Published in Development on October 01, 2009
Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS Genet (2012) 1.64
Heterogeneity and plasticity of epidermal stem cells. Development (2014) 1.08
Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation. Dev Biol (2010) 1.06
Architectural niche organization by LHX2 is linked to hair follicle stem cell function. Cell Stem Cell (2013) 1.04
MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability. PLoS One (2012) 1.00
Getting to the heart of myocardial stem cells and cell therapy. Circulation (2011) 0.95
CASK (LIN2) interacts with Cx43 in wounded skin and their coexpression affects cell migration. J Cell Sci (2012) 0.93
β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition. J Pathol (2012) 0.92
Delayed cutaneous wound healing and aberrant expression of hair follicle stem cell markers in mice selectively lacking Ctip2 in epidermis. PLoS One (2012) 0.88
Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1. Mol Cancer (2012) 0.86
Tension of knotted surgical sutures shows tissue specific rapid loss in a rodent model. BMC Surg (2011) 0.85
Interaction of nectin-like molecule 2 with integrin alpha6beta4 and inhibition of disassembly of integrin alpha6beta4 from hemidesmosomes. J Biol Chem (2011) 0.82
Beneficial autoimmunity at body surfaces - immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer. Front Immunol (2014) 0.79
Suppression of metastasis by mirtazapine via restoration of the Lin-7C/β-catenin pathway in human cancer cells. Sci Rep (2014) 0.79
CADM1 controls actin cytoskeleton assembly and regulates extracellular matrix adhesion in human mast cells. PLoS One (2014) 0.79
Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer. Clin Cancer Res (2010) 0.78
Dynamic regulation of a cell adhesion protein complex including CADM1 by combinatorial analysis of FRAP with exponential curve-fitting. PLoS One (2015) 0.77
Genetic variants in Cell Adhesion Molecule 1 (CADM1): a validation study of a novel endothelial cell venous thrombosis risk factor. Thromb Res (2014) 0.75
Defining the epithelial stem cell niche in skin. Science (2003) 14.93
Met, metastasis, motility and more. Nat Rev Mol Cell Biol (2003) 14.30
Wound repair and regeneration. Nature (2008) 12.30
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell (2004) 10.79
Capturing and profiling adult hair follicle stem cells. Nat Biotechnol (2004) 10.35
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell (2001) 8.41
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med (2005) 8.01
Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev (2006) 5.45
Sticky business: orchestrating cellular signals at adherens junctions. Cell (2003) 4.91
Links between signal transduction, transcription and adhesion in epithelial bud development. Nature (2003) 4.88
Scratching the surface of skin development. Nature (2007) 4.61
The tortoise and the hair: slow-cycling cells in the stem cell race. Cell (2009) 3.90
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development (2003) 3.84
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell (2009) 3.44
Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J (2002) 3.44
Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J Clin Invest (2006) 3.41
Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes. EMBO J (2000) 3.32
Stem cell depletion through epidermal deletion of Rac1. Science (2005) 3.26
Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development (2004) 3.24
Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat Rev Mol Cell Biol (2008) 2.93
Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. Proc Natl Acad Sci U S A (2006) 2.91
Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. Dev Cell (2005) 2.71
Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters. Curr Biol (2000) 2.58
Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia. Nat Genet (2000) 2.39
c-Myc promotes differentiation of human epidermal stem cells. Genes Dev (1997) 2.37
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization. Cancer Sci (2003) 2.03
Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A (2004) 1.99
Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. J Biol Chem (2005) 1.90
Epidermal stem cells: an update. Curr Opin Genet Dev (2006) 1.87
Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem (2003) 1.86
Skin gammadelta T-cell functions in homeostasis and wound healing. Immunol Rev (2007) 1.69
A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol (2004) 1.63
Mast cells are required for normal healing of skin wounds in mice. FASEB J (2006) 1.50
E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles. EMBO J (2003) 1.44
Involvement of TSLC1 in progression of esophageal squamous cell carcinoma. Cancer Res (2003) 1.27
Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule. Mol Cell Biol (2006) 1.21
Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis. Mol Cell Biol (2006) 1.19
Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily. Mol Cell Biol (2006) 1.17
Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture. J Cell Sci (2007) 1.08
Integrators of epidermal growth and differentiation: distinct functions for beta 1 and beta 4 integrins. Curr Opin Genet Dev (1997) 1.04
Different consequences of beta1 integrin deletion in neonatal and adult mouse epidermis reveal a context-dependent role of integrins in regulating proliferation, differentiation, and intercellular communication. J Invest Dermatol (2005) 1.01
Dermal fibroblast-derived growth factors restore the ability of beta(1) integrin-deficient embryonal stem cells to differentiate into keratinocytes. Dev Biol (2001) 1.01
Up-regulation of loricrin expression by cell adhesion molecule nectin-1 through Rap1-ERK signaling in keratinocytes. J Biol Chem (2007) 0.97
The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer. Cancer Res (2003) 0.97
The epidermal stem cell compartment: variation in expression levels of E-cadherin and catenins within the basal layer of human epidermis. J Histochem Cytochem (1997) 0.95
Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation. J Cell Sci (2008) 0.93
Tumor suppressor in lung cancer (TSLC)1 suppresses epithelial cell scattering and tubulogenesis. J Biol Chem (2005) 0.91
SgIGSF is a novel biliary-epithelial cell adhesion molecule mediating duct/ductule development. Hepatology (2007) 0.90
The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. J Cell Sci (2008) 0.85
Number of mast cells in the peritoneal cavity of mice: influence of microphthalmia transcription factor through transcription of newly found mast cell adhesion molecule, spermatogenic immunoglobulin superfamily. Am J Pathol (2004) 0.79
Distinct roles for the SgIGSF adhesion molecule and c-kit receptor tyrosine kinase in the interaction between mast cells and the mesentery. Biochem Biophys Res Commun (2004) 0.77
Autophagy mediates the mitotic senescence transition. Genes Dev (2009) 6.80
Extracellular-matrix tethering regulates stem-cell fate. Nat Mater (2012) 3.94
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development (2003) 3.84
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell (2013) 3.47
Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell (2009) 3.44
Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol (2010) 3.33
Stem cell depletion through epidermal deletion of Rac1. Science (2005) 3.26
Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development (2004) 3.24
Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat Rev Mol Cell Biol (2008) 2.93
Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. Proc Natl Acad Sci U S A (2006) 2.91
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development (2009) 2.82
Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours. Development (2002) 2.79
Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. Dev Cell (2005) 2.71
Contribution of stem cells and differentiated cells to epidermal tumours. Nat Rev Cancer (2003) 2.69
Lineage tracing. Cell (2012) 2.67
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol (2012) 2.51
Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem (2002) 2.31
Stem cells are dispensable for lung homeostasis but restore airways after injury. Proc Natl Acad Sci U S A (2009) 2.28
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med (2008) 2.25
Epithelial stem cells, wound healing and cancer. Nat Rev Cancer (2012) 2.23
Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment. Development (2003) 2.23
Epidermal stem cell diversity and quiescence. EMBO Mol Med (2009) 2.14
Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science (2010) 2.12
Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development (2006) 2.06
The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells. Development (2006) 2.04
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs. Circ Res (2007) 1.99
Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome. Nat Genet (2005) 1.98
Sic transit gloria: farewell to the epidermal transit amplifying cell? Cell Stem Cell (2007) 1.91
Molecular perspective on tight-junction assembly and epithelial polarity. Adv Drug Deliv Rev (2005) 1.88
The basement membrane of hair follicle stem cells is a muscle cell niche. Cell (2011) 1.88
Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem (2003) 1.86
Defining dermal adipose tissue. Exp Dermatol (2014) 1.84
Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3. Nat Cell Biol (2008) 1.79
Alternative entry receptors for herpes simplex virus and their roles in disease. Cell Host Microbe (2007) 1.78
Nectins establish a checkerboard-like cellular pattern in the auditory epithelium. Science (2011) 1.76
New roles for integrins in squamous-cell carcinoma. Nat Rev Cancer (2006) 1.75
Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis. Nat Protoc (2010) 1.72
Hair follicle dermal papilla cells at a glance. J Cell Sci (2011) 1.72
The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors. Curr Biol (2006) 1.71
Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1. J Cell Biol (2002) 1.65
Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1. J Cell Biol (2006) 1.65
The epidermis comprises autonomous compartments maintained by distinct stem cell populations. Cell Stem Cell (2013) 1.64
Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. J Biol Chem (2003) 1.60
Designer skin: lineage commitment in postnatal epidermis. Trends Cell Biol (2002) 1.59
Nectin: an adhesion molecule involved in formation of synapses. J Cell Biol (2002) 1.57
CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node. J Immunol (2009) 1.57
Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions. Curr Biol (2002) 1.55
Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway. Curr Biol (2003) 1.54
The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. PLoS One (2008) 1.53
Regulation of E-cadherin endocytosis by nectin through afadin, Rap1, and p120ctn. J Biol Chem (2005) 1.52
Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments. J Cell Biol (2004) 1.52
Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. Nat Genet (2005) 1.51
Deficiency of nectin-2 leads to cardiac fibrosis and dysfunction under chronic pressure overload. Hypertension (2009) 1.50
Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release. J Cell Biol (2004) 1.48
The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. PLoS Genet (2011) 1.48
SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release. Neuron (2006) 1.46
Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in Madin-Darby canine kidney cells. J Biol Chem (2005) 1.46
Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. PLoS One (2007) 1.45
Structural and functional associations of apical junctions with cytoskeleton. Biochim Biophys Acta (2007) 1.45
Involvement of Cdc42 and Rac small G proteins in invadopodia formation of RPMI7951 cells. Genes Cells (2003) 1.43
Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin. Development (2011) 1.43
Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells. Proc Natl Acad Sci U S A (2006) 1.42
Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis. Development (2003) 1.42
Human sebaceous tumors harbor inactivating mutations in LEF1. Nat Med (2006) 1.40
Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell (2013) 1.39
Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn (2002) 1.39
Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling. J Cell Sci (2003) 1.37
Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways. J Cell Sci (2003) 1.37
The roles of nectins in cell adhesions: cooperation with other cell adhesion molecules and growth factor receptors. Curr Opin Cell Biol (2007) 1.36
Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. J Clin Invest (2011) 1.35
Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions. J Cell Sci (2007) 1.35
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. Development (2005) 1.34
Nectins and nectin-like molecules: roles in cell adhesion, polarization, movement, and proliferation. IUBMB Life (2006) 1.32
Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery. J Cell Biol (2006) 1.31
Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell (2008) 1.31
Biology and pathology of nectins and nectin-like molecules. Curr Opin Cell Biol (2004) 1.31
Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo. J Invest Dermatol (2011) 1.30
Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis. J Cell Biol (2004) 1.30
She4p/Dim1p interacts with the motor domain of unconventional myosins in the budding yeast, Saccharomyces cerevisiae. Mol Biol Cell (2003) 1.29
Diverse epigenetic strategies interact to control epidermal differentiation. Nat Cell Biol (2012) 1.29
PKA-catalyzed phosphorylation of tomosyn and its implication in Ca2+-dependent exocytosis of neurotransmitter. J Cell Biol (2005) 1.29
Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions. J Invest Dermatol (2004) 1.27
Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions. J Biol Chem (2004) 1.26
A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. J Clin Invest (2004) 1.24
Loss of nectin-2 at Sertoli-spermatid junctions leads to male infertility and correlates with severe spermatozoan head and midpiece malformation, impaired binding to the zona pellucida, and oocyte penetration. Biol Reprod (2003) 1.24
Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth. J Cell Biol (2007) 1.23
Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt. J Cell Sci (2004) 1.22