunol (2012) 1.28

Mechanisms regulating dendritic cell specification and development. Immunol Rev (2010) 1.26

The fate of human Langerhans cells in hematopoietic stem cell transplantation. J Exp Med (2006) 1.24

Decreased migration of Langerhans precursor-like cells in response to human keratinocytes expressing human papillomavirus type 16 E6/E7 is related to reduced macrophage inflammatory protein-3alpha production. J Virol (2005) 1.24

Coordinated regulation of lymph node vascular-stromal growth first by CD11c+ cells and then by T and B cells. J Immunol (2011) 1.23

Vaginal epithelial dendritic cells renew from bone marrow precursors. Proc Natl Acad Sci U S A (2007) 1.21

CCR2 plays a critical role in dendritic cell maturation: possible role of CCL2 and NF-kappa B. J Immunol (2010) 1.20

Inflammation-driven carcinogenesis is mediated through STING. Nat Commun (2014) 1.19

DNA damage, apoptosis and langerhans cells--Activators of UV-induced immune tolerance. Photochem Photobiol (2008) 1.18

CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen. J Immunol (2005) 1.18

IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest (2008) 1.17

Intestinal macrophages: differentiation and involvement in intestinal immunopathologies. Semin Immunopathol (2009) 1.17

Human dendritic cell functional specialization in steady-state and inflammation. Front Immunol (2014) 1.16

A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J Clin Invest (2006) 1.16

Regulation of macrophage development and function in peripheral tissues. Nat Rev Immunol (2015) 1.16

Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration. Proc Natl Acad Sci U S A (2012) 1.15

Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cells. J Virol (2006) 1.14

The development and maintenance of resident macrophages. Nat Immunol (2015) 1.13

Mapping the life histories of T cells. Nat Rev Immunol (2010) 1.12

Langerhans cells are not required for the CD8 T cell response to epidermal self-antigens. J Immunol (2009) 1.12

Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response. J Immunol (2008) 1.11

Network of dendritic cells within the muscular layer of the mouse intestine. Proc Natl Acad Sci U S A (2005) 1.10

Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation. Blood (2007) 1.10

Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia. J Neuroinflammation (2013) 1.10

Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo. J Exp Med (2007) 1.10

Hallmarks of Tissue-Resident Lymphocytes. Cell (2016) 1.10

Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells. J Clin Invest (2012) 1.09

Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues. Mol Cell Biol (2006) 1.09

Gamma-ray irradiation impairs dendritic cell migration to CCL19 by down-regulation of CCR7 and induction of cell apoptosis. Int J Biol Sci (2011) 1.09

Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome. J Exp Med (2011) 1.09

Human dendritic cell subsets for vaccination. J Clin Immunol (2005) 1.09

Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation. J Exp Med (2013) 1.08

Flk2+ myeloid progenitors are the main source of Langerhans cells. Blood (2005) 1.07

Multicolor fate mapping of Langerhans cell homeostasis. J Exp Med (2013) 1.06

Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes. J Exp Med (2007) 1.06

Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants. Proc Natl Acad Sci U S A (2010) 1.06

HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells. J Exp Med (2009) 1.05

Regulation of dendritic cell differentiation and function by estrogen receptor ligands. Cell Immunol (2008) 1.05

NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity. J Immunol (2010) 1.04

Haematopoietic and immune defects associated with GATA2 mutation. Br J Haematol (2015) 1.04

Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice. J Immunol (2008) 1.02

Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis. Cancer Res (2013) 1.02

Articles cited by this

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell (1994) 27.85

Immunobiology of dendritic cells. Annu Rev Immunol (2000) 23.65

The origin and kinetics of mononuclear phagocytes. J Exp Med (1968) 14.96

Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell (1991) 13.70

Chemokines: a new classification system and their role in immunity. Immunity (2000) 13.03

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med (1985) 11.14

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest (1997) 7.58

GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature (1992) 7.41

Physiological migration of hematopoietic stem and progenitor cells. Science (2001) 7.02

Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med (1998) 6.52

Characterization of nonlymphoid cells derived from rat peripheral lymph. J Exp Med (1983) 5.63

Epidermal Langerhans cells are derived from cells originating in bone marrow. Nature (1979) 5.58

Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J Exp Med (1997) 4.57

The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature (1999) 4.55

CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc Natl Acad Sci U S A (1999) 3.00

Transforming growth factor beta1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells. J Exp Med (1998) 2.75

Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation. J Pathol (2001) 2.57

Origin and function of epidermal Langerhans cells. Immunol Rev (1980) 2.54

CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation. J Exp Med (2000) 2.40

Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. J Clin Invest (2001) 2.39

Macrophage inflammatory protein 3alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J Exp Med (2000) 2.38

Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J Immunol (1994) 2.29

Dermal-resident CD14+ cells differentiate into Langerhans cells. Nat Immunol (2001) 1.95

A mechanism for the impaired IFN-gamma production in C-C chemokine receptor 2 (CCR2) knockout mice: role of CCR2 in linking the innate and adaptive immune responses. J Immunol (2000) 1.92

Characterization of a common precursor population for dendritic cells. Nature (2002) 1.88

Stromal-cell derived factor is expressed by dendritic cells and endothelium in human skin. Am J Pathol (1999) 1.88

Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-beta1-dependent cells. Int Immunol (2001) 1.68

Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis. J Exp Med (1997) 1.65

Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int Immunol (2001) 1.50

Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces. Eur J Immunol (2002) 1.44

Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). J Invest Dermatol (1999) 1.37

Further evidence for the self-reproducing capacity of Langerhans cells in human skin. J Invest Dermatol (1987) 1.35

Antigen-bearing dendritic cells in the draining lymph nodes of contact sensitized mice: cluster formation with lymphocytes. Immunology (1991) 1.31

Macrophage-derived chemokine (MDC/CCL22) and CCR4 are involved in the formation of T lymphocyte-dendritic cell clusters in human inflamed skin and secondary lymphoid tissue. Am J Pathol (2001) 1.29

Keratinocyte-derived monocyte chemoattractant protein 1 (MCP-1): analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and Langerhans cells to skin. J Invest Dermatol (1995) 1.28

The role of chemokines in allergic contact dermatitis. Arch Dermatol Res (2002) 1.22

Biology of Langerhans cells: selective migration of Langerhans cells into allogeneic and xenogeneic grafts on nude mice. Proc Natl Acad Sci U S A (1983) 1.18

Multistep navigation of Langerhans/dendritic cells in and out of the skin. J Allergy Clin Immunol (2001) 1.15

Dendritic leukocytes: features of their in vivo physiology. Res Immunol (1990) 1.12

Monocyte chemotaxis and activating factor production by keratinocytes in response to IFN-gamma. J Immunol (1991) 1.09

Epidermal Langerhans cells--a cycling cell population. J Invest Dermatol (1985) 1.08

Ontogeny of Langerhans cells in human embryonic and fetal skin: expression of HLA-DR and OKT-6 determinants. J Invest Dermatol (1986) 1.05

The kinetics of allergen-induced transcription of messenger RNA for monocyte chemotactic protein-3 and RANTES in the skin of human atopic subjects: relationship to eosinophil, T cell, and macrophage recruitment. J Exp Med (1995) 1.04

The origin of Langerhans cells. J Invest Dermatol (1980) 0.97

Biology of Langerhans cells: analysis by experiments to deplete Langerhans cells from human skin. J Invest Dermatol (1984) 0.95

Epidermal Langerhans cells undergo mitosis during the early recovery phase after ultraviolet-B irradiation. J Invest Dermatol (1987) 0.94

An immunohistochemical and immunoelectron microscopic study of the ontogeny of rat Langerhans cell lineage with anti-macrophage and anti-Ia monoclonal antibodies. J Invest Dermatol (1989) 0.94

Development of ATPase-positive, immature Langerhans cells in the fetal mouse epidermis and their maturation during the early postnatal period. Cell Tissue Res (1987) 0.93

Murine epidermal Langerhans cells as a model to study tissue dendritic cells. Adv Exp Med Biol (1993) 0.92

The steady-state turnover of murine epidermal Langerhans cells. Br J Dermatol (1999) 0.90

The repopulation of murine Langerhans cells after depletion by mild heat injury. Br J Dermatol (1999) 0.85

Articles by these authors

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 17.42

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35

Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86

A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature (2004) 12.72

Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med (2004) 11.29

Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature (2005) 11.23

CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44

Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31

Little evidence for developmental plasticity of adult hematopoietic stem cells. Science (2002) 9.63

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature (2004) 8.36

Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol (2002) 7.78

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature (2007) 7.72

CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature (2006) 7.17

Development of a human adaptive immune system in cord blood cell-transplanted mice. Science (2004) 7.07

Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest (2007) 7.02

Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A (2005) 6.32

Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06

Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science (2007) 6.04

Stems cells and the pathways to aging and cancer. Cell (2008) 5.99

Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med (2005) 5.68

Germinal-center organization and cellular dynamics. Immunity (2007) 5.62

Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science (2005) 5.50

CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell (2009) 5.30

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell (2007) 5.28

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell (2009) 5.22

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol (2007) 5.22

Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc Natl Acad Sci U S A (2006) 5.21

Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. Cell (2004) 5.20

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med (2011) 5.16

Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol (2007) 5.14

Plasticity of adult stem cells. Cell (2004) 5.13

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature (2010) 5.05

Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol (2007) 4.91

Imaging of germinal center selection events during affinity maturation. Science (2006) 4.86

Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev (2003) 4.71

In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation (2006) 4.48

Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nat Immunol (2007) 4.46

Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol (2007) 4.42

Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci U S A (2003) 4.41

Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell (2002) 4.37

Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol (2006) 4.32

JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell (2004) 4.28

Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol (2004) 4.22

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20

Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci U S A (2003) 4.09

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med (2012) 4.05

Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med (2008) 4.04

Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol (2005) 4.01

Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity (2004) 4.00

Coronary arteries form by developmental reprogramming of venous cells. Nature (2010) 3.95

Cancer stem cells in solid tumors. Curr Opin Biotechnol (2007) 3.91

Endochondral ossification is required for haematopoietic stem-cell niche formation. Nature (2008) 3.87

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A (2009) 3.87

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat Med (2009) 3.82

Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding. Nat Biotechnol (2011) 3.81

Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med (2003) 3.74

Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol (2004) 3.65

Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat Immunol (2007) 3.63

Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell (2007) 3.59

Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci U S A (2002) 3.50

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci U S A (2010) 3.41

Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol (2007) 3.41

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci U S A (2014) 3.39

Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell (2010) 3.37

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature (2002) 3.35

Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A (2008) 3.27

Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (2013) 3.25

Dendritic cell homeostasis. Blood (2009) 3.18

Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med (2004) 3.17

Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet (2005) 3.11

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J Exp Med (2009) 3.07

Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice. Proc Natl Acad Sci U S A (2006) 3.07

S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity (2007) 3.05

An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nat Biotechnol (2011) 3.05

Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip. Nature (2011) 3.03

Integrin-mediated long-term B cell retention in the splenic marginal zone. Science (2002) 3.00

Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity (2005) 2.97

Isolation and characterization of a protochordate histocompatibility locus. Nature (2005) 2.96

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci U S A (2011) 2.96

Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med (2002) 2.96

The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci U S A (2006) 2.94

Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system. Annu Rev Med (2005) 2.92

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88

Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. PLoS One (2008) 2.85

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci U S A (2006) 2.83

Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci Transl Med (2010) 2.79

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A (2009) 2.76

FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant (2004) 2.70

Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science (2007) 2.69

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy. Blood (2011) 2.69