Published in PLoS One on August 22, 2007
Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95
Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell (2009) 5.51
Open chromatin in pluripotency and reprogramming. Nat Rev Mol Cell Biol (2011) 2.69
More than one way to skin . . . Genes Dev (2008) 1.95
MYC in mammalian epidermis: how can an oncogene stimulate differentiation? Nat Rev Cancer (2008) 1.78
Finding one's niche in the skin. Cell Stem Cell (2009) 1.77
Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell (2010) 1.75
Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell (2013) 1.61
N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor. Cancer Res (2008) 1.52
p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J Cell Biol (2011) 1.39
Epigenetic regulation of gene expression in keratinocytes. J Invest Dermatol (2012) 1.32
Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development (2011) 1.15
Epigenetic responses to environmental change and their evolutionary implications. Philos Trans R Soc Lond B Biol Sci (2009) 1.14
The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin. EMBO J (2011) 1.11
Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development (2011) 1.09
Mechanisms regulating epidermal stem cells. EMBO J (2012) 1.07
Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD. Am J Physiol Lung Cell Mol Physiol (2012) 1.04
Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation. EMBO Mol Med (2010) 1.02
Epigenetic regulation of skin: focus on the Polycomb complex. Cell Mol Life Sci (2012) 0.99
A subset of Drosophila Myc sites remain associated with mitotic chromosomes colocalized with insulator proteins. Nat Commun (2013) 0.97
Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and adipogenic differentiation. Stem Cells Int (2011) 0.96
The regulatory role of c-MYC on HDAC2 and PcG expression in human multipotent stem cells. J Cell Mol Med (2011) 0.93
p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Development (2014) 0.92
Epigenetic regulation of epidermal differentiation. Cold Spring Harb Perspect Med (2014) 0.91
Epithelial stem cells: an epigenetic and Wnt-centric perspective. J Cell Biochem (2010) 0.89
PI3-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation. Cell Res (2009) 0.88
Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. PLoS One (2011) 0.88
A cell cycle role for the epigenetic factor CTCF-L/BORIS. PLoS One (2012) 0.87
Post-translational control of Myc function during differentiation. Cell Cycle (2011) 0.85
Mitochondrial metabolism as a regulator of keratinocyte differentiation. Cell Logist (2013) 0.83
Regeneration of Hair Cells: Making Sense of All the Noise. Pharmaceuticals (Basel) (2011) 0.83
The Epigenetic Regulation of Wound Healing. Adv Wound Care (New Rochelle) (2014) 0.82
Modulatory role of sensory innervation on hair follicle stem cell progeny during wound healing of the rat skin. PLoS One (2012) 0.81
Alteration of skin wound healing in keratinocyte-specific mediator complex subunit 1 null mice. PLoS One (2014) 0.80
Genetically induced cell death in bulge stem cells reveals their redundancy for hair and epidermal regeneration. Stem Cells (2015) 0.78
Epidermal stem cells and their epigenetic regulation. Int J Mol Sci (2013) 0.77
Local microenvironment provides important cues for cell differentiation in lingual epithelia. PLoS One (2012) 0.77
Stem cells behind the barrier. Int J Mol Sci (2013) 0.76
Thyroid hormone signaling controls hair follicle stem cell function. Mol Biol Cell (2015) 0.76
Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells. Front Cell Dev Biol (2017) 0.75
The Role of p16(INK4a) Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer. Int J Mol Sci (2017) 0.75
Translating the histone code. Science (2001) 56.77
Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer (2006) 11.48
Genomic targets of the human c-Myc protein. Genes Dev (2003) 9.67
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem (1990) 9.21
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med (2005) 8.01
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev (2001) 6.36
The c-Myc target gene network. Semin Cancer Biol (2006) 5.98
A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells. Nucleic Acids Res (1990) 4.79
Myc-binding-site recognition in the human genome is determined by chromatin context. Nat Cell Biol (2006) 4.71
Myc influences global chromatin structure. EMBO J (2006) 4.71
Retracted Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1. Nature (2002) 4.18
Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr Biol (2002) 4.12
Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell (2005) 3.98
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol Cell Biol (2000) 3.86
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development (2003) 3.84
Epithelial stem cells: a folliculocentric view. J Invest Dermatol (2006) 3.49
The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis. Development (1999) 3.31
MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep (2003) 3.24
c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol (2001) 3.22
Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet (2001) 3.00
Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner. EMBO J (1995) 2.86
Analysis of genomic targets reveals complex functions of MYC. Nat Rev Cancer (2004) 2.83
Epigenetics and cancer. Genes Dev (2004) 2.72
Contribution of stem cells and differentiated cells to epidermal tumours. Nat Rev Cancer (2003) 2.69
Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50
c-Myc promotes differentiation of human epidermal stem cells. Genes Dev (1997) 2.37
Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment. Development (2003) 2.23
Mechanism of transcriptional activation by the Myc oncoproteins. Semin Cancer Biol (2006) 1.91
Identification and behavior of label-retaining cells in oral mucosa and skin. J Dent Res (1981) 1.88
Epidermal stem cells: an update. Curr Opin Genet Dev (2006) 1.87
A trans-tail histone code defined by monomethylated H4 Lys-20 and H3 Lys-9 demarcates distinct regions of silent chromatin. J Biol Chem (2006) 1.81
Stem cell self-renewal controlled by chromatin remodeling factors. Science (2005) 1.73
The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors. Curr Biol (2006) 1.71
Chromatin remodeling in neural development and plasticity. Curr Opin Cell Biol (2005) 1.70
Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1. J Cell Biol (2006) 1.65
Histone H4-lysine 20 monomethylation is increased in promoter and coding regions of active genes and correlates with hyperacetylation. J Biol Chem (2005) 1.61
Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO J (2004) 1.49
Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis. Development (2003) 1.42
The reorganisation of constitutive heterochromatin in differentiating muscle requires HDAC activity. Exp Cell Res (2005) 1.18
Epigenetic alchemy for cell fate conversion. Curr Opin Genet Dev (2006) 1.12
The role of histone modifications in epigenetic transitions during normal and perturbed development. Ernst Schering Res Found Workshop (2006) 0.96
Inhibition of histone deacetylation promotes abnormal epidermal differentiation and specifically suppresses the expression of the late differentiation marker profilaggrin. J Invest Dermatol (2006) 0.85
Chromatin-modulating agents as epigenetic anticancer drugs--'the die is cast'. Drug Discov Today (2006) 0.77
Chromatin signatures of pluripotent cell lines. Nat Cell Biol (2006) 12.88
Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell (2008) 7.80
Autophagy mediates the mitotic senescence transition. Genes Dev (2009) 6.80
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat Cell Biol (2007) 6.30
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A (2008) 5.97
Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature (2009) 5.96
A role for Dicer in immune regulation. J Exp Med (2006) 5.81
Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science (2002) 5.47
T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med (2005) 5.26
Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Mol Cell (2010) 4.36
Extracellular-matrix tethering regulates stem-cell fate. Nat Mater (2012) 3.94
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development (2003) 3.84
Epigenetic signatures of stem-cell identity. Nat Rev Genet (2007) 3.56
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell (2013) 3.47
Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell (2009) 3.44
Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol (2010) 3.33
Stem cell depletion through epidermal deletion of Rac1. Science (2005) 3.26
Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development (2004) 3.24
Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. Proc Natl Acad Sci U S A (2006) 2.91
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development (2009) 2.82
Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours. Development (2002) 2.79
Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. Dev Cell (2005) 2.71
Contribution of stem cells and differentiated cells to epidermal tumours. Nat Rev Cancer (2003) 2.69
Dynamic assembly of silent chromatin during thymocyte maturation. Nat Genet (2004) 2.68
Lineage tracing. Cell (2012) 2.67
Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity (2007) 2.65
A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature (2011) 2.58
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nat Cell Biol (2010) 2.55
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol (2012) 2.51
Neural induction promotes large-scale chromatin reorganisation of the Mash1 locus. J Cell Sci (2006) 2.37
Stem cells are dispensable for lung homeostasis but restore airways after injury. Proc Natl Acad Sci U S A (2009) 2.28
Epithelial stem cells, wound healing and cancer. Nat Rev Cancer (2012) 2.23
Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment. Development (2003) 2.23
Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication. Nat Cell Biol (2003) 2.21
CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. PLoS Genet (2010) 2.20
Epigenetic programming and reprogramming during development. Nat Struct Mol Biol (2013) 2.13
Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion. Mol Cell (2013) 2.10
Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development (2006) 2.06
Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments. Genome Res (2013) 2.05
The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells. Development (2006) 2.04
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2. PLoS Genet (2008) 2.01
ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell (2010) 1.98
Sic transit gloria: farewell to the epidermal transit amplifying cell? Cell Stem Cell (2007) 1.91
The basement membrane of hair follicle stem cells is a muscle cell niche. Cell (2011) 1.88
Defining dermal adipose tissue. Exp Dermatol (2014) 1.84
Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Mol Cell Biol (2006) 1.81
Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3. Nat Cell Biol (2008) 1.79
Nuclear repositioning marks the selective exclusion of lineage-inappropriate transcription factor loci during T helper cell differentiation. Eur J Immunol (2004) 1.76
New roles for integrins in squamous-cell carcinoma. Nat Rev Cancer (2006) 1.75
Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis. Nat Protoc (2010) 1.72
Hair follicle dermal papilla cells at a glance. J Cell Sci (2011) 1.72
The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors. Curr Biol (2006) 1.71
Chromatin structure and gene regulation in the immune system. Annu Rev Immunol (2001) 1.68
Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes Dev (2009) 1.67
Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1. J Cell Biol (2006) 1.65
Epigenetic aspects of differentiation. J Cell Sci (2004) 1.64
Chromatin states in pluripotent, differentiated, and reprogrammed cells. Curr Opin Genet Dev (2011) 1.62
Designer skin: lineage commitment in postnatal epidermis. Trends Cell Biol (2002) 1.59
Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway. Curr Biol (2003) 1.54
The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. PLoS One (2008) 1.53
Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. Nat Genet (2005) 1.51
Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation. Blood (2013) 1.51
Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO J (2004) 1.49
The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells. Genome Biol (2007) 1.49
The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. PLoS Genet (2011) 1.48
Runx proteins regulate Foxp3 expression. J Exp Med (2009) 1.45
Role of DNA methylation in stable gene repression. J Biol Chem (2007) 1.45
Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin. Development (2011) 1.43
Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis. Development (2003) 1.42
Human sebaceous tumors harbor inactivating mutations in LEF1. Nat Med (2006) 1.40
A dynamic switch in the replication timing of key regulator genes in embryonic stem cells upon neural induction. Cell Cycle (2004) 1.39
Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling. J Cell Sci (2003) 1.37
Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways. J Cell Sci (2003) 1.37
Is REST required for ESC pluripotency? Nature (2009) 1.34
Stem cells primed for action: polycomb repressive complexes restrain the expression of lineage-specific regulators in embryonic stem cells. Cell Cycle (2006) 1.32
Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage. Cell Stem Cell (2010) 1.32
Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell (2008) 1.31
Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo. J Invest Dermatol (2011) 1.30
Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis. J Cell Biol (2004) 1.30
Diverse epigenetic strategies interact to control epidermal differentiation. Nat Cell Biol (2012) 1.29
Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions. J Invest Dermatol (2004) 1.27
REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells. Development (2009) 1.25
Inactive yet indispensable: the tale of Jarid2. Trends Cell Biol (2010) 1.24
Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt. J Cell Sci (2004) 1.22
Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin. Stem Cells (2008) 1.22
Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate. Proc Natl Acad Sci U S A (2010) 1.22
Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier. J Cell Biol (2007) 1.22
What is the point of large-scale collections of human induced pluripotent stem cells? Nat Biotechnol (2013) 1.20
Epidermal label-retaining cells: background and recent applications. J Investig Dermatol Symp Proc (2004) 1.20
The interfollicular epidermis of adult mouse tail comprises two distinct cell lineages that are differentially regulated by Wnt, Edaradd, and Lrig1. Stem Cell Reports (2013) 1.20
Nuclear organisation and gene expression. Curr Opin Cell Biol (2002) 1.19
Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming. J Cell Sci (2006) 1.19
Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling. Dev Biol (2008) 1.19
The reorganisation of constitutive heterochromatin in differentiating muscle requires HDAC activity. Exp Cell Res (2005) 1.18
A tumor-associated beta 1 integrin mutation that abrogates epithelial differentiation control. J Cell Biol (2003) 1.18
A year in the life of eLife. Elife (2013) 1.14
Role of LIM kinases in normal and psoriatic human epidermis. Mol Biol Cell (2006) 1.14
DNA synthesis is required for reprogramming mediated by stem cell fusion. Cell (2013) 1.14
Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis. J Invest Dermatol (2007) 1.11